Cheap flights from Chicago O'Hare Intl Airport to Missouri from $59

In general, October is the cheapest month to fly from Chicago O'Hare Intl Airport to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $294. If you aren’t able to travel to Missouri during the month of October, then flying in December is also cheap. Prices for this month can be found on momondo for an average of $319.

The cheapest day to depart from Chicago O'Hare Intl Airport to Missouri is on a Saturday when prices can be found for as low as $264. Flights from Chicago O'Hare Intl Airport to Missouri on a Monday will generally be more expensive and average around $542. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Chicago O'Hare Intl Airport to Missouri at noon for as low as $341. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the afternoon, with an average ticket price of $528. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Chicago O'Hare Intl to Kirksville Cannon Memorial for the best Chicago O'Hare Intl - Missouri flight prices

You are more likely to see cheaper flights to Missouri from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $437 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Chicago O'Hare Intl Airport for as low as $167 on momondo.

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Contour, and Delta are the most popular carriers operating from Chicago O'Hare Intl to Missouri

United Airlines, American Airlines and Contour are the top three most popular airlines that fly to Missouri from Chicago O'Hare Intl Airport according to our data. United Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 4 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

The number of flights available between Chicago O'Hare Intl Airport and Missouri is 125 per day as of August 2026. The most frequent departure time is 5:00PM, with 42% of daily flights leaving in the afternoon.

As of August 2026, 881 flights take off from Chicago O'Hare Intl Airport and land in Missouri each week. The most common flight departure day for this route is Sat, with 17% of weekly flights taking off on this day.