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Cheap flights from Panama to Detroit from $415

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to Detroit departing on 2/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama to Detroit

Recent round-trip flight deals from Panama to Detroit

Enter your travel dates to find the best prices.
Delta Logo
2:20 pm - 9:24 amPTY-DTW
18h 04m1 stop
Delta Logo
6:30 am - 12:55 pmDTW-PTY
7h 25m1 stop
$791Delta
Find Deal
Fri, Apr 24 - Tue, Apr 28
United Airlines Logo
10:00 am - 11:44 pmPTY-DTW
12h 44m1 stop
United Airlines Logo
2:15 pm - 4:04 amDTW-PTY
14h 49m2 stops
$796United Airlines
Find Deal
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
2:53 pm - 11:57 pmPTY-DTW
9h 04m1 stop
American Airlines Logo
5:30 am - 1:27 pmDTW-PTY
7h 57m1 stop
$864American Airlines
Find Deal
Thu, Jan 1 - Fri, Jan 30
American Airlines Logo
2:53 pm - 11:57 pmPTY-DTW
9h 04m1 stop
American Airlines Logo
6:00 am - 3:38 pmDTW-PTY
9h 38m2 stops
$869American Airlines
Find Deal
Thu, Jan 1 - Fri, Jan 30
American Airlines Logo
1:55 pm - 8:53 amPTY-DTW
17h 58m2 stops
American Airlines Logo
5:52 pm - 12:15 pmDTW-PTY
19h 23m2 stops
$887American Airlines
Find Deal
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
2:53 pm - 11:57 pmPTY-DTW
9h 04m1 stop
American Airlines Logo
5:30 am - 3:38 pmDTW-PTY
10h 08m1 stop
$892American Airlines
Find Deal
Thu, Jan 1 - Fri, Jan 30
American Airlines Logo
2:53 pm - 11:57 pmPTY-DTW
9h 04m1 stop
American Airlines Logo
6:00 am - 3:38 pmDTW-PTY
9h 38m2 stops
$897American Airlines
Find Deal
Thu, Jan 1 - Fri, Jan 30
American Airlines Logo
2:53 pm - 12:12 pmPTY-DTW
21h 19m2 stops
American Airlines Logo
6:00 am - 3:38 pmDTW-PTY
9h 38m2 stops
$929American Airlines
Find Deal
Thu, Jan 1 - Fri, Jan 30
Delta Logo
3:37 pm - 8:00 amPTY-DTW
16h 23m1 stop
Delta Logo
8:05 am - 7:59 pmDTW-PTY
11h 54m1 stop
$985Delta
Find Deal
Mon, Nov 24 - Sat, Nov 29
United Airlines Logo
4:41 pm - 3:27 pmPTY-DTW
22h 46m2 stops
United Airlines Logo
2:17 pm - 2:45 pmDTW-PTY
24h 28m2 stops
$999United Airlines
Find Deal
Mon, Nov 24 - Sat, Nov 29

Delta flights from Panama to Detroit

Our best Delta deals on Panama to Detroit flight tickets
Delta
Apr 24
PTY2:20 pmPanama City Tocumen Intl
18h 04m
1 stop
DTW9:24 amDetroit Metropolitan Wayne County
Apr 28
DTW6:30 amDetroit Metropolitan Wayne County
7h 25m
1 stop
PTY12:55 pmPanama City Tocumen Intl
$791
Find similar
Delta
Nov 24
PTY3:37 pmPanama City Tocumen Intl
16h 23m
1 stop
DTW8:00 amDetroit Metropolitan Wayne County
Nov 29
DTW8:05 amDetroit Metropolitan Wayne County
11h 54m
1 stop
PTY7:59 pmPanama City Tocumen Intl
$985
Find similar

American Airlines flights from Panama to Detroit

Our best American Airlines deals on Panama to Detroit flight tickets
American Airlines
Jan 1
PTY2:53 pmPanama City Tocumen Intl
9h 04m
1 stop
DTW11:57 pmDetroit Metropolitan Wayne County
Jan 30
DTW5:30 amDetroit Metropolitan Wayne County
7h 57m
1 stop
PTY1:27 pmPanama City Tocumen Intl
$864
Find similar
American Airlines
Jan 1
PTY2:53 pmPanama City Tocumen Intl
9h 04m
1 stop
DTW11:57 pmDetroit Metropolitan Wayne County
Jan 30
DTW6:00 amDetroit Metropolitan Wayne County
9h 38m
2 stops
PTY3:38 pmPanama City Tocumen Intl
$869
Find similar
American Airlines
Apr 24
PTY1:55 pmPanama City Tocumen Intl
17h 58m
2 stops
DTW8:53 amDetroit Metropolitan Wayne County
Apr 28
DTW5:52 pmDetroit Metropolitan Wayne County
19h 23m
2 stops
PTY12:15 pmPanama City Tocumen Intl
$887
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Panama to Detroit that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Fri 4/24

2:20 pm-9:24 am

1 stop18h 04m

Detroit Metropolitan Wayne County

Tue 4/28

6:30 am-12:55 pm

1 stop7h 25m

$791

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Fri 4/24

10:00 am-11:44 pm

1 stop12h 44m

Detroit Metropolitan Wayne County

Tue 4/28

2:15 pm-4:04 am

2 stops14h 49m

$796

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Thu 1/1

2:53 pm-11:57 pm

1 stop9h 04m

Detroit Metropolitan Wayne County

Fri 1/30

5:30 am-1:27 pm

1 stop7h 57m

$864

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Thu 1/1

2:53 pm-11:57 pm

1 stop9h 04m

Detroit Metropolitan Wayne County

Fri 1/30

6:00 am-3:38 pm

2 stops9h 38m

$869

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Fri 4/24

1:55 pm-8:53 am

2 stops17h 58m

Detroit Metropolitan Wayne County

Tue 4/28

5:52 pm-12:15 pm

2 stops19h 23m

$887

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Thu 1/1

2:53 pm-11:57 pm

1 stop9h 04m

Detroit Metropolitan Wayne County

Fri 1/30

5:30 am-3:38 pm

1 stop10h 08m

$892

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Thu 1/1

2:53 pm-11:57 pm

1 stop9h 04m

Detroit Metropolitan Wayne County

Fri 1/30

6:00 am-3:38 pm

2 stops9h 38m

$897

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Thu 1/1

2:53 pm-12:12 pm

2 stops21h 19m

Detroit Metropolitan Wayne County

Fri 1/30

6:00 am-3:38 pm

2 stops9h 38m

$929

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Mon 11/24

3:37 pm-8:00 am

1 stop16h 23m

Detroit Metropolitan Wayne County

Sat 11/29

8:05 am-7:59 pm

1 stop11h 54m

$985

Panama CityDetroit

PTY - DTW

PTYDTW

Panama City Tocumen Intl

Mon 11/24

4:41 pm-3:27 pm

2 stops22h 46m

Detroit Metropolitan Wayne County

Sat 11/29

2:17 pm-2:45 pm

2 stops24h 28m

$999

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from Panama to Detroit

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Detroit?

On average, the least expensive day to fly to Detroit from Panama is on a Thursday. momondo users have found tickets for Thursday departures for as low as $625. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Panama to Detroit for around $773.

What is the cheapest time of day to depart on your flight to Detroit?

At noon is the cheapest time of day to fly from Panama to Detroit when you can find flight prices for as low as $733. Flying to Detroit at noon is an ideal time because this is during off-peak travel hours. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $738 on average. Flights to Detroit from Panama in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

Cheap Panama to Detroit flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to Detroit

Direct flights

None
There are no direct flights from Panama to Detroit. There are no popular flight routes from Panama to Detroit.
Search flight deals

  • When did momondo last update prices for flights from Panama to Detroit?

    Prices for flights from Panama to Detroit are refreshed on a daily basis.

  • How old do you have to be to fly from Panama to Detroit?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to Detroit.

  • What documentation or ID do you need to fly to Detroit?

    The travel and health documents required for your trip to Detroit can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Detroit. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Port Huron
Roseville

Why use momondo?

Why should I use momondo to find a flight deal from Panama to Detroit?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama to Detroit for you.

Can I find flights from Panama to Detroit with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Detroit from Panama with this policy.

How can momondo help me find flights from Panama to Detroit?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to Detroit.

I’m not ready to book a flight from Panama to Detroit right now. Can momondo alert me if prices change?

Price alerts on flights to Detroit from Panama are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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