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Cheap flights from Melbourne, Florida to Knoxville from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Knoxville departing on 6/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Melbourne, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:45 pm - 11:52 pm
MLB
-
TYS
5h 07m
1 stop
Delta Logo
5:45 am - 10:26 am
TYS
-
MLB
4h 41m
1 stop
$275Delta
Fri, Aug 14 - Tue, Aug 18
American Airlines Logo
7:07 pm - 11:47 pm
MLB
-
TYS
4h 40m
1 stop
American Airlines Logo
7:59 pm - 11:52 pm
TYS
-
MLB
3h 53m
1 stop
$330American Airlines
Fri, May 29 - Mon, Jun 1
Delta Logo
6:41 pm - 12:01 am
MLB
-
TYS
5h 20m
1 stop
Delta Logo
7:33 pm - 11:46 pm
TYS
-
MLB
4h 13m
1 stop
$363Delta
Sat, May 23 - Wed, May 27
Delta Logo
7:18 pm - 11:56 pm
MLB
-
TYS
4h 38m
1 stop
Delta Logo
7:33 pm - 11:46 pm
TYS
-
MLB
4h 13m
1 stop
$383Delta
Thu, May 28 - Mon, Jun 1
Delta Logo
7:18 pm - 11:56 pm
MLB
-
TYS
4h 38m
1 stop
Delta Logo
7:33 pm - 11:46 pm
TYS
-
MLB
4h 13m
1 stop
$441Delta
Thu, May 28 - Mon, Jun 1
Delta Logo
5:46 am - 9:34 am
MLB
-
TYS
3h 48m
1 stop
Delta Logo
5:40 am - 10:25 am
TYS
-
MLB
4h 45m
1 stop
$443Delta
Sun, May 24 - Sun, May 31
American Airlines Logo
11:52 am - 11:59 pm
MLB
-
TYS
12h 07m
2 stops
American Airlines Logo
6:07 pm - 11:52 pm
TYS
-
MLB
5h 45m
1 stop
$444American Airlines
Tue, May 26 - Sat, May 30
American Airlines Logo
6:02 am - 7:16 pm
MLB
-
TYS
13h 14m
2 stops
American Airlines Logo
1:00 pm - 6:37 pm
TYS
-
MLB
5h 37m
1 stop
$529American Airlines
Sat, May 23 - Wed, May 27
Delta Logo
5:37 am - 9:38 am
MLB
-
TYS
4h 01m
1 stop
Delta Logo
5:40 am - 10:28 am
TYS
-
MLB
4h 48m
1 stop
$550Delta
Thu, Jul 2 - Sun, Jul 5
American Airlines Logo
6:02 am - 6:14 pm
MLB
-
TYS
12h 12m
2 stops
American Airlines Logo
11:18 am - 11:52 pm
TYS
-
MLB
12h 34m
2 stops
$735American Airlines
Sat, May 23 - Wed, May 27

Delta flights from Melbourne, Florida to Knoxville

Our best Delta deals on Melbourne, Florida to Knoxville flight tickets
Delta
Aug 14
MLB6:45 pmMelbourne
5h 07m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Aug 18
TYS5:45 amKnoxville McGhee Tyson
4h 41m
1 stop
MLB10:26 amMelbourne
$275
Delta
May 23
MLB6:41 pmMelbourne
5h 20m
1 stop
TYS12:01 amKnoxville McGhee Tyson
May 27
TYS7:33 pmKnoxville McGhee Tyson
4h 13m
1 stop
MLB11:46 pmMelbourne
$363
Delta
May 28
MLB7:18 pmMelbourne
4h 38m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 1
TYS7:33 pmKnoxville McGhee Tyson
4h 13m
1 stop
MLB11:46 pmMelbourne
$383

American Airlines flights from Melbourne, Florida to Knoxville

Our best American Airlines deals on Melbourne, Florida to Knoxville flight tickets
American Airlines
May 29
MLB7:07 pmMelbourne
4h 40m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Jun 1
TYS7:59 pmKnoxville McGhee Tyson
3h 53m
1 stop
MLB11:52 pmMelbourne
$330
American Airlines
May 26
MLB11:52 amMelbourne
12h 07m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
May 30
TYS6:07 pmKnoxville McGhee Tyson
5h 45m
1 stop
MLB11:52 pmMelbourne
$444
American Airlines
May 23
MLB6:02 amMelbourne
13h 14m
2 stops
TYS7:16 pmKnoxville McGhee Tyson
May 27
TYS1:00 pmKnoxville McGhee Tyson
5h 37m
1 stop
MLB6:37 pmMelbourne
$529

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from Melbourne, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 8/14

6:45 pm-11:52 pm

1 stop5h 07m

Knoxville McGhee Tyson

Tue 8/18

5:45 am-10:26 am

1 stop4h 41m

$275
Quickest round-trip

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 5/29

7:07 pm-11:47 pm

1 stop4h 40m

Knoxville McGhee Tyson

Mon 6/1

7:59 pm-11:52 pm

1 stop3h 53m

$330

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 5/23

6:41 pm-12:01 am

1 stop5h 20m

Knoxville McGhee Tyson

Wed 5/27

7:33 pm-11:46 pm

1 stop4h 13m

$363

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 5/28

7:18 pm-11:56 pm

1 stop4h 38m

Knoxville McGhee Tyson

Mon 6/1

7:33 pm-11:46 pm

1 stop4h 13m

$383

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 5/28

7:18 pm-11:56 pm

1 stop4h 38m

Knoxville McGhee Tyson

Mon 6/1

7:33 pm-11:46 pm

1 stop4h 13m

$441

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sun 5/24

5:46 am-9:34 am

1 stop3h 48m

Knoxville McGhee Tyson

Sun 5/31

5:40 am-10:25 am

1 stop4h 45m

$443

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Tue 5/26

11:52 am-11:59 pm

2 stops12h 07m

Knoxville McGhee Tyson

Sat 5/30

6:07 pm-11:52 pm

1 stop5h 45m

$444

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 5/23

6:02 am-7:16 pm

2 stops13h 14m

Knoxville McGhee Tyson

Wed 5/27

1:00 pm-6:37 pm

1 stop5h 37m

$529

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 7/2

5:37 am-9:38 am

1 stop4h 01m

Knoxville McGhee Tyson

Sun 7/5

5:40 am-10:28 am

1 stop4h 48m

$550

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 5/23

6:02 am-6:14 pm

2 stops12h 12m

Knoxville McGhee Tyson

Wed 5/27

11:18 am-11:52 pm

2 stops12h 34m

$735

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Melbourne, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Melbourne, Florida to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $135. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Melbourne, Florida to Knoxville for around $186.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Melbourne, Florida to Knoxville when you can find flight prices for as low as $138. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $173.

When to book flights from Melbourne, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Knoxville (MLB to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Knoxville

Fastest flight time

3h 48m

Direct flights

None
The fastest flight from Melbourne, Florida to Knoxville takes 3h 48m
There are no direct flights from Melbourne, Florida to Knoxville. There are no popular flight routes from Melbourne, Florida to Knoxville.
Search flight deals

Frequently asked questions about flying from Melbourne, Florida to Knoxville

  • How far is Melbourne to Knoxville McGhee Tyson by plane?

    The straight-line distance from Melbourne to Knoxville McGhee Tyson is 577.3 mi. In terms of flight time, this usually takes a little over 3h 48m.

  • When did momondo last update prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Melbourne Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Melbourne to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Melbourne to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Melbourne with this policy.

How can momondo help me find flights from Melbourne to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Melbourne.

I’m not ready to book a flight from Melbourne to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Melbourne and alert you when they change.

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