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Cheap flights from Michigan to Florence from $283

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Michigan to Florence departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Michigan to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:06 pm - 5:21 pm
DTW
-
FLO
4h 15m
1 stop
American Airlines Logo
6:25 pm - 12:36 am
FLO
-
DTW
6h 11m
1 stop
$353American Airlines
Tue, Mar 17 - Sat, Mar 21
American Airlines Logo
11:03 am - 5:21 pm
DTW
-
FLO
6h 18m
1 stop
American Airlines Logo
5:16 am - 12:32 pm
FLO
-
DTW
7h 16m
2 stops
$358American Airlines
Tue, Mar 17 - Sat, Mar 21
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
6:25 pm - 12:36 am
FLO
-
DTW
6h 11m
1 stop
$373American Airlines
Thu, Mar 19 - Sat, Mar 21
American Airlines Logo
7:55 pm - 11:57 pm
DTW
-
FLO
4h 02m
1 stop
American Airlines Logo
5:16 am - 12:32 pm
FLO
-
DTW
7h 16m
2 stops
$378American Airlines
Thu, Mar 19 - Sat, Mar 21
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
5:16 am - 9:25 am
FLO
-
DTW
4h 09m
1 stop
$382American Airlines
Sun, Mar 1 - Sat, Mar 7
American Airlines Logo
1:29 pm - 11:57 pm
DTW
-
FLO
10h 28m
2 stops
American Airlines Logo
5:16 am - 9:25 am
FLO
-
DTW
4h 09m
1 stop
$387American Airlines
Sun, Mar 1 - Sat, Mar 7
American Airlines Logo
11:36 am - 5:50 pm
DTW
-
FLO
6h 14m
1 stop
American Airlines Logo
6:20 pm - 11:03 pm
FLO
-
DTW
4h 43m
1 stop
$389American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
11:36 am - 5:50 pm
DTW
-
FLO
6h 14m
1 stop
American Airlines Logo
5:16 am - 4:48 pm
FLO
-
DTW
11h 32m
2 stops
$394American Airlines
Sat, Mar 14 - Wed, Mar 18
American Airlines Logo
7:45 pm - 11:57 pm
DTW
-
FLO
4h 12m
1 stop
American Airlines Logo
5:16 am - 9:25 am
FLO
-
DTW
4h 09m
1 stop
$409American Airlines
Sat, Mar 14 - Fri, Mar 20
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
6:15 am - 12:16 pm
FLO
-
DTW
6h 01m
1 stop
$416American Airlines
Fri, Mar 13 - Tue, Mar 17

American Airlines flights from Michigan to Florence, South Carolina

Our best American Airlines deals on Michigan to Florence, South Carolina flight tickets
American Airlines
Mar 17
DTW1:06 pmDetroit Metropolitan Wayne County
4h 15m
1 stop
FLO5:21 pmFlorence
Mar 21
FLO6:25 pmFlorence
6h 11m
1 stop
DTW12:36 amDetroit Metropolitan Wayne County
$353
American Airlines
Mar 17
DTW11:03 amDetroit Metropolitan Wayne County
6h 18m
1 stop
FLO5:21 pmFlorence
Mar 21
FLO5:16 amFlorence
7h 16m
2 stops
DTW12:32 pmDetroit Metropolitan Wayne County
$358
American Airlines
Mar 19
DTW11:55 amDetroit Metropolitan Wayne County
5h 55m
1 stop
FLO5:50 pmFlorence
Mar 21
FLO6:25 pmFlorence
6h 11m
1 stop
DTW12:36 amDetroit Metropolitan Wayne County
$373

momondo Fare Finder

 
Customize your flight search to find flights from Michigan to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Michigan to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/17

1:06 pm-5:21 pm

1 stop4h 15m

Florence

Sat 3/21

6:25 pm-12:36 am

1 stop6h 11m

$353

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/17

11:03 am-5:21 pm

1 stop6h 18m

Florence

Sat 3/21

5:16 am-12:32 pm

2 stops7h 16m

$358

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 3/19

11:55 am-5:50 pm

1 stop5h 55m

Florence

Sat 3/21

6:25 pm-12:36 am

1 stop6h 11m

$373

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 3/19

7:55 pm-11:57 pm

1 stop4h 02m

Florence

Sat 3/21

5:16 am-12:32 pm

2 stops7h 16m

$378

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 3/1

11:55 am-5:50 pm

1 stop5h 55m

Florence

Sat 3/7

5:16 am-9:25 am

1 stop4h 09m

$382

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 3/1

1:29 pm-11:57 pm

2 stops10h 28m

Florence

Sat 3/7

5:16 am-9:25 am

1 stop4h 09m

$387

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 3/14

11:36 am-5:50 pm

1 stop6h 14m

Florence

Wed 3/18

6:20 pm-11:03 pm

1 stop4h 43m

$389

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 3/14

11:36 am-5:50 pm

1 stop6h 14m

Florence

Wed 3/18

5:16 am-4:48 pm

2 stops11h 32m

$394

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 3/14

7:45 pm-11:57 pm

1 stop4h 12m

Florence

Fri 3/20

5:16 am-9:25 am

1 stop4h 09m

$409

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 3/13

11:55 am-5:50 pm

1 stop5h 55m

Florence

Tue 3/17

6:15 am-12:16 pm

1 stop6h 01m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Michigan to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Michigan to Florence?

American Airlines is the most popular carrier operating from Michigan to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Florence, South Carolina from Michigan according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Michigan to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Michigan to Florence, South Carolina

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Michigan to Florence, South Carolina takes 4h 02m
There are no direct flights from Michigan to Florence, South Carolina. There are no popular flight routes from Michigan to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Michigan to Florence Airport?

    Prices for flights from Michigan to Florence Airport are updated daily.

  • How old do you have to be to fly from Michigan to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Michigan to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Michigan to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Michigan to Florence for you.

Can I find flights from Michigan to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Michigan which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Michigan to Florence?

Once you have performed a search for Michigan to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Michigan to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Michigan to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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