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Cheap flights from Panama City, Florida to Key West from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Key West departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:32 pm - 8:06 pmECP-EYW
5h 34m1 stop
Delta Logo
6:10 pm - 10:37 pmEYW-ECP
5h 27m1 stop
$317Delta
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Thu, Dec 11 - Tue, Dec 16
American Airlines Logo
2:43 pm - 9:45 pmECP-EYW
6h 02m1 stop
American Airlines Logo
1:33 pm - 11:10 pmEYW-ECP
10h 37m2 stops
$322American Airlines
Find Deal
Thu, Dec 11 - Tue, Dec 16
Delta Logo
10:01 am - 5:13 pmECP-EYW
6h 12m1 stop
Delta Logo
7:10 am - 12:47 pmEYW-ECP
6h 37m1 stop
$327Delta
Find Deal
Mon, Jan 5 - Mon, Jan 12
Delta Logo
6:00 am - 2:03 pmECP-EYW
7h 03m1 stop
Delta Logo
2:58 pm - 8:32 pmEYW-ECP
6h 34m1 stop
$419Delta
Find Deal
Fri, Nov 14 - Sun, Nov 16
Delta Logo
6:00 am - 2:03 pmECP-EYW
7h 03m1 stop
Delta Logo
7:40 am - 12:47 pmEYW-ECP
6h 07m1 stop
$434Delta
Find Deal
Fri, Nov 14 - Mon, Nov 17
American Airlines Logo
2:37 pm - 9:47 pmECP-EYW
6h 10m1 stop
American Airlines Logo
4:53 pm - 11:49 pmEYW-ECP
7h 56m1 stop
$483American Airlines
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Fri, Nov 21 - Wed, Nov 26
American Airlines Logo
7:15 am - 5:06 pmECP-EYW
8h 51m2 stops
American Airlines Logo
4:53 pm - 11:49 pmEYW-ECP
7h 56m1 stop
$488American Airlines
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Fri, Nov 21 - Wed, Nov 26
United Airlines Logo
2:22 pm - 1:46 pmECP-EYW
22h 24m3 stops
United Airlines Logo
4:00 pm - 4:04 pmEYW-ECP
25h 04m2 stops
$880United Airlines
Find Deal
Sat, Nov 22 - Wed, Nov 26
United Airlines Logo
3:00 pm - 2:04 pmECP-EYW
22h 04m3 stops
United Airlines Logo
4:00 pm - 9:19 amEYW-ECP
18h 19m2 stops
$918United Airlines
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Mon, Nov 17 - Fri, Nov 21
United Airlines Logo
3:00 pm - 2:04 pmECP-EYW
22h 04m3 stops
United Airlines Logo
4:00 pm - 9:19 amEYW-ECP
18h 19m2 stops
$958United Airlines
Find Deal
Mon, Nov 17 - Fri, Nov 21

Delta flights from Panama City, Florida to Key West

Our best Delta deals on Panama City, Florida to Key West flight tickets
Delta
Dec 11
ECP1:32 pmPanama City NW Florida Beaches
5h 34m
1 stop
EYW8:06 pmKey West
Dec 16
EYW6:10 pmKey West
5h 27m
1 stop
ECP10:37 pmPanama City NW Florida Beaches
$317
Find similar
Delta
Jan 5
ECP10:01 amPanama City NW Florida Beaches
6h 12m
1 stop
EYW5:13 pmKey West
Jan 12
EYW7:10 amKey West
6h 37m
1 stop
ECP12:47 pmPanama City NW Florida Beaches
$327
Find similar
Delta
Nov 14
ECP6:00 amPanama City NW Florida Beaches
7h 03m
1 stop
EYW2:03 pmKey West
Nov 16
EYW2:58 pmKey West
6h 34m
1 stop
ECP8:32 pmPanama City NW Florida Beaches
$419
Find similar

United Airlines flights from Panama City, Florida to Key West

Our best United Airlines deals on Panama City, Florida to Key West flight tickets
United Airlines
Nov 22
ECP2:22 pmPanama City NW Florida Beaches
22h 24m
3 stops
EYW1:46 pmKey West
Nov 26
EYW4:00 pmKey West
25h 04m
2 stops
ECP4:04 pmPanama City NW Florida Beaches
$880
Find similar
United Airlines
Nov 17
ECP3:00 pmPanama City NW Florida Beaches
22h 04m
3 stops
EYW2:04 pmKey West
Nov 21
EYW4:00 pmKey West
18h 19m
2 stops
ECP9:19 amPanama City NW Florida Beaches
$918
Find similar
United Airlines
Nov 17
ECP3:00 pmPanama City NW Florida Beaches
22h 04m
3 stops
EYW2:04 pmKey West
Nov 21
EYW4:00 pmKey West
18h 19m
2 stops
ECP9:19 amPanama City NW Florida Beaches
$958
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Tue 12/16

6:10 pm-10:37 pm

1 stop5h 27m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

2:43 pm-9:45 pm

1 stop6h 02m

Key West

Tue 12/16

1:33 pm-11:10 pm

2 stops10h 37m

$322

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 1/5

10:01 am-5:13 pm

1 stop6h 12m

Key West

Mon 1/12

7:10 am-12:47 pm

1 stop6h 37m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/14

6:00 am-2:03 pm

1 stop7h 03m

Key West

Sun 11/16

2:58 pm-8:32 pm

1 stop6h 34m

$419

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/14

6:00 am-2:03 pm

1 stop7h 03m

Key West

Mon 11/17

7:40 am-12:47 pm

1 stop6h 07m

$434

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/21

2:37 pm-9:47 pm

1 stop6h 10m

Key West

Wed 11/26

4:53 pm-11:49 pm

1 stop7h 56m

$483

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 11/21

7:15 am-5:06 pm

2 stops8h 51m

Key West

Wed 11/26

4:53 pm-11:49 pm

1 stop7h 56m

$488

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Sat 11/22

2:22 pm-1:46 pm

3 stops22h 24m

Key West

Wed 11/26

4:00 pm-4:04 pm

2 stops25h 04m

$880

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 11/17

3:00 pm-2:04 pm

3 stops22h 04m

Key West

Fri 11/21

4:00 pm-9:19 am

2 stops18h 19m

$918

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 11/17

3:00 pm-2:04 pm

3 stops22h 04m

Key West

Fri 11/21

4:00 pm-9:19 am

2 stops18h 19m

$958

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Panama City, Florida to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, October is the cheapest month to fly from Panama City, Florida to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $306. If you are unable to visit Key West during the month of October, then departing from Panama City, Florida during the month July is also very affordable. Most momondo users find prices during this month for around $392.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Panama City, Florida is on a Sunday. momondo users have found tickets for Sunday departures for as low as $414. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Panama City, Florida to Key West for around $628.

When to book flights from Panama City, Florida to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Key West (ECP to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Key West

Direct flights

None
There are no direct flights from Panama City, Florida to Key West. There are no popular flight routes from Panama City, Florida to Key West.
Search flight deals

  • How far is Panama City NW Florida Beaches to Key West by plane?

    Panama City NW Florida Beaches and Key West are 453.5 mi apart from one another. 4h 31m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Key West Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Key West Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Key West Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Key West?

Best airlines flying from Panama City, Florida to Key West

Compare and see reviews for airlines that fly from Panama City, Florida to Key West with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $306Free CancellationRating
7.9
8,003 reviews
Search Delta flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Key West?

It is quick and easy to find Panama City to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Panama City to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Key West?

Once all potential Panama City to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Key West right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Key West from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Key West trip

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