Cheap flights from Missouri to Key West from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Key West departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Delta Logo
10:15 am - 5:15 pmSTL-EYW
6h 00m1 stop
Delta Logo
7:00 am - 12:21 pmEYW-STL
6h 21m1 stop
$223Delta
Find Deal
Sat, Sep 13 - Tue, Sep 16
American Airlines Logo
6:10 am - 5:46 pmSTL-EYW
10h 36m2 stops
American Airlines Logo
6:17 pm - 11:07 pmEYW-STL
5h 50m1 stop
$228American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
American Airlines Logo
7:23 am - 5:46 pmSTL-EYW
9h 23m2 stops
American Airlines Logo
11:25 am - 6:32 pmEYW-STL
8h 07m2 stops
$233American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
Delta Logo
1:26 pm - 8:12 pmSTL-EYW
5h 46m1 stop
Delta Logo
6:20 pm - 10:02 pmEYW-STL
4h 42m1 stop
$241Delta
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
8:43 am - 7:07 pmSTL-EYW
9h 24m2 stops
American Airlines Logo
7:31 pm - 11:59 pmEYW-STL
5h 28m1 stop
$246American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
9:23 am - 7:07 pmSTL-EYW
8h 44m2 stops
American Airlines Logo
11:25 am - 8:32 pmEYW-STL
10h 07m2 stops
$251American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
8:54 am - 7:29 pmSTL-EYW
9h 35m2 stops
American Airlines Logo
6:33 pm - 11:07 pmEYW-STL
5h 34m1 stop
$256American Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
United Airlines Logo
6:00 am - 3:09 pmMCI-EYW
8h 09m1 stop
United Airlines Logo
3:02 pm - 11:44 pmEYW-MCI
9h 42m1 stop
$349United Airlines
Find Deal
Sat, Dec 13 - Wed, Dec 17
United Airlines Logo
8:00 am - 3:06 pmMCI-EYW
6h 06m1 stop
United Airlines Logo
4:50 pm - 10:42 pmEYW-MCI
6h 52m1 stop
$393United Airlines
Find Deal
Sun, Jan 11 - Fri, Jan 16
Spirit Airlines Logo
7:00 am - 1:30 pmMCI-EYW
29h 30m3 stops
Spirit Airlines Logo
2:25 pm - 12:40 amEYW-MCI
35h 15m3 stops
$487Spirit Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16

American Airlines flights from Missouri to Key West

Our best American Airlines deals on Missouri to Key West flight tickets
American Airlines
Sep 13
STL6:10 amLambert-St Louis
10h 36m
2 stops
EYW5:46 pmKey West
Sep 16
EYW6:17 pmKey West
5h 50m
1 stop
STL11:07 pmLambert-St Louis
American Airlines
Sep 13
STL7:23 amLambert-St Louis
9h 23m
2 stops
EYW5:46 pmKey West
Sep 16
EYW11:25 amKey West
8h 07m
2 stops
STL6:32 pmLambert-St Louis
American Airlines
Aug 27
STL8:43 amLambert-St Louis
9h 24m
2 stops
EYW7:07 pmKey West
Sep 3
EYW7:31 pmKey West
5h 28m
1 stop
STL11:59 pmLambert-St Louis

Delta flights from Missouri to Key West

Our best Delta deals on Missouri to Key West flight tickets
Delta
Sep 13
STL10:15 amLambert-St Louis
6h 00m
1 stop
EYW5:15 pmKey West
Sep 16
EYW7:00 amKey West
6h 21m
1 stop
STL12:21 pmLambert-St Louis
Delta
Aug 27
STL1:26 pmLambert-St Louis
5h 46m
1 stop
EYW8:12 pmKey West
Sep 3
EYW6:20 pmKey West
4h 42m
1 stop
STL10:02 pmLambert-St Louis
Delta
Oct 22
STL1:30 pmLambert-St Louis
5h 36m
1 stop
EYW8:06 pmKey West
Oct 28
EYW7:40 amKey West
5h 55m
1 stop
STL12:35 pmLambert-St Louis

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 9/13

10:15 am-5:15 pm

1 stop6h 00m

Key West

Tue 9/16

7:00 am-12:21 pm

1 stop6h 21m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 9/13

6:10 am-5:46 pm

2 stops10h 36m

Key West

Tue 9/16

6:17 pm-11:07 pm

1 stop5h 50m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 9/13

7:23 am-5:46 pm

2 stops9h 23m

Key West

Tue 9/16

11:25 am-6:32 pm

2 stops8h 07m

$233

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 8/27

1:26 pm-8:12 pm

1 stop5h 46m

Key West

Wed 9/3

6:20 pm-10:02 pm

1 stop4h 42m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 8/27

8:43 am-7:07 pm

2 stops9h 24m

Key West

Wed 9/3

7:31 pm-11:59 pm

1 stop5h 28m

$246

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 8/27

9:23 am-7:07 pm

2 stops8h 44m

Key West

Wed 9/3

11:25 am-8:32 pm

2 stops10h 07m

$251

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 11/8

8:54 am-7:29 pm

2 stops9h 35m

Key West

Tue 11/11

6:33 pm-11:07 pm

1 stop5h 34m

$256

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sat 12/13

6:00 am-3:09 pm

1 stop8h 09m

Key West

Wed 12/17

3:02 pm-11:44 pm

1 stop9h 42m

$349

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sun 1/11

8:00 am-3:06 pm

1 stop6h 06m

Key West

Fri 1/16

4:50 pm-10:42 pm

1 stop6h 52m

$393

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Thu 11/13

7:00 am-1:30 pm

3 stops29h 30m

Key West

Sun 11/16

2:25 pm-12:40 am

3 stops35h 15m

$487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Missouri to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, December is the cheapest month to fly from Missouri to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $378. If you are unable to visit Key West during the month of December, then departing from Missouri during the month August is also very affordable. Most momondo users find prices during this month for around $381.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Missouri is on a Friday. momondo users have found tickets for Friday departures for as low as $376. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Key West for around $557.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Missouri to Key West at noon for as low as $394. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the afternoon, with an average ticket price of $470. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $435 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Missouri for as low as $335 on momondo.

Cheap Missouri to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Key West

Best Price Found

$140

Fastest flight time

4h 48m

Direct flights

None

Airports in Key West

1 airport
The best one-way flight to Key West from Missouri in the past 72 hours is $140. The best round-trip flight deal from Missouri to Key West found on momondo in the last 72 hours is $223.
The fastest flight from Missouri to Key West takes 4h 48m
There are no direct flights from Missouri to Key West. Popular non-direct routes for this connection are Springfield-Branson Airport - Key West Airport, Lambert-St Louis Airport - Key West Airport and Kansas City Airport - Key West Airport.
There is 1 airport near Key West: Key West (EYW)

  • When did momondo last update prices for flights from Missouri to Key West Airport?

    Prices for flights from Missouri to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Key West Airport?

  • How old do you have to be to fly from Missouri to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.


Best airlines flying from Missouri to Key West

Compare and see reviews for airlines that fly from Missouri to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $189Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $245Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Key West?

It is quick and easy to find Missouri to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Missouri to Key West with flexible booking policies on momondo?

Flights from Missouri to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Missouri.

I’m not ready to book a flight from Missouri to Key West right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Key West flights. All you need is a valid email address and we will do the rest; it is that quick and easy.


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Tue 8/5
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