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Cheap flights from Knoxville to St. Louis from $98

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to St. Louis departing on 5/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:55 pm - 8:55 am
TYS
-
STL
21h 00m
2 stops
Multiple Airlines Logo
4:19 pm - 6:21 pm
STL
-
TYS
25h 02m
1 stop
$243Multiple Airlines
Fri, May 29 - Tue, Jun 2
Southwest Logo
8:15 am - 3:15 pm
TYS
-
STL
8h 00m
1 stop
Southwest Logo
5:45 am - 2:20 pm
STL
-
TYS
7h 35m
1 stop
$249Southwest
Wed, May 20 - Tue, May 26
Southwest Logo
2:55 pm - 10:20 pm
TYS
-
STL
8h 25m
2 stops
Southwest Logo
2:30 pm - 7:40 pm
STL
-
TYS
4h 10m
1 stop
$254Southwest
Wed, May 20 - Tue, May 26
Southwest Logo
12:50 pm - 7:15 pm
TYS
-
STL
7h 25m
2 stops
Southwest Logo
10:25 am - 8:50 pm
STL
-
TYS
9h 25m
2 stops
$259Southwest
Wed, May 20 - Tue, May 26
Southwest Logo
5:50 pm - 10:00 pm
TYS
-
STL
5h 10m
1 stop
Southwest Logo
6:20 am - 1:20 pm
STL
-
TYS
6h 00m
1 stop
$263Southwest
Tue, May 26 - Sat, May 30
Southwest Logo
7:05 am - 2:30 pm
TYS
-
STL
8h 25m
2 stops
Southwest Logo
2:25 pm - 6:30 pm
STL
-
TYS
3h 05m
1 stop
$268Southwest
Tue, May 26 - Sat, May 30
Southwest Logo
7:05 am - 2:30 pm
TYS
-
STL
8h 25m
2 stops
Southwest Logo
10:35 am - 6:30 pm
STL
-
TYS
6h 55m
2 stops
$273Southwest
Tue, May 26 - Sat, May 30
Southwest Logo
6:45 pm - 8:55 pm
TYS
-
STL
3h 10m
1 stop
Southwest Logo
2:30 pm - 7:40 pm
STL
-
TYS
4h 10m
1 stop
$274Southwest
Fri, May 29 - Tue, Jun 2
Multiple Airlines Logo
1:15 pm - 12:21 am
TYS
-
STL
12h 06m
1 stop
Multiple Airlines Logo
5:27 pm - 4:15 pm
STL
-
TYS
21h 48m
2 stops
$275Multiple Airlines
Mon, May 18 - Mon, May 25
Southwest Logo
2:45 pm - 6:55 pm
TYS
-
STL
5h 10m
1 stop
Southwest Logo
2:10 pm - 8:20 pm
STL
-
TYS
5h 10m
1 stop
$277Southwest
Thu, May 28 - Mon, Jun 1

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United Airlines flights from Knoxville to St. Louis

Our best United Airlines deals on Knoxville to St. Louis flight tickets
United Airlines
May 28
TYS6:30 amKnoxville McGhee Tyson
6h 41m
1 stop
STL12:11 pmLambert-St Louis
Jun 1
STL5:41 pmLambert-St Louis
5h 49m
1 stop
TYS12:30 amKnoxville McGhee Tyson
$277
United Airlines
Aug 18
TYS6:30 amKnoxville McGhee Tyson
6h 43m
1 stop
STL12:13 pmLambert-St Louis
Aug 19
STL9:16 amLambert-St Louis
6h 43m
1 stop
TYS4:59 pmKnoxville McGhee Tyson
$319
United Airlines
Jun 4
TYS6:30 amKnoxville McGhee Tyson
6h 41m
1 stop
STL12:11 pmLambert-St Louis
Jun 8
STL9:23 amLambert-St Louis
14h 07m
1 stop
TYS12:30 amKnoxville McGhee Tyson
$458

Southwest flights from Knoxville to St. Louis

Our best Southwest deals on Knoxville to St. Louis flight tickets
Southwest
May 20
TYS8:15 amKnoxville McGhee Tyson
8h 00m
1 stop
STL3:15 pmLambert-St Louis
May 26
STL5:45 amLambert-St Louis
7h 35m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
$249
Southwest
May 20
TYS2:55 pmKnoxville McGhee Tyson
8h 25m
2 stops
STL10:20 pmLambert-St Louis
May 26
STL2:30 pmLambert-St Louis
4h 10m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
$254
Southwest
May 20
TYS12:50 pmKnoxville McGhee Tyson
7h 25m
2 stops
STL7:15 pmLambert-St Louis
May 26
STL10:25 amLambert-St Louis
9h 25m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
$259

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/29

12:55 pm-8:55 am

2 stops21h 00m

Lambert-St Louis

Tue 6/2

4:19 pm-6:21 pm

1 stop25h 02m

$243

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/20

8:15 am-3:15 pm

1 stop8h 00m

Lambert-St Louis

Tue 5/26

5:45 am-2:20 pm

1 stop7h 35m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/20

2:55 pm-10:20 pm

2 stops8h 25m

Lambert-St Louis

Tue 5/26

2:30 pm-7:40 pm

1 stop4h 10m

$254

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/20

12:50 pm-7:15 pm

2 stops7h 25m

Lambert-St Louis

Tue 5/26

10:25 am-8:50 pm

2 stops9h 25m

$259

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/26

5:50 pm-10:00 pm

1 stop5h 10m

Lambert-St Louis

Sat 5/30

6:20 am-1:20 pm

1 stop6h 00m

$263

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/26

7:05 am-2:30 pm

2 stops8h 25m

Lambert-St Louis

Sat 5/30

2:25 pm-6:30 pm

1 stop3h 05m

$268

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/26

7:05 am-2:30 pm

2 stops8h 25m

Lambert-St Louis

Sat 5/30

10:35 am-6:30 pm

2 stops6h 55m

$273
Quickest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/29

6:45 pm-8:55 pm

1 stop3h 10m

Lambert-St Louis

Tue 6/2

2:30 pm-7:40 pm

1 stop4h 10m

$274

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 5/18

1:15 pm-12:21 am

1 stop12h 06m

Lambert-St Louis

Mon 5/25

5:27 pm-4:15 pm

2 stops21h 48m

$275

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 5/28

2:45 pm-6:55 pm

1 stop5h 10m

Lambert-St Louis

Mon 6/1

2:10 pm-8:20 pm

1 stop5h 10m

$277

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, May is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. The month of January is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $294.

How have Knoxville to St. Louis flight prices changed over time?

As of May 2026, prices for Knoxville to St. Louis flights are approximately 141% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Fastest flight time

3h 10m

Direct flights

None
The fastest flight from Knoxville to St. Louis takes 3h 10m
There are no direct flights from Knoxville to St. Louis. There are no popular flight routes from Knoxville to St. Louis.
Search flight deals

Frequently asked questions about flying from Knoxville to St. Louis

  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 3h 10m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?

Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,684 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,464 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Wentzville
Alton
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

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