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Cheap flights from Ohio to Florence from $368

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to Florence departing on 1/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Ohio to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:45 am - 5:09 pm
PIT
-
FLO
9h 24m2 stops
American Airlines Logo
6:15 am - 6:14 pm
FLO
-
PIT
11h 59m2 stops
$368American Airlines
Sun, Jan 18 - Sun, Jan 25
American Airlines Logo
7:04 pm - 10:43 pm
PIT
-
FLO
3h 39m1 stop
American Airlines Logo
6:15 am - 7:09 pm
FLO
-
PIT
12h 54m2 stops
$371American Airlines
Sun, Jan 18 - Sun, Jan 25
American Airlines Logo
6:00 am - 5:09 pm
CLE
-
FLO
11h 09m2 stops
American Airlines Logo
6:15 am - 6:38 pm
FLO
-
CLE
12h 23m2 stops
$378American Airlines
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
1:10 pm - 5:09 pm
CLE
-
FLO
3h 59m1 stop
American Airlines Logo
6:15 am - 10:17 am
FLO
-
CLE
4h 02m1 stop
$421American Airlines
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
12:44 pm - 11:11 pm
CLE
-
FLO
10h 27m2 stops
American Airlines Logo
6:15 am - 10:17 am
FLO
-
CLE
4h 02m1 stop
$426American Airlines
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
6:10 am - 5:09 pm
CMH
-
FLO
10h 59m2 stops
American Airlines Logo
6:15 am - 6:39 pm
FLO
-
CMH
12h 24m2 stops
$429American Airlines
Wed, Jan 7 - Wed, Jan 14
American Airlines Logo
1:18 pm - 5:45 pm
CLE
-
FLO
4h 27m1 stop
American Airlines Logo
5:16 am - 9:01 am
FLO
-
CLE
3h 45m1 stop
$475American Airlines
Thu, Mar 5 - Thu, Mar 12
American Airlines Logo
7:04 pm - 10:43 pm
PIT
-
FLO
3h 39m1 stop
American Airlines Logo
6:15 am - 10:27 am
FLO
-
PIT
4h 12m1 stop
$477American Airlines
Sun, Jan 18 - Sun, Jan 25
American Airlines Logo
1:18 pm - 5:45 pm
CLE
-
FLO
4h 27m1 stop
American Airlines Logo
5:16 am - 1:01 pm
FLO
-
CLE
7h 45m2 stops
$480American Airlines
Thu, Mar 5 - Thu, Mar 12
American Airlines Logo
7:10 pm - 10:43 pm
CMH
-
FLO
3h 33m1 stop
American Airlines Logo
5:36 pm - 11:22 pm
FLO
-
CMH
5h 46m1 stop
$481American Airlines
Wed, Jan 7 - Wed, Jan 14

American Airlines flights from Ohio to Florence, South Carolina

Our best American Airlines deals on Ohio to Florence, South Carolina flight tickets
American Airlines
Jan 6
DTW6:17 pmDetroit Metropolitan Wayne County
4h 26m
1 stop
FLO10:43 pmFlorence
Jan 10
FLO5:36 pmFlorence
6h 20m
1 stop
DTW11:56 pmDetroit Metropolitan Wayne County
$335
Find similar
American Airlines
Jan 6
DTW8:00 amDetroit Metropolitan Wayne County
9h 09m
2 stops
FLO5:09 pmFlorence
Jan 10
FLO6:15 amFlorence
5h 56m
1 stop
DTW12:11 pmDetroit Metropolitan Wayne County
$340
Find similar
American Airlines
Jan 6
DTW8:00 amDetroit Metropolitan Wayne County
9h 09m
2 stops
FLO5:09 pmFlorence
Jan 10
FLO6:15 amFlorence
7h 17m
2 stops
DTW1:32 pmDetroit Metropolitan Wayne County
$345
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Ohio to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Ohio to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sun 1/18

7:45 am-5:09 pm

2 stops9h 24m

Florence

Sun 1/25

6:15 am-6:14 pm

2 stops11h 59m

$368

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sun 1/18

7:04 pm-10:43 pm

1 stop3h 39m

Florence

Sun 1/25

6:15 am-7:09 pm

2 stops12h 54m

$371

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 1/17

6:00 am-5:09 pm

2 stops11h 09m

Florence

Sat 1/24

6:15 am-6:38 pm

2 stops12h 23m

$378

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 1/17

1:10 pm-5:09 pm

1 stop3h 59m

Florence

Sat 1/24

6:15 am-10:17 am

1 stop4h 02m

$421

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 1/17

12:44 pm-11:11 pm

2 stops10h 27m

Florence

Sat 1/24

6:15 am-10:17 am

1 stop4h 02m

$426

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 1/7

6:10 am-5:09 pm

2 stops10h 59m

Florence

Wed 1/14

6:15 am-6:39 pm

2 stops12h 24m

$429

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 3/5

1:18 pm-5:45 pm

1 stop4h 27m

Florence

Thu 3/12

5:16 am-9:01 am

1 stop3h 45m

$475

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sun 1/18

7:04 pm-10:43 pm

1 stop3h 39m

Florence

Sun 1/25

6:15 am-10:27 am

1 stop4h 12m

$477

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 3/5

1:18 pm-5:45 pm

1 stop4h 27m

Florence

Thu 3/12

5:16 am-1:01 pm

2 stops7h 45m

$480

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 1/7

7:10 pm-10:43 pm

1 stop3h 33m

Florence

Wed 1/14

5:36 pm-11:22 pm

1 stop5h 46m

$481

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Ohio to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Ohio to Florence?

American Airlines is the most popular carrier operating from Ohio to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Ohio according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Ohio to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to Florence, South Carolina

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Ohio to Florence, South Carolina takes 4h 05m
There are no direct flights from Ohio to Florence, South Carolina. There are no popular flight routes from Ohio to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Ohio to Florence Airport?

    Prices for flights from Ohio to Florence Airport refresh daily.

  • How old do you have to be to fly from Ohio to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Ohio to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to Florence?

Finding the right flight to Florence from Ohio is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Ohio to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Ohio which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Ohio to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Ohio.

I’m not ready to book a flight from Ohio to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Ohio to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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