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Cheap flights from Panama City, Florida to Key West from $307

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Key West departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:56 am - 6:23 pm
ECP
-
EYW
7h 27m1 stop
American Airlines Logo
8:08 am - 1:30 pm
EYW
-
ECP
6h 22m1 stop
$307American Airlines
Wed, Apr 8 - Wed, Apr 15
American Airlines Logo
9:56 am - 6:21 pm
ECP
-
EYW
7h 25m2 stops
American Airlines Logo
8:08 am - 1:30 pm
EYW
-
ECP
6h 22m1 stop
$312American Airlines
Wed, Apr 8 - Wed, Apr 15
American Airlines Logo
4:09 pm - 10:44 pm
ECP
-
EYW
5h 35m1 stop
American Airlines Logo
7:08 am - 11:33 am
EYW
-
ECP
5h 25m1 stop
$353American Airlines
Mon, Jan 5 - Mon, Jan 12
American Airlines Logo
4:30 pm - 10:43 pm
ECP
-
EYW
5h 13m1 stop
American Airlines Logo
6:20 pm - 10:37 pm
EYW
-
ECP
5h 17m1 stop
$387American Airlines
Thu, Feb 12 - Wed, Feb 18
American Airlines Logo
12:03 pm - 6:01 pm
ECP
-
EYW
4h 58m1 stop
American Airlines Logo
7:08 am - 11:33 am
EYW
-
ECP
5h 25m1 stop
$398American Airlines
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
4:30 pm - 10:43 pm
ECP
-
EYW
5h 13m1 stop
American Airlines Logo
6:20 pm - 10:37 pm
EYW
-
ECP
5h 17m1 stop
$407American Airlines
Thu, Feb 12 - Tue, Feb 17
Delta Logo
6:00 am - 11:29 am
ECP
-
EYW
4h 29m1 stop
Delta Logo
6:06 pm - 10:51 pm
EYW
-
ECP
5h 45m1 stop
$473Delta
Thu, Jan 8 - Sun, Jan 11
American Airlines Logo
4:30 pm - 10:43 pm
ECP
-
EYW
5h 13m1 stop
American Airlines Logo
6:20 pm - 10:37 pm
EYW
-
ECP
5h 17m1 stop
$479American Airlines
Fri, Feb 13 - Wed, Feb 18
American Airlines Logo
4:30 pm - 10:43 pm
ECP
-
EYW
5h 13m1 stop
American Airlines Logo
6:20 pm - 10:37 pm
EYW
-
ECP
5h 17m1 stop
$499American Airlines
Fri, Feb 13 - Tue, Feb 17
American Airlines Logo
1:34 pm - 4:07 pm
ECP
-
EYW
25h 33m1 stop
American Airlines Logo
5:21 pm - 11:33 am
EYW
-
ECP
19h 12m2 stops
$514American Airlines
Tue, Jan 20 - Tue, Jan 27

American Airlines flights from Panama City, Florida to Key West

Our best American Airlines deals on Panama City, Florida to Key West flight tickets
American Airlines
Apr 8
ECP9:56 amPanama City NW Florida Beaches
7h 27m
1 stop
EYW6:23 pmKey West
Apr 15
EYW8:08 amKey West
6h 22m
1 stop
ECP1:30 pmPanama City NW Florida Beaches
$307
Find similar
American Airlines
Apr 8
ECP9:56 amPanama City NW Florida Beaches
7h 25m
2 stops
EYW6:21 pmKey West
Apr 15
EYW8:08 amKey West
6h 22m
1 stop
ECP1:30 pmPanama City NW Florida Beaches
$312
Find similar
American Airlines
Jan 5
ECP4:09 pmPanama City NW Florida Beaches
5h 35m
1 stop
EYW10:44 pmKey West
Jan 12
EYW7:08 amKey West
5h 25m
1 stop
ECP11:33 amPanama City NW Florida Beaches
$353
Find similar

United Airlines flights from Panama City, Florida to Key West

Our best United Airlines deals on Panama City, Florida to Key West flight tickets
United Airlines
Feb 13
ECP5:00 pmPanama City NW Florida Beaches
21h 53m
1 stop
EYW3:53 pmKey West
Feb 18
EYW6:35 pmKey West
18h 29m
2 stops
ECP12:04 pmPanama City NW Florida Beaches
$826
Find similar
United Airlines
Jan 31
ECP6:30 amPanama City NW Florida Beaches
32h 52m
2 stops
EYW4:22 pmKey West
Feb 4
EYW4:15 pmKey West
30h 44m
2 stops
ECP9:59 pmPanama City NW Florida Beaches
$842
Find similar
United Airlines
Feb 13
ECP5:00 pmPanama City NW Florida Beaches
20h 51m
3 stops
EYW2:51 pmKey West
Feb 17
EYW3:56 pmKey West
21h 08m
2 stops
ECP12:04 pmPanama City NW Florida Beaches
$1,036
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/8

9:56 am-6:23 pm

1 stop7h 27m

Key West

Wed 4/15

8:08 am-1:30 pm

1 stop6h 22m

$307

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 4/8

9:56 am-6:21 pm

2 stops7h 25m

Key West

Wed 4/15

8:08 am-1:30 pm

1 stop6h 22m

$312

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 1/5

4:09 pm-10:44 pm

1 stop5h 35m

Key West

Mon 1/12

7:08 am-11:33 am

1 stop5h 25m

$353

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 2/12

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Wed 2/18

6:20 pm-10:37 pm

1 stop5h 17m

$387

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 1/20

12:03 pm-6:01 pm

1 stop4h 58m

Key West

Tue 1/27

7:08 am-11:33 am

1 stop5h 25m

$398

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 2/12

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Tue 2/17

6:20 pm-10:37 pm

1 stop5h 17m

$407

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 1/8

6:00 am-11:29 am

1 stop4h 29m

Key West

Sun 1/11

6:06 pm-10:51 pm

1 stop5h 45m

$473

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 2/13

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Wed 2/18

6:20 pm-10:37 pm

1 stop5h 17m

$479

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 2/13

4:30 pm-10:43 pm

1 stop5h 13m

Key West

Tue 2/17

6:20 pm-10:37 pm

1 stop5h 17m

$499

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 1/20

1:34 pm-4:07 pm

1 stop25h 33m

Key West

Tue 1/27

5:21 pm-11:33 am

2 stops19h 12m

$514

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Panama City, Florida to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and Key West?

What is the cheapest month to fly to Key West?

In general, October is the cheapest month to fly from Panama City, Florida to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $306. If you are unable to visit Key West during the month of October, then departing from Panama City, Florida during the month January is also very affordable. Most momondo users find prices during this month for around $336.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Panama City, Florida is on a Sunday. momondo users have found tickets for Sunday departures for as low as $414. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Panama City, Florida to Key West for around $628.

When to book flights from Panama City, Florida to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Key West (ECP to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Key West

Fastest flight time

4h 29m

Direct flights

None
The fastest flight from Panama City, Florida to Key West takes 4h 29m
There are no direct flights from Panama City, Florida to Key West. There are no popular flight routes from Panama City, Florida to Key West.
Search flight deals

  • How far is Panama City NW Florida Beaches to Key West by plane?

    Panama City NW Florida Beaches and Key West are 453.5 mi apart from one another. 4h 29m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Key West Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Key West Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Key West Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Key West?

Best airlines flying from Panama City, Florida to Key West

Compare and see reviews for airlines that fly from Panama City, Florida to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $306Free CancellationRating
7.9
8,005 reviews
Search Delta flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Key West?

It is quick and easy to find Panama City to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Panama City to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Key West?

Once all potential Panama City to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Key West right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Key West from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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