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Cheap flights from Melbourne, Florida to Knoxville from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Knoxville departing on 8/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Melbourne, Florida to Knoxville

Cheap round-trip flights

American Airlines Logo
5:46 pm - 11:03 pmMLB-TYS
5h 17m1 stop
American Airlines Logo
5:43 pm - 11:02 pmTYS-MLB
5h 19m1 stop
$269American Airlines
Find Deal
Fri, Sep 5 - Wed, Sep 10
American Airlines Logo
1:50 pm - 11:20 pmMLB-TYS
9h 30m2 stops
American Airlines Logo
6:20 pm - 10:11 pmTYS-MLB
3h 51m1 stop
$274American Airlines
Find Deal
Wed, Dec 3 - Mon, Dec 8
Delta Logo
6:46 pm - 11:48 pmMLB-TYS
5h 02m1 stop
Delta Logo
5:20 pm - 2:04 pmTYS-MLB
20h 44m2 stops
$346Delta
Find Deal
Sat, Sep 6 - Tue, Sep 9
American Airlines Logo
5:46 pm - 11:03 pmMLB-TYS
5h 17m1 stop
American Airlines Logo
6:00 am - 5:15 pmTYS-MLB
11h 15m2 stops
$371American Airlines
Find Deal
Fri, Sep 5 - Wed, Sep 10
American Airlines Logo
6:05 am - 12:59 pmMLB-TYS
6h 54m1 stop
American Airlines Logo
5:51 pm - 12:19 amTYS-MLB
6h 28m1 stop
$383American Airlines
Find Deal
Sun, Nov 9 - Sat, Nov 15
Delta Logo
5:55 am - 9:13 amMLB-TYS
3h 18m1 stop
Delta Logo
7:20 pm - 10:44 pmTYS-MLB
3h 24m1 stop
$454Delta
Find Deal
Thu, Jan 15 - Mon, Jan 19
American Airlines Logo
5:35 pm - 10:09 pmMLB-TYS
4h 34m1 stop
American Airlines Logo
7:00 am - 1:12 pmTYS-MLB
6h 12m1 stop
$460American Airlines
Find Deal
Sun, Oct 5 - Fri, Oct 10
Delta Logo
2:29 pm - 7:03 pmMLB-TYS
4h 34m1 stop
Delta Logo
5:45 am - 10:45 amTYS-MLB
5h 00m1 stop
$469Delta
Find Deal
Thu, Sep 4 - Sun, Sep 7
Delta Logo
5:50 am - 10:42 amMLB-TYS
4h 52m1 stop
Delta Logo
5:45 am - 10:45 amTYS-MLB
5h 00m1 stop
$479Delta
Find Deal
Fri, Aug 29 - Mon, Sep 1
Logo
11:34 am - 4:47 pmMLB-TYS
29h 13m3 stops
Logo
9:00 am - 8:40 amTYS-MLB
23h 40m2 stops
$495
Find Deal
Sun, Aug 24 - Thu, Aug 28

Delta flights from Melbourne, Florida to Knoxville

Our best Delta deals on Melbourne, Florida to Knoxville flight tickets
Delta
Aug 14
MLB5:50 amMelbourne
4h 54m
1 stop
TYS10:44 amKnoxville McGhee Tyson
Aug 18
TYS6:14 pmKnoxville McGhee Tyson
5h 15m
1 stop
MLB11:29 pmMelbourne
$344
Find similar
Delta
Sep 6
MLB6:46 pmMelbourne
5h 02m
1 stop
TYS11:48 pmKnoxville McGhee Tyson
Sep 9
TYS5:20 pmKnoxville McGhee Tyson
20h 44m
2 stops
MLB2:04 pmMelbourne
$346
Find similar
Delta
Jan 15
MLB5:55 amMelbourne
3h 18m
1 stop
TYS9:13 amKnoxville McGhee Tyson
Jan 19
TYS7:20 pmKnoxville McGhee Tyson
3h 24m
1 stop
MLB10:44 pmMelbourne
$454
Find similar

American Airlines flights from Melbourne, Florida to Knoxville

Our best American Airlines deals on Melbourne, Florida to Knoxville flight tickets
American Airlines
Sep 5
MLB5:46 pmMelbourne
5h 17m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
Sep 10
TYS5:43 pmKnoxville McGhee Tyson
5h 19m
1 stop
MLB11:02 pmMelbourne
$269
Find similar
American Airlines
Dec 3
MLB1:50 pmMelbourne
9h 30m
2 stops
TYS11:20 pmKnoxville McGhee Tyson
Dec 8
TYS6:20 pmKnoxville McGhee Tyson
3h 51m
1 stop
MLB10:11 pmMelbourne
$274
Find similar
American Airlines
Sep 5
MLB5:46 pmMelbourne
5h 17m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
Sep 10
TYS6:00 amKnoxville McGhee Tyson
11h 15m
2 stops
MLB5:15 pmMelbourne
$371
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2025.
Use the filters below to find and compare flights from Melbourne, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 9/5

5:46 pm-11:03 pm

1 stop5h 17m

Knoxville McGhee Tyson

Wed 9/10

5:43 pm-11:02 pm

1 stop5h 19m

$269

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Wed 12/3

1:50 pm-11:20 pm

2 stops9h 30m

Knoxville McGhee Tyson

Mon 12/8

6:20 pm-10:11 pm

1 stop3h 51m

$274

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 9/6

6:46 pm-11:48 pm

1 stop5h 02m

Knoxville McGhee Tyson

Tue 9/9

5:20 pm-2:04 pm

2 stops20h 44m

$346

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 9/5

5:46 pm-11:03 pm

1 stop5h 17m

Knoxville McGhee Tyson

Wed 9/10

6:00 am-5:15 pm

2 stops11h 15m

$371

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sun 11/9

6:05 am-12:59 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sat 11/15

5:51 pm-12:19 am

1 stop6h 28m

$383

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 1/15

5:55 am-9:13 am

1 stop3h 18m

Knoxville McGhee Tyson

Mon 1/19

7:20 pm-10:44 pm

1 stop3h 24m

$454

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sun 10/5

5:35 pm-10:09 pm

1 stop4h 34m

Knoxville McGhee Tyson

Fri 10/10

7:00 am-1:12 pm

1 stop6h 12m

$460

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 9/4

2:29 pm-7:03 pm

1 stop4h 34m

Knoxville McGhee Tyson

Sun 9/7

5:45 am-10:45 am

1 stop5h 00m

$469

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 8/29

5:50 am-10:42 am

1 stop4h 52m

Knoxville McGhee Tyson

Mon 9/1

5:45 am-10:45 am

1 stop5h 00m

$479

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sun 8/24

11:34 am-4:47 pm

3 stops29h 13m

Knoxville McGhee Tyson

Thu 8/28

9:00 am-8:40 am

2 stops23h 40m

$495

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Melbourne, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Melbourne, Florida to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $134. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Melbourne, Florida to Knoxville for around $154.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Melbourne, Florida to Knoxville when you can find flight prices for as low as $131. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $151.

When to book flights from Melbourne, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Knoxville (MLB to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Knoxville

Best Price Found

$249

Fastest flight time

3h 18m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Melbourne, Florida in the past 72 hours is $249. The best round-trip flight deal from Melbourne, Florida to Knoxville found on momondo in the last 72 hours is $269.
The fastest flight from Melbourne, Florida to Knoxville takes 3h 18m
There are no direct flights from Melbourne, Florida to Knoxville. Popular non-direct route for this connection is Melbourne Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Melbourne to Knoxville McGhee Tyson by plane?

    The straight-line distance from Melbourne to Knoxville McGhee Tyson is 577.3 mi. In terms of flight time, this usually takes a little over 3h 18m.

  • When did momondo last update prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Melbourne Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Melbourne, Florida to Knoxville?

Best airlines flying from Melbourne, Florida to Knoxville

Compare and see reviews for airlines that fly from Melbourne, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $279Free CancellationRating
8.0
7,979 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Melbourne to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Melbourne to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Melbourne with this policy.

How can momondo help me find flights from Melbourne to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Melbourne.

I’m not ready to book a flight from Melbourne to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Melbourne and alert you when they change.

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