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Cheap flights from Panama City, Florida to Key West from $268

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Key West departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:38 am - 5:23 pm
ECP
-
EYW
4h 45m
1 stop
Delta Logo
1:59 pm - 6:35 pm
EYW
-
ECP
5h 36m
1 stop
$347Delta
Wed, Jul 29 - Wed, Aug 5
Delta Logo
1:36 pm - 7:51 pm
ECP
-
EYW
5h 15m
1 stop
Delta Logo
2:24 pm - 6:50 pm
EYW
-
ECP
5h 26m
1 stop
$357Delta
Thu, Jul 16 - Wed, Jul 22
Delta Logo
1:36 pm - 7:51 pm
ECP
-
EYW
5h 15m
1 stop
Delta Logo
7:50 am - 1:54 pm
EYW
-
ECP
7h 04m
1 stop
$367Delta
Fri, Jul 17 - Fri, Jul 24
Delta Logo
2:47 pm - 7:51 pm
ECP
-
EYW
4h 04m
1 stop
Delta Logo
7:50 am - 12:31 pm
EYW
-
ECP
5h 41m
1 stop
$377Delta
Tue, Jul 7 - Thu, Jul 16
Delta Logo
6:00 am - 11:00 am
ECP
-
EYW
4h 00m
1 stop
Delta Logo
6:18 pm - 11:37 pm
EYW
-
ECP
6h 19m
1 stop
$387Delta
Fri, Jul 10 - Mon, Jul 13
Delta Logo
11:43 am - 7:53 pm
ECP
-
EYW
7h 10m
1 stop
Delta Logo
7:50 am - 1:54 pm
EYW
-
ECP
7h 04m
1 stop
$403Delta
Mon, Jun 29 - Thu, Jul 9
American Airlines Logo
11:00 am - 6:49 pm
ECP
-
EYW
6h 49m
1 stop
American Airlines Logo
7:33 pm - 11:37 pm
EYW
-
ECP
5h 04m
1 stop
$413American Airlines
Mon, Jun 29 - Tue, Jul 28
Delta Logo
6:00 am - 10:47 am
ECP
-
EYW
3h 47m
1 stop
Delta Logo
6:00 pm - 10:46 pm
EYW
-
ECP
5h 46m
1 stop
$428Delta
Wed, Sep 9 - Sun, Sep 13
Delta Logo
6:00 am - 10:47 am
ECP
-
EYW
3h 47m
1 stop
Delta Logo
6:00 pm - 10:46 pm
EYW
-
ECP
5h 46m
1 stop
$433Delta
Wed, Sep 9 - Sun, Sep 13
American Airlines Logo
7:05 am - 4:11 pm
ECP
-
EYW
8h 06m
1 stop
American Airlines Logo
7:33 pm - 11:37 pm
EYW
-
ECP
5h 04m
1 stop
$447American Airlines
Wed, Jul 8 - Fri, Jul 17

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American Airlines flights from Panama City, Florida to Key West

Our best American Airlines deals on Panama City, Florida to Key West flight tickets
American Airlines
Jun 29
ECP11:00 amPanama City NW Florida Beaches
6h 49m
1 stop
EYW6:49 pmKey West
Jul 28
EYW7:33 pmKey West
5h 04m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$413
American Airlines
Jul 8
ECP7:05 amPanama City NW Florida Beaches
8h 06m
1 stop
EYW4:11 pmKey West
Jul 17
EYW7:33 pmKey West
5h 04m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$447
American Airlines
Jun 29
ECP11:00 amPanama City NW Florida Beaches
6h 49m
1 stop
EYW6:49 pmKey West
Jul 3
EYW7:33 pmKey West
5h 04m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$449

Delta flights from Panama City, Florida to Key West

Our best Delta deals on Panama City, Florida to Key West flight tickets
Delta
Jul 29
ECP11:38 amPanama City NW Florida Beaches
4h 45m
1 stop
EYW5:23 pmKey West
Aug 5
EYW1:59 pmKey West
5h 36m
1 stop
ECP6:35 pmPanama City NW Florida Beaches
$347
Delta
Jul 16
ECP1:36 pmPanama City NW Florida Beaches
5h 15m
1 stop
EYW7:51 pmKey West
Jul 22
EYW2:24 pmKey West
5h 26m
1 stop
ECP6:50 pmPanama City NW Florida Beaches
$357
Delta
Jul 17
ECP1:36 pmPanama City NW Florida Beaches
5h 15m
1 stop
EYW7:51 pmKey West
Jul 24
EYW7:50 amKey West
7h 04m
1 stop
ECP1:54 pmPanama City NW Florida Beaches
$367

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 7/29

11:38 am-5:23 pm

1 stop4h 45m

Key West

Wed 8/5

1:59 pm-6:35 pm

1 stop5h 36m

$347

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 7/16

1:36 pm-7:51 pm

1 stop5h 15m

Key West

Wed 7/22

2:24 pm-6:50 pm

1 stop5h 26m

$357

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 7/17

1:36 pm-7:51 pm

1 stop5h 15m

Key West

Fri 7/24

7:50 am-1:54 pm

1 stop7h 04m

$367

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 7/7

2:47 pm-7:51 pm

1 stop4h 04m

Key West

Thu 7/16

7:50 am-12:31 pm

1 stop5h 41m

$377

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 7/10

6:00 am-11:00 am

1 stop4h 00m

Key West

Mon 7/13

6:18 pm-11:37 pm

1 stop6h 19m

$387

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 6/29

11:43 am-7:53 pm

1 stop7h 10m

Key West

Thu 7/9

7:50 am-1:54 pm

1 stop7h 04m

$403

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 6/29

11:00 am-6:49 pm

1 stop6h 49m

Key West

Tue 7/28

7:33 pm-11:37 pm

1 stop5h 04m

$413
Quickest round-trip

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 9/9

6:00 am-10:47 am

1 stop3h 47m

Key West

Sun 9/13

6:00 pm-10:46 pm

1 stop5h 46m

$428

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 9/9

6:00 am-10:47 am

1 stop3h 47m

Key West

Sun 9/13

6:00 pm-10:46 pm

1 stop5h 46m

$433

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 7/8

7:05 am-4:11 pm

1 stop8h 06m

Key West

Fri 7/17

7:33 pm-11:37 pm

1 stop5h 04m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Panama City, Florida to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, November is the cheapest month to fly from Panama City, Florida to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $317. If you are unable to visit Key West during the month of November, then departing from Panama City, Florida during the month February is also very affordable. Most momondo users find prices during this month for around $332.

When to book flights from Panama City, Florida to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Key West (ECP to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Key West

Fastest flight time

3h 47m

Direct flights

None
The fastest flight from Panama City, Florida to Key West takes 3h 47m
There are no direct flights from Panama City, Florida to Key West. There are no popular flight routes from Panama City, Florida to Key West.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Key West

  • How far is Panama City NW Florida Beaches to Key West by plane?

    Panama City NW Florida Beaches and Key West are 453.5 mi apart from one another. 3h 47m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Key West Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Key West Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Key West Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Key West?

Best airlines flying from Panama City, Florida to Key West

Compare and see reviews for airlines that fly from Panama City, Florida to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $306Free CancellationRating
7.8
8,417 reviews
Search Delta flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Key West?

It is quick and easy to find Panama City to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Panama City to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Key West?

Once all potential Panama City to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Key West right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Key West from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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