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Cheap flights from Missouri to Key West from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Key West departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:29 pm - 10:19 amSTL  Lambert-St Louis-EYW Key West
42h 50m2 stops Atlanta Hartsfield-Jackson Orlando
Multiple Airlines Logo
10:59 am - 4:34 pmEYW  Key West-STL Lambert-St Louis
6h 35m1 stop Orlando
$238Multiple Airlines
Fri, Sep 25 - Fri, Oct 2
Allegiant Air Logo
10:48 am - 12:02 pmSGF  Springfield-Branson-EYW Key West
24h 14m1 stop Tampa St. Petersburg
Allegiant Air Logo
8:34 am - 2:10 pmEYW  Key West-SGF Springfield-Branson
6h 36m1 stop Orlando Sanford Intl
$255Allegiant Air
Tue, Sep 29 - Fri, Oct 16
Multiple Airlines Logo
9:46 am - 12:36 pmMCI  Kansas City-EYW Key West
25h 50m2 stops Fort Lauderdale Tampa
Multiple Airlines Logo
9:54 am - 10:11 amEYW  Key West-MCI Kansas City
25h 17m1 stop Tampa St. Petersburg
$277Multiple Airlines
Mon, Nov 9 - Sat, Nov 14
American Airlines Logo
5:00 am - 10:56 amSTL  Lambert-St Louis-EYW Key West
4h 56m1 stop Miami
American Airlines Logo
6:27 pm - 10:42 pmEYW  Key West-STL Lambert-St Louis
5h 15m1 stop Charlotte Douglas
$303American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
6:53 am - 1:11 pmSTL  Lambert-St Louis-EYW Key West
5h 18m1 stop Charlotte Douglas
American Airlines Logo
6:27 pm - 10:42 pmEYW  Key West-STL Lambert-St Louis
5h 15m1 stop Charlotte Douglas
$303American Airlines
Tue, Sep 22 - Tue, Sep 29
American Airlines Logo
10:35 am - 6:01 pmSTL  Lambert-St Louis-EYW Key West
6h 26m1 stop Charlotte Douglas
American Airlines Logo
4:49 pm - 11:59 pmEYW  Key West-STL Lambert-St Louis
8h 10m1 stop Chicago O'Hare Intl
$303American Airlines
Wed, Dec 2 - Sat, Dec 12
Delta Logo
7:04 am - 12:53 pmMCI  Kansas City-EYW Key West
4h 49m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:19 pm - 11:51 pmEYW  Key West-MCI Kansas City
6h 32m1 stop Atlanta Hartsfield-Jackson
$307Delta
Tue, Sep 8 - Tue, Sep 15
United Airlines Logo
5:00 am - 1:11 pmSTL  Lambert-St Louis-EYW Key West
7h 11m1 stop Chicago O'Hare Intl
United Airlines Logo
3:50 pm - 11:00 pmEYW  Key West-STL Lambert-St Louis
8h 10m1 stop Newark
$316United Airlines
Wed, Dec 16 - Sun, Dec 20
United Airlines Logo
6:00 am - 1:11 pmSTL  Lambert-St Louis-EYW Key West
6h 11m1 stop Chicago O'Hare Intl
United Airlines Logo
4:05 pm - 9:13 pmEYW  Key West-STL Lambert-St Louis
6h 08m1 stop Chicago O'Hare Intl
$321United Airlines
Mon, Dec 7 - Sat, Dec 12
Delta Logo
2:26 pm - 8:00 pmMCI  Kansas City-EYW Key West
4h 34m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:40 am - 1:21 pmEYW  Key West-MCI Kansas City
6h 41m1 stop Atlanta Hartsfield-Jackson
$340Delta
Sat, Sep 12 - Sat, Sep 19

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Delta flights from Missouri to Key West

Our best Delta deals on Missouri to Key West flight tickets
Delta
Sep 8
MCI7:04 amKansas City
4h 49m
1 stop
EYW12:53 pmKey West
Sep 15
EYW6:19 pmKey West
6h 32m
1 stop
MCI11:51 pmKansas City
$307
Delta
Oct 23
MCI6:00 amKansas City
5h 53m
1 stop
EYW12:53 pmKey West
Oct 27
EYW7:40 amKey West
6h 54m
1 stop
MCI1:34 pmKansas City
$340
Delta
Dec 10
SGF11:46 amSpringfield-Branson
7h 16m
1 stop
EYW8:02 pmKey West
Dec 15
EYW6:02 pmKey West
5h 34m
1 stop
SGF10:36 pmSpringfield-Branson
$354

American Airlines flights from Missouri to Key West

Our best American Airlines deals on Missouri to Key West flight tickets
American Airlines
Sep 22
STL6:53 amLambert-St Louis
5h 18m
1 stop
EYW1:11 pmKey West
Sep 29
EYW6:27 pmKey West
5h 15m
1 stop
STL10:42 pmLambert-St Louis
$303
American Airlines
Dec 16
SGF7:14 amSpringfield-Branson
8h 18m
1 stop
EYW4:32 pmKey West
Dec 21
EYW5:16 pmKey West
6h 25m
1 stop
SGF10:41 pmSpringfield-Branson
$329
American Airlines
Sep 22
STL5:00 amLambert-St Louis
4h 57m
1 stop
EYW10:57 amKey West
Sep 26
EYW7:47 pmKey West
5h 12m
1 stop
STL11:59 pmLambert-St Louis
$353

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Fri 9/25

2:29 pm-10:19 am

2 stops42h 50m

Key West

Fri 10/2

10:59 am-4:34 pm

1 stop6h 35m

$238

SpringfieldKey West

SGF Springfield-Branson - EYW Key West

SGFEYW

Springfield-Branson

Tue 9/29

10:48 am-12:02 pm

1 stop24h 14m

Key West

Fri 10/16

8:34 am-2:10 pm

1 stop6h 36m

$255

Kansas CityKey West

MCI Kansas City - EYW Key West

MCIEYW

Kansas City

Mon 11/9

9:46 am-12:36 pm

2 stops25h 50m

Key West

Sat 11/14

9:54 am-10:11 am

1 stop25h 17m

$277
Quickest round-trip

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Tue 9/8

5:00 am-10:56 am

1 stop4h 56m

Key West

Tue 9/15

6:27 pm-10:42 pm

1 stop5h 15m

$303

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Tue 9/22

6:53 am-1:11 pm

1 stop5h 18m

Key West

Tue 9/29

6:27 pm-10:42 pm

1 stop5h 15m

$303

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Wed 12/2

10:35 am-6:01 pm

1 stop6h 26m

Key West

Sat 12/12

4:49 pm-11:59 pm

1 stop8h 10m

$303

Kansas CityKey West

MCI Kansas City - EYW Key West

MCIEYW

Kansas City

Tue 9/8

7:04 am-12:53 pm

1 stop4h 49m

Key West

Tue 9/15

6:19 pm-11:51 pm

1 stop6h 32m

$307

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Wed 12/16

5:00 am-1:11 pm

1 stop7h 11m

Key West

Sun 12/20

3:50 pm-11:00 pm

1 stop8h 10m

$316

St. LouisKey West

STL Lambert-St Louis - EYW Key West

STLEYW

Lambert-St Louis

Mon 12/7

6:00 am-1:11 pm

1 stop6h 11m

Key West

Sat 12/12

4:05 pm-9:13 pm

1 stop6h 08m

$321

Kansas CityKey West

MCI Kansas City - EYW Key West

MCIEYW

Kansas City

Sat 9/12

2:26 pm-8:00 pm

1 stop4h 34m

Key West

Sat 9/19

7:40 am-1:21 pm

1 stop6h 41m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Missouri to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, January is the cheapest month to fly from Missouri to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $364. If you are unable to visit Key West during the month of January, then departing from Missouri during the month February is also very affordable. Most momondo users find prices during this month for around $398.

How far in advance should I book a flight from Missouri to Key West?

You are more likely to see cheaper flights to Key West from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Missouri for as low as $333 on momondo.

Can stopping save me money on Missouri to Key West flights?

You could potentially save up to 46% on your flight if you consider stops on a Missouri to Key West flight.

Cheap Missouri to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Key West

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Missouri to Key West takes 4h 31m
There are no direct flights from Missouri to Key West. There are no popular flight routes from Missouri to Key West.
Search flight deals

Frequently asked questions about flying from Missouri to Key West

  • When did momondo last update prices for flights from Missouri to Key West Airport?

    Prices for flights from Missouri to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Key West Airport?

  • How old do you have to be to fly from Missouri to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Key West

Compare and see reviews for airlines that fly from Missouri to Key West with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $222Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights
DeltaPriceFrom $242Free CancellationRating
7.8
8,502 reviews
Search Delta flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Key West?

It is quick and easy to find Missouri to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Missouri to Key West with flexible booking policies on momondo?

Flights from Missouri to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Missouri.

I’m not ready to book a flight from Missouri to Key West right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Key West flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Key West trip

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