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Cheap flights from Panama City to Charleston from $386

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Charleston departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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American Airlines Logo
2:27 pm - 11:55 pmPTY-CHS
9h 28m1 stop
American Airlines Logo
9:37 am - 3:00 pmCHS-PTY
5h 23m1 stop
$386American Airlines
Find Deal
Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:27 pm - 11:41 amPTY-CHS
21h 14m2 stops
American Airlines Logo
9:37 am - 3:00 pmCHS-PTY
5h 23m1 stop
$390American Airlines
Find Deal
Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:27 pm - 9:48 amPTY-CHS
19h 21m2 stops
American Airlines Logo
6:30 pm - 1:10 pmCHS-PTY
18h 40m2 stops
$409American Airlines
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Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:53 pm - 5:23 pmPTY-CHS
26h 30m1 stop
American Airlines Logo
6:00 am - 1:53 pmCHS-PTY
7h 53m1 stop
$411American Airlines
Find Deal
Wed, Dec 24 - Sat, Jan 3
American Airlines Logo
2:53 pm - 2:20 pmPTY-CHS
23h 27m2 stops
American Airlines Logo
8:08 pm - 1:53 pmCHS-PTY
17h 45m2 stops
$416American Airlines
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Wed, Dec 24 - Sat, Jan 3
Multiple Airlines Logo
7:50 pm - 1:30 pmPTY-CHS
17h 40m2 stops
Multiple Airlines Logo
2:35 pm - 6:55 pmCHS-PTY
28h 20m3 stops
$1,004Multiple Airlines
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Wed, Dec 24 - Sat, Jan 3
Multiple Airlines Logo
11:25 am - 1:30 pmPTY-CHS
26h 05m3 stops
Multiple Airlines Logo
2:35 pm - 6:55 pmCHS-PTY
28h 20m3 stops
$1,024Multiple Airlines
Find Deal
Wed, Dec 24 - Sat, Jan 3

American Airlines flights from Panama City to Charleston

Our best American Airlines deals on Panama City to Charleston flight tickets
American Airlines
Feb 6
PTY2:27 pmPanama City Tocumen Intl
9h 28m
1 stop
CHS11:55 pmCharleston
Mar 6
CHS9:37 amCharleston
5h 23m
1 stop
PTY3:00 pmPanama City Tocumen Intl
$386
Find similar
American Airlines
Feb 6
PTY2:27 pmPanama City Tocumen Intl
21h 14m
2 stops
CHS11:41 amCharleston
Mar 6
CHS9:37 amCharleston
5h 23m
1 stop
PTY3:00 pmPanama City Tocumen Intl
$390
Find similar
American Airlines
Feb 6
PTY2:27 pmPanama City Tocumen Intl
19h 21m
2 stops
CHS9:48 amCharleston
Mar 6
CHS6:30 pmCharleston
18h 40m
2 stops
PTY1:10 pmPanama City Tocumen Intl
$409
Find similar

United Airlines flights from Panama City to Charleston

Our best United Airlines deals on Panama City to Charleston flight tickets
United Airlines
Oct 17
PTY10:00 amPanama City Tocumen Intl
29h 44m
1 stop
CHS4:44 pmCharleston
Nov 1
CHS5:05 pmCharleston
22h 40m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$583
Find similar
United Airlines
Oct 17
PTY3:30 pmPanama City Tocumen Intl
24h 14m
1 stop
CHS4:44 pmCharleston
Nov 1
CHS5:05 pmCharleston
27h 33m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$601
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momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Panama City to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 2/6

2:27 pm-11:55 pm

1 stop9h 28m

Charleston

Fri 3/6

9:37 am-3:00 pm

1 stop5h 23m

$386

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 2/6

2:27 pm-11:41 am

2 stops21h 14m

Charleston

Fri 3/6

9:37 am-3:00 pm

1 stop5h 23m

$390

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 2/6

2:27 pm-9:48 am

2 stops19h 21m

Charleston

Fri 3/6

6:30 pm-1:10 pm

2 stops18h 40m

$409

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 12/24

2:53 pm-5:23 pm

1 stop26h 30m

Charleston

Sat 1/3

6:00 am-1:53 pm

1 stop7h 53m

$411

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 12/24

2:53 pm-2:20 pm

2 stops23h 27m

Charleston

Sat 1/3

8:08 pm-1:53 pm

2 stops17h 45m

$416

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 12/24

7:50 pm-1:30 pm

2 stops17h 40m

Charleston

Sat 1/3

2:35 pm-6:55 pm

3 stops28h 20m

$1,004

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 12/24

11:25 am-1:30 pm

3 stops26h 05m

Charleston

Sat 1/3

2:35 pm-6:55 pm

3 stops28h 20m

$1,024

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Charleston from

How to get the cheapest flight ticket from Panama City to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Charleston?

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Panama City to Charleston is on a Wednesday. Travelers who choose to depart for Charleston on a Wednesday will often find tickets for as low as $502. The most expensive day to fly to Charleston is Sunday, with ticket prices averaging around $552.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the evening when flights can be purchased for as low as $469. In the afternoon is when there is more demand to fly to Charleston, so prices are often more expensive at around $554 per ticket.

When to book flights from Panama City to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Charleston (PTY to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Charleston

Direct flights

None
There are no direct flights from Panama City to Charleston. There are no popular flight routes from Panama City to Charleston.
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  • How far is Panama City Tocumen Intl to Charleston by plane?

    The distance between Panama City Tocumen Intl and Charleston is about 1643.0 mi. A reasonable flight in good conditions will take 9h 28m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Charleston Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Charleston Airport refresh daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Charleston Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Charleston Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The required travel and health documents for your Charleston Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Charleston Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Panama City to Charleston?

Best airlines flying from Panama City to Charleston

Compare and see reviews for airlines that fly from Panama City to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $397Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Charleston?

It is quick and easy to find Panama City to Charleston flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Charleston that suits you.

Can I find flights from Panama City to Charleston with flexible booking policies on momondo?

momondo does allow users to show only those flights to Charleston from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Charleston?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Charleston.

I’m not ready to book a flight from Panama City to Charleston right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Charleston flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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