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Cheap flights from Panama City, Florida to Key West from $377

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Key West departing on 5/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:50 pm - 7:49 pm
ECP
-
EYW
4h 59m
1 stop
Delta Logo
7:30 am - 10:53 am
EYW
-
ECP
4h 23m
1 stop
$377Delta
Fri, May 15 - Tue, May 19
American Airlines Logo
4:40 pm - 10:36 pm
ECP
-
EYW
4h 56m
1 stop
American Airlines Logo
3:58 pm - 11:46 pm
EYW
-
ECP
8h 48m
2 stops
$392American Airlines
Sat, May 2 - Sat, May 9
Delta Logo
5:49 am - 10:46 am
ECP
-
EYW
3h 57m
1 stop
Delta Logo
6:18 pm - 11:12 pm
EYW
-
ECP
5h 54m
1 stop
$464Delta
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
11:00 am - 6:47 pm
ECP
-
EYW
6h 47m
1 stop
American Airlines Logo
7:29 pm - 11:37 pm
EYW
-
ECP
5h 08m
1 stop
$473American Airlines
Sat, Jul 4 - Sat, Jul 11
American Airlines Logo
7:05 am - 7:25 pm
ECP
-
EYW
11h 20m
2 stops
American Airlines Logo
7:29 pm - 11:37 pm
EYW
-
ECP
5h 08m
1 stop
$478American Airlines
Sat, Jul 4 - Sat, Jul 11
American Airlines Logo
4:40 pm - 10:36 pm
ECP
-
EYW
4h 56m
1 stop
American Airlines Logo
8:20 am - 3:23 pm
EYW
-
ECP
8h 03m
1 stop
$484American Airlines
Sat, May 16 - Tue, May 19
Delta Logo
5:49 am - 10:46 am
ECP
-
EYW
3h 57m
1 stop
Delta Logo
6:18 pm - 11:12 pm
EYW
-
ECP
5h 54m
1 stop
$489Delta
Thu, Apr 23 - Sat, Apr 25
American Airlines Logo
7:21 am - 4:30 pm
ECP
-
EYW
8h 09m
2 stops
American Airlines Logo
3:58 pm - 11:46 pm
EYW
-
ECP
8h 48m
2 stops
$494American Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
11:14 am - 6:27 pm
ECP
-
EYW
6h 13m
2 stops
American Airlines Logo
3:00 pm - 6:50 pm
EYW
-
ECP
4h 50m
1 stop
$498American Airlines
Wed, Sep 9 - Sun, Sep 13
Delta Logo
2:47 pm - 7:45 pm
ECP
-
EYW
3h 58m
1 stop
Delta Logo
2:35 pm - 7:36 pm
EYW
-
ECP
6h 01m
1 stop
$503Delta
Sun, Jul 26 - Sun, Aug 2

Delta flights from Panama City, Florida to Key West

Our best Delta deals on Panama City, Florida to Key West flight tickets
Delta
May 15
ECP1:50 pmPanama City NW Florida Beaches
4h 59m
1 stop
EYW7:49 pmKey West
May 19
EYW7:30 amKey West
4h 23m
1 stop
ECP10:53 amPanama City NW Florida Beaches
$377
Delta
Apr 22
ECP5:49 amPanama City NW Florida Beaches
3h 57m
1 stop
EYW10:46 amKey West
Apr 25
EYW6:18 pmKey West
5h 54m
1 stop
ECP11:12 pmPanama City NW Florida Beaches
$464
Delta
Apr 23
ECP5:49 amPanama City NW Florida Beaches
3h 57m
1 stop
EYW10:46 amKey West
Apr 25
EYW6:18 pmKey West
5h 54m
1 stop
ECP11:12 pmPanama City NW Florida Beaches
$489

American Airlines flights from Panama City, Florida to Key West

Our best American Airlines deals on Panama City, Florida to Key West flight tickets
American Airlines
May 2
ECP4:40 pmPanama City NW Florida Beaches
4h 56m
1 stop
EYW10:36 pmKey West
May 9
EYW3:58 pmKey West
8h 48m
2 stops
ECP11:46 pmPanama City NW Florida Beaches
$392
American Airlines
Jul 4
ECP11:00 amPanama City NW Florida Beaches
6h 47m
1 stop
EYW6:47 pmKey West
Jul 11
EYW7:29 pmKey West
5h 08m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$473
American Airlines
Jul 4
ECP7:05 amPanama City NW Florida Beaches
11h 20m
2 stops
EYW7:25 pmKey West
Jul 11
EYW7:29 pmKey West
5h 08m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$478

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 5/15

1:50 pm-7:49 pm

1 stop4h 59m

Key West

Tue 5/19

7:30 am-10:53 am

1 stop4h 23m

$377

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 5/2

4:40 pm-10:36 pm

1 stop4h 56m

Key West

Sat 5/9

3:58 pm-11:46 pm

2 stops8h 48m

$392

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/22

5:49 am-10:46 am

1 stop3h 57m

Key West

Sat 4/25

6:18 pm-11:12 pm

1 stop5h 54m

$464

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 7/4

11:00 am-6:47 pm

1 stop6h 47m

Key West

Sat 7/11

7:29 pm-11:37 pm

1 stop5h 08m

$473

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 7/4

7:05 am-7:25 pm

2 stops11h 20m

Key West

Sat 7/11

7:29 pm-11:37 pm

1 stop5h 08m

$478

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 5/16

4:40 pm-10:36 pm

1 stop4h 56m

Key West

Tue 5/19

8:20 am-3:23 pm

1 stop8h 03m

$484

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 4/23

5:49 am-10:46 am

1 stop3h 57m

Key West

Sat 4/25

6:18 pm-11:12 pm

1 stop5h 54m

$489

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/22

7:21 am-4:30 pm

2 stops8h 09m

Key West

Sat 4/25

3:58 pm-11:46 pm

2 stops8h 48m

$494

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 9/9

11:14 am-6:27 pm

2 stops6h 13m

Key West

Sun 9/13

3:00 pm-6:50 pm

1 stop4h 50m

$498

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sun 7/26

2:47 pm-7:45 pm

1 stop3h 58m

Key West

Sun 8/2

2:35 pm-7:36 pm

1 stop6h 01m

$503

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Panama City, Florida to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and Key West?

What is the cheapest month to fly to Key West?

In general, October is the cheapest month to fly from Panama City, Florida to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $306. If you are unable to visit Key West during the month of October, then departing from Panama City, Florida during the month February is also very affordable. Most momondo users find prices during this month for around $332.

When to book flights from Panama City, Florida to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Key West (ECP to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Key West

Fastest flight time

3h 48m

Direct flights

None
The fastest flight from Panama City, Florida to Key West takes 3h 48m
There are no direct flights from Panama City, Florida to Key West. There are no popular flight routes from Panama City, Florida to Key West.
Search flight deals

  • How far is Panama City NW Florida Beaches to Key West by plane?

    Panama City NW Florida Beaches and Key West are 453.5 mi apart from one another. 3h 48m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Key West Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Key West Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Key West Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Key West?

Best airlines flying from Panama City, Florida to Key West

Compare and see reviews for airlines that fly from Panama City, Florida to Key West with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.1
11,468 reviews
Search American Airlines flights
DeltaPriceFrom $306Free CancellationRating
7.9
8,288 reviews
Search Delta flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Key West?

It is quick and easy to find Panama City to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Panama City to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Key West?

Once all potential Panama City to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Key West right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Key West from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Key West trip

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