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Cheap flights from Missouri to Key West from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Key West departing on 3/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:22 pm - 9:06 am
STL
-
EYW
35h 44m
2 stops
Multiple Airlines Logo
9:46 am - 7:02 am
EYW
-
STL
22h 16m
1 stop
$221Multiple Airlines
Fri, Feb 27 - Thu, Mar 5
Multiple Airlines Logo
2:09 pm - 12:21 pm
STL
-
EYW
21h 12m
2 stops
Multiple Airlines Logo
11:51 am - 11:19 pm
EYW
-
STL
12h 28m
1 stop
$222Multiple Airlines
Mon, Mar 9 - Wed, Mar 11
American Airlines Logo
11:22 am - 7:12 pm
STL
-
EYW
6h 50m
1 stop
American Airlines Logo
7:42 pm - 11:58 pm
EYW
-
STL
5h 16m
1 stop
$223American Airlines
Wed, Mar 18 - Wed, Mar 25
United Airlines Logo
5:00 am - 4:36 pm
STL
-
EYW
10h 36m
2 stops
United Airlines Logo
4:05 pm - 9:42 pm
EYW
-
STL
6h 37m
1 stop
$228United Airlines
Wed, Mar 18 - Wed, Mar 25
Multiple Airlines Logo
2:51 pm - 9:06 am
STL
-
EYW
17h 15m
2 stops
Multiple Airlines Logo
1:06 pm - 11:41 am
EYW
-
STL
23h 35m
1 stop
$231Multiple Airlines
Sat, Feb 21 - Fri, Feb 27
Delta Logo
12:04 pm - 7:41 pm
STL
-
EYW
6h 37m
1 stop
Delta Logo
6:25 pm - 11:58 pm
EYW
-
STL
6h 33m
1 stop
$251Delta
Tue, Mar 24 - Thu, Apr 2
Delta Logo
1:25 pm - 7:41 pm
MCI
-
EYW
5h 16m
1 stop
Delta Logo
7:33 am - 1:58 pm
EYW
-
MCI
7h 25m
1 stop
$283Delta
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
3:30 pm - 10:37 pm
MCI
-
EYW
6h 07m
1 stop
American Airlines Logo
7:42 pm - 12:39 am
EYW
-
MCI
5h 57m
1 stop
$286American Airlines
Sat, Mar 7 - Thu, Mar 12
Spirit Airlines Logo
11:26 am - 1:30 pm
MCI
-
EYW
25h 04m
1 stop
Spirit Airlines Logo
2:25 pm - 10:30 am
EYW
-
MCI
21h 05m
1 stop
$296Spirit Airlines
Thu, Feb 26 - Thu, Mar 5
United Airlines Logo
3:15 pm - 10:09 pm
SGF
-
EYW
5h 54m
1 stop
United Airlines Logo
6:40 pm - 9:59 pm
EYW
-
SGF
28h 19m
2 stops
$518United Airlines
Sat, Feb 21 - Mon, Feb 23

American Airlines flights from Missouri to Key West

Our best American Airlines deals on Missouri to Key West flight tickets
American Airlines
Mar 18
STL11:22 amLambert-St Louis
6h 50m
1 stop
EYW7:12 pmKey West
Mar 25
EYW7:42 pmKey West
5h 16m
1 stop
STL11:58 pmLambert-St Louis
$223
American Airlines
Mar 7
MCI3:30 pmKansas City
6h 07m
1 stop
EYW10:37 pmKey West
Mar 12
EYW7:42 pmKey West
5h 57m
1 stop
MCI12:39 amKansas City
$286
American Airlines
Mar 18
STL11:22 amLambert-St Louis
6h 50m
1 stop
EYW7:12 pmKey West
Mar 25
EYW7:45 amKey West
8h 50m
2 stops
STL3:35 pmLambert-St Louis
$291

United Airlines flights from Missouri to Key West

Our best United Airlines deals on Missouri to Key West flight tickets
United Airlines
Mar 18
STL5:00 amLambert-St Louis
10h 36m
2 stops
EYW4:36 pmKey West
Mar 25
EYW4:05 pmKey West
6h 37m
1 stop
STL9:42 pmLambert-St Louis
$228
United Airlines
Feb 21
STL1:11 pmLambert-St Louis
7h 58m
1 stop
EYW10:09 pmKey West
Feb 25
EYW3:56 pmKey West
6h 09m
1 stop
STL9:05 pmLambert-St Louis
$309
United Airlines
Feb 14
MCI8:00 amKansas City
5h 51m
1 stop
EYW2:51 pmKey West
Feb 20
EYW7:00 amKey West
8h 24m
1 stop
MCI2:24 pmKansas City
$364

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 2/27

8:22 pm-9:06 am

2 stops35h 44m

Key West

Thu 3/5

9:46 am-7:02 am

1 stop22h 16m

$221

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 3/9

2:09 pm-12:21 pm

2 stops21h 12m

Key West

Wed 3/11

11:51 am-11:19 pm

1 stop12h 28m

$222

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

11:22 am-7:12 pm

1 stop6h 50m

Key West

Wed 3/25

7:42 pm-11:58 pm

1 stop5h 16m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

5:00 am-4:36 pm

2 stops10h 36m

Key West

Wed 3/25

4:05 pm-9:42 pm

1 stop6h 37m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 2/21

2:51 pm-9:06 am

2 stops17h 15m

Key West

Fri 2/27

1:06 pm-11:41 am

1 stop23h 35m

$231

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 3/24

12:04 pm-7:41 pm

1 stop6h 37m

Key West

Thu 4/2

6:25 pm-11:58 pm

1 stop6h 33m

$251

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 4/7

1:25 pm-7:41 pm

1 stop5h 16m

Key West

Tue 4/14

7:33 am-1:58 pm

1 stop7h 25m

$283

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sat 3/7

3:30 pm-10:37 pm

1 stop6h 07m

Key West

Thu 3/12

7:42 pm-12:39 am

1 stop5h 57m

$286

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Thu 2/26

11:26 am-1:30 pm

1 stop25h 04m

Key West

Thu 3/5

2:25 pm-10:30 am

1 stop21h 05m

$296

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Sat 2/21

3:15 pm-10:09 pm

1 stop5h 54m

Key West

Mon 2/23

6:40 pm-9:59 pm

2 stops28h 19m

$518

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Missouri to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, December is the cheapest month to fly from Missouri to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. If you are unable to visit Key West during the month of December, then departing from Missouri during the month August is also very affordable. Most momondo users find prices during this month for around $363.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Missouri for as low as $295 on momondo.

Cheap Missouri to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Key West

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Missouri to Key West takes 4h 45m
There are no direct flights from Missouri to Key West. There are no popular flight routes from Missouri to Key West.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Key West Airport?

    Prices for flights from Missouri to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Key West Airport?

  • How old do you have to be to fly from Missouri to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Key West

Compare and see reviews for airlines that fly from Missouri to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $189Free CancellationRating
7.9
8,173 reviews
Search Delta flights
American AirlinesPriceFrom $222Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights
United AirlinesPriceFrom $245Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Key West?

It is quick and easy to find Missouri to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Missouri to Key West with flexible booking policies on momondo?

Flights from Missouri to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Missouri.

I’m not ready to book a flight from Missouri to Key West right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Key West flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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