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Cheap flights from Missouri to Key West from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Key West departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 3:24 pm
STL
-
EYW
8h 24m
1 stop
American Airlines Logo
6:49 pm - 11:46 pm
EYW
-
STL
5h 57m
1 stop
$223American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
12:59 pm - 10:58 pm
STL
-
EYW
8h 59m
2 stops
American Airlines Logo
6:49 pm - 11:46 pm
EYW
-
STL
5h 57m
1 stop
$228American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
6:00 am - 3:26 pm
STL
-
EYW
8h 26m
1 stop
American Airlines Logo
2:26 pm - 8:16 pm
EYW
-
STL
6h 50m
1 stop
$251American Airlines
Wed, Mar 18 - Wed, Mar 25
Multiple Airlines Logo
11:27 am - 11:11 am
STL
-
EYW
22h 44m
2 stops
Multiple Airlines Logo
11:51 am - 11:25 pm
EYW
-
STL
12h 34m
1 stop
$262Multiple Airlines
Tue, Mar 24 - Wed, Apr 1
Multiple Airlines Logo
4:51 pm - 9:06 am
STL
-
EYW
15h 15m
1 stop
Multiple Airlines Logo
11:51 am - 5:34 pm
EYW
-
STL
30h 43m
2 stops
$270Multiple Airlines
Wed, Mar 25 - Wed, Apr 1
Delta Logo
10:49 am - 5:23 pm
MCI
-
EYW
5h 34m
1 stop
Delta Logo
11:48 am - 5:31 pm
EYW
-
MCI
6h 43m
1 stop
$283Delta
Wed, May 6 - Wed, May 13
Delta Logo
10:49 am - 5:23 pm
MCI
-
EYW
5h 34m
1 stop
Delta Logo
6:18 pm - 11:50 pm
EYW
-
MCI
6h 32m
1 stop
$311Delta
Tue, Apr 28 - Sat, May 2
United Airlines Logo
7:40 am - 3:06 pm
JLN
-
EYW
6h 26m
1 stop
United Airlines Logo
4:05 pm - 11:14 pm
EYW
-
JLN
8h 09m
1 stop
$354United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
7:40 am - 3:06 pm
JLN
-
EYW
6h 26m
1 stop
United Airlines Logo
7:00 am - 5:11 pm
EYW
-
JLN
11h 11m
2 stops
$364United Airlines
Sat, Aug 22 - Wed, Aug 26
Allegiant Air Logo
8:30 pm - 2:09 pm
SGF
-
EYW
16h 39m
1 stop
Allegiant Air Logo
2:59 pm - 10:00 am
EYW
-
SGF
20h 01m
1 stop
$536Allegiant Air
Thu, Mar 12 - Mon, Mar 16

United Airlines flights from Missouri to Key West

Our best United Airlines deals on Missouri to Key West flight tickets
United Airlines
Mar 4
STL7:41 amLambert-St Louis
6h 19m
1 stop
EYW3:00 pmKey West
Mar 11
EYW5:30 pmKey West
7h 21m
1 stop
STL11:51 pmLambert-St Louis
$329
United Airlines
Mar 4
STL6:25 amLambert-St Louis
8h 42m
2 stops
EYW4:07 pmKey West
Mar 11
EYW5:30 pmKey West
7h 21m
1 stop
STL11:51 pmLambert-St Louis
$334
United Airlines
Aug 22
JLN7:40 amJoplin
6h 26m
1 stop
EYW3:06 pmKey West
Aug 26
EYW4:05 pmKey West
8h 09m
1 stop
JLN11:14 pmJoplin
$354

American Airlines flights from Missouri to Key West

Our best American Airlines deals on Missouri to Key West flight tickets
American Airlines
Apr 7
STL6:00 amLambert-St Louis
8h 24m
1 stop
EYW3:24 pmKey West
Apr 14
EYW6:49 pmKey West
5h 57m
1 stop
STL11:46 pmLambert-St Louis
$223
American Airlines
Apr 7
STL12:59 pmLambert-St Louis
8h 59m
2 stops
EYW10:58 pmKey West
Apr 14
EYW6:49 pmKey West
5h 57m
1 stop
STL11:46 pmLambert-St Louis
$228
American Airlines
Mar 18
STL6:00 amLambert-St Louis
8h 26m
1 stop
EYW3:26 pmKey West
Mar 25
EYW2:26 pmKey West
6h 50m
1 stop
STL8:16 pmLambert-St Louis
$251

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 4/7

6:00 am-3:24 pm

1 stop8h 24m

Key West

Tue 4/14

6:49 pm-11:46 pm

1 stop5h 57m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 4/7

12:59 pm-10:58 pm

2 stops8h 59m

Key West

Tue 4/14

6:49 pm-11:46 pm

1 stop5h 57m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

6:00 am-3:26 pm

1 stop8h 26m

Key West

Wed 3/25

2:26 pm-8:16 pm

1 stop6h 50m

$251

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 3/24

11:27 am-11:11 am

2 stops22h 44m

Key West

Wed 4/1

11:51 am-11:25 pm

1 stop12h 34m

$262

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/25

4:51 pm-9:06 am

1 stop15h 15m

Key West

Wed 4/1

11:51 am-5:34 pm

2 stops30h 43m

$270

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 5/6

10:49 am-5:23 pm

1 stop5h 34m

Key West

Wed 5/13

11:48 am-5:31 pm

1 stop6h 43m

$283

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 4/28

10:49 am-5:23 pm

1 stop5h 34m

Key West

Sat 5/2

6:18 pm-11:50 pm

1 stop6h 32m

$311

JoplinKey West

JLN - EYW

JLNEYW

Joplin

Sat 8/22

7:40 am-3:06 pm

1 stop6h 26m

Key West

Wed 8/26

4:05 pm-11:14 pm

1 stop8h 09m

$354

JoplinKey West

JLN - EYW

JLNEYW

Joplin

Sat 8/22

7:40 am-3:06 pm

1 stop6h 26m

Key West

Wed 8/26

7:00 am-5:11 pm

2 stops11h 11m

$364

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Thu 3/12

8:30 pm-2:09 pm

1 stop16h 39m

Key West

Mon 3/16

2:59 pm-10:00 am

1 stop20h 01m

$536

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Missouri to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, December is the cheapest month to fly from Missouri to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. If you are unable to visit Key West during the month of December, then departing from Missouri during the month January is also very affordable. Most momondo users find prices during this month for around $328.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Missouri for as low as $290 on momondo.

Cheap Missouri to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Key West

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Missouri to Key West takes 4h 25m
There are no direct flights from Missouri to Key West. There are no popular flight routes from Missouri to Key West.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Key West Airport?

    Prices for flights from Missouri to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Key West Airport?

  • How old do you have to be to fly from Missouri to Key West Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Key West

Compare and see reviews for airlines that fly from Missouri to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $164Free CancellationRating
7.9
8,237 reviews
Search Delta flights
American AirlinesPriceFrom $222Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
9,348 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Key West?

It is quick and easy to find Missouri to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Missouri to Key West with flexible booking policies on momondo?

Flights from Missouri to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from Missouri.

I’m not ready to book a flight from Missouri to Key West right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to Key West flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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