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Cheap flights from Missouri to Buffalo from $84

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Buffalo departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
10:35 am - 12:18 pmSTL  Lambert-St Louis-BUF Buffalo
24h 43m1 stop Atlanta Hartsfield-Jackson
Frontier Logo
1:13 pm - 9:40 amBUF  Buffalo-STL Lambert-St Louis
21h 27m1 stop Atlanta Hartsfield-Jackson
$143Frontier
Mon, Oct 12 - Wed, Oct 14
Frontier Logo
2:29 pm - 5:45 pmSTL  Lambert-St Louis-BUF Buffalo
26h 16m2 stops Atlanta Hartsfield-Jackson Orlando
Frontier Logo
1:13 pm - 9:40 amBUF  Buffalo-STL Lambert-St Louis
21h 27m1 stop Atlanta Hartsfield-Jackson
$211Frontier
Wed, Sep 30 - Fri, Oct 9
Southwest Logo
6:30 am - 11:20 amSTL  Lambert-St Louis-BUF Buffalo
3h 50m1 stop Chicago Midway
Southwest Logo
8:55 am - 2:50 pmBUF  Buffalo-STL Lambert-St Louis
6h 55m1 stop Baltimore/Washington
$227Southwest
Wed, Sep 23 - Wed, Sep 30
Southwest Logo
9:25 am - 5:35 pmSTL  Lambert-St Louis-BUF Buffalo
7h 10m1 stop Baltimore/Washington
Southwest Logo
7:20 pm - 12:30 amBUF  Buffalo-STL Lambert-St Louis
6h 10m1 stop Orlando
$227Southwest
Sat, Oct 3 - Mon, Oct 5
American Airlines Logo
11:01 am - 5:18 pmSTL  Lambert-St Louis-BUF Buffalo
5h 17m1 stop Chicago O'Hare Intl
American Airlines Logo
2:55 pm - 8:32 pmBUF  Buffalo-STL Lambert-St Louis
6h 37m1 stop Washington, D.C. Reagan-National
$227American Airlines
Wed, Sep 30 - Tue, Oct 13
American Airlines Logo
11:01 am - 5:18 pmSTL  Lambert-St Louis-BUF Buffalo
5h 17m1 stop Chicago O'Hare Intl
American Airlines Logo
2:55 pm - 8:32 pmBUF  Buffalo-STL Lambert-St Louis
6h 37m1 stop Washington, D.C. Reagan-National
$227American Airlines
Wed, Sep 30 - Tue, Oct 13
United Airlines Logo
9:43 am - 4:55 pmSTL  Lambert-St Louis-BUF Buffalo
6h 12m1 stop Chicago O'Hare Intl
United Airlines Logo
6:30 am - 10:12 amBUF  Buffalo-STL Lambert-St Louis
4h 42m1 stop Chicago O'Hare Intl
$248United Airlines
Tue, Sep 8 - Thu, Sep 10
United Airlines Logo
1:43 pm - 10:37 pmMCI  Kansas City-BUF Buffalo
7h 54m1 stop Denver Intl
United Airlines Logo
7:00 am - 10:25 amBUF  Buffalo-MCI Kansas City
4h 25m1 stop Chicago O'Hare Intl
$255United Airlines
Sat, Sep 12 - Wed, Sep 16
Delta Logo
6:05 pm - 11:59 pmSTL  Lambert-St Louis-BUF Buffalo
4h 54m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:10 am - 9:44 amBUF  Buffalo-STL Lambert-St Louis
4h 34m1 stop Detroit Metropolitan Wayne County
$257Delta
Mon, Oct 12 - Fri, Oct 16
Delta Logo
4:00 pm - 11:52 pmSGF  Springfield-Branson-BUF Buffalo
6h 52m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:20 pm - 9:19 pmBUF  Buffalo-SGF Springfield-Branson
4h 59m1 stop Atlanta Hartsfield-Jackson
$271Delta
Sat, Oct 3 - Sat, Oct 10

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Southwest flights from Missouri to Buffalo

Our best Southwest deals on Missouri to Buffalo flight tickets
Southwest
Sep 23
STL6:30 amLambert-St Louis
6h 50m
2 stops
BUF2:20 pmBuffalo
Sep 30
BUF8:55 amBuffalo
6h 55m
1 stop
STL2:50 pmLambert-St Louis
$232
Southwest
Sep 23
STL1:50 pmLambert-St Louis
7h 00m
1 stop
BUF9:50 pmBuffalo
Sep 30
BUF6:00 amBuffalo
6h 20m
2 stops
STL11:20 amLambert-St Louis
$233
Southwest
Sep 23
STL6:30 amLambert-St Louis
6h 50m
2 stops
BUF2:20 pmBuffalo
Sep 30
BUF6:00 amBuffalo
6h 20m
2 stops
STL11:20 amLambert-St Louis
$238

American Airlines flights from Missouri to Buffalo

Our best American Airlines deals on Missouri to Buffalo flight tickets
American Airlines
Sep 30
STL11:01 amLambert-St Louis
5h 17m
1 stop
BUF5:18 pmBuffalo
Oct 13
BUF2:55 pmBuffalo
6h 37m
1 stop
STL8:32 pmLambert-St Louis
$227
American Airlines
Sep 7
STL4:50 pmLambert-St Louis
6h 12m
1 stop
BUF12:02 amBuffalo
Sep 14
BUF6:56 pmBuffalo
6h 31m
1 stop
STL12:27 amLambert-St Louis
$249
American Airlines
Sep 5
MCI3:47 pmKansas City
7h 15m
1 stop
BUF12:02 amBuffalo
Sep 8
BUF5:00 amBuffalo
4h 53m
1 stop
MCI8:53 amKansas City
$255

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Mon 10/12

10:35 am-12:18 pm

1 stop24h 43m

Buffalo

Wed 10/14

1:13 pm-9:40 am

1 stop21h 27m

$143

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Wed 9/30

2:29 pm-5:45 pm

2 stops26h 16m

Buffalo

Fri 10/9

1:13 pm-9:40 am

1 stop21h 27m

$211

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Wed 9/23

6:30 am-11:20 am

1 stop3h 50m

Buffalo

Wed 9/30

8:55 am-2:50 pm

1 stop6h 55m

$227

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Sat 10/3

9:25 am-5:35 pm

1 stop7h 10m

Buffalo

Mon 10/5

7:20 pm-12:30 am

1 stop6h 10m

$227

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Wed 9/30

11:01 am-5:18 pm

1 stop5h 17m

Buffalo

Tue 10/13

2:55 pm-8:32 pm

1 stop6h 37m

$227

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Wed 9/30

11:01 am-5:18 pm

1 stop5h 17m

Buffalo

Tue 10/13

2:55 pm-8:32 pm

1 stop6h 37m

$227

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Tue 9/8

9:43 am-4:55 pm

1 stop6h 12m

Buffalo

Thu 9/10

6:30 am-10:12 am

1 stop4h 42m

$248

Kansas CityBuffalo

MCI Kansas City - BUF Buffalo

MCIBUF

Kansas City

Sat 9/12

1:43 pm-10:37 pm

1 stop7h 54m

Buffalo

Wed 9/16

7:00 am-10:25 am

1 stop4h 25m

$255
Quickest round-trip

St. LouisBuffalo

STL Lambert-St Louis - BUF Buffalo

STLBUF

Lambert-St Louis

Mon 10/12

6:05 pm-11:59 pm

1 stop4h 54m

Buffalo

Fri 10/16

6:10 am-9:44 am

1 stop4h 34m

$257

SpringfieldBuffalo

SGF Springfield-Branson - BUF Buffalo

SGFBUF

Springfield-Branson

Sat 10/3

4:00 pm-11:52 pm

1 stop6h 52m

Buffalo

Sat 10/10

5:20 pm-9:19 pm

1 stop4h 59m

$271

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Missouri to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Missouri during February instead. Flights to Buffalo in February, while not as cheap as those in September, still average around $337.

Cheap Missouri to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Buffalo

Fastest flight time

3h 39m

Direct flights

None
The fastest flight from Missouri to Buffalo takes 3h 39m
There are no direct flights from Missouri to Buffalo. There are no popular flight routes from Missouri to Buffalo.
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Frequently asked questions about flying from Missouri to Buffalo

  • When did momondo last update prices for flights from Missouri to Buffalo Airport?

    Prices for flights from Missouri to Buffalo Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Missouri to Buffalo Airport?

  • How old do you have to be to fly from Missouri to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Buffalo

Compare and see reviews for airlines that fly from Missouri to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $115Free CancellationRating
5.6
2,701 reviews
Search Frontier flights
United AirlinesPriceFrom $145Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights
American AirlinesPriceFrom $221Free CancellationRating
7.1
11,911 reviews
Search American Airlines flights
DeltaPriceFrom $226Free CancellationRating
7.8
8,505 reviews
Search Delta flights
SouthwestPriceFrom $274Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Missouri to Buffalo for you.

Can I find flights from Missouri to Buffalo with flexible booking policies on momondo?

Flights from Missouri to Buffalo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Buffalo?

momondo helps you find the best flight between Missouri and Buffalo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Buffalo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Buffalo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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