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Cheap flights from Missouri to Key West from $166

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Key West departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Missouri to Key West

Cheap round-trip flights

Delta Logo
6:00 am - 11:31 amSTL-EYW
4h 31m1 stop
Delta Logo
6:18 pm - 9:58 pmEYW-STL
4h 40m1 stop
$223Delta
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Tue, Nov 11 - Tue, Nov 18
American Airlines Logo
10:15 am - 7:23 pmSTL-EYW
8h 08m2 stops
American Airlines Logo
4:10 pm - 10:27 pmEYW-STL
7h 17m1 stop
$228American Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
American Airlines Logo
6:00 am - 4:27 pmSTL-EYW
9h 27m2 stops
American Airlines Logo
7:52 pm - 11:56 pmEYW-STL
5h 04m1 stop
$230American Airlines
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Sat, Oct 25 - Sat, Nov 1
American Airlines Logo
2:11 pm - 11:07 pmSTL-EYW
7h 56m2 stops
American Airlines Logo
7:00 am - 3:27 pmEYW-STL
9h 27m2 stops
$233American Airlines
Find Deal
Wed, Dec 3 - Sat, Dec 6
Multiple Airlines Logo
10:09 am - 8:15 amMCI-EYW
21h 06m1 stop
Multiple Airlines Logo
10:47 am - 4:34 pmEYW-MCI
6h 47m1 stop
$240Multiple Airlines
Find Deal
Wed, Nov 5 - Sat, Nov 8
United Airlines Logo
6:30 am - 3:19 pmSTL-EYW
7h 49m1 stop
United Airlines Logo
3:00 pm - 11:44 pmEYW-STL
9h 44m1 stop
$241United Airlines
Find Deal
Mon, Oct 27 - Sat, Nov 1
American Airlines Logo
8:41 am - 7:22 pmSTL-EYW
9h 41m2 stops
American Airlines Logo
7:52 pm - 11:56 pmEYW-STL
5h 04m1 stop
$246American Airlines
Find Deal
Mon, Oct 27 - Sat, Nov 1
United Airlines Logo
6:30 am - 5:13 pmSTL-EYW
9h 43m2 stops
United Airlines Logo
1:25 pm - 7:22 pmEYW-STL
6h 57m1 stop
$326United Airlines
Find Deal
Tue, Dec 23 - Fri, Dec 26
Allegiant Air Logo
8:27 pm - 9:45 pmSGF-EYW
24h 18m1 stop
Allegiant Air Logo
3:46 pm - 8:20 amEYW-SGF
17h 34m1 stop
$411Allegiant Air
Find Deal
Fri, Jan 2 - Sun, Jan 11
Allegiant Air Logo
8:27 pm - 9:45 pmSGF-EYW
24h 18m1 stop
Allegiant Air Logo
3:46 pm - 8:20 amEYW-SGF
17h 34m1 stop
$412Allegiant Air
Find Deal
Fri, Jan 2 - Sun, Jan 11

American Airlines flights from Missouri to Key West

Our best American Airlines deals on Missouri to Key West flight tickets
American Airlines
Nov 11
STL10:15 amLambert-St Louis
8h 08m
2 stops
EYW7:23 pmKey West
Nov 18
EYW4:10 pmKey West
7h 17m
1 stop
STL10:27 pmLambert-St Louis
$228
Find similar
American Airlines
Oct 25
STL6:00 amLambert-St Louis
9h 27m
2 stops
EYW4:27 pmKey West
Nov 1
EYW7:52 pmKey West
5h 04m
1 stop
STL11:56 pmLambert-St Louis
$230
Find similar
American Airlines
Dec 3
STL2:11 pmLambert-St Louis
7h 56m
2 stops
EYW11:07 pmKey West
Dec 6
EYW7:00 amKey West
9h 27m
2 stops
STL3:27 pmLambert-St Louis
$233
Find similar

United Airlines flights from Missouri to Key West

Our best United Airlines deals on Missouri to Key West flight tickets
United Airlines
Oct 27
STL6:30 amLambert-St Louis
7h 49m
1 stop
EYW3:19 pmKey West
Nov 1
EYW3:00 pmKey West
9h 44m
1 stop
STL11:44 pmLambert-St Louis
$241
Find similar
United Airlines
Dec 23
STL6:30 amLambert-St Louis
9h 43m
2 stops
EYW5:13 pmKey West
Dec 26
EYW1:25 pmKey West
6h 57m
1 stop
STL7:22 pmLambert-St Louis
$326
Find similar
United Airlines
Sep 24
STL7:08 amLambert-St Louis
6h 47m
1 stop
EYW2:55 pmKey West
Oct 1
EYW3:12 pmKey West
9h 45m
1 stop
STL11:57 pmLambert-St Louis
$388
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 18, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/11

6:00 am-11:31 am

1 stop4h 31m

Key West

Tue 11/18

6:18 pm-9:58 pm

1 stop4h 40m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/11

10:15 am-7:23 pm

2 stops8h 08m

Key West

Tue 11/18

4:10 pm-10:27 pm

1 stop7h 17m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 10/25

6:00 am-4:27 pm

2 stops9h 27m

Key West

Sat 11/1

7:52 pm-11:56 pm

1 stop5h 04m

$230

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 12/3

2:11 pm-11:07 pm

2 stops7h 56m

Key West

Sat 12/6

7:00 am-3:27 pm

2 stops9h 27m

$233

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 11/5

10:09 am-8:15 am

1 stop21h 06m

Key West

Sat 11/8

10:47 am-4:34 pm

1 stop6h 47m

$240

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 10/27

6:30 am-3:19 pm

1 stop7h 49m

Key West

Sat 11/1

3:00 pm-11:44 pm

1 stop9h 44m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 10/27

8:41 am-7:22 pm

2 stops9h 41m

Key West

Sat 11/1

7:52 pm-11:56 pm

1 stop5h 04m

$246

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 12/23

6:30 am-5:13 pm

2 stops9h 43m

Key West

Fri 12/26

1:25 pm-7:22 pm

1 stop6h 57m

$326

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Fri 1/2

8:27 pm-9:45 pm

1 stop24h 18m

Key West

Sun 1/11

3:46 pm-8:20 am

1 stop17h 34m

$411

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Fri 1/2

8:27 pm-9:45 pm

1 stop24h 18m

Key West

Sun 1/11

3:46 pm-8:20 am

1 stop17h 34m

$412

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Missouri to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, August is the cheapest month to fly from Missouri to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $353. If you are unable to visit Key West during the month of August, then departing from Missouri during the month December is also very affordable. Most momondo users find prices during this month for around $378.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Missouri is on a Friday. momondo users have found tickets for Friday departures for as low as $376. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Key West for around $557.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from Missouri to Key West at noon for as low as $394. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the afternoon, with an average ticket price of $470. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $427 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Missouri for as low as $334 on momondo.

Cheap Missouri to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Key West

Direct flights

None
There are no direct flights from Missouri to Key West. There are no popular flight routes from Missouri to Key West.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Key West Airport?

    Prices for flights from Missouri to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Key West Airport?

  • How old do you have to be to fly from Missouri to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Key West

Compare and see reviews for airlines that fly from Missouri to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $189Free CancellationRating
7.9
7,964 reviews
Search Delta flights
United AirlinesPriceFrom $245Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
American AirlinesPriceFrom $246Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Key West?

It is quick and easy to find Missouri to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Missouri to Key West with flexible booking policies on momondo?

Flights from Missouri to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Missouri.

I’m not ready to book a flight from Missouri to Key West right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Key West flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Key West trip

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