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Cheap flights from Manchester, New Hampshire to Knoxville from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Knoxville departing on 2/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Manchester, New Hampshire to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:45 pm - 8:50 pm
MHT
-
TYS
5h 05m
1 stop
Southwest Logo
8:15 am - 3:05 pm
TYS
-
MHT
6h 50m
1 stop
$315Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
3:45 pm - 8:50 pm
MHT
-
TYS
5h 05m
1 stop
Southwest Logo
12:50 pm - 10:30 pm
TYS
-
MHT
9h 40m
2 stops
$320Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
5:35 am - 5:10 pm
MHT
-
TYS
11h 35m
2 stops
Southwest Logo
7:05 am - 5:10 pm
TYS
-
MHT
10h 05m
2 stops
$325Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
5:35 am - 5:10 pm
MHT
-
TYS
11h 35m
2 stops
Southwest Logo
12:50 pm - 10:30 pm
TYS
-
MHT
9h 40m
2 stops
$326Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
5:40 am - 5:40 pm
MHT
-
TYS
12h 00m
2 stops
Southwest Logo
8:15 am - 9:05 pm
TYS
-
MHT
12h 50m
2 stops
$331Southwest
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
6:00 am - 11:11 am
MHT
-
TYS
5h 11m
1 stop
American Airlines Logo
6:10 am - 11:21 am
TYS
-
MHT
5h 11m
1 stop
$336American Airlines
Fri, Mar 6 - Mon, Mar 9
Southwest Logo
3:10 pm - 10:10 pm
MHT
-
TYS
7h 00m
1 stop
Southwest Logo
7:25 pm - 8:00 am
TYS
-
MHT
12h 35m
2 stops
$347Southwest
Fri, Mar 6 - Mon, Mar 9
Southwest Logo
9:10 am - 6:45 pm
MHT
-
TYS
9h 35m
2 stops
Southwest Logo
7:25 pm - 8:00 am
TYS
-
MHT
12h 35m
2 stops
$352Southwest
Fri, Mar 6 - Mon, Mar 9
Southwest Logo
3:55 pm - 9:15 pm
MHT
-
TYS
5h 20m
1 stop
Southwest Logo
8:10 am - 12:25 pm
TYS
-
MHT
4h 15m
1 stop
$353Southwest
Wed, Jul 1 - Wed, Jul 8
Southwest Logo
3:55 pm - 9:15 pm
MHT
-
TYS
5h 20m
1 stop
Southwest Logo
7:10 am - 4:15 pm
TYS
-
MHT
9h 05m
2 stops
$358Southwest
Wed, Jul 1 - Wed, Jul 8

American Airlines flights from Manchester, New Hampshire to Knoxville

Our best American Airlines deals on Manchester, New Hampshire to Knoxville flight tickets
American Airlines
Mar 6
MHT6:00 amManchester
5h 11m
1 stop
TYS11:11 amKnoxville McGhee Tyson
Mar 9
TYS6:10 amKnoxville McGhee Tyson
5h 11m
1 stop
MHT11:21 amManchester
$336
American Airlines
Apr 14
MHT12:15 pmManchester
5h 33m
1 stop
TYS5:48 pmKnoxville McGhee Tyson
Apr 21
TYS6:32 amKnoxville McGhee Tyson
6h 56m
1 stop
MHT1:28 pmManchester
$381
American Airlines
Apr 14
MHT10:32 amManchester
8h 57m
2 stops
TYS7:29 pmKnoxville McGhee Tyson
Apr 21
TYS5:47 amKnoxville McGhee Tyson
5h 33m
1 stop
MHT11:20 amManchester
$386

United Airlines flights from Manchester, New Hampshire to Knoxville

Our best United Airlines deals on Manchester, New Hampshire to Knoxville flight tickets
United Airlines
Mar 3
MHT2:33 pmManchester
4h 56m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
Mar 11
TYS9:40 amKnoxville McGhee Tyson
4h 04m
1 stop
MHT1:44 pmManchester
$385
United Airlines
Mar 3
MHT2:33 pmManchester
4h 56m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
Mar 11
TYS10:55 amKnoxville McGhee Tyson
7h 58m
2 stops
MHT6:53 pmManchester
$425
United Airlines
Mar 26
MHT2:19 pmManchester
5h 10m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
Mar 29
TYS9:40 amKnoxville McGhee Tyson
4h 15m
1 stop
MHT1:55 pmManchester
$427

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 5/5

3:45 pm-8:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-3:05 pm

1 stop6h 50m

$315

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 5/5

3:45 pm-8:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-10:30 pm

2 stops9h 40m

$320

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 5/5

5:35 am-5:10 pm

2 stops11h 35m

Knoxville McGhee Tyson

Tue 5/12

7:05 am-5:10 pm

2 stops10h 05m

$325

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 5/5

5:35 am-5:10 pm

2 stops11h 35m

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-10:30 pm

2 stops9h 40m

$326

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 3/31

5:40 am-5:40 pm

2 stops12h 00m

Knoxville McGhee Tyson

Tue 4/7

8:15 am-9:05 pm

2 stops12h 50m

$331

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Fri 3/6

6:00 am-11:11 am

1 stop5h 11m

Knoxville McGhee Tyson

Mon 3/9

6:10 am-11:21 am

1 stop5h 11m

$336

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Fri 3/6

3:10 pm-10:10 pm

1 stop7h 00m

Knoxville McGhee Tyson

Mon 3/9

7:25 pm-8:00 am

2 stops12h 35m

$347

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Fri 3/6

9:10 am-6:45 pm

2 stops9h 35m

Knoxville McGhee Tyson

Mon 3/9

7:25 pm-8:00 am

2 stops12h 35m

$352

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 7/1

3:55 pm-9:15 pm

1 stop5h 20m

Knoxville McGhee Tyson

Wed 7/8

8:10 am-12:25 pm

1 stop4h 15m

$353

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 7/1

3:55 pm-9:15 pm

1 stop5h 20m

Knoxville McGhee Tyson

Wed 7/8

7:10 am-4:15 pm

2 stops9h 05m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Manchester, New Hampshire to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Manchester, New Hampshire, with most prices found around $323. If you aren’t able to travel during the month of August, then book flights to Knoxville from Manchester, New Hampshire during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $354.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Manchester, New Hampshire to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $127. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Manchester, New Hampshire to Knoxville for around $217.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Manchester, New Hampshire when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Manchester, New Hampshire for as low as $333 on momondo.

When to book flights from Manchester, New Hampshire to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Knoxville (MHT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Knoxville

Fastest flight time

4h 30m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Knoxville takes 4h 30m
There are no direct flights from Manchester, New Hampshire to Knoxville. There are no popular flight routes from Manchester, New Hampshire to Knoxville.
Search flight deals

  • How far is Manchester to Knoxville McGhee Tyson by plane?

    A flight from Manchester to Knoxville McGhee Tyson will travel around 821.5 mi. In terms of flight time, this usually takes a little over 4h 30m.

  • When did momondo last update prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Manchester Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Manchester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Knoxville?

Best airlines flying from Manchester, New Hampshire to Knoxville

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,198 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,197 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Murphy
Alcoa
Crossville
Maryville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Manchester.

Can I find flights from Manchester to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Manchester which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Manchester to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Manchester to Knoxville.

I’m not ready to book a flight from Manchester to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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