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Cheap flights from Manchester, New Hampshire to Knoxville from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Knoxville departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Manchester, New Hampshire to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:58 pm - 7:29 pm
MHT
-
TYS
5h 31m
1 stop
American Airlines Logo
5:06 pm - 10:51 pm
TYS
-
MHT
5h 45m
1 stop
$265American Airlines
Tue, Apr 14 - Tue, Apr 21
American Airlines Logo
6:00 am - 1:11 pm
MHT
-
TYS
7h 11m
1 stop
American Airlines Logo
6:38 pm - 11:40 pm
TYS
-
MHT
5h 02m
1 stop
$311American Airlines
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
3:45 pm - 8:50 pm
MHT
-
TYS
5h 05m
1 stop
Southwest Logo
8:10 am - 4:15 pm
TYS
-
MHT
8h 05m
2 stops
$316Southwest
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
6:00 am - 2:22 pm
MHT
-
TYS
8h 22m
2 stops
American Airlines Logo
5:06 pm - 10:51 pm
TYS
-
MHT
5h 45m
1 stop
$319American Airlines
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
9:10 am - 5:10 pm
MHT
-
TYS
8h 00m
2 stops
Southwest Logo
12:45 pm - 10:45 pm
TYS
-
MHT
10h 00m
2 stops
$321Southwest
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
1:58 pm - 9:26 pm
MHT
-
TYS
7h 28m
1 stop
American Airlines Logo
5:06 pm - 10:51 pm
TYS
-
MHT
5h 45m
1 stop
$331American Airlines
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
3:45 pm - 8:50 pm
MHT
-
TYS
5h 05m
1 stop
Southwest Logo
7:45 am - 12:05 pm
TYS
-
MHT
4h 20m
1 stop
$347Southwest
Wed, May 27 - Sun, May 31
Southwest Logo
9:10 am - 5:10 pm
MHT
-
TYS
8h 00m
2 stops
Southwest Logo
7:45 am - 12:05 pm
TYS
-
MHT
4h 20m
1 stop
$352Southwest
Wed, May 27 - Sun, May 31
Southwest Logo
3:15 pm - 9:15 pm
MHT
-
TYS
6h 00m
1 stop
Southwest Logo
7:45 am - 11:50 am
TYS
-
MHT
4h 05m
1 stop
$377Southwest
Fri, May 8 - Sat, May 9
American Airlines Logo
4:42 pm - 9:26 pm
MHT
-
TYS
4h 44m
1 stop
American Airlines Logo
7:00 am - 1:28 pm
TYS
-
MHT
6h 28m
1 stop
$381American Airlines
Tue, Apr 14 - Tue, Apr 21

American Airlines flights from Manchester, New Hampshire to Knoxville

Our best American Airlines deals on Manchester, New Hampshire to Knoxville flight tickets
American Airlines
Apr 14
MHT1:58 pmManchester
5h 31m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
Apr 21
TYS5:06 pmKnoxville McGhee Tyson
5h 45m
1 stop
MHT10:51 pmManchester
$265
American Airlines
Apr 14
MHT6:00 amManchester
7h 11m
1 stop
TYS1:11 pmKnoxville McGhee Tyson
Apr 21
TYS6:38 pmKnoxville McGhee Tyson
5h 02m
1 stop
MHT11:40 pmManchester
$311
American Airlines
Apr 14
MHT6:00 amManchester
8h 22m
2 stops
TYS2:22 pmKnoxville McGhee Tyson
Apr 21
TYS5:06 pmKnoxville McGhee Tyson
5h 45m
1 stop
MHT10:51 pmManchester
$319

Southwest flights from Manchester, New Hampshire to Knoxville

Our best Southwest deals on Manchester, New Hampshire to Knoxville flight tickets
Southwest
Jun 2
MHT3:45 pmManchester
5h 05m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
Jun 9
TYS8:10 amKnoxville McGhee Tyson
8h 05m
2 stops
MHT4:15 pmManchester
$316
Southwest
Jun 2
MHT9:10 amManchester
8h 00m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
Jun 9
TYS12:45 pmKnoxville McGhee Tyson
10h 00m
2 stops
MHT10:45 pmManchester
$321
Southwest
May 27
MHT3:45 pmManchester
5h 05m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
May 31
TYS7:45 amKnoxville McGhee Tyson
4h 20m
1 stop
MHT12:05 pmManchester
$347

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 4/14

1:58 pm-7:29 pm

1 stop5h 31m

Knoxville McGhee Tyson

Tue 4/21

5:06 pm-10:51 pm

1 stop5h 45m

$265

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 4/14

6:00 am-1:11 pm

1 stop7h 11m

Knoxville McGhee Tyson

Tue 4/21

6:38 pm-11:40 pm

1 stop5h 02m

$311

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 6/2

3:45 pm-8:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Tue 6/9

8:10 am-4:15 pm

2 stops8h 05m

$316

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 4/14

6:00 am-2:22 pm

2 stops8h 22m

Knoxville McGhee Tyson

Tue 4/21

5:06 pm-10:51 pm

1 stop5h 45m

$319

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 6/2

9:10 am-5:10 pm

2 stops8h 00m

Knoxville McGhee Tyson

Tue 6/9

12:45 pm-10:45 pm

2 stops10h 00m

$321

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 4/14

1:58 pm-9:26 pm

1 stop7h 28m

Knoxville McGhee Tyson

Tue 4/21

5:06 pm-10:51 pm

1 stop5h 45m

$331
Quickest round-trip

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 5/27

3:45 pm-8:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sun 5/31

7:45 am-12:05 pm

1 stop4h 20m

$347

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Wed 5/27

9:10 am-5:10 pm

2 stops8h 00m

Knoxville McGhee Tyson

Sun 5/31

7:45 am-12:05 pm

1 stop4h 20m

$352

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Fri 5/8

3:15 pm-9:15 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sat 5/9

7:45 am-11:50 am

1 stop4h 05m

$377

ManchesterKnoxville

MHT - TYS

MHTTYS

Manchester

Tue 4/14

4:42 pm-9:26 pm

1 stop4h 44m

Knoxville McGhee Tyson

Tue 4/21

7:00 am-1:28 pm

1 stop6h 28m

$381

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Manchester, New Hampshire to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Manchester, New Hampshire, with most prices found around $323. If you aren’t able to travel during the month of August, then book flights to Knoxville from Manchester, New Hampshire during June instead. Flights to Knoxville in June, while not as cheap as those in August, still average around $329.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Manchester, New Hampshire to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $127. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Manchester, New Hampshire to Knoxville for around $352.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Manchester, New Hampshire when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $450 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Manchester, New Hampshire for as low as $278 on momondo.

Can stopping save me money on Manchester, New Hampshire to Knoxville flights?

You could potentially save up to 14% on your flight if you consider stops on a Manchester, New Hampshire to Knoxville flight.

When to book flights from Manchester, New Hampshire to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Knoxville (MHT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Knoxville

Fastest flight time

5h 02m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Knoxville takes 5h 02m
There are no direct flights from Manchester, New Hampshire to Knoxville. There are no popular flight routes from Manchester, New Hampshire to Knoxville.
Search flight deals

  • How far is Manchester to Knoxville McGhee Tyson by plane?

    A flight from Manchester to Knoxville McGhee Tyson will travel around 821.5 mi. In terms of flight time, this usually takes a little over 5h 02m.

  • When did momondo last update prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Manchester Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Manchester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Knoxville?

Best airlines flying from Manchester, New Hampshire to Knoxville

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,467 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights
SouthwestPriceFrom $325Free CancellationRating
8.0
4,328 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Manchester.

Can I find flights from Manchester to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Manchester which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Manchester to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Manchester to Knoxville.

I’m not ready to book a flight from Manchester to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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