Cheap flights from New York LaGuardia Airport to Panama City from $130

The cheapest month to fly to Panama City, Florida from New York LaGuardia Airport is in November. Flight prices, which tend to average around $298, are often lower during this time because this is during the off-season. The month of September is another great option to travel to Panama City, Florida, with average flight prices from New York LaGuardia Airport averaging around $335.

Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $368. On the other hand, Sunday is the most expensive day to depart from New York LaGuardia Airport because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $722.

Fly from New York LaGuardia to Panama City NW Florida Beaches for the best New York LaGuardia - Panama City NW Florida Beaches flight prices

You are more likely to see cheaper flights to Panama City, Florida from New York LaGuardia Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $408 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from New York LaGuardia Airport for as low as $269 on momondo.

There are 3 cabin classes available to choose from on New York LaGuardia to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 20% on your flight if you consider stops on a New York LaGuardia Airport to Panama City, Florida flight.

Southwest and Delta are the most popular carriers operating from New York LaGuardia to Panama City NW Florida Beaches

Delta, American Airlines and Southwest are the top three most popular airlines that fly to Panama City, Florida from New York LaGuardia Airport according to our data. Delta is the first choice among our users, with 64% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 4 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

Washington, D.C. (DCA) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Charlotte (CLT) offer the lowest average round-trip price of $278.

Flights connecting via Washington, D.C. (DCA) have the shortest average one-way travel time: 4h 32m.

Washington, D.C. (DCA) has the shortest average layover time for this route: 0h 47m.

1 flights are operational daily from New York LaGuardia Airport to Panama City, Florida as of February 2026. The most popular departure time for this route is 9:00AM, with 100% of flights per day taking off at noon.

As of February 2026, 7 flights take off from New York LaGuardia Airport and land in Panama City, Florida each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.