What is the cheapest airline that flies from Missouri to Buffalo?

Frontier, American Airlines, and Delta are the most popular carriers operating from Missouri to Buffalo

How long does it take to fly to Buffalo?

On average, it takes 4h 05m to fly from Missouri to Buffalo if you fly out of St. Louis (the most popular airport in Missouri) and into Buffalo (the most popular airport in Buffalo). If you’re flying out of Columbia and into Buffalo, then the flight time is around 4h 18m.

What airlines fly to Buffalo?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Buffalo from Missouri according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 4 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Missouri to Buffalo Airport?

Prices for flights from Missouri to Buffalo Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Missouri to Buffalo Airport?

The number of operators available for flights from Missouri to Buffalo Airport is 4 as of May 2026.

How old do you have to be to fly from Missouri to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$62 Cheap Flights from Missouri to Buffalo in 2026

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Find the cheapest flights from Missouri to Buffalo

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:06 pm - 10:55 am

STL

BUF

16h 49m

1 stop

11:35 am - 5:30 pm

BUF

STL

6h 55m

1 stop

$121Frontier

Mon, Jun 22 - Thu, Jun 25

5:33 pm - 10:40 am

STL

BUF

16h 07m

1 stop

2:50 pm - 8:52 am

BUF

STL

19h 02m

1 stop

$123Frontier

Mon, Aug 24 - Fri, Aug 28

5:27 pm - 11:28 am

STL

BUF

17h 01m

1 stop

11:36 am - 5:33 pm

BUF

STL

6h 57m

1 stop

$124Frontier

Fri, Jun 5 - Sun, Jun 7

6:31 pm - 1:55 pm

STL

BUF

18h 24m

1 stop

11:35 am - 8:52 am

BUF

STL

22h 17m

1 stop

$126Frontier

Tue, Jun 16 - Thu, Jun 18

6:40 pm - 12:14 am

COU

BUF

4h 34m

1 stop

6:00 am - 10:06 am

BUF

COU

5h 06m

1 stop

$298American Airlines

Wed, Jun 3 - Wed, Jun 10

3:25 pm - 11:59 pm

COU

BUF

7h 34m

2 stops

7:00 am - 10:13 am

BUF

COU

4h 13m

1 stop

$304United Airlines

Wed, Jul 22 - Wed, Jul 29

3:25 pm - 9:03 pm

COU

BUF

4h 38m

1 stop

7:00 am - 10:13 am

BUF

COU

4h 13m

1 stop

$308United Airlines

Tue, Jun 9 - Tue, Jun 16

7:16 am - 5:51 pm

COU

BUF

9h 35m

2 stops

6:00 am - 10:06 am

BUF

COU

5h 06m

1 stop

$314American Airlines

Tue, Jun 9 - Tue, Jun 16

3:30 pm - 11:59 pm

SGF

BUF

7h 29m

1 stop

6:29 am - 3:20 pm

BUF

SGF

9h 51m

2 stops

$498Delta

Tue, Jun 23 - Sat, Jun 27

3:30 pm - 11:59 pm

SGF

BUF

7h 29m

1 stop

6:00 am - 3:27 pm

BUF

SGF

10h 27m

1 stop

$514Delta

Thu, Jun 25 - Mon, Jun 29

American Airlines flights from Missouri to Buffalo

Our best American Airlines deals on Missouri to Buffalo flight tickets

American Airlines

Jun 3

COU6:40 pmColumbia Regional

4h 34m

1 stop

BUF12:14 amBuffalo

Jun 10

BUF6:00 amBuffalo

5h 06m

1 stop

COU10:06 amColumbia Regional

$298

American Airlines

Jun 9

COU7:16 amColumbia Regional

9h 35m

2 stops

BUF5:51 pmBuffalo

Jun 16

BUF6:00 amBuffalo

5h 06m

1 stop

COU10:06 amColumbia Regional

$314

American Airlines

May 24

STL1:45 pmLambert-St Louis

7h 12m

1 stop

BUF9:57 pmBuffalo

Jun 17

BUF10:44 amBuffalo

7h 14m

1 stop

STL4:58 pmLambert-St Louis

$317

Frontier flights from Missouri to Buffalo

Our best Frontier deals on Missouri to Buffalo flight tickets

Frontier

Jun 22

STL5:06 pmLambert-St Louis

16h 49m

1 stop

BUF10:55 amBuffalo

Jun 25

BUF11:35 amBuffalo

6h 55m

1 stop

STL5:30 pmLambert-St Louis

$121

Frontier

Aug 24

STL5:33 pmLambert-St Louis

16h 07m

1 stop

BUF10:40 amBuffalo

Aug 28

BUF2:50 pmBuffalo

19h 02m

1 stop

STL8:52 amLambert-St Louis

$123

Frontier

Jun 5

STL5:27 pmLambert-St Louis

17h 01m

1 stop

BUF11:28 amBuffalo

Jun 7

BUF11:36 amBuffalo

6h 57m

1 stop

STL5:33 pmLambert-St Louis

$124

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Mon 6/22

5:06 pm-10:55 am

1 stop16h 49m

Buffalo

Thu 6/25

11:35 am-5:30 pm

1 stop6h 55m

$121

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Mon 8/24

5:33 pm-10:40 am

1 stop16h 07m

Buffalo

Fri 8/28

2:50 pm-8:52 am

1 stop19h 02m

$123

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 6/5

5:27 pm-11:28 am

1 stop17h 01m

Buffalo

Sun 6/7

11:36 am-5:33 pm

1 stop6h 57m

$124

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Tue 6/16

6:31 pm-1:55 pm

1 stop18h 24m

Buffalo

Thu 6/18

11:35 am-8:52 am

1 stop22h 17m

$126

ColumbiaBuffalo

COU - BUF

COUBUF

Columbia Regional

Wed 6/3

6:40 pm-12:14 am

1 stop4h 34m

Buffalo

Wed 6/10

6:00 am-10:06 am

1 stop5h 06m

$298

ColumbiaBuffalo

COU - BUF

COUBUF

Columbia Regional

Wed 7/22

3:25 pm-11:59 pm

2 stops7h 34m

Buffalo

Wed 7/29

7:00 am-10:13 am

1 stop4h 13m

$304

Quickest round-trip

ColumbiaBuffalo

COU - BUF

COUBUF

Columbia Regional

Tue 6/9

3:25 pm-9:03 pm

1 stop4h 38m

Buffalo

Tue 6/16

7:00 am-10:13 am

1 stop4h 13m

$308

ColumbiaBuffalo

COU - BUF

COUBUF

Columbia Regional

Tue 6/9

7:16 am-5:51 pm

2 stops9h 35m

Buffalo

Tue 6/16

6:00 am-10:06 am

1 stop5h 06m

$314

SpringfieldBuffalo

SGF - BUF

SGFBUF

Springfield-Branson

Tue 6/23

3:30 pm-11:59 pm

1 stop7h 29m

Buffalo

Sat 6/27

6:29 am-3:20 pm

2 stops9h 51m

$498

SpringfieldBuffalo

SGF - BUF

SGFBUF

Springfield-Branson

Thu 6/25

3:30 pm-11:59 pm

1 stop7h 29m

Buffalo

Mon 6/29

6:00 am-3:27 pm

1 stop10h 27m

$514

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Missouri to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Missouri during October instead. Flights to Buffalo in October, while not as cheap as those in September, still average around $124.

Cheap Missouri to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Buffalo

Fastest flight time	4h 05m
Direct flights	None

The fastest flight from Missouri to Buffalo takes 4h 05m

There are no direct flights from Missouri to Buffalo. There are no popular flight routes from Missouri to Buffalo.

Search flight deals

Frequently asked questions about flying from Missouri to Buffalo

When did momondo last update prices for flights from Missouri to Buffalo Airport?
Prices for flights from Missouri to Buffalo Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Missouri to Buffalo Airport?
The number of operators available for flights from Missouri to Buffalo Airport is 4 as of May 2026.
How old do you have to be to fly from Missouri to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Missouri to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents you'll need for your trip to Buffalo Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Buffalo Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Buffalo

Compare and see reviews for airlines that fly from Missouri to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $221	Free Cancellation	Rating 7.1 11,674 reviews	Search American Airlines flights
Delta	PriceFrom $233	Free Cancellation	Rating 7.9 8,455 reviews	Search Delta flights
United Airlines	PriceFrom $268	Free Cancellation	Rating 7.4 9,698 reviews	Search United Airlines flights
Southwest	PriceFrom $291	Free Cancellation	Rating 7.9 4,301 reviews	Search Southwest flights

Batavia

Cheektowaga

Amherst

Tonawanda

Grand Island

Williamsville

Orchard Park

West Seneca

Bowmansville

Lockport

East Aurora

Eden

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Missouri to Buffalo for you.

Can I find flights from Missouri to Buffalo with flexible booking policies on momondo?

Flights from Missouri to Buffalo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Buffalo?

momondo helps you find the best flight between Missouri and Buffalo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Buffalo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Buffalo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Missouri to Buffalo from $62

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Buffalo departing on 6/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Missouri to Buffalo

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What airlines fly to Buffalo?

How long does it take to fly to Buffalo?

Cheap Missouri to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Buffalo

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Frequently asked questions about flying from Missouri to Buffalo

Best airlines flying from Missouri to Buffalo

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Traveling to a place near Buffalo?

Why use momondo?

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

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Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Buffalo

List of cabin classes available on flights landing in Buffalo. Availability may vary depending on flight origin and airline.

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