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Cheap flights from Michigan to Florence from $207

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Michigan to Florence departing on 6/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Michigan to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:30 am - 2:56 pm
ORD
-
FLO
6h 26m
1 stop
American Airlines Logo
6:24 am - 10:47 am
FLO
-
ORD
5h 23m
1 stop
$346American Airlines
Wed, Aug 12 - Fri, Aug 21
American Airlines Logo
6:34 am - 2:56 pm
ORD
-
FLO
7h 22m
2 stops
American Airlines Logo
6:24 am - 10:47 am
FLO
-
ORD
5h 23m
1 stop
$351American Airlines
Wed, Aug 12 - Fri, Aug 21
American Airlines Logo
8:35 am - 3:40 pm
ORD
-
FLO
6h 05m
1 stop
American Airlines Logo
6:31 pm - 11:39 pm
FLO
-
ORD
6h 08m
1 stop
$379American Airlines
Fri, Sep 18 - Mon, Sep 21
American Airlines Logo
10:33 am - 10:00 pm
DTW
-
FLO
11h 27m
2 stops
American Airlines Logo
5:05 am - 4:59 pm
FLO
-
DTW
11h 54m
2 stops
$395American Airlines
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
4:49 pm - 10:00 pm
ORD
-
FLO
4h 11m
1 stop
American Airlines Logo
2:35 pm - 5:50 pm
FLO
-
ORD
4h 15m
1 stop
$419American Airlines
Sat, Jun 6 - Sat, Jun 13
American Airlines Logo
6:29 am - 2:10 pm
ORD
-
FLO
6h 41m
1 stop
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
$424American Airlines
Mon, Jun 15 - Sun, Jun 21
American Airlines Logo
10:33 am - 10:00 pm
DTW
-
FLO
11h 27m
2 stops
American Airlines Logo
5:05 am - 4:59 pm
FLO
-
DTW
11h 54m
2 stops
$426American Airlines
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
$429American Airlines
Mon, Jun 15 - Sun, Jun 21
American Airlines Logo
4:49 pm - 10:00 pm
ORD
-
FLO
4h 11m
1 stop
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
$435American Airlines
Mon, Jun 8 - Fri, Jun 12
American Airlines Logo
10:01 am - 2:10 pm
DTW
-
FLO
4h 09m
1 stop
American Airlines Logo
5:05 am - 4:59 pm
FLO
-
DTW
11h 54m
2 stops
$438American Airlines
Wed, Jun 17 - Wed, Jun 24

American Airlines flights from Michigan to Florence, South Carolina

Our best American Airlines deals on Michigan to Florence, South Carolina flight tickets
American Airlines
Aug 12
ORD7:30 amChicago O'Hare Intl
6h 26m
1 stop
FLO2:56 pmFlorence
Aug 21
FLO6:24 amFlorence
5h 23m
1 stop
ORD10:47 amChicago O'Hare Intl
$346
American Airlines
Aug 12
ORD6:34 amChicago O'Hare Intl
7h 22m
2 stops
FLO2:56 pmFlorence
Aug 21
FLO6:24 amFlorence
5h 23m
1 stop
ORD10:47 amChicago O'Hare Intl
$351
American Airlines
Sep 18
ORD8:35 amChicago O'Hare Intl
6h 05m
1 stop
FLO3:40 pmFlorence
Sep 21
FLO6:31 pmFlorence
6h 08m
1 stop
ORD11:39 pmChicago O'Hare Intl
$379

momondo Fare Finder

 
Customize your flight search to find flights from Michigan to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from Michigan to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 8/12

7:30 am-2:56 pm

1 stop6h 26m

Florence

Fri 8/21

6:24 am-10:47 am

1 stop5h 23m

$346

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 8/12

6:34 am-2:56 pm

2 stops7h 22m

Florence

Fri 8/21

6:24 am-10:47 am

1 stop5h 23m

$351

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 9/18

8:35 am-3:40 pm

1 stop6h 05m

Florence

Mon 9/21

6:31 pm-11:39 pm

1 stop6h 08m

$379

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 6/17

10:33 am-10:00 pm

2 stops11h 27m

Florence

Wed 6/24

5:05 am-4:59 pm

2 stops11h 54m

$395
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/6

4:49 pm-10:00 pm

1 stop4h 11m

Florence

Sat 6/13

2:35 pm-5:50 pm

1 stop4h 15m

$419

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 6/15

6:29 am-2:10 pm

1 stop6h 41m

Florence

Sun 6/21

5:05 am-9:02 am

1 stop4h 57m

$424

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 6/17

10:33 am-10:00 pm

2 stops11h 27m

Florence

Tue 6/23

5:05 am-4:59 pm

2 stops11h 54m

$426

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 6/15

5:00 am-2:10 pm

2 stops8h 10m

Florence

Sun 6/21

5:05 am-9:02 am

1 stop4h 57m

$429

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 6/8

4:49 pm-10:00 pm

1 stop4h 11m

Florence

Fri 6/12

5:05 am-9:02 am

1 stop4h 57m

$435

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 6/17

10:01 am-2:10 pm

1 stop4h 09m

Florence

Wed 6/24

5:05 am-4:59 pm

2 stops11h 54m

$438

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Michigan to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Michigan to Florence?

American Airlines is the most popular carrier operating from Michigan to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Florence, South Carolina from Michigan according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Michigan to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Michigan to Florence, South Carolina

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from Michigan to Florence, South Carolina takes 4h 54m
There are no direct flights from Michigan to Florence, South Carolina. There are no popular flight routes from Michigan to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Michigan to Florence, South Carolina

  • When did momondo last update prices for flights from Michigan to Florence Airport?

    Prices for flights from Michigan to Florence Airport are updated daily.

  • How old do you have to be to fly from Michigan to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Michigan to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Michigan to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Michigan to Florence for you.

Can I find flights from Michigan to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Michigan which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Michigan to Florence?

Once you have performed a search for Michigan to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Michigan to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Michigan to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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