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Cheap flights from Knoxville to St. Louis from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to St. Louis departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:22 pm - 10:33 pm
TYS
-
STL
28h 11m2 stops
Multiple Airlines Logo
8:50 am - 5:28 pm
STL
-
TYS
7h 38m1 stop
$236Multiple Airlines
Tue, Jan 6 - Mon, Jan 12
Multiple Airlines Logo
12:55 pm - 11:33 pm
TYS
-
STL
11h 38m1 stop
Multiple Airlines Logo
8:22 pm - 8:39 am
STL
-
TYS
35h 17m2 stops
$238Multiple Airlines
Fri, Jan 30 - Fri, Feb 6
Multiple Airlines Logo
4:23 pm - 10:02 am
TYS
-
STL
18h 39m1 stop
Multiple Airlines Logo
8:32 pm - 5:53 pm
STL
-
TYS
20h 21m2 stops
$247Multiple Airlines
Sun, Jan 11 - Wed, Jan 14
Multiple Airlines Logo
6:00 am - 10:34 pm
TYS
-
STL
17h 34m1 stop
Multiple Airlines Logo
5:42 pm - 6:36 pm
STL
-
TYS
23h 54m1 stop
$251Multiple Airlines
Fri, Jan 16 - Wed, Jan 21
Multiple Airlines Logo
7:15 am - 6:51 am
TYS
-
STL
24h 36m2 stops
Multiple Airlines Logo
5:42 pm - 1:10 pm
STL
-
TYS
18h 28m1 stop
$261Multiple Airlines
Fri, Jan 16 - Wed, Jan 21
Frontier Logo
4:23 pm - 10:02 am
TYS
-
STL
18h 39m1 stop
Frontier Logo
3:43 pm - 7:23 pm
STL
-
TYS
26h 40m1 stop
$263Frontier
Sun, Jan 11 - Wed, Jan 14
Multiple Airlines Logo
11:59 am - 2:48 pm
TYS
-
STL
27h 49m2 stops
Multiple Airlines Logo
3:43 pm - 7:23 pm
STL
-
TYS
26h 40m1 stop
$267Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
American Airlines Logo
6:51 pm - 10:59 pm
TYS
-
STL
5h 08m1 stop
American Airlines Logo
3:37 pm - 10:47 pm
STL
-
TYS
6h 10m1 stop
$279American Airlines
Thu, Jan 29 - Thu, Feb 5
Multiple Airlines Logo
4:23 pm - 10:02 am
TYS
-
STL
18h 39m1 stop
Multiple Airlines Logo
8:32 pm - 5:53 pm
STL
-
TYS
20h 21m2 stops
$281Multiple Airlines
Sun, Jan 11 - Wed, Jan 14
American Airlines Logo
12:15 pm - 6:14 pm
TYS
-
STL
6h 59m2 stops
American Airlines Logo
3:37 pm - 10:47 pm
STL
-
TYS
6h 10m1 stop
$284American Airlines
Thu, Jan 29 - Thu, Feb 5

United Airlines flights from Knoxville to St. Louis

Our best United Airlines deals on Knoxville to St. Louis flight tickets
United Airlines
Jan 18
TYS6:45 amKnoxville McGhee Tyson
5h 17m
1 stop
STL11:02 amLambert-St Louis
Jan 22
STL8:30 amLambert-St Louis
5h 19m
1 stop
TYS2:49 pmKnoxville McGhee Tyson
$299
Find similar
United Airlines
Jan 16
TYS6:45 amKnoxville McGhee Tyson
6h 44m
1 stop
STL12:29 pmLambert-St Louis
Jan 21
STL8:05 amLambert-St Louis
4h 19m
1 stop
TYS1:24 pmKnoxville McGhee Tyson
$389
Find similar
United Airlines
Jan 16
TYS4:55 pmKnoxville McGhee Tyson
6h 05m
1 stop
STL10:00 pmLambert-St Louis
Jan 22
STL8:30 amLambert-St Louis
5h 19m
1 stop
TYS2:49 pmKnoxville McGhee Tyson
$403
Find similar

American Airlines flights from Knoxville to St. Louis

Our best American Airlines deals on Knoxville to St. Louis flight tickets
American Airlines
Jan 29
TYS6:51 pmKnoxville McGhee Tyson
5h 08m
1 stop
STL10:59 pmLambert-St Louis
Feb 5
STL3:37 pmLambert-St Louis
6h 10m
1 stop
TYS10:47 pmKnoxville McGhee Tyson
$279
Find similar
American Airlines
Jan 29
TYS12:15 pmKnoxville McGhee Tyson
6h 59m
2 stops
STL6:14 pmLambert-St Louis
Feb 5
STL3:37 pmLambert-St Louis
6h 10m
1 stop
TYS10:47 pmKnoxville McGhee Tyson
$284
Find similar
American Airlines
Jan 6
TYS4:00 pmKnoxville McGhee Tyson
6h 51m
2 stops
STL9:51 pmLambert-St Louis
Jan 12
STL6:52 amLambert-St Louis
6h 02m
1 stop
TYS1:54 pmKnoxville McGhee Tyson
$304
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 1/6

7:22 pm-10:33 pm

2 stops28h 11m

Lambert-St Louis

Mon 1/12

8:50 am-5:28 pm

1 stop7h 38m

$236

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 1/30

12:55 pm-11:33 pm

1 stop11h 38m

Lambert-St Louis

Fri 2/6

8:22 pm-8:39 am

2 stops35h 17m

$238

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-10:02 am

1 stop18h 39m

Lambert-St Louis

Wed 1/14

8:32 pm-5:53 pm

2 stops20h 21m

$247

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 1/16

6:00 am-10:34 pm

1 stop17h 34m

Lambert-St Louis

Wed 1/21

5:42 pm-6:36 pm

1 stop23h 54m

$251

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 1/16

7:15 am-6:51 am

2 stops24h 36m

Lambert-St Louis

Wed 1/21

5:42 pm-1:10 pm

1 stop18h 28m

$261

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-10:02 am

1 stop18h 39m

Lambert-St Louis

Wed 1/14

3:43 pm-7:23 pm

1 stop26h 40m

$263

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 1/10

11:59 am-2:48 pm

2 stops27h 49m

Lambert-St Louis

Wed 1/14

3:43 pm-7:23 pm

1 stop26h 40m

$267

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 1/29

6:51 pm-10:59 pm

1 stop5h 08m

Lambert-St Louis

Thu 2/5

3:37 pm-10:47 pm

1 stop6h 10m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-10:02 am

1 stop18h 39m

Lambert-St Louis

Wed 1/14

8:32 pm-5:53 pm

2 stops20h 21m

$281

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 1/29

12:15 pm-6:14 pm

2 stops6h 59m

Lambert-St Louis

Thu 2/5

3:37 pm-10:47 pm

1 stop6h 10m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, July is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. The month of April is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $284.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $259. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $539. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $265 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $288 per ticket.

How have Knoxville to St. Louis flight prices changed over time?

As of December 2025, prices for Knoxville to St. Louis flights are approximately 18% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Fastest flight time

6h 29m

Direct flights

None
The fastest flight from Knoxville to St. Louis takes 6h 29m
There are no direct flights from Knoxville to St. Louis. There are no popular flight routes from Knoxville to St. Louis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 6h 29m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?

Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
St. Peters
Collinsville
Alton
Clayton
Festus
Glencoe
Farmington
Eureka
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

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