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Cheap flights from Melbourne, Florida to Knoxville from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Knoxville departing on 5/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Melbourne, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:35 pm - 10:24 pm
MLB
-
TYS
4h 49m
1 stop
American Airlines Logo
1:15 pm - 5:05 pm
TYS
-
MLB
3h 50m
1 stop
$328American Airlines
Sat, Apr 25 - Sat, May 2
Delta Logo
3:14 pm - 7:01 pm
MLB
-
TYS
3h 47m
1 stop
Delta Logo
5:15 pm - 9:39 pm
TYS
-
MLB
4h 24m
1 stop
$337Delta
Tue, Apr 14 - Sat, Apr 18
Delta Logo
7:18 pm - 11:56 pm
MLB
-
TYS
4h 38m
1 stop
Delta Logo
5:40 am - 10:25 am
TYS
-
MLB
4h 45m
1 stop
$357Delta
Fri, May 22 - Mon, May 25
Delta Logo
3:14 pm - 7:01 pm
MLB
-
TYS
3h 47m
1 stop
Delta Logo
5:40 am - 11:28 am
TYS
-
MLB
5h 48m
1 stop
$363Delta
Wed, Apr 15 - Sun, Apr 19
Delta Logo
2:49 pm - 7:55 pm
MLB
-
TYS
5h 06m
1 stop
Delta Logo
5:40 am - 10:28 am
TYS
-
MLB
4h 48m
1 stop
$367Delta
Fri, Jun 26 - Sun, Jun 28
Delta Logo
7:24 pm - 11:57 pm
MLB
-
TYS
4h 33m
1 stop
Delta Logo
5:40 am - 10:28 am
TYS
-
MLB
4h 48m
1 stop
$378Delta
Thu, Jun 25 - Sun, Jun 28
Delta Logo
7:18 pm - 11:56 pm
MLB
-
TYS
4h 38m
1 stop
Delta Logo
5:40 am - 10:25 am
TYS
-
MLB
4h 45m
1 stop
$418Delta
Thu, May 21 - Mon, May 25
American Airlines Logo
6:22 am - 9:50 pm
MLB
-
TYS
15h 28m
2 stops
American Airlines Logo
12:01 pm - 12:14 am
TYS
-
MLB
12h 13m
2 stops
$479American Airlines
Sat, Apr 25 - Sat, May 2
American Airlines Logo
6:22 am - 8:18 pm
MLB
-
TYS
13h 56m
2 stops
American Airlines Logo
1:15 pm - 5:05 pm
TYS
-
MLB
3h 50m
1 stop
$486American Airlines
Sat, Apr 25 - Sat, May 2
Delta Logo
6:00 am - 9:22 am
MLB
-
TYS
3h 22m
1 stop
Delta Logo
5:54 pm - 11:50 pm
TYS
-
MLB
5h 56m
1 stop
$563Delta
Thu, Apr 16 - Thu, Apr 16

Delta flights from Melbourne, Florida to Knoxville

Our best Delta deals on Melbourne, Florida to Knoxville flight tickets
Delta
Apr 14
MLB3:14 pmMelbourne
3h 47m
1 stop
TYS7:01 pmKnoxville McGhee Tyson
Apr 18
TYS5:15 pmKnoxville McGhee Tyson
4h 24m
1 stop
MLB9:39 pmMelbourne
$337
Delta
May 22
MLB7:18 pmMelbourne
4h 38m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 25
TYS5:40 amKnoxville McGhee Tyson
4h 45m
1 stop
MLB10:25 amMelbourne
$357
Delta
Apr 15
MLB3:14 pmMelbourne
3h 47m
1 stop
TYS7:01 pmKnoxville McGhee Tyson
Apr 19
TYS5:40 amKnoxville McGhee Tyson
5h 48m
1 stop
MLB11:28 amMelbourne
$363

American Airlines flights from Melbourne, Florida to Knoxville

Our best American Airlines deals on Melbourne, Florida to Knoxville flight tickets
American Airlines
Apr 25
MLB5:35 pmMelbourne
4h 49m
1 stop
TYS10:24 pmKnoxville McGhee Tyson
May 2
TYS1:15 pmKnoxville McGhee Tyson
3h 50m
1 stop
MLB5:05 pmMelbourne
$328
American Airlines
Apr 25
MLB6:22 amMelbourne
15h 28m
2 stops
TYS9:50 pmKnoxville McGhee Tyson
May 2
TYS12:01 pmKnoxville McGhee Tyson
12h 13m
2 stops
MLB12:14 amMelbourne
$479
American Airlines
Apr 25
MLB6:22 amMelbourne
13h 56m
2 stops
TYS8:18 pmKnoxville McGhee Tyson
May 2
TYS1:15 pmKnoxville McGhee Tyson
3h 50m
1 stop
MLB5:05 pmMelbourne
$486

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Melbourne, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 4/25

5:35 pm-10:24 pm

1 stop4h 49m

Knoxville McGhee Tyson

Sat 5/2

1:15 pm-5:05 pm

1 stop3h 50m

$328
Quickest round-trip

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Tue 4/14

3:14 pm-7:01 pm

1 stop3h 47m

Knoxville McGhee Tyson

Sat 4/18

5:15 pm-9:39 pm

1 stop4h 24m

$337

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 5/22

7:18 pm-11:56 pm

1 stop4h 38m

Knoxville McGhee Tyson

Mon 5/25

5:40 am-10:25 am

1 stop4h 45m

$357

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Wed 4/15

3:14 pm-7:01 pm

1 stop3h 47m

Knoxville McGhee Tyson

Sun 4/19

5:40 am-11:28 am

1 stop5h 48m

$363

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Fri 6/26

2:49 pm-7:55 pm

1 stop5h 06m

Knoxville McGhee Tyson

Sun 6/28

5:40 am-10:28 am

1 stop4h 48m

$367

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 6/25

7:24 pm-11:57 pm

1 stop4h 33m

Knoxville McGhee Tyson

Sun 6/28

5:40 am-10:28 am

1 stop4h 48m

$378

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 5/21

7:18 pm-11:56 pm

1 stop4h 38m

Knoxville McGhee Tyson

Mon 5/25

5:40 am-10:25 am

1 stop4h 45m

$418

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 4/25

6:22 am-9:50 pm

2 stops15h 28m

Knoxville McGhee Tyson

Sat 5/2

12:01 pm-12:14 am

2 stops12h 13m

$479

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Sat 4/25

6:22 am-8:18 pm

2 stops13h 56m

Knoxville McGhee Tyson

Sat 5/2

1:15 pm-5:05 pm

1 stop3h 50m

$486

MelbourneKnoxville

MLB - TYS

MLBTYS

Melbourne

Thu 4/16

6:00 am-9:22 am

1 stop3h 22m

Knoxville McGhee Tyson

Thu 4/16

5:54 pm-11:50 pm

1 stop5h 56m

$563

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Melbourne, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Melbourne, Florida to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $131. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Melbourne, Florida to Knoxville for around $181.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Melbourne, Florida to Knoxville when you can find flight prices for as low as $138. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $164.

When to book flights from Melbourne, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Knoxville (MLB to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Knoxville

Fastest flight time

3h 16m

Direct flights

None
The fastest flight from Melbourne, Florida to Knoxville takes 3h 16m
There are no direct flights from Melbourne, Florida to Knoxville. There are no popular flight routes from Melbourne, Florida to Knoxville.
Search flight deals

  • How far is Melbourne to Knoxville McGhee Tyson by plane?

    The straight-line distance from Melbourne to Knoxville McGhee Tyson is 577.3 mi. In terms of flight time, this usually takes a little over 3h 16m.

  • When did momondo last update prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Melbourne Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Melbourne Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Melbourne to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Melbourne to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Melbourne with this policy.

How can momondo help me find flights from Melbourne to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Melbourne.

I’m not ready to book a flight from Melbourne to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Melbourne and alert you when they change.

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