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Cheap flights from Knoxville to St. Louis from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to St. Louis departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:30 am - 10:12 amTYS-STL
27h 42m2 stops
Multiple Airlines Logo
7:45 pm - 1:24 pmSTL-TYS
16h 39m1 stop
$273Multiple Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
Multiple Airlines Logo
7:00 am - 9:40 amTYS-STL
27h 40m2 stops
Multiple Airlines Logo
4:13 pm - 9:30 pmSTL-TYS
28h 17m1 stop
$276Multiple Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20
Delta Logo
5:40 am - 10:45 amTYS-STL
6h 05m1 stop
Delta Logo
9:30 am - 1:44 pmSTL-TYS
3h 14m1 stop
$279Delta
Find Deal
Fri, Dec 12 - Sun, Dec 14
Multiple Airlines Logo
8:00 am - 8:12 pmTYS-STL
13h 12m1 stop
Multiple Airlines Logo
9:54 pm - 3:53 pmSTL-TYS
16h 59m2 stops
$281Multiple Airlines
Find Deal
Mon, Nov 17 - Thu, Nov 20
Multiple Airlines Logo
8:00 am - 8:12 pmTYS-STL
13h 12m1 stop
Multiple Airlines Logo
4:13 pm - 8:45 pmSTL-TYS
27h 32m1 stop
$295Multiple Airlines
Find Deal
Mon, Nov 17 - Thu, Nov 20
American Airlines Logo
8:04 pm - 12:05 amTYS-STL
5h 01m1 stop
American Airlines Logo
7:11 am - 12:59 pmSTL-TYS
4h 48m1 stop
$333American Airlines
Find Deal
Wed, Nov 26 - Fri, Nov 28
American Airlines Logo
7:29 pm - 11:56 pmTYS-STL
5h 27m1 stop
American Airlines Logo
5:16 am - 11:28 amSTL-TYS
5h 12m1 stop
$388American Airlines
Find Deal
Sat, Dec 27 - Mon, Dec 29
Delta Logo
7:39 am - 1:51 pmTYS-STL
7h 12m1 stop
Delta Logo
9:33 am - 4:51 pmSTL-TYS
6h 18m1 stop
$407Delta
Find Deal
Sat, Nov 15 - Wed, Nov 19
United Airlines Logo
4:37 pm - 10:22 pmTYS-STL
6h 45m1 stop
United Airlines Logo
6:15 am - 1:19 pmSTL-TYS
6h 04m1 stop
$467United Airlines
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Sat, Nov 15 - Wed, Nov 19
United Airlines Logo
10:50 am - 2:24 pmTYS-STL
4h 34m1 stop
United Airlines Logo
4:35 pm - 11:44 pmSTL-TYS
6h 09m1 stop
$527United Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10

Delta flights from Knoxville to St. Louis

Our best Delta deals on Knoxville to St. Louis flight tickets
Delta
Dec 12
TYS5:40 amKnoxville McGhee Tyson
6h 05m
1 stop
STL10:45 amLambert-St Louis
Dec 14
STL9:30 amLambert-St Louis
3h 14m
1 stop
TYS1:44 pmKnoxville McGhee Tyson
$279
Find similar
Delta
Nov 15
TYS7:39 amKnoxville McGhee Tyson
7h 12m
1 stop
STL1:51 pmLambert-St Louis
Nov 19
STL9:33 amLambert-St Louis
6h 18m
1 stop
TYS4:51 pmKnoxville McGhee Tyson
$407
Find similar
Delta
Nov 7
TYS10:25 amKnoxville McGhee Tyson
5h 18m
1 stop
STL2:43 pmLambert-St Louis
Nov 11
STL11:39 amLambert-St Louis
6h 23m
1 stop
TYS7:02 pmKnoxville McGhee Tyson
$507
Find similar

American Airlines flights from Knoxville to St. Louis

Our best American Airlines deals on Knoxville to St. Louis flight tickets
American Airlines
Nov 26
TYS8:04 pmKnoxville McGhee Tyson
5h 01m
1 stop
STL12:05 amLambert-St Louis
Nov 28
STL7:11 amLambert-St Louis
4h 48m
1 stop
TYS12:59 pmKnoxville McGhee Tyson
$333
Find similar
American Airlines
Dec 27
TYS7:29 pmKnoxville McGhee Tyson
5h 27m
1 stop
STL11:56 pmLambert-St Louis
Dec 29
STL5:16 amLambert-St Louis
5h 12m
1 stop
TYS11:28 amKnoxville McGhee Tyson
$388
Find similar
American Airlines
Nov 22
TYS2:45 pmKnoxville McGhee Tyson
4h 09m
1 stop
STL5:54 pmLambert-St Louis
Nov 30
STL7:58 pmLambert-St Louis
5h 33m
1 stop
TYS2:31 amKnoxville McGhee Tyson
$399
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 11/15

7:30 am-10:12 am

2 stops27h 42m

Lambert-St Louis

Wed 11/19

7:45 pm-1:24 pm

1 stop16h 39m

$273

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 11/16

7:00 am-9:40 am

2 stops27h 40m

Lambert-St Louis

Thu 11/20

4:13 pm-9:30 pm

1 stop28h 17m

$276

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 12/12

5:40 am-10:45 am

1 stop6h 05m

Lambert-St Louis

Sun 12/14

9:30 am-1:44 pm

1 stop3h 14m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 11/17

8:00 am-8:12 pm

1 stop13h 12m

Lambert-St Louis

Thu 11/20

9:54 pm-3:53 pm

2 stops16h 59m

$281

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 11/17

8:00 am-8:12 pm

1 stop13h 12m

Lambert-St Louis

Thu 11/20

4:13 pm-8:45 pm

1 stop27h 32m

$295

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 11/26

8:04 pm-12:05 am

1 stop5h 01m

Lambert-St Louis

Fri 11/28

7:11 am-12:59 pm

1 stop4h 48m

$333

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 12/27

7:29 pm-11:56 pm

1 stop5h 27m

Lambert-St Louis

Mon 12/29

5:16 am-11:28 am

1 stop5h 12m

$388

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 11/15

7:39 am-1:51 pm

1 stop7h 12m

Lambert-St Louis

Wed 11/19

9:33 am-4:51 pm

1 stop6h 18m

$407

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 11/15

4:37 pm-10:22 pm

1 stop6h 45m

Lambert-St Louis

Wed 11/19

6:15 am-1:19 pm

1 stop6h 04m

$467

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 11/6

10:50 am-2:24 pm

1 stop4h 34m

Lambert-St Louis

Mon 11/10

4:35 pm-11:44 pm

1 stop6h 09m

$527

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, April is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $284. The month of July is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $288.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $259. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $539. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $265 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $288 per ticket.

How have Knoxville to St. Louis flight prices changed over time?

As of November 2025, prices for Knoxville to St. Louis flights are approximately 60% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Direct flights

None
There are no direct flights from Knoxville to St. Louis. There are no popular flight routes from Knoxville to St. Louis.
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  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 3h 53m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?

Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights
United AirlinesPriceFrom $213Free CancellationRating
7.4
8,994 reviews
Search United Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
7,997 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Wentzville
Fenton
Collinsville
St. Peters
Alton
Farmington
Festus
Glencoe
Edwardsville
Clayton
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

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