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Cheap flights from Ohio to Florence from $307

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to Florence departing on 7/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Ohio to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:27 am - 10:00 pm
PIT
-
FLO
10h 33m
2 stops
American Airlines Logo
5:05 am - 4:17 pm
FLO
-
PIT
11h 12m
2 stops
$365American Airlines
Wed, Jun 10 - Wed, Jun 17
American Airlines Logo
3:31 pm - 10:00 pm
PIT
-
FLO
6h 29m
1 stop
American Airlines Logo
5:05 am - 4:17 pm
FLO
-
PIT
11h 12m
2 stops
$419American Airlines
Wed, Jun 10 - Wed, Jun 17
American Airlines Logo
3:31 pm - 10:00 pm
PIT
-
FLO
6h 29m
1 stop
American Airlines Logo
5:05 am - 8:54 am
FLO
-
PIT
3h 49m
1 stop
$473American Airlines
Wed, Jun 10 - Wed, Jun 17
American Airlines Logo
6:05 am - 3:40 pm
PIT
-
FLO
9h 35m
2 stops
American Airlines Logo
11:20 am - 4:06 pm
FLO
-
PIT
4h 46m
1 stop
$510American Airlines
Mon, Sep 14 - Sun, Sep 20
American Airlines Logo
6:05 am - 3:40 pm
PIT
-
FLO
9h 35m
2 stops
American Airlines Logo
11:20 am - 7:31 pm
FLO
-
PIT
8h 11m
2 stops
$515American Airlines
Mon, Sep 14 - Sun, Sep 20
American Airlines Logo
10:40 am - 10:00 pm
DTW
-
FLO
11h 20m
2 stops
American Airlines Logo
5:05 am - 9:17 am
FLO
-
DTW
4h 12m
1 stop
$520American Airlines
Tue, Jun 9 - Mon, Jun 15
American Airlines Logo
10:40 am - 10:00 pm
DTW
-
FLO
11h 20m
2 stops
American Airlines Logo
2:35 pm - 10:44 pm
FLO
-
DTW
8h 09m
2 stops
$525American Airlines
Tue, Jun 9 - Mon, Jun 15
American Airlines Logo
5:28 pm - 10:00 pm
CVG
-
FLO
4h 32m
1 stop
American Airlines Logo
5:05 am - 8:43 am
FLO
-
CVG
3h 38m
1 stop
$541American Airlines
Tue, May 26 - Sat, May 30
American Airlines Logo
5:28 pm - 11:58 pm
PIT
-
FLO
6h 30m
1 stop
American Airlines Logo
5:09 am - 8:36 am
FLO
-
PIT
3h 27m
1 stop
$543American Airlines
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
6:00 am - 2:10 pm
CVG
-
FLO
8h 10m
2 stops
American Airlines Logo
5:05 am - 8:43 am
FLO
-
CVG
3h 38m
1 stop
$546American Airlines
Tue, May 26 - Sat, May 30

American Airlines flights from Ohio to Florence, South Carolina

Our best American Airlines deals on Ohio to Florence, South Carolina flight tickets
American Airlines
Jun 10
PIT11:27 amPittsburgh
10h 33m
2 stops
FLO10:00 pmFlorence
Jun 17
FLO5:05 amFlorence
11h 12m
2 stops
PIT4:17 pmPittsburgh
$365
American Airlines
Jun 10
PIT3:31 pmPittsburgh
6h 29m
1 stop
FLO10:00 pmFlorence
Jun 17
FLO5:05 amFlorence
11h 12m
2 stops
PIT4:17 pmPittsburgh
$419
American Airlines
Jun 10
PIT3:31 pmPittsburgh
6h 29m
1 stop
FLO10:00 pmFlorence
Jun 17
FLO5:05 amFlorence
3h 49m
1 stop
PIT8:54 amPittsburgh
$473

momondo Fare Finder

 
Customize your flight search to find flights from Ohio to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Ohio to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Wed 6/10

11:27 am-10:00 pm

2 stops10h 33m

Florence

Wed 6/17

5:05 am-4:17 pm

2 stops11h 12m

$365

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Wed 6/10

3:31 pm-10:00 pm

1 stop6h 29m

Florence

Wed 6/17

5:05 am-4:17 pm

2 stops11h 12m

$419

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Wed 6/10

3:31 pm-10:00 pm

1 stop6h 29m

Florence

Wed 6/17

5:05 am-8:54 am

1 stop3h 49m

$473

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Mon 9/14

6:05 am-3:40 pm

2 stops9h 35m

Florence

Sun 9/20

11:20 am-4:06 pm

1 stop4h 46m

$510

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Mon 9/14

6:05 am-3:40 pm

2 stops9h 35m

Florence

Sun 9/20

11:20 am-7:31 pm

2 stops8h 11m

$515

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 6/9

10:40 am-10:00 pm

2 stops11h 20m

Florence

Mon 6/15

5:05 am-9:17 am

1 stop4h 12m

$520

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 6/9

10:40 am-10:00 pm

2 stops11h 20m

Florence

Mon 6/15

2:35 pm-10:44 pm

2 stops8h 09m

$525
Quickest round-trip

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Tue 5/26

5:28 pm-10:00 pm

1 stop4h 32m

Florence

Sat 5/30

5:05 am-8:43 am

1 stop3h 38m

$541

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sat 8/15

5:28 pm-11:58 pm

1 stop6h 30m

Florence

Sat 8/22

5:09 am-8:36 am

1 stop3h 27m

$543

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Tue 5/26

6:00 am-2:10 pm

2 stops8h 10m

Florence

Sat 5/30

5:05 am-8:43 am

1 stop3h 38m

$546

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Ohio to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Ohio to Florence?

American Airlines is the most popular carrier operating from Ohio to Florence

What airlines fly to Florence, South Carolina?

Breeze Airways, American Airlines and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Ohio according to our data. Breeze Airways is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Ohio to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to Florence, South Carolina

Fastest flight time

3h 29m

Direct flights

None
The fastest flight from Ohio to Florence, South Carolina takes 3h 29m
There are no direct flights from Ohio to Florence, South Carolina. There are no popular flight routes from Ohio to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Ohio to Florence, South Carolina

  • When did momondo last update prices for flights from Ohio to Florence Airport?

    Prices for flights from Ohio to Florence Airport refresh daily.

  • How old do you have to be to fly from Ohio to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Ohio to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington
Bennettsville
Lake City

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to Florence?

Finding the right flight to Florence from Ohio is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Ohio to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Ohio which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Ohio to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Ohio.

I’m not ready to book a flight from Ohio to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Ohio to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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