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Cheap flights from Manchester, New Hampshire to Knoxville from $212

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Knoxville departing on 12/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Manchester, New Hampshire to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
2:17 pm - 7:27 pm
MHT
-
TYS
5h 10m1 stop
United Airlines Logo
9:40 am - 1:58 pm
TYS
-
MHT
4h 18m1 stop
$249United Airlines
Wed, Feb 11 - Sat, Feb 14
American Airlines Logo
5:30 am - 3:20 pm
MHT
-
TYS
9h 50m2 stops
American Airlines Logo
5:00 pm - 12:07 am
TYS
-
MHT
7h 07m1 stop
$254American Airlines
Wed, Feb 11 - Sat, Feb 14
American Airlines Logo
5:30 am - 1:54 pm
MHT
-
TYS
8h 24m2 stops
American Airlines Logo
9:13 am - 5:33 pm
TYS
-
MHT
8h 20m2 stops
$259American Airlines
Wed, Feb 11 - Sat, Feb 14
United Airlines Logo
7:26 pm - 11:59 pm
MHT
-
TYS
4h 33m1 stop
United Airlines Logo
2:25 pm - 6:51 pm
TYS
-
MHT
4h 26m1 stop
$323United Airlines
Sat, Jan 3 - Sat, Jan 10
United Airlines Logo
7:26 pm - 11:59 pm
MHT
-
TYS
4h 33m1 stop
United Airlines Logo
11:07 am - 6:51 pm
TYS
-
MHT
7h 44m2 stops
$328United Airlines
Sat, Jan 3 - Sat, Jan 10
American Airlines Logo
6:00 am - 12:52 pm
MHT
-
TYS
6h 52m2 stops
American Airlines Logo
7:54 am - 4:32 pm
TYS
-
MHT
8h 38m2 stops
$333American Airlines
Sat, Jan 3 - Sat, Jan 10
American Airlines Logo
4:06 pm - 8:56 pm
MHT
-
TYS
4h 50m1 stop
American Airlines Logo
11:19 am - 4:31 pm
TYS
-
MHT
5h 12m1 stop
$353American Airlines
Tue, Jan 6 - Tue, Jan 13
United Airlines Logo
2:17 pm - 7:27 pm
MHT
-
TYS
5h 10m1 stop
United Airlines Logo
9:30 am - 1:42 pm
TYS
-
MHT
4h 12m1 stop
$355United Airlines
Wed, Jan 21 - Sun, Jan 25
United Airlines Logo
2:17 pm - 7:27 pm
MHT
-
TYS
5h 10m1 stop
United Airlines Logo
9:30 am - 1:42 pm
TYS
-
MHT
4h 12m1 stop
$357United Airlines
Wed, Jan 7 - Thu, Jan 8
American Airlines Logo
4:06 pm - 8:56 pm
MHT
-
TYS
4h 50m1 stop
American Airlines Logo
10:11 am - 4:31 pm
TYS
-
MHT
6h 20m2 stops
$358American Airlines
Tue, Jan 6 - Tue, Jan 13

Southwest flights from Manchester, New Hampshire to Knoxville

Our best Southwest deals on Manchester, New Hampshire to Knoxville flight tickets
Southwest
Mar 19
MHT5:20 pmManchester
4h 50m
1 stop
TYS10:10 pmKnoxville McGhee Tyson
Mar 22
TYS7:25 pmKnoxville McGhee Tyson
13h 05m
2 stops
MHT8:30 amManchester
$408
Find similar
Southwest
Mar 19
MHT5:20 pmManchester
4h 50m
1 stop
TYS10:10 pmKnoxville McGhee Tyson
Mar 22
TYS7:40 amKnoxville McGhee Tyson
4h 15m
1 stop
MHT11:55 amManchester
$467
Find similar

American Airlines flights from Manchester, New Hampshire to Knoxville

Our best American Airlines deals on Manchester, New Hampshire to Knoxville flight tickets
American Airlines
Feb 11
MHT5:30 amManchester
9h 50m
2 stops
TYS3:20 pmKnoxville McGhee Tyson
Feb 14
TYS5:00 pmKnoxville McGhee Tyson
7h 07m
1 stop
MHT12:07 amManchester
$254
Find similar
American Airlines
Feb 11
MHT5:30 amManchester
8h 24m
2 stops
TYS1:54 pmKnoxville McGhee Tyson
Feb 14
TYS9:13 amKnoxville McGhee Tyson
8h 20m
2 stops
MHT5:33 pmManchester
$259
Find similar
American Airlines
Jan 3
MHT6:00 amManchester
6h 52m
2 stops
TYS12:52 pmKnoxville McGhee Tyson
Jan 10
TYS7:54 amKnoxville McGhee Tyson
8h 38m
2 stops
MHT4:32 pmManchester
$333
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Manchester, New Hampshire to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 2/11

2:17 pm-7:27 pm

1 stop5h 10m

Knoxville McGhee Tyson

Sat 2/14

9:40 am-1:58 pm

1 stop4h 18m

$249

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 2/11

5:30 am-3:20 pm

2 stops9h 50m

Knoxville McGhee Tyson

Sat 2/14

5:00 pm-12:07 am

1 stop7h 07m

$254

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 2/11

5:30 am-1:54 pm

2 stops8h 24m

Knoxville McGhee Tyson

Sat 2/14

9:13 am-5:33 pm

2 stops8h 20m

$259

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Sat 1/3

7:26 pm-11:59 pm

1 stop4h 33m

Knoxville McGhee Tyson

Sat 1/10

2:25 pm-6:51 pm

1 stop4h 26m

$323

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Sat 1/3

7:26 pm-11:59 pm

1 stop4h 33m

Knoxville McGhee Tyson

Sat 1/10

11:07 am-6:51 pm

2 stops7h 44m

$328

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Sat 1/3

6:00 am-12:52 pm

2 stops6h 52m

Knoxville McGhee Tyson

Sat 1/10

7:54 am-4:32 pm

2 stops8h 38m

$333

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 1/6

4:06 pm-8:56 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 1/13

11:19 am-4:31 pm

1 stop5h 12m

$353

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 1/21

2:17 pm-7:27 pm

1 stop5h 10m

Knoxville McGhee Tyson

Sun 1/25

9:30 am-1:42 pm

1 stop4h 12m

$355

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 1/7

2:17 pm-7:27 pm

1 stop5h 10m

Knoxville McGhee Tyson

Thu 1/8

9:30 am-1:42 pm

1 stop4h 12m

$357

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 1/6

4:06 pm-8:56 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 1/13

10:11 am-4:31 pm

2 stops6h 20m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Manchester, New Hampshire to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Manchester, New Hampshire, with most prices found around $323. If you aren’t able to travel during the month of August, then book flights to Knoxville from Manchester, New Hampshire during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $354.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Manchester, New Hampshire to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $127. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Manchester, New Hampshire to Knoxville for around $210.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Manchester, New Hampshire to Knoxville when you can find flight prices for as low as $192. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $604.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Manchester, New Hampshire when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $469 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Manchester, New Hampshire for as low as $292 on momondo.

Can stopping save me money on Manchester, New Hampshire to Knoxville flights?

You could potentially save up to 1% on your flight if you consider stops on a Manchester, New Hampshire to Knoxville flight.

When to book flights from Manchester, New Hampshire to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Knoxville (MHT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Knoxville

Fastest flight time

4h 30m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Knoxville takes 4h 30m
There are no direct flights from Manchester, New Hampshire to Knoxville. There are no popular flight routes from Manchester, New Hampshire to Knoxville.
Search flight deals

  • How far is Manchester to Knoxville McGhee Tyson by plane?

    A flight from Manchester to Knoxville McGhee Tyson will travel around 821.5 mi. In terms of flight time, this usually takes a little over 4h 33m.

  • When did momondo last update prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Manchester Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Manchester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Knoxville?

Best airlines flying from Manchester, New Hampshire to Knoxville

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,089 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Manchester.

Can I find flights from Manchester to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Manchester which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Manchester to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Manchester to Knoxville.

I’m not ready to book a flight from Manchester to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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