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Cheap flights from Louisville to Panama City from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Panama City departing on 11/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 10:26 amSDF-ECP
5h 26m1 stop
Delta Logo
7:02 am - 2:12 pmECP-SDF
6h 10m1 stop
$297Delta
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Wed, Nov 19 - Tue, Dec 2
American Airlines Logo
12:43 pm - 11:15 pmSDF-ECP
11h 32m2 stops
American Airlines Logo
5:55 pm - 11:59 pmECP-SDF
5h 04m1 stop
$301American Airlines
Find Deal
Wed, Nov 19 - Tue, Dec 2
Delta Logo
5:45 pm - 10:42 pmSDF-ECP
5h 57m1 stop
Delta Logo
9:23 am - 1:50 pmECP-SDF
3h 27m1 stop
$302Delta
Find Deal
Sun, Jan 11 - Sat, Jan 17
American Airlines Logo
6:03 am - 1:04 pmSDF-ECP
8h 01m1 stop
American Airlines Logo
12:03 pm - 11:20 pmECP-SDF
10h 17m2 stops
$307American Airlines
Find Deal
Sun, Jan 11 - Sat, Jan 17
American Airlines Logo
11:08 am - 5:33 pmSDF-ECP
7h 25m2 stops
American Airlines Logo
12:03 pm - 11:20 pmECP-SDF
10h 17m2 stops
$312American Airlines
Find Deal
Sun, Jan 11 - Sat, Jan 17
United Airlines Logo
9:15 am - 4:03 pmSDF-ECP
7h 48m1 stop
United Airlines Logo
3:00 pm - 9:57 pmECP-SDF
5h 57m1 stop
$323United Airlines
Find Deal
Mon, Nov 10 - Fri, Nov 14
American Airlines Logo
6:50 am - 5:15 pmSDF-ECP
11h 25m2 stops
American Airlines Logo
5:55 pm - 11:59 pmECP-SDF
5h 04m1 stop
$328American Airlines
Find Deal
Mon, Nov 10 - Fri, Nov 14
United Airlines Logo
9:15 am - 4:24 pmSDF-ECP
8h 09m1 stop
United Airlines Logo
3:00 pm - 9:57 pmECP-SDF
5h 57m1 stop
$377United Airlines
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Sat, Nov 15 - Wed, Nov 19
Southwest Logo
6:55 am - 3:45 pmSDF-ECP
9h 50m1 stop
Southwest Logo
7:15 am - 3:55 pmECP-SDF
7h 40m1 stop
$383Southwest
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Tue, Feb 17 - Sun, Feb 22
Southwest Logo
7:20 am - 12:55 pmSDF-ECP
6h 35m1 stop
Southwest Logo
7:15 am - 4:35 pmECP-SDF
8h 20m2 stops
$432Southwest
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Sun, Nov 2 - Wed, Nov 5

Delta flights from Louisville to Panama City, Florida

Our best Delta deals on Louisville to Panama City, Florida flight tickets
Delta
Nov 19
SDF6:00 amLouisville Intl
5h 26m
1 stop
ECP10:26 amPanama City NW Florida Beaches
Dec 2
ECP7:02 amPanama City NW Florida Beaches
6h 10m
1 stop
SDF2:12 pmLouisville Intl
$297
Find similar
Delta
Jan 11
SDF5:45 pmLouisville Intl
5h 57m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
Jan 17
ECP9:23 amPanama City NW Florida Beaches
3h 27m
1 stop
SDF1:50 pmLouisville Intl
$302
Find similar
Delta
Nov 21
SDF6:00 amLouisville Intl
3h 35m
1 stop
ECP8:35 amPanama City NW Florida Beaches
Dec 2
ECP10:00 amPanama City NW Florida Beaches
3h 12m
1 stop
SDF2:12 pmLouisville Intl
$332
Find similar

American Airlines flights from Louisville to Panama City, Florida

Our best American Airlines deals on Louisville to Panama City, Florida flight tickets
American Airlines
Nov 19
SDF12:43 pmLouisville Intl
11h 32m
2 stops
ECP11:15 pmPanama City NW Florida Beaches
Dec 2
ECP5:55 pmPanama City NW Florida Beaches
5h 04m
1 stop
SDF11:59 pmLouisville Intl
$301
Find similar
American Airlines
Jan 11
SDF6:03 amLouisville Intl
8h 01m
1 stop
ECP1:04 pmPanama City NW Florida Beaches
Jan 17
ECP12:03 pmPanama City NW Florida Beaches
10h 17m
2 stops
SDF11:20 pmLouisville Intl
$307
Find similar
American Airlines
Jan 11
SDF11:08 amLouisville Intl
7h 25m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Jan 17
ECP12:03 pmPanama City NW Florida Beaches
10h 17m
2 stops
SDF11:20 pmLouisville Intl
$312
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 18, 2025.
Use the filters below to find and compare flights from Louisville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Wed 11/19

6:00 am-10:26 am

1 stop5h 26m

Panama City NW Florida Beaches

Tue 12/2

7:02 am-2:12 pm

1 stop6h 10m

$297

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Wed 11/19

12:43 pm-11:15 pm

2 stops11h 32m

Panama City NW Florida Beaches

Tue 12/2

5:55 pm-11:59 pm

1 stop5h 04m

$301

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 1/11

5:45 pm-10:42 pm

1 stop5h 57m

Panama City NW Florida Beaches

Sat 1/17

9:23 am-1:50 pm

1 stop3h 27m

$302

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 1/11

6:03 am-1:04 pm

1 stop8h 01m

Panama City NW Florida Beaches

Sat 1/17

12:03 pm-11:20 pm

2 stops10h 17m

$307

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 1/11

11:08 am-5:33 pm

2 stops7h 25m

Panama City NW Florida Beaches

Sat 1/17

12:03 pm-11:20 pm

2 stops10h 17m

$312

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Mon 11/10

9:15 am-4:03 pm

1 stop7h 48m

Panama City NW Florida Beaches

Fri 11/14

3:00 pm-9:57 pm

1 stop5h 57m

$323

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Mon 11/10

6:50 am-5:15 pm

2 stops11h 25m

Panama City NW Florida Beaches

Fri 11/14

5:55 pm-11:59 pm

1 stop5h 04m

$328

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sat 11/15

9:15 am-4:24 pm

1 stop8h 09m

Panama City NW Florida Beaches

Wed 11/19

3:00 pm-9:57 pm

1 stop5h 57m

$377

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Tue 2/17

6:55 am-3:45 pm

1 stop9h 50m

Panama City NW Florida Beaches

Sun 2/22

7:15 am-3:55 pm

1 stop7h 40m

$383

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 11/2

7:20 am-12:55 pm

1 stop6h 35m

Panama City NW Florida Beaches

Wed 11/5

7:15 am-4:35 pm

2 stops8h 20m

$432

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Louisville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Louisville is in August. Flight prices, which tend to average around $288, are often lower during this time because this is during the off-season. The month of October is another great option to travel to Panama City, Florida, with average flight prices from Louisville averaging around $311.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $336. On the other hand, Tuesday is the most expensive day to depart from Louisville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $375.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Louisville when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Louisville for as low as $293 on momondo.

How have Louisville to Panama City, Florida flight prices changed over time?

As of October 2025, prices for Louisville to Panama City, Florida flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from Louisville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Panama City, Florida (SDF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Panama City, Florida

Direct flights

None
There are no direct flights from Louisville to Panama City, Florida. There are no popular flight routes from Louisville to Panama City, Florida.
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  • How far is Louisville Intl to Panama City NW Florida Beaches by plane?

    A flight from Louisville Intl to Panama City NW Florida Beaches will travel around 558.6 mi. Typically, this will take 3h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Louisville Intl Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Louisville Intl Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Panama City, Florida?

Best airlines flying from Louisville to Panama City, Florida

Compare and see reviews for airlines that fly from Louisville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
7,975 reviews
Search Delta flights
American AirlinesPriceFrom $256Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
SouthwestPriceFrom $338Free CancellationRating
8.0
4,243 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Panama City with flexible booking policies on momondo?

Yes. All flights to Panama City from Louisville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Louisville to Panama City?

Once you have performed a search for Louisville to Panama City flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Louisville to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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