Cheap flights from North Carolina to St. Louis from $70

In general, October is the cheapest month to fly from North Carolina to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $350. The month of January is another great option to travel to St. Louis, with average flight prices from North Carolina averaging around $351.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $370. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $431. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from North Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $372 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $526 per ticket.

Fly from Raleigh-Durham to Lambert-St Louis for the best North Carolina - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from North Carolina for as low as $196 on momondo.

There are 3 cabin classes available to choose from on North Carolina to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, United Airlines, and Southwest are the most popular carriers operating from North Carolina to Lambert-St Louis

American Airlines, Southwest and Delta are the top three most popular airlines that fly to St. Louis from North Carolina according to our data. American Airlines is the first choice among our users, with 57% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between North Carolina and St. Louis is 6 per day as of March 2026. The most frequent departure time is 6:00PM, with 37% of daily flights leaving at noon.

The number of flights available between North Carolina and St. Louis is 44 per week as of March 2026. The most frequent departure day is Sat, with 20% of weekly flights leaving on this day.