Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to St. Louis from $109

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:40 am - 9:01 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 21m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:33 pm - 8:14 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 41m1 stop Atlanta Hartsfield-Jackson
$217Delta
Tue, Dec 1 - Tue, Dec 1
Southwest Logo
1:00 pm - 5:40 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 40m1 stop Orlando
Southwest Logo
4:30 pm - 8:35 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 05m1 stop Nashville Intl
$220Southwest
Thu, Dec 3 - Sun, Dec 6
Southwest Logo
2:40 pm - 9:10 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
7h 30m1 stop Dallas Love Field
Southwest Logo
2:40 pm - 8:35 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 55m2 stops Kansas City Nashville Intl
$225Southwest
Thu, Dec 3 - Sun, Dec 6
Southwest Logo
7:55 am - 7:25 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
12h 30m2 stops Baltimore/Washington Pittsburgh
Southwest Logo
5:10 am - 3:00 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
8h 50m2 stops Houston Hobby Dallas Love Field
$236Southwest
Thu, Dec 3 - Sun, Dec 6
American Airlines Logo
4:20 pm - 9:57 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 37m1 stop Charlotte Douglas
American Airlines Logo
8:13 am - 1:41 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 28m1 stop Charlotte Douglas
$245American Airlines
Fri, Feb 5 - Tue, Feb 9
American Airlines Logo
5:32 pm - 11:34 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
7h 02m1 stop Dallas/Fort Worth
American Airlines Logo
5:02 am - 11:02 amSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 00m1 stop Chicago O'Hare Intl
$259American Airlines
Fri, Dec 11 - Mon, Dec 14
Delta Logo
12:32 pm - 4:24 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 52m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 1:39 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 39m1 stop Atlanta Hartsfield-Jackson
$259Delta
Fri, Dec 18 - Sat, Dec 19
Delta Logo
4:01 pm - 9:38 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 37m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 1:39 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 39m1 stop Atlanta Hartsfield-Jackson
$279Delta
Fri, Dec 18 - Sat, Dec 19
United Airlines Logo
6:00 am - 10:30 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 30m1 stop Chicago O'Hare Intl
United Airlines Logo
5:25 am - 1:20 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 55m1 stop Chicago O'Hare Intl
$283United Airlines
Sun, Dec 13 - Mon, Dec 14
Multiple Airlines Logo
6:10 am - 11:59 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
18h 49m1 stop Orlando Sanford Intl
Multiple Airlines Logo
6:05 pm - 3:42 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
20h 37m1 stop Orlando
$333Multiple Airlines
Sun, Nov 22 - Wed, Nov 25

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Knoxville to St. Louis

Our best American Airlines deals on Knoxville to St. Louis flight tickets
American Airlines
Dec 11
TYS5:32 pmKnoxville McGhee Tyson
7h 02m
1 stop
STL11:34 pmLambert-St Louis
Dec 14
STL5:02 amLambert-St Louis
5h 00m
1 stop
TYS11:02 amKnoxville McGhee Tyson
$259
American Airlines
Dec 11
TYS5:32 pmKnoxville McGhee Tyson
7h 02m
1 stop
STL11:34 pmLambert-St Louis
Dec 13
STL11:37 amLambert-St Louis
4h 06m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
$278
American Airlines
Dec 25
TYS9:16 amKnoxville McGhee Tyson
7h 48m
1 stop
STL4:04 pmLambert-St Louis
Jan 1
STL6:00 amLambert-St Louis
4h 02m
1 stop
TYS11:02 amKnoxville McGhee Tyson
$291

Delta flights from Knoxville to St. Louis

Our best Delta deals on Knoxville to St. Louis flight tickets
Delta
Dec 1
TYS5:40 amKnoxville McGhee Tyson
4h 21m
1 stop
STL9:01 amLambert-St Louis
Dec 1
STL2:33 pmLambert-St Louis
4h 41m
1 stop
TYS8:14 pmKnoxville McGhee Tyson
$217
Delta
Dec 14
TYS6:17 pmKnoxville McGhee Tyson
6h 48m
1 stop
STL12:05 amLambert-St Louis
Dec 18
STL5:31 pmLambert-St Louis
3h 25m
1 stop
TYS9:56 pmKnoxville McGhee Tyson
$245
Delta
Dec 18
TYS4:01 pmKnoxville McGhee Tyson
6h 37m
1 stop
STL9:38 pmLambert-St Louis
Dec 20
STL7:15 pmLambert-St Louis
3h 35m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
$287

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Tue 12/1

5:40 am-9:01 am

1 stop4h 21m

Lambert-St Louis

Tue 12/1

2:33 pm-8:14 pm

1 stop4h 41m

$217
Quickest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

1:00 pm-5:40 pm

1 stop5h 40m

Lambert-St Louis

Sun 12/6

4:30 pm-8:35 pm

1 stop3h 05m

$220

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

2:40 pm-9:10 pm

1 stop7h 30m

Lambert-St Louis

Sun 12/6

2:40 pm-8:35 pm

2 stops4h 55m

$225

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

7:55 am-7:25 pm

2 stops12h 30m

Lambert-St Louis

Sun 12/6

5:10 am-3:00 pm

2 stops8h 50m

$236

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 2/5

4:20 pm-9:57 pm

1 stop6h 37m

Lambert-St Louis

Tue 2/9

8:13 am-1:41 pm

1 stop4h 28m

$245

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/11

5:32 pm-11:34 pm

1 stop7h 02m

Lambert-St Louis

Mon 12/14

5:02 am-11:02 am

1 stop5h 00m

$259

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/18

12:32 pm-4:24 pm

1 stop4h 52m

Lambert-St Louis

Sat 12/19

6:00 am-1:39 pm

1 stop6h 39m

$259

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/18

4:01 pm-9:38 pm

1 stop6h 37m

Lambert-St Louis

Sat 12/19

6:00 am-1:39 pm

1 stop6h 39m

$279

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Sun 12/13

6:00 am-10:30 am

1 stop5h 30m

Lambert-St Louis

Mon 12/14

5:25 am-1:20 pm

1 stop6h 55m

$283

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Sun 11/22

6:10 am-11:59 pm

1 stop18h 49m

Lambert-St Louis

Wed 11/25

6:05 pm-3:42 pm

1 stop20h 37m

$333

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $313 to $578.
The lowest price recently found on this route was $217.

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of January is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $294.

How have Knoxville to St. Louis flight prices changed over time?

As of October 2026, prices for Knoxville to St. Louis flights are approximately 40% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Best Price Found

$109

Fastest flight time

4h 25m

Direct flights

None
The best one-way flight to St. Louis from Knoxville in the past 72 hours is $109. The best round-trip flight deal from Knoxville to St. Louis found on momondo in the last 72 hours is $217.
The fastest flight from Knoxville to St. Louis takes 4h 25m
There are no direct flights from Knoxville to St. Louis. There are no popular flight routes from Knoxville to St. Louis.
Search flight deals

Frequently asked questions about flying from Knoxville to St. Louis

  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 4h 25m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?

Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $167Free CancellationRating
7.0
12,193 reviews
Search American Airlines flights
SouthwestPriceFrom $236Free CancellationRating
7.9
4,220 reviews
Search Southwest flights
DeltaPriceFrom $258Free CancellationRating
7.8
8,682 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Maryland Heights
St. Peters
Alton
Collinsville
Florissant
Farmington
Hermann
Festus
Clayton
Fenton
Edwardsville
O'Fallon
Eureka
Wentzville
Litchfield
Grafton
Waterloo

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 11/26
Thu 12/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States