What is the cheapest airline that flies from Knoxville McGhee Tyson to Missouri?

Southwest, Delta, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Missouri

What airlines fly to Missouri?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Missouri from Knoxville according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 3 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of March 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$117 Cheap Flights from Knoxville to Missouri in 2026

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Find the cheapest flights from Knoxville to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:35 am - 12:40 pm

TYS

STL

7h 05m

2 stops

2:25 pm - 8:05 pm

STL

TYS

4h 40m

1 stop

$238Southwest

Wed, Apr 1 - Wed, Apr 1

11:26 am - 7:54 am

TYS

MCI

21h 28m

1 stop

2:51 pm - 3:33 pm

MCI

TYS

23h 42m

1 stop

$240Multiple Airlines

Wed, May 6 - Sat, May 9

5:00 am - 8:35 am

TYS

STL

4h 35m

1 stop

4:13 pm - 11:51 pm

STL

TYS

6h 38m

1 stop

$253American Airlines

Wed, Apr 1 - Wed, Apr 1

8:48 pm - 11:56 pm

TYS

STL

4h 08m

1 stop

12:27 pm - 8:18 pm

STL

TYS

6h 51m

1 stop

$254American Airlines

Thu, May 7 - Tue, May 12

10:04 am - 3:10 pm

TYS

SGF

6h 06m

1 stop

6:55 pm - 11:57 pm

SGF

TYS

4h 02m

1 stop

$269Delta

Fri, Apr 3 - Sun, Apr 12

7:00 am - 10:27 am

TYS

MCI

4h 27m

1 stop

4:29 pm - 11:41 pm

MCI

TYS

6h 12m

1 stop

$277United Airlines

Sat, Apr 11 - Wed, Apr 15

5:54 pm - 11:50 pm

TYS

MCI

6h 56m

1 stop

6:38 pm - 11:56 pm

MCI

TYS

4h 18m

1 stop

$279Delta

Wed, May 6 - Mon, May 11

9:54 pm - 10:00 am

TYS

SGF

13h 06m

1 stop

8:19 pm - 11:32 pm

SGF

TYS

26h 13m

1 stop

$326Allegiant Air

Mon, Mar 16 - Sun, Mar 22

8:30 am - 1:18 pm

TYS

JLN

5h 48m

1 stop

1:54 pm - 10:38 pm

JLN

TYS

7h 44m

1 stop

$334United Airlines

Sat, Aug 29 - Wed, Sep 2

8:00 am - 10:00 am

TYS

SGF

27h 00m

2 stops

8:19 pm - 11:32 pm

SGF

TYS

26h 13m

1 stop

$413Allegiant Air

Mon, Mar 16 - Sun, Mar 22

American Airlines flights from Knoxville to Missouri

Our best American Airlines deals on Knoxville to Missouri flight tickets

American Airlines

Apr 1

TYS5:00 amKnoxville McGhee Tyson

4h 35m

1 stop

STL8:35 amLambert-St Louis

Apr 1

STL4:13 pmLambert-St Louis

6h 38m

1 stop

TYS11:51 pmKnoxville McGhee Tyson

$253

American Airlines

May 7

TYS8:48 pmKnoxville McGhee Tyson

4h 08m

1 stop

STL11:56 pmLambert-St Louis

May 12

STL12:27 pmLambert-St Louis

6h 51m

1 stop

TYS8:18 pmKnoxville McGhee Tyson

$254

American Airlines

May 7

TYS8:48 pmKnoxville McGhee Tyson

4h 08m

1 stop

STL11:56 pmLambert-St Louis

May 12

STL3:24 pmLambert-St Louis

6h 32m

1 stop

TYS10:56 pmKnoxville McGhee Tyson

$265

Southwest flights from Knoxville to Missouri

Our best Southwest deals on Knoxville to Missouri flight tickets

Southwest

Apr 1

TYS6:35 amKnoxville McGhee Tyson

7h 05m

2 stops

STL12:40 pmLambert-St Louis

Apr 1

STL2:25 pmLambert-St Louis

4h 40m

1 stop

TYS8:05 pmKnoxville McGhee Tyson

$238

Southwest

Mar 25

TYS6:20 pmKnoxville McGhee Tyson

5h 20m

1 stop

STL10:40 pmLambert-St Louis

Mar 28

STL12:40 pmLambert-St Louis

8h 30m

1 stop

TYS10:10 pmKnoxville McGhee Tyson

$250

Southwest

Mar 25

TYS6:35 amKnoxville McGhee Tyson

9h 00m

2 stops

STL2:35 pmLambert-St Louis

Mar 28

STL12:40 pmLambert-St Louis

8h 30m

1 stop

TYS10:10 pmKnoxville McGhee Tyson

$256

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 4/1

6:35 am-12:40 pm

2 stops7h 05m

Lambert-St Louis

Wed 4/1

2:25 pm-8:05 pm

1 stop4h 40m

$238

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/6

11:26 am-7:54 am

1 stop21h 28m

Kansas City

Sat 5/9

2:51 pm-3:33 pm

1 stop23h 42m

$240

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 4/1

5:00 am-8:35 am

1 stop4h 35m

Lambert-St Louis

Wed 4/1

4:13 pm-11:51 pm

1 stop6h 38m

$253

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 5/7

8:48 pm-11:56 pm

1 stop4h 08m

Lambert-St Louis

Tue 5/12

12:27 pm-8:18 pm

1 stop6h 51m

$254

Quickest round-trip

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 4/3

10:04 am-3:10 pm

1 stop6h 06m

Springfield-Branson

Sun 4/12

6:55 pm-11:57 pm

1 stop4h 02m

$269

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 4/11

7:00 am-10:27 am

1 stop4h 27m

Kansas City

Wed 4/15

4:29 pm-11:41 pm

1 stop6h 12m

$277

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/6

5:54 pm-11:50 pm

1 stop6h 56m

Kansas City

Mon 5/11

6:38 pm-11:56 pm

1 stop4h 18m

$279

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Mon 3/16

9:54 pm-10:00 am

1 stop13h 06m

Springfield-Branson

Sun 3/22

8:19 pm-11:32 pm

1 stop26h 13m

$326

KnoxvilleJoplin

TYS - JLN

TYSJLN

Knoxville McGhee Tyson

Sat 8/29

8:30 am-1:18 pm

1 stop5h 48m

Joplin

Wed 9/2

1:54 pm-10:38 pm

1 stop7h 44m

$334

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Mon 3/16

8:00 am-10:00 am

2 stops27h 00m

Springfield-Branson

Sun 3/22

8:19 pm-11:32 pm

1 stop26h 13m

$413

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, June is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $278. If you aren’t able to travel to Missouri during the month of June, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $288.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Fastest flight time	4h 05m
Direct flights	None

The fastest flight from Knoxville to Missouri takes 4h 05m

There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.

Search flight deals

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?
Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of March 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.1 11,392 reviews	Search American Airlines flights
Delta	PriceFrom $228	Free Cancellation	Rating 7.9 8,258 reviews	Search Delta flights
United Airlines	PriceFrom $249	Free Cancellation	Rating 7.4 9,403 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.