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Cheap flights from Melbourne, Florida to Knoxville from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Knoxville departing on 2/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Melbourne, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:35 pm - 11:45 pm
MLB
-
TYS
5h 10m
1 stop
Delta Logo
5:40 am - 10:30 am
TYS
-
MLB
4h 50m
1 stop
$329Delta
lun., feb. 9 - mié., feb. 11
Delta Logo
6:35 pm - 11:45 pm
MLB
-
TYS
5h 10m
1 stop
Delta Logo
10:07 am - 2:24 pm
TYS
-
MLB
4h 17m
1 stop
$415Delta
vie., ene. 30 - mar., feb. 3
American Airlines Logo
7:00 am - 11:45 am
MLB
-
TYS
4h 45m
1 stop
American Airlines Logo
6:20 am - 5:26 pm
TYS
-
MLB
11h 06m
2 stops
$436American Airlines
vie., ene. 30 - mar., feb. 3
Delta Logo
6:00 am - 9:21 am
MLB
-
TYS
3h 21m
1 stop
Delta Logo
6:42 pm - 10:40 pm
TYS
-
MLB
3h 58m
1 stop
$443Delta
jue., ene. 29 - lun., feb. 2
American Airlines Logo
12:39 pm - 11:59 pm
MLB
-
TYS
11h 20m
2 stops
American Airlines Logo
7:11 pm - 11:40 pm
TYS
-
MLB
4h 29m
1 stop
$448American Airlines
jue., ene. 29 - lun., feb. 2
American Airlines Logo
7:00 am - 9:44 pm
MLB
-
TYS
14h 44m
2 stops
American Airlines Logo
11:19 am - 11:40 pm
TYS
-
MLB
12h 21m
2 stops
$487American Airlines
jue., ene. 29 - lun., feb. 2
Delta Logo
6:35 pm - 11:46 pm
MLB
-
TYS
5h 11m
1 stop
Delta Logo
5:30 am - 10:34 am
TYS
-
MLB
5h 04m
1 stop
$539Delta
vie., may. 15 - dom., may. 17
American Airlines Logo
12:39 pm - 11:59 pm
MLB
-
TYS
11h 20m
2 stops
American Airlines Logo
6:20 am - 5:26 pm
TYS
-
MLB
11h 06m
2 stops
$585American Airlines
vie., ene. 30 - mar., feb. 3
American Airlines Logo
5:35 pm - 10:25 pm
MLB
-
TYS
4h 50m
1 stop
American Airlines Logo
6:54 am - 11:23 am
TYS
-
MLB
4h 29m
1 stop
$687American Airlines
vie., may. 1 - dom., may. 10
American Airlines Logo
6:22 am - 5:48 pm
MLB
-
TYS
11h 26m
2 stops
American Airlines Logo
5:00 am - 11:23 am
TYS
-
MLB
6h 23m
1 stop
$849American Airlines
vie., may. 1 - dom., may. 10

Delta flights from Melbourne, Florida to Knoxville

Our best Delta deals on Melbourne, Florida to Knoxville flight tickets
Delta
Jan 30
MLB6:35 pmMelbourne
5h 10m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
Feb 3
TYS10:07 amKnoxville McGhee Tyson
4h 17m
1 stop
MLB2:24 pmMelbourne
$415
Delta
Jan 20
MLB6:00 amMelbourne
3h 21m
1 stop
TYS9:21 amKnoxville McGhee Tyson
Jan 28
TYS7:00 amKnoxville McGhee Tyson
3h 30m
1 stop
MLB10:30 amMelbourne
$421
Delta
Jan 29
MLB6:00 amMelbourne
3h 21m
1 stop
TYS9:21 amKnoxville McGhee Tyson
Feb 2
TYS6:42 pmKnoxville McGhee Tyson
3h 58m
1 stop
MLB10:40 pmMelbourne
$443

American Airlines flights from Melbourne, Florida to Knoxville

Our best American Airlines deals on Melbourne, Florida to Knoxville flight tickets
American Airlines
Jan 21
MLB4:21 pmMelbourne
6h 33m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Jan 27
TYS6:20 amKnoxville McGhee Tyson
11h 06m
2 stops
MLB5:26 pmMelbourne
$426
American Airlines
Jan 21
MLB12:39 pmMelbourne
11h 20m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Jan 27
TYS6:20 amKnoxville McGhee Tyson
11h 06m
2 stops
MLB5:26 pmMelbourne
$432
American Airlines
Jan 30
MLB7:00 amMelbourne
4h 45m
1 stop
TYS11:45 amKnoxville McGhee Tyson
Feb 3
TYS6:20 amKnoxville McGhee Tyson
11h 06m
2 stops
MLB5:26 pmMelbourne
$436

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 16, 2026.
Use the filters below to find and compare flights from Melbourne, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

lun. 2/9

6:35 pm-11:45 pm

1 stop5h 10m

Knoxville McGhee Tyson

mié. 2/11

5:40 am-10:30 am

1 stop4h 50m

$329

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 1/30

6:35 pm-11:45 pm

1 stop5h 10m

Knoxville McGhee Tyson

mar. 2/3

10:07 am-2:24 pm

1 stop4h 17m

$415

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 1/30

7:00 am-11:45 am

1 stop4h 45m

Knoxville McGhee Tyson

mar. 2/3

6:20 am-5:26 pm

2 stops11h 06m

$436

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

jue. 1/29

6:00 am-9:21 am

1 stop3h 21m

Knoxville McGhee Tyson

lun. 2/2

6:42 pm-10:40 pm

1 stop3h 58m

$443

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

jue. 1/29

12:39 pm-11:59 pm

2 stops11h 20m

Knoxville McGhee Tyson

lun. 2/2

7:11 pm-11:40 pm

1 stop4h 29m

$448

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

jue. 1/29

7:00 am-9:44 pm

2 stops14h 44m

Knoxville McGhee Tyson

lun. 2/2

11:19 am-11:40 pm

2 stops12h 21m

$487

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 5/15

6:35 pm-11:46 pm

1 stop5h 11m

Knoxville McGhee Tyson

dom. 5/17

5:30 am-10:34 am

1 stop5h 04m

$539

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 1/30

12:39 pm-11:59 pm

2 stops11h 20m

Knoxville McGhee Tyson

mar. 2/3

6:20 am-5:26 pm

2 stops11h 06m

$585

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 5/1

5:35 pm-10:25 pm

1 stop4h 50m

Knoxville McGhee Tyson

dom. 5/10

6:54 am-11:23 am

1 stop4h 29m

$687

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

vie. 5/1

6:22 am-5:48 pm

2 stops11h 26m

Knoxville McGhee Tyson

dom. 5/10

5:00 am-11:23 am

1 stop6h 23m

$849

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Melbourne, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Melbourne, Florida to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $127. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Melbourne, Florida to Knoxville for around $172.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Melbourne, Florida to Knoxville when you can find flight prices for as low as $131. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $150.

When to book flights from Melbourne, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Knoxville (MLB to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Knoxville

Fastest flight time

3h 21m

Direct flights

None
The fastest flight from Melbourne, Florida to Knoxville takes 3h 21m
There are no direct flights from Melbourne, Florida to Knoxville. There are no popular flight routes from Melbourne, Florida to Knoxville.
Search flight deals

  • How far is Melbourne to Knoxville McGhee Tyson by plane?

    The straight-line distance from Melbourne to Knoxville McGhee Tyson is 577.3 mi. In terms of flight time, this usually takes a little over 3h 21m.

  • When did momondo last update prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Melbourne Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Melbourne, Florida to Knoxville?

Best airlines flying from Melbourne, Florida to Knoxville

Compare and see reviews for airlines that fly from Melbourne, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $315Free CancellationRating
7.2
11,136 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Murphy
Maryville
Alcoa
Crossville
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Melbourne to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Melbourne to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Melbourne with this policy.

How can momondo help me find flights from Melbourne to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Melbourne.

I’m not ready to book a flight from Melbourne to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Melbourne and alert you when they change.

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