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Cheap flights from Missouri to Buffalo from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Buffalo departing on 1/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:18 am - 6:36 pm
STL
-
BUF
6h 18m1 stop
Frontier Logo
12:29 pm - 11:33 pm
BUF
-
STL
12h 04m1 stop
$268Frontier
Fri, Jan 30 - Sat, Jan 31
American Airlines Logo
6:24 pm - 11:59 pm
SGF
-
BUF
4h 35m1 stop
American Airlines Logo
7:00 am - 12:15 pm
BUF
-
SGF
6h 15m1 stop
$274American Airlines
Sun, Jan 4 - Sun, Jan 11
Multiple Airlines Logo
5:04 pm - 11:34 am
MCI
-
BUF
17h 30m1 stop
Multiple Airlines Logo
11:02 am - 4:09 pm
BUF
-
MCI
30h 07m1 stop
$284Multiple Airlines
Fri, Jan 23 - Sun, Jan 25
Delta Logo
4:01 pm - 11:56 pm
MCI
-
BUF
6h 55m1 stop
Delta Logo
12:25 pm - 5:00 pm
BUF
-
MCI
5h 35m1 stop
$293Delta
Sat, Jan 17 - Sat, Jan 24
Delta Logo
6:00 am - 2:10 pm
MCI
-
BUF
7h 10m1 stop
Delta Logo
5:35 pm - 11:04 pm
BUF
-
MCI
6h 29m1 stop
$295Delta
Thu, Jan 15 - Sun, Jan 18
United Airlines Logo
3:24 pm - 8:29 pm
MCI
-
BUF
4h 05m1 stop
United Airlines Logo
9:55 am - 5:41 pm
BUF
-
MCI
8h 46m2 stops
$298United Airlines
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
8:00 am - 7:25 pm
MCI
-
BUF
10h 25m2 stops
United Airlines Logo
8:30 am - 2:27 pm
BUF
-
MCI
6h 57m1 stop
$300United Airlines
Thu, Jan 15 - Sun, Jan 18
Frontier Logo
7:52 am - 10:49 am
STL
-
BUF
25h 57m1 stop
Frontier Logo
9:25 pm - 7:07 am
BUF
-
STL
10h 42m1 stop
$300Frontier
Fri, Mar 6 - Sun, Mar 8
Southwest Logo
6:50 am - 12:30 pm
STL
-
BUF
4h 40m1 stop
Southwest Logo
12:20 pm - 7:00 pm
BUF
-
STL
7h 40m1 stop
$312Southwest
Fri, Jan 30 - Wed, Feb 4
Southwest Logo
8:20 am - 5:05 pm
STL
-
BUF
7h 45m2 stops
Southwest Logo
12:10 pm - 6:55 pm
BUF
-
STL
7h 45m1 stop
$317Southwest
Fri, Jan 30 - Tue, Feb 3

Frontier flights from Missouri to Buffalo

Our best Frontier deals on Missouri to Buffalo flight tickets
Frontier
Jan 30
STL11:18 amLambert-St Louis
6h 18m
1 stop
BUF6:36 pmBuffalo
Jan 31
BUF12:29 pmBuffalo
12h 04m
1 stop
STL11:33 pmLambert-St Louis
$268
Find similar
Frontier
Mar 6
STL7:52 amLambert-St Louis
25h 57m
1 stop
BUF10:49 amBuffalo
Mar 8
BUF9:25 pmBuffalo
10h 42m
1 stop
STL7:07 amLambert-St Louis
$300
Find similar
Frontier
Mar 6
STL7:52 amLambert-St Louis
11h 38m
1 stop
BUF8:30 pmBuffalo
Mar 8
BUF9:25 pmBuffalo
10h 42m
1 stop
STL7:07 amLambert-St Louis
$331
Find similar

American Airlines flights from Missouri to Buffalo

Our best American Airlines deals on Missouri to Buffalo flight tickets
American Airlines
Jan 4
SGF6:24 pmSpringfield-Branson
4h 35m
1 stop
BUF11:59 pmBuffalo
Jan 11
BUF7:00 amBuffalo
6h 15m
1 stop
SGF12:15 pmSpringfield-Branson
$274
Find similar
American Airlines
Jan 6
SGF5:39 pmSpringfield-Branson
5h 02m
1 stop
BUF11:41 pmBuffalo
Jan 12
BUF11:27 amBuffalo
10h 33m
2 stops
SGF9:00 pmSpringfield-Branson
$314
Find similar
American Airlines
Jan 6
SGF12:26 pmSpringfield-Branson
9h 14m
2 stops
BUF10:40 pmBuffalo
Jan 12
BUF11:27 amBuffalo
9h 58m
2 stops
SGF8:25 pmSpringfield-Branson
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 1/30

11:18 am-6:36 pm

1 stop6h 18m

Buffalo

Sat 1/31

12:29 pm-11:33 pm

1 stop12h 04m

$268

SpringfieldBuffalo

SGF - BUF

SGFBUF

Springfield-Branson

Sun 1/4

6:24 pm-11:59 pm

1 stop4h 35m

Buffalo

Sun 1/11

7:00 am-12:15 pm

1 stop6h 15m

$274

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Fri 1/23

5:04 pm-11:34 am

1 stop17h 30m

Buffalo

Sun 1/25

11:02 am-4:09 pm

1 stop30h 07m

$284

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Sat 1/17

4:01 pm-11:56 pm

1 stop6h 55m

Buffalo

Sat 1/24

12:25 pm-5:00 pm

1 stop5h 35m

$293

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Thu 1/15

6:00 am-2:10 pm

1 stop7h 10m

Buffalo

Sun 1/18

5:35 pm-11:04 pm

1 stop6h 29m

$295

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Sat 1/17

3:24 pm-8:29 pm

1 stop4h 05m

Buffalo

Sat 1/24

9:55 am-5:41 pm

2 stops8h 46m

$298

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Thu 1/15

8:00 am-7:25 pm

2 stops10h 25m

Buffalo

Sun 1/18

8:30 am-2:27 pm

1 stop6h 57m

$300

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 3/6

7:52 am-10:49 am

1 stop25h 57m

Buffalo

Sun 3/8

9:25 pm-7:07 am

1 stop10h 42m

$300

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 1/30

6:50 am-12:30 pm

1 stop4h 40m

Buffalo

Wed 2/4

12:20 pm-7:00 pm

1 stop7h 40m

$312

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 1/30

8:20 am-5:05 pm

2 stops7h 45m

Buffalo

Tue 2/3

12:10 pm-6:55 pm

1 stop7h 45m

$317

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Missouri to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of January, then book flights to Buffalo from Missouri during November instead. Flights to Buffalo in November, while not as cheap as those in January, still average around $331.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Wednesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $332. Flights from Missouri to Buffalo on a Saturday will generally be more expensive and average around $386. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the evening is the cheapest time of day to fly from Missouri to Buffalo when you can find flight prices for as low as $248. Flying to Buffalo in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Buffalo, so prices are often more expensive at around $371 per ticket.

How far in advance should I book a flight to Buffalo?

You are more likely to see cheaper flights to Buffalo from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Buffalo for around $377 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Buffalo from Missouri for as low as $285 on momondo.

Cheap Missouri to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Buffalo

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Missouri to Buffalo takes 3h 45m
There are no direct flights from Missouri to Buffalo. There are no popular flight routes from Missouri to Buffalo.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Buffalo Airport?

    Prices for flights from Missouri to Buffalo Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Buffalo Airport?

  • How old do you have to be to fly from Missouri to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Missouri to Buffalo?

Best airlines flying from Missouri to Buffalo

Compare and see reviews for airlines that fly from Missouri to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $167Free CancellationRating
7.4
9,100 reviews
Search United Airlines flights
American AirlinesPriceFrom $221Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,021 reviews
Search Delta flights
SouthwestPriceFrom $296Free CancellationRating
8.0
4,257 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Missouri to Buffalo for you.

Can I find flights from Missouri to Buffalo with flexible booking policies on momondo?

Flights from Missouri to Buffalo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Buffalo?

momondo helps you find the best flight between Missouri and Buffalo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Buffalo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Buffalo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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