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Cheap flights from Manchester, New Hampshire to Knoxville from $156

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Knoxville departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Manchester, New Hampshire to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:33 am - 5:45 pmMHT  Manchester-TYS Knoxville McGhee Tyson
7h 12m1 stop Philadelphia
American Airlines Logo
6:16 pm - 11:58 pmTYS  Knoxville McGhee Tyson-MHT Manchester
5h 42m1 stop Washington, D.C. Reagan-National
$251American Airlines
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
6:00 am - 10:25 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 25m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:05 pm - 11:36 pmTYS  Knoxville McGhee Tyson-MHT Manchester
5h 31m1 stop Philadelphia
$251American Airlines
Tue, Oct 6 - Sat, Oct 10
American Airlines Logo
6:00 am - 11:18 amMHT  Manchester-TYS Knoxville McGhee Tyson
5h 18m1 stop Philadelphia
American Airlines Logo
3:55 pm - 10:49 pmTYS  Knoxville McGhee Tyson-MHT Manchester
6h 54m1 stop Philadelphia
$251American Airlines
Tue, Dec 1 - Tue, Dec 8
American Airlines Logo
6:00 am - 10:38 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 38m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:15 am - 10:44 amTYS  Knoxville McGhee Tyson-MHT Manchester
4h 29m1 stop Charlotte Douglas
$251American Airlines
Wed, Sep 23 - Sat, Sep 26
Southwest Logo
1:00 pm - 7:45 pmMHT  Manchester-TYS Knoxville McGhee Tyson
6h 45m1 stop Baltimore/Washington
Southwest Logo
12:50 pm - 11:50 pmTYS  Knoxville McGhee Tyson-MHT Manchester
11h 00m2 stops Orlando Baltimore/Washington
$263Southwest
Sat, Nov 7 - Mon, Nov 9
United Airlines Logo
7:41 pm - 11:59 pmMHT  Manchester-TYS Knoxville McGhee Tyson
4h 18m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
7:20 pm - 11:59 pmTYS  Knoxville McGhee Tyson-MHT Manchester
4h 39m1 stop Washington, D.C. Dulles Intl
$329United Airlines
Fri, Sep 18 - Mon, Sep 21
United Airlines Logo
9:25 am - 8:53 pmMHT  Manchester-TYS Knoxville McGhee Tyson
11h 28m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
9:45 am - 2:08 pmTYS  Knoxville McGhee Tyson-MHT Manchester
4h 23m1 stop Washington, D.C. Dulles Intl
$334United Airlines
Wed, Sep 2 - Sun, Sep 6
Southwest Logo
3:35 pm - 8:45 pmMHT  Manchester-TYS Knoxville McGhee Tyson
5h 10m1 stop Baltimore/Washington
Southwest Logo
7:55 am - 12:05 pmTYS  Knoxville McGhee Tyson-MHT Manchester
4h 10m1 stop Baltimore/Washington
$340Southwest
Mon, Nov 16 - Wed, Nov 18
United Airlines Logo
9:25 am - 8:53 pmMHT  Manchester-TYS Knoxville McGhee Tyson
11h 28m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
7:00 am - 7:00 pmTYS  Knoxville McGhee Tyson-MHT Manchester
12h 00m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$340United Airlines
Wed, Sep 2 - Sun, Sep 6
Southwest Logo
3:35 pm - 8:45 pmMHT  Manchester-TYS Knoxville McGhee Tyson
5h 10m1 stop Baltimore/Washington
Southwest Logo
1:00 pm - 10:05 pmTYS  Knoxville McGhee Tyson-MHT Manchester
9h 05m2 stops Orlando Baltimore/Washington
$345Southwest
Mon, Nov 16 - Wed, Nov 18

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Southwest flights from Manchester, New Hampshire to Knoxville

Our best Southwest deals on Manchester, New Hampshire to Knoxville flight tickets
Southwest
Nov 7
MHT1:00 pmManchester
6h 45m
1 stop
TYS7:45 pmKnoxville McGhee Tyson
Nov 9
TYS12:50 pmKnoxville McGhee Tyson
11h 00m
2 stops
MHT11:50 pmManchester
$263
Southwest
Nov 16
MHT5:35 amManchester
11h 05m
2 stops
TYS4:40 pmKnoxville McGhee Tyson
Nov 18
TYS1:00 pmKnoxville McGhee Tyson
9h 05m
2 stops
MHT10:05 pmManchester
$350
Southwest
Sep 30
MHT5:35 amManchester
13h 25m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
Oct 5
TYS7:25 pmKnoxville McGhee Tyson
12h 45m
2 stops
MHT8:10 amManchester
$367

American Airlines flights from Manchester, New Hampshire to Knoxville

Our best American Airlines deals on Manchester, New Hampshire to Knoxville flight tickets
American Airlines
Dec 1
MHT5:52 amManchester
5h 11m
1 stop
TYS11:03 amKnoxville McGhee Tyson
Dec 8
TYS11:36 amKnoxville McGhee Tyson
5h 16m
1 stop
MHT4:52 pmManchester
$251
American Airlines
Sep 2
MHT10:33 amManchester
7h 31m
1 stop
TYS6:04 pmKnoxville McGhee Tyson
Sep 6
TYS7:07 amKnoxville McGhee Tyson
4h 32m
1 stop
MHT11:39 amManchester
$289
American Airlines
Sep 4
MHT2:42 pmManchester
5h 25m
1 stop
TYS8:07 pmKnoxville McGhee Tyson
Sep 6
TYS7:07 amKnoxville McGhee Tyson
4h 32m
1 stop
MHT11:39 amManchester
$311

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Thu 9/10

10:33 am-5:45 pm

1 stop7h 12m

Knoxville McGhee Tyson

Wed 9/16

6:16 pm-11:58 pm

1 stop5h 42m

$251

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Tue 10/6

6:00 am-10:25 am

1 stop4h 25m

Knoxville McGhee Tyson

Sat 10/10

6:05 pm-11:36 pm

1 stop5h 31m

$251

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Tue 12/1

6:00 am-11:18 am

1 stop5h 18m

Knoxville McGhee Tyson

Tue 12/8

3:55 pm-10:49 pm

1 stop6h 54m

$251

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Wed 9/23

6:00 am-10:38 am

1 stop4h 38m

Knoxville McGhee Tyson

Sat 9/26

6:15 am-10:44 am

1 stop4h 29m

$251

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Sat 11/7

1:00 pm-7:45 pm

1 stop6h 45m

Knoxville McGhee Tyson

Mon 11/9

12:50 pm-11:50 pm

2 stops11h 00m

$263
Quickest round-trip

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Fri 9/18

7:41 pm-11:59 pm

1 stop4h 18m

Knoxville McGhee Tyson

Mon 9/21

7:20 pm-11:59 pm

1 stop4h 39m

$329

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Wed 9/2

9:25 am-8:53 pm

2 stops11h 28m

Knoxville McGhee Tyson

Sun 9/6

9:45 am-2:08 pm

1 stop4h 23m

$334

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Mon 11/16

3:35 pm-8:45 pm

1 stop5h 10m

Knoxville McGhee Tyson

Wed 11/18

7:55 am-12:05 pm

1 stop4h 10m

$340

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Wed 9/2

9:25 am-8:53 pm

2 stops11h 28m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-7:00 pm

2 stops12h 00m

$340

ManchesterKnoxville

MHT Manchester - TYS Knoxville McGhee Tyson

MHTTYS

Manchester

Mon 11/16

3:35 pm-8:45 pm

1 stop5h 10m

Knoxville McGhee Tyson

Wed 11/18

1:00 pm-10:05 pm

2 stops9h 05m

$345

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Manchester, New Hampshire to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Manchester, New Hampshire and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $323 to $491.
The lowest price recently found on this route was $251.

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Manchester, New Hampshire, with most prices found around $328. If you aren’t able to travel during the month of September, then book flights to Knoxville from Manchester, New Hampshire during August instead. Flights to Knoxville in August, while not as cheap as those in September, still average around $397.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Manchester, New Hampshire to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $197. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Manchester, New Hampshire to Knoxville for around $352.

Can stopping save me money on Manchester, New Hampshire to Knoxville flights?

You could potentially save up to 48% on your flight if you consider stops on a Manchester, New Hampshire to Knoxville flight.

When to book flights from Manchester, New Hampshire to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Knoxville (MHT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Knoxville

Fastest flight time

4h 18m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Knoxville takes 4h 18m
There are no direct flights from Manchester, New Hampshire to Knoxville. There are no popular flight routes from Manchester, New Hampshire to Knoxville.
Search flight deals

Frequently asked questions about flying from Manchester, New Hampshire to Knoxville

  • How far is Manchester to Knoxville McGhee Tyson by plane?

    A flight from Manchester to Knoxville McGhee Tyson will travel around 821.5 mi. In terms of flight time, this usually takes a little over 4h 18m.

  • When did momondo last update prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Manchester Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Manchester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Manchester Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Manchester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Knoxville?

Best airlines flying from Manchester, New Hampshire to Knoxville

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $254Free CancellationRating
7.1
11,927 reviews
Search American Airlines flights
United AirlinesPriceFrom $279Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights
SouthwestPriceFrom $325Free CancellationRating
8.0
4,220 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Manchester.

Can I find flights from Manchester to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Manchester which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Manchester to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Manchester to Knoxville.

I’m not ready to book a flight from Manchester to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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