What is the cheapest airline that flies from Knoxville McGhee Tyson to Missouri?

American Airlines, Delta, and Southwest are the most popular carriers operating from Knoxville McGhee Tyson to Missouri

What airlines fly to Missouri?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Missouri from Knoxville according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 4 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of September 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$144 Cheap Flights from Knoxville to Missouri in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:32 pm - 11:33 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 01m1 stop Dallas/Fort Worth

3:51 pm - 9:40 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 49m1 stop Washington, D.C. Reagan-National

$243American Airlines

Thu, Nov 5 - Mon, Nov 9

5:32 pm - 9:59 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 27m1 stop Dallas/Fort Worth

7:24 am - 2:05 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 41m1 stop Dallas/Fort Worth

$243American Airlines

Thu, Dec 3 - Sat, Dec 5

7:17 am - 12:35 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 18m1 stop Washington, D.C. Reagan-National

11:31 am - 6:20 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 49m1 stop Chicago O'Hare Intl

$243American Airlines

Wed, Oct 14 - Sat, Oct 17

7:55 am - 7:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 30m2 stops Baltimore/Washington Pittsburgh

7:00 am - 12:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 00m1 stop Nashville Intl

$254Southwest

Thu, Dec 3 - Sat, Dec 5

7:05 am - 2:05 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 00m2 stops Nashville Intl Atlanta Hartsfield-Jackson

5:40 am - 3:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

8h 20m1 stop Dallas Love Field

$254Southwest

Thu, Nov 5 - Mon, Nov 9

6:00 am - 10:48 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 48m1 stop Chicago O'Hare Intl

3:11 pm - 8:49 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 38m1 stop Chicago O'Hare Intl

$255United Airlines

Thu, Oct 1 - Mon, Oct 5

7:55 am - 7:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 30m2 stops Baltimore/Washington Pittsburgh

5:45 am - 12:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 15m2 stops Chicago Midway Nashville Intl

$259Southwest

Thu, Dec 3 - Sat, Dec 5

2:38 pm - 7:56 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 18m1 stop Atlanta Hartsfield-Jackson

10:00 am - 5:22 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 22m1 stop Atlanta Hartsfield-Jackson

$273Delta

Fri, Nov 6 - Tue, Nov 10

10:56 am - 4:04 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 08m1 stop Atlanta Hartsfield-Jackson

9:00 am - 3:57 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

5h 57m1 stop Atlanta Hartsfield-Jackson

$283Delta

Fri, Dec 25 - Fri, Jan 1

1:37 pm - 1:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

24h 33m2 stops Washington, D.C. Dulles Intl Atlanta Hartsfield-Jackson

5:19 pm - 1:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

18h 41m1 stop Orlando

$302Multiple Airlines

Thu, Oct 1 - Mon, Oct 5

Cheap last minute flights

Enter your travel dates to find the best prices.

5:38 pm - 10:36 amTYS Knoxville McGhee Tyson-SGF Springfield-Branson

17h 58m1 stop Orlando Sanford Intl

10:48 am - 4:28 pmSGF Springfield-Branson-TYS Knoxville McGhee Tyson

28h 40m1 stop Tampa St. Petersburg

$523Allegiant Air

Sun, Sep 13 - Tue, Sep 15

8:20 am - 4:34 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

9h 14m1 stop Orlando

5:19 pm - 7:34 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

25h 15m2 stops Orlando Philadelphia

$559Multiple Airlines

Fri, Sep 11 - Sun, Sep 13

8:00 am - 7:17 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

12h 17m2 stops Austin Bergstrom Denver Intl

5:19 pm - 8:39 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

26h 20m1 stop Orlando

$573Multiple Airlines

Fri, Sep 11 - Sun, Sep 13

5:38 pm - 4:34 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

23h 56m1 stop Orlando Sanford Intl

2:29 pm - 10:04 amSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

18h 35m2 stops Atlanta Hartsfield-Jackson Fort Lauderdale

$600Multiple Airlines

Sun, Sep 13 - Wed, Sep 16

3:35 pm - 8:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 05m1 stop Dallas Love Field

6:00 am - 2:00 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 00m1 stop Dallas Love Field

$609Southwest

Sat, Sep 12 - Sun, Sep 13

7:35 am - 2:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 50m1 stop Nashville Intl

7:15 am - 12:05 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 50m1 stop Nashville Intl

$613Southwest

Sun, Sep 13 - Wed, Sep 16

7:35 am - 2:25 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 50m1 stop Nashville Intl

7:05 am - 2:20 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 15m1 stop Dallas Love Field

$613Southwest

Sun, Sep 13 - Tue, Sep 15

4:48 pm - 8:44 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 56m1 stop Chicago O'Hare Intl

6:53 am - 12:01 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 08m1 stop Charlotte Douglas

$637American Airlines

Mon, Sep 14 - Thu, Sep 17

7:30 am - 12:15 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 45m1 stop Dallas/Fort Worth

12:50 pm - 5:37 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 47m1 stop Charlotte Douglas

$649American Airlines

Fri, Sep 11 - Sun, Sep 13

2:43 pm - 6:40 pmTYS Knoxville McGhee Tyson-MCI Kansas City

4h 57m1 stop Dallas/Fort Worth

5:24 pm - 11:22 pmMCI Kansas City-TYS Knoxville McGhee Tyson

4h 58m1 stop Dallas/Fort Worth

$702American Airlines

Mon, Sep 14 - Tue, Sep 15

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United Airlines flights from Knoxville to Missouri

Our best United Airlines deals on Knoxville to Missouri flight tickets

United Airlines

Oct 1

TYS6:00 amKnoxville McGhee Tyson

5h 48m

1 stop

STL10:48 amLambert-St Louis

Oct 5

STL3:11 pmLambert-St Louis

4h 38m

1 stop

TYS8:49 pmKnoxville McGhee Tyson

$255

United Airlines

Oct 10

TYS6:03 pmKnoxville McGhee Tyson

4h 57m

1 stop

MCI10:00 pmKansas City

Oct 13

MCI6:00 amKansas City

7h 42m

2 stops

TYS2:42 pmKnoxville McGhee Tyson

$308

United Airlines

Oct 22

TYS6:00 amKnoxville McGhee Tyson

7h 13m

1 stop

STL12:13 pmLambert-St Louis

Oct 26

STL1:08 pmLambert-St Louis

6h 46m

1 stop

TYS8:54 pmKnoxville McGhee Tyson

$313

Southwest flights from Knoxville to Missouri

Our best Southwest deals on Knoxville to Missouri flight tickets

Southwest

Nov 5

TYS7:05 amKnoxville McGhee Tyson

8h 00m

2 stops

STL2:05 pmLambert-St Louis

Nov 9

STL5:40 amLambert-St Louis

8h 20m

1 stop

TYS3:00 pmKnoxville McGhee Tyson

$254

Southwest

Dec 3

TYS7:55 amKnoxville McGhee Tyson

12h 30m

2 stops

STL7:25 pmLambert-St Louis

Dec 5

STL5:45 amLambert-St Louis

5h 15m

2 stops

TYS12:00 pmKnoxville McGhee Tyson

$259

Southwest

Oct 28

TYS7:15 amKnoxville McGhee Tyson

3h 45m

1 stop

MCI10:00 amKansas City

Nov 3

MCI10:25 amKansas City

8h 20m

2 stops

TYS7:45 pmKnoxville McGhee Tyson

$292

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 11/5

5:32 pm-11:33 pm

1 stop7h 01m

Lambert-St Louis

Mon 11/9

3:51 pm-9:40 pm

1 stop4h 49m

$243

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

5:32 pm-9:59 pm

1 stop5h 27m

Lambert-St Louis

Sat 12/5

7:24 am-2:05 pm

1 stop5h 41m

$243

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Wed 10/14

7:17 am-12:35 pm

1 stop6h 18m

Lambert-St Louis

Sat 10/17

11:31 am-6:20 pm

1 stop5h 49m

$243

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

7:55 am-7:25 pm

2 stops12h 30m

Lambert-St Louis

Sat 12/5

7:00 am-12:00 pm

1 stop4h 00m

$254

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 11/5

7:05 am-2:05 pm

2 stops8h 00m

Lambert-St Louis

Mon 11/9

5:40 am-3:00 pm

1 stop8h 20m

$254

Quickest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 10/1

6:00 am-10:48 am

1 stop5h 48m

Lambert-St Louis

Mon 10/5

3:11 pm-8:49 pm

1 stop4h 38m

$255

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

7:55 am-7:25 pm

2 stops12h 30m

Lambert-St Louis

Sat 12/5

5:45 am-12:00 pm

2 stops5h 15m

$259

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 11/6

2:38 pm-7:56 pm

1 stop6h 18m

Lambert-St Louis

Tue 11/10

10:00 am-5:22 pm

1 stop6h 22m

$273

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/25

10:56 am-4:04 pm

1 stop6h 08m

Lambert-St Louis

Fri 1/1

9:00 am-3:57 pm

1 stop5h 57m

$283

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 10/1

1:37 pm-1:10 pm

2 stops24h 33m

Lambert-St Louis

Mon 10/5

5:19 pm-1:00 pm

1 stop18h 41m

$302

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, June is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $308. If you aren’t able to travel to Missouri during the month of June, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $339.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Best Price Found	$144
Fastest flight time	3h 43m
Direct flights	None

The best one-way flight to Missouri from Knoxville in the past 72 hours is $144. The best round-trip flight deal from Knoxville to Missouri found on momondo in the last 72 hours is $243.

The fastest flight from Knoxville to Missouri takes 3h 43m

There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.

Search flight deals

Frequently asked questions about flying from Knoxville to Missouri

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?
Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of September 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $167	Free Cancellation	Rating 7.1 12,049 reviews	Search American Airlines flights
Southwest	PriceFrom $236	Free Cancellation	Rating 8.0 4,196 reviews	Search Southwest flights
Delta	PriceFrom $248	Free Cancellation	Rating 7.8 8,554 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.