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Cheap flights from Myrtle Beach to Indianapolis from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Indianapolis departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:30 am - 10:03 amMYR  Myrtle Beach Intl-IND Indianapolis
3h 33m1 stop Charlotte Douglas
American Airlines Logo
6:04 am - 11:25 amIND  Indianapolis-MYR Myrtle Beach Intl
5h 21m1 stop Washington, D.C. Reagan-National
$257American Airlines
Thu, Oct 15 - Tue, Oct 20
American Airlines Logo
10:17 am - 3:31 pmMYR  Myrtle Beach Intl-IND Indianapolis
5h 14m1 stop Charlotte Douglas
American Airlines Logo
6:04 am - 11:31 amIND  Indianapolis-MYR Myrtle Beach Intl
5h 27m1 stop Washington, D.C. Reagan-National
$257American Airlines
Tue, Nov 10 - Thu, Nov 12
American Airlines Logo
5:03 pm - 9:05 pmMYR  Myrtle Beach Intl-IND Indianapolis
4h 02m1 stop Charlotte Douglas
American Airlines Logo
4:24 pm - 10:29 pmIND  Indianapolis-MYR Myrtle Beach Intl
6h 05m1 stop Charlotte Douglas
$257American Airlines
Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
8:12 pm - 12:37 amMYR  Myrtle Beach Intl-IND Indianapolis
4h 25m1 stop Charlotte Douglas
American Airlines Logo
7:58 pm - 11:47 pmIND  Indianapolis-MYR Myrtle Beach Intl
3h 49m1 stop Charlotte Douglas
$257American Airlines
Mon, Oct 19 - Sat, Oct 24
American Airlines Logo
5:00 am - 10:03 amMYR  Myrtle Beach Intl-IND Indianapolis
5h 03m1 stop Charlotte Douglas
American Airlines Logo
6:08 am - 11:13 amIND  Indianapolis-MYR Myrtle Beach Intl
5h 05m1 stop Charlotte Douglas
$257American Airlines
Sat, Oct 24 - Sat, Oct 31
American Airlines Logo
12:14 pm - 5:58 pmMYR  Myrtle Beach Intl-IND Indianapolis
5h 44m1 stop Charlotte Douglas
American Airlines Logo
6:48 pm - 10:38 pmIND  Indianapolis-MYR Myrtle Beach Intl
3h 50m1 stop Charlotte Douglas
$259American Airlines
Thu, Sep 3 - Mon, Sep 7
Southwest Logo
7:50 pm - 12:40 amMYR  Myrtle Beach Intl-IND Indianapolis
4h 50m1 stop Baltimore/Washington
Southwest Logo
6:50 am - 1:30 pmIND  Indianapolis-MYR Myrtle Beach Intl
6h 40m2 stops Chicago Midway Nashville Intl
$262Southwest
Thu, Oct 15 - Tue, Oct 20
United Airlines Logo
11:27 am - 11:47 pmMYR  Myrtle Beach Intl-IND Indianapolis
12h 20m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
11:01 am - 5:11 pmIND  Indianapolis-MYR Myrtle Beach Intl
6h 10m1 stop Newark
$262United Airlines
Wed, Nov 11 - Wed, Nov 18
Southwest Logo
8:10 am - 4:40 pmMYR  Myrtle Beach Intl-IND Indianapolis
8h 30m2 stops Baltimore/Washington Orlando
Southwest Logo
1:05 pm - 6:55 pmIND  Indianapolis-MYR Myrtle Beach Intl
5h 50m1 stop Baltimore/Washington
$263Southwest
Tue, Nov 10 - Thu, Nov 12
Multiple Airlines Logo
2:41 pm - 10:25 amMYR  Myrtle Beach Intl-IND Indianapolis
19h 44m1 stop Orlando
Multiple Airlines Logo
7:48 pm - 8:52 amIND  Indianapolis-MYR Myrtle Beach Intl
37h 04m2 stops Atlanta Hartsfield-Jackson Philadelphia
$263Multiple Airlines
Fri, Sep 25 - Fri, Oct 2

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Southwest flights from Myrtle Beach to Indianapolis

Our best Southwest deals on Myrtle Beach to Indianapolis flight tickets
Southwest
Oct 15
MYR7:50 pmMyrtle Beach Intl
4h 50m
1 stop
IND12:40 amIndianapolis
Oct 20
IND6:50 amIndianapolis
6h 40m
2 stops
MYR1:30 pmMyrtle Beach Intl
$262
Southwest
Sep 3
MYR6:40 amMyrtle Beach Intl
8h 10m
2 stops
IND2:50 pmIndianapolis
Sep 7
IND5:25 amIndianapolis
4h 50m
1 stop
MYR10:15 amMyrtle Beach Intl
$264
Southwest
Oct 15
MYR3:55 pmMyrtle Beach Intl
8h 45m
2 stops
IND12:40 amIndianapolis
Oct 20
IND6:50 amIndianapolis
6h 40m
2 stops
MYR1:30 pmMyrtle Beach Intl
$268

American Airlines flights from Myrtle Beach to Indianapolis

Our best American Airlines deals on Myrtle Beach to Indianapolis flight tickets
American Airlines
Oct 15
MYR6:30 amMyrtle Beach Intl
3h 33m
1 stop
IND10:03 amIndianapolis
Oct 20
IND6:04 amIndianapolis
5h 21m
1 stop
MYR11:25 amMyrtle Beach Intl
$257
American Airlines
Sep 3
MYR12:14 pmMyrtle Beach Intl
5h 44m
1 stop
IND5:58 pmIndianapolis
Sep 7
IND6:48 pmIndianapolis
3h 50m
1 stop
MYR10:38 pmMyrtle Beach Intl
$259
American Airlines
Oct 2
MYR6:30 amMyrtle Beach Intl
3h 26m
1 stop
IND9:56 amIndianapolis
Oct 5
IND4:06 pmIndianapolis
6h 09m
1 stop
MYR10:15 pmMyrtle Beach Intl
$292

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Thu 10/15

6:30 am-10:03 am

1 stop3h 33m

Indianapolis

Tue 10/20

6:04 am-11:25 am

1 stop5h 21m

$257

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Tue 11/10

10:17 am-3:31 pm

1 stop5h 14m

Indianapolis

Thu 11/12

6:04 am-11:31 am

1 stop5h 27m

$257

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Wed 11/11

5:03 pm-9:05 pm

1 stop4h 02m

Indianapolis

Wed 11/18

4:24 pm-10:29 pm

1 stop6h 05m

$257
Quickest round-trip

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Mon 10/19

8:12 pm-12:37 am

1 stop4h 25m

Indianapolis

Sat 10/24

7:58 pm-11:47 pm

1 stop3h 49m

$257

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Sat 10/24

5:00 am-10:03 am

1 stop5h 03m

Indianapolis

Sat 10/31

6:08 am-11:13 am

1 stop5h 05m

$257

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Thu 9/3

12:14 pm-5:58 pm

1 stop5h 44m

Indianapolis

Mon 9/7

6:48 pm-10:38 pm

1 stop3h 50m

$259

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Thu 10/15

7:50 pm-12:40 am

1 stop4h 50m

Indianapolis

Tue 10/20

6:50 am-1:30 pm

2 stops6h 40m

$262

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Wed 11/11

11:27 am-11:47 pm

2 stops12h 20m

Indianapolis

Wed 11/18

11:01 am-5:11 pm

1 stop6h 10m

$262

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Tue 11/10

8:10 am-4:40 pm

2 stops8h 30m

Indianapolis

Thu 11/12

1:05 pm-6:55 pm

1 stop5h 50m

$263

Myrtle BeachIndianapolis

MYR Myrtle Beach Intl - IND Indianapolis

MYRIND

Myrtle Beach Intl

Fri 9/25

2:41 pm-10:25 am

1 stop19h 44m

Indianapolis

Fri 10/2

7:48 pm-8:52 am

2 stops37h 04m

$263

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Myrtle Beach to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, January is the cheapest month to fly from Myrtle Beach to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you are unable to visit Indianapolis during the month of January, then departing from Myrtle Beach during the month April is also very affordable. Most momondo users find prices during this month for around $288.

What is the cheapest Myrtle Beach Intl to Indianapolis flight route?

Fly from Myrtle Beach Intl to Indianapolis for the best Myrtle Beach Intl - Indianapolis flight prices

What cabin class options are available on Myrtle Beach to Indianapolis flights?

There is only 1 cabin class available to choose from on Myrtle Beach to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Indianapolis flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Indianapolis.

How have Myrtle Beach to Indianapolis flight prices changed over time?

As of August 2026, prices for Myrtle Beach to Indianapolis flights are approximately 177% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Indianapolis (MYR to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Indianapolis

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Myrtle Beach to Indianapolis takes 4h 02m
There are no direct flights from Myrtle Beach to Indianapolis. There are no popular flight routes from Myrtle Beach to Indianapolis.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Indianapolis

  • How far is Myrtle Beach Intl to Indianapolis by plane?

    A flight from Myrtle Beach Intl to Indianapolis will travel around 581.0 mi. Flights usually cover this in 4h 02m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Indianapolis Airport?

    Prices for flights from Myrtle Beach Intl Airport to Indianapolis Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Indianapolis Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Indianapolis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Myrtle Beach to Indianapolis?

  • What is the most popular airline from Myrtle Beach to Indianapolis?

Best airlines flying from Myrtle Beach to Indianapolis

Compare and see reviews for airlines that fly from Myrtle Beach to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,923 reviews
Search American Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Greenwood
Anderson
Plainfield
Noblesville
Carmel
West Lafayette
Speedway
Fishers
Franklin
Westfield
Seymour
Shelbyville
Brownsburg
Crawfordsville
Greenfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Indianapolis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Indianapolis from Myrtle Beach.

Can I find flights from Myrtle Beach to Indianapolis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Indianapolis from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Indianapolis?

Once all potential Myrtle Beach to Indianapolis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Myrtle Beach to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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