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Cheap flights from Ohio to Florence from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to Florence departing on 7/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Ohio to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:56 am - 1:18 pm
DTW
-
FLO
5h 22m
1 stop
American Airlines Logo
5:09 am - 9:21 am
FLO
-
DTW
4h 12m
1 stop
$481American Airlines
Sat, Oct 3 - Sat, Oct 10
American Airlines Logo
8:40 am - 10:58 pm
DTW
-
FLO
14h 18m
2 stops
American Airlines Logo
2:34 pm - 7:15 pm
FLO
-
DTW
4h 41m
1 stop
$495American Airlines
Sat, Oct 3 - Sat, Oct 10
American Airlines Logo
9:14 am - 2:10 pm
CMH
-
FLO
4h 56m
1 stop
American Airlines Logo
2:35 pm - 5:54 pm
FLO
-
CMH
3h 19m
1 stop
$511American Airlines
Tue, Jul 28 - Tue, Aug 4
American Airlines Logo
4:23 pm - 10:59 pm
CMH
-
FLO
6h 36m
1 stop
American Airlines Logo
3:22 pm - 7:39 pm
FLO
-
CMH
4h 17m
1 stop
$518American Airlines
Thu, Aug 20 - Tue, Aug 25
American Airlines Logo
1:55 pm - 11:37 pm
CMH
-
FLO
9h 42m
2 stops
American Airlines Logo
2:35 pm - 5:54 pm
FLO
-
CMH
3h 19m
1 stop
$526American Airlines
Tue, Jul 28 - Tue, Aug 4
American Airlines Logo
8:01 pm - 11:37 pm
PIT
-
FLO
3h 36m
1 stop
American Airlines Logo
5:17 am - 9:30 am
FLO
-
PIT
4h 13m
1 stop
$529American Airlines
Sat, Jul 25 - Tue, Jul 28
American Airlines Logo
9:30 am - 2:10 pm
DTW
-
FLO
4h 40m
1 stop
American Airlines Logo
5:17 am - 9:17 am
FLO
-
DTW
4h 00m
1 stop
$541American Airlines
Tue, Jul 14 - Sat, Jul 18
American Airlines Logo
7:41 am - 2:10 pm
CVG
-
FLO
6h 29m
1 stop
American Airlines Logo
5:17 am - 8:41 am
FLO
-
CVG
3h 24m
1 stop
$541American Airlines
Tue, Jul 14 - Sat, Jul 18
American Airlines Logo
6:17 pm - 11:37 pm
DAY
-
FLO
5h 20m
1 stop
American Airlines Logo
2:35 pm - 8:37 pm
FLO
-
DAY
6h 02m
1 stop
$541American Airlines
Sat, Jul 11 - Wed, Jul 15
American Airlines Logo
10:00 am - 2:10 pm
DTW
-
FLO
4h 10m
1 stop
American Airlines Logo
5:17 am - 9:17 am
FLO
-
DTW
4h 00m
1 stop
$555American Airlines
Fri, Jul 31 - Sun, Aug 2

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American Airlines flights from Ohio to Florence, South Carolina

Our best American Airlines deals on Ohio to Florence, South Carolina flight tickets
American Airlines
Oct 3
DTW7:56 amDetroit Metropolitan Wayne County
5h 22m
1 stop
FLO1:18 pmFlorence
Oct 10
FLO5:09 amFlorence
4h 12m
1 stop
DTW9:21 amDetroit Metropolitan Wayne County
$481
American Airlines
Oct 3
DTW8:40 amDetroit Metropolitan Wayne County
14h 18m
2 stops
FLO10:58 pmFlorence
Oct 10
FLO2:34 pmFlorence
4h 41m
1 stop
DTW7:15 pmDetroit Metropolitan Wayne County
$495
American Airlines
Jul 28
CMH9:14 amColumbus
4h 56m
1 stop
FLO2:10 pmFlorence
Aug 4
FLO2:35 pmFlorence
3h 19m
1 stop
CMH5:54 pmColumbus
$511

momondo Fare Finder

 
Customize your flight search to find flights from Ohio to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Ohio to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/3

7:56 am-1:18 pm

1 stop5h 22m

Florence

Sat 10/10

5:09 am-9:21 am

1 stop4h 12m

$481

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/3

8:40 am-10:58 pm

2 stops14h 18m

Florence

Sat 10/10

2:34 pm-7:15 pm

1 stop4h 41m

$495

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Tue 7/28

9:14 am-2:10 pm

1 stop4h 56m

Florence

Tue 8/4

2:35 pm-5:54 pm

1 stop3h 19m

$511

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Thu 8/20

4:23 pm-10:59 pm

1 stop6h 36m

Florence

Tue 8/25

3:22 pm-7:39 pm

1 stop4h 17m

$518

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Tue 7/28

1:55 pm-11:37 pm

2 stops9h 42m

Florence

Tue 8/4

2:35 pm-5:54 pm

1 stop3h 19m

$526
Quickest round-trip

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sat 7/25

8:01 pm-11:37 pm

1 stop3h 36m

Florence

Tue 7/28

5:17 am-9:30 am

1 stop4h 13m

$529

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 7/14

9:30 am-2:10 pm

1 stop4h 40m

Florence

Sat 7/18

5:17 am-9:17 am

1 stop4h 00m

$541

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Tue 7/14

7:41 am-2:10 pm

1 stop6h 29m

Florence

Sat 7/18

5:17 am-8:41 am

1 stop3h 24m

$541

DaytonFlorence

DAY - FLO

DAYFLO

Dayton

Sat 7/11

6:17 pm-11:37 pm

1 stop5h 20m

Florence

Wed 7/15

2:35 pm-8:37 pm

1 stop6h 02m

$541

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 7/31

10:00 am-2:10 pm

1 stop4h 10m

Florence

Sun 8/2

5:17 am-9:17 am

1 stop4h 00m

$555

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Ohio to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Ohio to Florence?

American Airlines is the most popular carrier operating from Ohio to Florence

What airlines fly to Florence, South Carolina?

Breeze Airways, American Airlines and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Ohio according to our data. Breeze Airways is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Ohio to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to Florence, South Carolina

Fastest flight time

3h 35m

Direct flights

None
The fastest flight from Ohio to Florence, South Carolina takes 3h 35m
There are no direct flights from Ohio to Florence, South Carolina. There are no popular flight routes from Ohio to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Ohio to Florence, South Carolina

  • When did momondo last update prices for flights from Ohio to Florence Airport?

    Prices for flights from Ohio to Florence Airport refresh daily.

  • How old do you have to be to fly from Ohio to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Ohio to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to Florence?

Finding the right flight to Florence from Ohio is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Ohio to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Ohio which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Ohio to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Ohio.

I’m not ready to book a flight from Ohio to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Ohio to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Florence, South Carolina trip

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