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Cheap flights from Michigan to Florence from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Michigan to Florence departing on 5/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Michigan to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:26 pm - 9:47 pm
ORD
-
FLO
5h 21m
1 stop
American Airlines Logo
2:35 pm - 7:48 pm
FLO
-
ORD
6h 13m
1 stop
$279American Airlines
Wed, May 6 - Sat, May 23
American Airlines Logo
1:54 pm - 9:47 pm
ORD
-
FLO
6h 53m
1 stop
American Airlines Logo
5:20 am - 8:30 am
FLO
-
ORD
4h 10m
1 stop
$348American Airlines
Thu, Apr 16 - Sat, Apr 18
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$369American Airlines
Wed, Apr 29 - Wed, May 6
American Airlines Logo
10:11 am - 3:50 pm
DTW
-
FLO
5h 39m
1 stop
American Airlines Logo
5:20 am - 4:34 pm
FLO
-
DTW
11h 14m
2 stops
$374American Airlines
Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:00 am - 3:50 pm
DTW
-
FLO
9h 50m
2 stops
American Airlines Logo
4:16 pm - 12:45 am
FLO
-
DTW
8h 29m
2 stops
$379American Airlines
Wed, Apr 29 - Wed, May 6
American Airlines Logo
11:12 am - 3:32 pm
DTW
-
FLO
4h 20m
1 stop
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$395American Airlines
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
6:00 am - 3:32 pm
DTW
-
FLO
9h 32m
2 stops
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$400American Airlines
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
11:55 am - 10:42 pm
DTW
-
FLO
10h 47m
2 stops
American Airlines Logo
5:20 am - 12:49 pm
FLO
-
DTW
7h 29m
2 stops
$405American Airlines
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
1:45 pm - 9:47 pm
ORD
-
FLO
7h 02m
2 stops
American Airlines Logo
2:35 pm - 7:48 pm
FLO
-
ORD
6h 13m
1 stop
$412American Airlines
Wed, May 6 - Sat, May 23
American Airlines Logo
6:40 am - 2:10 pm
ORD
-
FLO
6h 30m
2 stops
American Airlines Logo
2:35 pm - 7:54 pm
FLO
-
ORD
6h 19m
1 stop
$416American Airlines
Wed, Jul 8 - Tue, Jul 14

American Airlines flights from Michigan to Florence, South Carolina

Our best American Airlines deals on Michigan to Florence, South Carolina flight tickets
American Airlines
May 6
ORD3:26 pmChicago O'Hare Intl
5h 21m
1 stop
FLO9:47 pmFlorence
May 23
FLO2:35 pmFlorence
6h 13m
1 stop
ORD7:48 pmChicago O'Hare Intl
$279
American Airlines
Apr 16
ORD1:54 pmChicago O'Hare Intl
6h 53m
1 stop
FLO9:47 pmFlorence
Apr 18
FLO5:20 amFlorence
4h 10m
1 stop
ORD8:30 amChicago O'Hare Intl
$348
American Airlines
Apr 29
DTW10:11 amDetroit Metropolitan Wayne County
5h 39m
1 stop
FLO3:50 pmFlorence
May 6
FLO5:20 amFlorence
4h 07m
1 stop
DTW9:27 amDetroit Metropolitan Wayne County
$369

momondo Fare Finder

 
Customize your flight search to find flights from Michigan to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Michigan to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 5/6

3:26 pm-9:47 pm

1 stop5h 21m

Florence

Sat 5/23

2:35 pm-7:48 pm

1 stop6h 13m

$279

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 4/16

1:54 pm-9:47 pm

1 stop6h 53m

Florence

Sat 4/18

5:20 am-8:30 am

1 stop4h 10m

$348

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/29

10:11 am-3:50 pm

1 stop5h 39m

Florence

Wed 5/6

5:20 am-9:27 am

1 stop4h 07m

$369

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/29

10:11 am-3:50 pm

1 stop5h 39m

Florence

Wed 5/6

5:20 am-4:34 pm

2 stops11h 14m

$374

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/29

6:00 am-3:50 pm

2 stops9h 50m

Florence

Wed 5/6

4:16 pm-12:45 am

2 stops8h 29m

$379
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 4/14

11:12 am-3:32 pm

1 stop4h 20m

Florence

Sat 4/18

5:20 am-9:27 am

1 stop4h 07m

$395

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 4/14

6:00 am-3:32 pm

2 stops9h 32m

Florence

Sat 4/18

5:20 am-9:27 am

1 stop4h 07m

$400

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 4/14

11:55 am-10:42 pm

2 stops10h 47m

Florence

Sat 4/18

5:20 am-12:49 pm

2 stops7h 29m

$405

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 5/6

1:45 pm-9:47 pm

2 stops7h 02m

Florence

Sat 5/23

2:35 pm-7:48 pm

1 stop6h 13m

$412

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 7/8

6:40 am-2:10 pm

2 stops6h 30m

Florence

Tue 7/14

2:35 pm-7:54 pm

1 stop6h 19m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Michigan to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Michigan to Florence?

American Airlines is the most popular carrier operating from Michigan to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Florence, South Carolina from Michigan according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Michigan to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Michigan to Florence, South Carolina

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Michigan to Florence, South Carolina takes 4h 02m
There are no direct flights from Michigan to Florence, South Carolina. There are no popular flight routes from Michigan to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Michigan to Florence, South Carolina

  • When did momondo last update prices for flights from Michigan to Florence Airport?

    Prices for flights from Michigan to Florence Airport are updated daily.

  • How old do you have to be to fly from Michigan to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Michigan to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Michigan to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Michigan to Florence for you.

Can I find flights from Michigan to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Michigan which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Michigan to Florence?

Once you have performed a search for Michigan to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Michigan to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Michigan to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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