Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Ohio to Florence from $323

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to Florence departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Ohio to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$323American Airlines
Wed, May 6 - Sat, May 9
American Airlines Logo
3:30 pm - 9:47 pm
DTW
-
FLO
6h 17m
1 stop
American Airlines Logo
5:20 am - 12:49 pm
FLO
-
DTW
7h 29m
2 stops
$328American Airlines
Wed, May 6 - Sat, May 9
American Airlines Logo
6:00 am - 3:50 pm
DTW
-
FLO
9h 50m
2 stops
American Airlines Logo
5:20 am - 12:49 pm
FLO
-
DTW
7h 29m
2 stops
$333American Airlines
Wed, May 6 - Sat, May 9
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
4:16 pm - 10:28 pm
FLO
-
DTW
6h 12m
1 stop
$363American Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
4:16 pm - 12:45 am
FLO
-
DTW
8h 29m
2 stops
$368American Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
5:00 am - 3:50 pm
DTW
-
FLO
10h 50m
2 stops
American Airlines Logo
4:16 pm - 12:45 am
FLO
-
DTW
8h 29m
2 stops
$373American Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$422American Airlines
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
5:00 am - 3:50 pm
DTW
-
FLO
10h 50m
2 stops
American Airlines Logo
5:20 am - 11:17 am
FLO
-
DTW
5h 57m
1 stop
$427American Airlines
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
1:33 pm - 9:47 pm
DTW
-
FLO
8h 14m
2 stops
American Airlines Logo
5:20 am - 12:57 pm
FLO
-
DTW
7h 37m
2 stops
$432American Airlines
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
10:52 am - 10:42 pm
CLE
-
FLO
11h 50m
2 stops
American Airlines Logo
5:20 am - 9:15 am
FLO
-
CLE
3h 55m
1 stop
$528American Airlines
Tue, Apr 7 - Sat, Apr 11

American Airlines flights from Ohio to Florence, South Carolina

Our best American Airlines deals on Ohio to Florence, South Carolina flight tickets
American Airlines
May 6
DTW10:11 amDetroit Metropolitan Wayne County
5h 39m
1 stop
FLO3:50 pmFlorence
May 9
FLO5:20 amFlorence
4h 07m
1 stop
DTW9:27 amDetroit Metropolitan Wayne County
$323
American Airlines
May 6
DTW3:30 pmDetroit Metropolitan Wayne County
6h 17m
1 stop
FLO9:47 pmFlorence
May 9
FLO5:20 amFlorence
7h 29m
2 stops
DTW12:49 pmDetroit Metropolitan Wayne County
$328
American Airlines
May 6
DTW6:00 amDetroit Metropolitan Wayne County
9h 50m
2 stops
FLO3:50 pmFlorence
May 9
FLO5:20 amFlorence
7h 29m
2 stops
DTW12:49 pmDetroit Metropolitan Wayne County
$333

momondo Fare Finder

 
Customize your flight search to find flights from Ohio to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Ohio to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 5/6

10:11 am-3:50 pm

1 stop5h 39m

Florence

Sat 5/9

5:20 am-9:27 am

1 stop4h 07m

$323

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 5/6

3:30 pm-9:47 pm

1 stop6h 17m

Florence

Sat 5/9

5:20 am-12:49 pm

2 stops7h 29m

$328

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 5/6

6:00 am-3:50 pm

2 stops9h 50m

Florence

Sat 5/9

5:20 am-12:49 pm

2 stops7h 29m

$333

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/14

10:11 am-3:50 pm

1 stop5h 39m

Florence

Mon 5/18

4:16 pm-10:28 pm

1 stop6h 12m

$363

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/14

10:11 am-3:50 pm

1 stop5h 39m

Florence

Mon 5/18

4:16 pm-12:45 am

2 stops8h 29m

$368

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/14

5:00 am-3:50 pm

2 stops10h 50m

Florence

Mon 5/18

4:16 pm-12:45 am

2 stops8h 29m

$373

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/8

10:11 am-3:50 pm

1 stop5h 39m

Florence

Sun 4/12

5:20 am-9:27 am

1 stop4h 07m

$422

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/8

5:00 am-3:50 pm

2 stops10h 50m

Florence

Sun 4/12

5:20 am-11:17 am

1 stop5h 57m

$427

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/8

1:33 pm-9:47 pm

2 stops8h 14m

Florence

Sun 4/12

5:20 am-12:57 pm

2 stops7h 37m

$432

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 4/7

10:52 am-10:42 pm

2 stops11h 50m

Florence

Sat 4/11

5:20 am-9:15 am

1 stop3h 55m

$528

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

See travel insights to Florence from

How to get the cheapest flight ticket from Ohio to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Ohio to Florence?

American Airlines is the most popular carrier operating from Ohio to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Ohio according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Ohio to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to Florence, South Carolina

Fastest flight time

3h 38m

Direct flights

None
The fastest flight from Ohio to Florence, South Carolina takes 3h 38m
There are no direct flights from Ohio to Florence, South Carolina. There are no popular flight routes from Ohio to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Ohio to Florence Airport?

    Prices for flights from Ohio to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Ohio to Florence Airport?

  • How old do you have to be to fly from Ohio to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Ohio to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Ohio to Florence, South Carolina

Compare and see reviews for airlines that fly from Ohio to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $420Free CancellationRating
7.1
11,496 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to Florence?

Finding the right flight to Florence from Ohio is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Ohio to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Ohio which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Ohio to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Ohio.

I’m not ready to book a flight from Ohio to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Ohio to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 4/25
Sat 5/2
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States