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Cheap flights from Knoxville to St. Louis from $145

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:17 am - 12:35 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 18m1 stop Washington, D.C. Reagan-National
American Airlines Logo
11:31 am - 6:20 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 49m1 stop Chicago O'Hare Intl
$243American Airlines
Wed, Oct 14 - Sat, Oct 17
American Airlines Logo
5:32 pm - 9:59 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 27m1 stop Dallas/Fort Worth
American Airlines Logo
7:24 am - 2:05 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 41m1 stop Dallas/Fort Worth
$243American Airlines
Thu, Dec 3 - Sat, Dec 5
Southwest Logo
7:55 am - 7:25 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
12h 30m2 stops Baltimore/Washington Pittsburgh
Southwest Logo
7:00 am - 12:00 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 00m1 stop Nashville Intl
$254Southwest
Thu, Dec 3 - Sat, Dec 5
United Airlines Logo
6:00 am - 10:48 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 48m1 stop Chicago O'Hare Intl
United Airlines Logo
3:11 pm - 8:49 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 38m1 stop Chicago O'Hare Intl
$255United Airlines
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
7:55 am - 7:25 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
12h 30m2 stops Baltimore/Washington Pittsburgh
Southwest Logo
5:45 am - 12:00 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 15m2 stops Chicago Midway Nashville Intl
$259Southwest
Thu, Dec 3 - Sat, Dec 5
Delta Logo
10:56 am - 4:04 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 08m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:00 am - 3:57 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 57m1 stop Atlanta Hartsfield-Jackson
$267Delta
Fri, Dec 25 - Fri, Jan 1
American Airlines Logo
8:15 pm - 12:27 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 12m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 11:05 amSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 05m1 stop Chicago O'Hare Intl
$278American Airlines
Wed, Sep 30 - Wed, Oct 7
Delta Logo
10:56 am - 4:04 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 08m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:00 am - 3:57 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 57m1 stop Atlanta Hartsfield-Jackson
$283Delta
Fri, Dec 25 - Fri, Jan 1
Multiple Airlines Logo
1:37 pm - 1:10 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
24h 33m2 stops Washington, D.C. Dulles Intl Atlanta Hartsfield-Jackson
Multiple Airlines Logo
5:19 pm - 1:00 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
18h 41m1 stop Orlando
$302Multiple Airlines
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
12:40 pm - 4:40 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 00m1 stop Orlando
Southwest Logo
8:25 am - 7:45 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
10h 20m2 stops Austin Bergstrom Nashville Intl
$372Southwest
Fri, Dec 18 - Thu, Dec 24

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Delta flights from Knoxville to St. Louis

Our best Delta deals on Knoxville to St. Louis flight tickets
Delta
Dec 25
TYS10:56 amKnoxville McGhee Tyson
6h 08m
1 stop
STL4:04 pmLambert-St Louis
Jan 1
STL9:00 amLambert-St Louis
5h 57m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
$267
Delta
Dec 25
TYS10:56 amKnoxville McGhee Tyson
6h 08m
1 stop
STL4:04 pmLambert-St Louis
Jan 1
STL9:00 amLambert-St Louis
5h 57m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
$283
Delta
Dec 25
TYS10:56 amKnoxville McGhee Tyson
6h 08m
1 stop
STL4:04 pmLambert-St Louis
Jan 1
STL9:00 amLambert-St Louis
5h 57m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
$285

United Airlines flights from Knoxville to St. Louis

Our best United Airlines deals on Knoxville to St. Louis flight tickets
United Airlines
Oct 1
TYS6:00 amKnoxville McGhee Tyson
5h 48m
1 stop
STL10:48 amLambert-St Louis
Oct 5
STL3:11 pmLambert-St Louis
4h 38m
1 stop
TYS8:49 pmKnoxville McGhee Tyson
$255
United Airlines
Oct 22
TYS6:00 amKnoxville McGhee Tyson
7h 13m
1 stop
STL12:13 pmLambert-St Louis
Oct 26
STL1:08 pmLambert-St Louis
6h 46m
1 stop
TYS8:54 pmKnoxville McGhee Tyson
$313
United Airlines
Oct 22
TYS7:15 amKnoxville McGhee Tyson
7h 55m
1 stop
STL2:10 pmLambert-St Louis
Oct 26
STL1:08 pmLambert-St Louis
6h 46m
1 stop
TYS8:54 pmKnoxville McGhee Tyson
$359

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

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Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Wed 10/14

7:17 am-12:35 pm

1 stop6h 18m

Lambert-St Louis

Sat 10/17

11:31 am-6:20 pm

1 stop5h 49m

$243

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

5:32 pm-9:59 pm

1 stop5h 27m

Lambert-St Louis

Sat 12/5

7:24 am-2:05 pm

1 stop5h 41m

$243

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

7:55 am-7:25 pm

2 stops12h 30m

Lambert-St Louis

Sat 12/5

7:00 am-12:00 pm

1 stop4h 00m

$254

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 10/1

6:00 am-10:48 am

1 stop5h 48m

Lambert-St Louis

Mon 10/5

3:11 pm-8:49 pm

1 stop4h 38m

$255

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

7:55 am-7:25 pm

2 stops12h 30m

Lambert-St Louis

Sat 12/5

5:45 am-12:00 pm

2 stops5h 15m

$259

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/25

10:56 am-4:04 pm

1 stop6h 08m

Lambert-St Louis

Fri 1/1

9:00 am-3:57 pm

1 stop5h 57m

$267
Quickest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Wed 9/30

8:15 pm-12:27 am

1 stop5h 12m

Lambert-St Louis

Wed 10/7

5:00 am-11:05 am

1 stop5h 05m

$278

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/25

10:56 am-4:04 pm

1 stop6h 08m

Lambert-St Louis

Fri 1/1

9:00 am-3:57 pm

1 stop5h 57m

$283

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 10/1

1:37 pm-1:10 pm

2 stops24h 33m

Lambert-St Louis

Mon 10/5

5:19 pm-1:00 pm

1 stop18h 41m

$302

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/18

12:40 pm-4:40 pm

1 stop5h 00m

Lambert-St Louis

Thu 12/24

8:25 am-7:45 pm

2 stops10h 20m

$372

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $298 to $609.
The lowest price recently found on this route was $243.

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of January is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $294.

How have Knoxville to St. Louis flight prices changed over time?

As of September 2026, prices for Knoxville to St. Louis flights are approximately 31% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Best Price Found

$145

Fastest flight time

4h 13m

Direct flights

None
The best one-way flight to St. Louis from Knoxville in the past 72 hours is $145. The best round-trip flight deal from Knoxville to St. Louis found on momondo in the last 72 hours is $243.
The fastest flight from Knoxville to St. Louis takes 4h 13m
There are no direct flights from Knoxville to St. Louis. There are no popular flight routes from Knoxville to St. Louis.
Search flight deals

Frequently asked questions about flying from Knoxville to St. Louis

  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 4h 13m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?

Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $167Free CancellationRating
7.1
12,050 reviews
Search American Airlines flights
SouthwestPriceFrom $236Free CancellationRating
8.0
4,191 reviews
Search Southwest flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,568 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
St. Peters
Maryland Heights
Alton
Collinsville
Florissant
Hermann
Clayton
O'Fallon
Farmington
Fenton
Festus
Edwardsville
Wentzville
Eureka
Litchfield
Grafton
Waterloo

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

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