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Cheap flights from Ohio to Florence from $439

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to Florence departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

American Airlines Logo
11:30 am - 5:12 pmDTW-FLO
5h 42m1 stop
American Airlines Logo
5:14 am - 5:01 pmFLO-DTW
11h 47m2 stops
$439American Airlines
Find Deal
Wed, Sep 17 - Thu, Sep 25
American Airlines Logo
6:00 am - 5:12 pmDTW-FLO
11h 12m2 stops
American Airlines Logo
5:14 am - 5:01 pmFLO-DTW
11h 47m2 stops
$444American Airlines
Find Deal
Wed, Sep 17 - Thu, Sep 25
American Airlines Logo
7:23 pm - 10:45 amDAY-FLO
15h 22m2 stops
American Airlines Logo
6:32 pm - 9:13 amFLO-DAY
14h 41m2 stops
$462American Airlines
Find Deal
Wed, Nov 19 - Mon, Dec 22
American Airlines Logo
11:30 am - 5:12 pmDTW-FLO
5h 42m1 stop
American Airlines Logo
4:57 pm - 10:29 pmFLO-DTW
5h 32m1 stop
$470American Airlines
Find Deal
Wed, Sep 17 - Thu, Sep 25
American Airlines Logo
6:28 pm - 11:41 pmCAK-FLO
5h 13m1 stop
American Airlines Logo
6:33 pm - 10:26 pmFLO-CAK
3h 53m1 stop
$475American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
11:30 am - 5:12 pmDTW-FLO
5h 42m1 stop
American Airlines Logo
5:14 am - 9:23 amFLO-DTW
4h 09m1 stop
$480American Airlines
Find Deal
Wed, Sep 17 - Sun, Sep 21
American Airlines Logo
6:15 am - 10:45 amCAK-FLO
4h 30m1 stop
American Airlines Logo
5:15 am - 4:42 pmFLO-CAK
11h 27m2 stops
$480American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
6:51 pm - 11:16 pmDTW-FLO
4h 25m1 stop
American Airlines Logo
5:14 am - 2:46 pmFLO-DTW
9h 32m2 stops
$485American Airlines
Find Deal
Wed, Sep 17 - Sun, Sep 21
American Airlines Logo
2:31 pm - 11:41 pmCAK-FLO
9h 10m2 stops
American Airlines Logo
5:15 am - 2:01 pmFLO-CAK
8h 46m2 stops
$485American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
9:49 am - 5:12 pmDTW-FLO
7h 23m2 stops
American Airlines Logo
5:14 am - 1:08 pmFLO-DTW
7h 54m2 stops
$490American Airlines
Find Deal
Wed, Sep 17 - Sun, Sep 21

American Airlines flights from Ohio to Florence, South Carolina

Our best American Airlines deals on Ohio to Florence, South Carolina flight tickets
American Airlines
Sep 17
DTW11:30 amDetroit Metropolitan Wayne County
5h 42m
1 stop
FLO5:12 pmFlorence
Sep 25
FLO5:14 amFlorence
11h 47m
2 stops
DTW5:01 pmDetroit Metropolitan Wayne County
$439
Find similar
American Airlines
Sep 17
DTW6:00 amDetroit Metropolitan Wayne County
11h 12m
2 stops
FLO5:12 pmFlorence
Sep 25
FLO5:14 amFlorence
11h 47m
2 stops
DTW5:01 pmDetroit Metropolitan Wayne County
$444
Find similar
American Airlines
Nov 19
DAY7:23 pmDayton
15h 22m
2 stops
FLO10:45 amFlorence
Dec 22
FLO6:32 pmFlorence
14h 41m
2 stops
DAY9:13 amDayton
$462
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Ohio to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 3, 2025.
Use the filters below to find and compare flights from Ohio to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

11:30 am-5:12 pm

1 stop5h 42m

Florence

Thu 9/25

5:14 am-5:01 pm

2 stops11h 47m

$439

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

6:00 am-5:12 pm

2 stops11h 12m

Florence

Thu 9/25

5:14 am-5:01 pm

2 stops11h 47m

$444

DaytonFlorence

DAY - FLO

DAYFLO

Dayton

Wed 11/19

7:23 pm-10:45 am

2 stops15h 22m

Florence

Mon 12/22

6:32 pm-9:13 am

2 stops14h 41m

$462

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

11:30 am-5:12 pm

1 stop5h 42m

Florence

Thu 9/25

4:57 pm-10:29 pm

1 stop5h 32m

$470

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Fri 11/21

6:28 pm-11:41 pm

1 stop5h 13m

Florence

Sun 11/23

6:33 pm-10:26 pm

1 stop3h 53m

$475

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

11:30 am-5:12 pm

1 stop5h 42m

Florence

Sun 9/21

5:14 am-9:23 am

1 stop4h 09m

$480

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Fri 11/21

6:15 am-10:45 am

1 stop4h 30m

Florence

Sun 11/23

5:15 am-4:42 pm

2 stops11h 27m

$480

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

6:51 pm-11:16 pm

1 stop4h 25m

Florence

Sun 9/21

5:14 am-2:46 pm

2 stops9h 32m

$485

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Fri 11/21

2:31 pm-11:41 pm

2 stops9h 10m

Florence

Sun 11/23

5:15 am-2:01 pm

2 stops8h 46m

$485

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/17

9:49 am-5:12 pm

2 stops7h 23m

Florence

Sun 9/21

5:14 am-1:08 pm

2 stops7h 54m

$490

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Ohio to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Ohio according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Ohio to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to Florence, South Carolina

Direct flights

None
There are no direct flights from Ohio to Florence, South Carolina. There are no popular flight routes from Ohio to Florence, South Carolina.
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  • When did momondo last update prices for flights from Ohio to Florence Airport?

    Prices for flights from Ohio to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Ohio to Florence Airport?

  • How old do you have to be to fly from Ohio to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Ohio to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Ohio to Florence, South Carolina

Compare and see reviews for airlines that fly from Ohio to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $360Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to Florence?

Finding the right flight to Florence from Ohio is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Ohio to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Ohio which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Ohio to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Ohio.

I’m not ready to book a flight from Ohio to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Ohio to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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