What airlines fly to Missouri?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Missouri from Knoxville according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 4 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Missouri?

Frontier, Southwest, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Missouri

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of June 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$125 Cheap Flights from Knoxville to Missouri in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:19 pm - 7:23 pm

TYS

STL

24h 04m

1 stop

8:08 pm - 7:24 pm

STL

TYS

22h 16m

1 stop

$259Frontier

Fri, Jul 17 - Tue, Jul 21

7:10 am - 1:05 pm

TYS

STL

6h 55m

2 stops

3:10 pm - 8:25 pm

STL

TYS

4h 15m

1 stop

$274Southwest

Tue, Jul 28 - Tue, Jul 28

8:19 pm - 7:23 pm

TYS

STL

24h 04m

1 stop

8:08 pm - 7:24 pm

STL

TYS

22h 16m

1 stop

$282Frontier

Wed, Jul 22 - Sun, Jul 26

5:40 pm - 11:55 pm

TYS

STL

7h 15m

1 stop

8:00 am - 3:45 pm

STL

TYS

6h 45m

1 stop

$284Southwest

Wed, Jul 1 - Sun, Jul 5

3:53 pm - 11:59 pm

TYS

STL

9h 06m

1 stop

6:34 pm - 10:00 pm

STL

TYS

26h 26m

2 stops

$285Multiple Airlines

Thu, Jul 16 - Sun, Jul 19

4:20 pm - 12:00 pm

TYS

SGF

20h 40m

1 stop

10:52 am - 12:16 pm

SGF

TYS

24h 24m

1 stop

$298Allegiant Air

Tue, Jul 14 - Tue, Aug 11

2:08 pm - 8:02 pm

TYS

SGF

6h 54m

1 stop

12:50 pm - 3:03 pm

SGF

TYS

25h 13m

1 stop

$321Allegiant Air

Sun, Jul 12 - Wed, Jul 15

6:32 pm - 12:17 am

TYS

MCI

6h 45m

1 stop

11:26 am - 7:30 pm

MCI

TYS

7h 04m

1 stop

$332American Airlines

Fri, Jul 3 - Fri, Jul 10

5:45 am - 2:32 pm

TYS

SGF

9h 47m

2 stops

3:07 pm - 8:44 pm

SGF

TYS

4h 37m

1 stop

$387United Airlines

Sat, Jul 4 - Sat, Jul 11

4:50 pm - 11:42 pm

TYS

SGF

7h 52m

1 stop

3:05 pm - 9:45 pm

SGF

TYS

5h 40m

1 stop

$389United Airlines

Sat, Aug 22 - Wed, Aug 26

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Delta flights from Knoxville to Missouri

Our best Delta deals on Knoxville to Missouri flight tickets

Delta

Jul 17

TYS5:40 amKnoxville McGhee Tyson

3h 39m

1 stop

STL8:19 amLambert-St Louis

Jul 21

STL1:22 pmLambert-St Louis

5h 50m

1 stop

TYS8:12 pmKnoxville McGhee Tyson

$308

Delta

Sep 13

TYS10:05 amKnoxville McGhee Tyson

8h 25m

1 stop

MCI5:30 pmKansas City

Sep 21

MCI6:45 pmKansas City

4h 05m

1 stop

TYS11:50 pmKnoxville McGhee Tyson

$403

Delta

Sep 12

TYS5:30 amKnoxville McGhee Tyson

4h 57m

1 stop

MCI9:27 amKansas City

Sep 21

MCI6:45 pmKansas City

4h 05m

1 stop

TYS11:50 pmKnoxville McGhee Tyson

$423

Southwest flights from Knoxville to Missouri

Our best Southwest deals on Knoxville to Missouri flight tickets

Southwest

Jul 28

TYS7:10 amKnoxville McGhee Tyson

6h 55m

2 stops

STL1:05 pmLambert-St Louis

Jul 28

STL3:10 pmLambert-St Louis

4h 15m

1 stop

TYS8:25 pmKnoxville McGhee Tyson

$274

Southwest

Jul 1

TYS5:40 pmKnoxville McGhee Tyson

7h 15m

1 stop

STL11:55 pmLambert-St Louis

Jul 5

STL8:00 amLambert-St Louis

6h 45m

1 stop

TYS3:45 pmKnoxville McGhee Tyson

$284

Southwest

Jul 1

TYS5:40 pmKnoxville McGhee Tyson

7h 15m

1 stop

STL11:55 pmLambert-St Louis

Jul 4

STL10:15 amLambert-St Louis

7h 00m

2 stops

TYS6:15 pmKnoxville McGhee Tyson

$289

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 7/17

8:19 pm-7:23 pm

1 stop24h 04m

Lambert-St Louis

Tue 7/21

8:08 pm-7:24 pm

1 stop22h 16m

$259

Quickest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 7/28

7:10 am-1:05 pm

2 stops6h 55m

Lambert-St Louis

Tue 7/28

3:10 pm-8:25 pm

1 stop4h 15m

$274

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 7/22

8:19 pm-7:23 pm

1 stop24h 04m

Lambert-St Louis

Sun 7/26

8:08 pm-7:24 pm

1 stop22h 16m

$282

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 7/1

5:40 pm-11:55 pm

1 stop7h 15m

Lambert-St Louis

Sun 7/5

8:00 am-3:45 pm

1 stop6h 45m

$284

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/16

3:53 pm-11:59 pm

1 stop9h 06m

Lambert-St Louis

Sun 7/19

6:34 pm-10:00 pm

2 stops26h 26m

$285

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Tue 7/14

4:20 pm-12:00 pm

1 stop20h 40m

Springfield-Branson

Tue 8/11

10:52 am-12:16 pm

1 stop24h 24m

$298

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Sun 7/12

2:08 pm-8:02 pm

1 stop6h 54m

Springfield-Branson

Wed 7/15

12:50 pm-3:03 pm

1 stop25h 13m

$321

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Fri 7/3

6:32 pm-12:17 am

1 stop6h 45m

Kansas City

Fri 7/10

11:26 am-7:30 pm

1 stop7h 04m

$332

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Sat 7/4

5:45 am-2:32 pm

2 stops9h 47m

Springfield-Branson

Sat 7/11

3:07 pm-8:44 pm

1 stop4h 37m

$387

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Sat 8/22

4:50 pm-11:42 pm

1 stop7h 52m

Springfield-Branson

Wed 8/26

3:05 pm-9:45 pm

1 stop5h 40m

$389

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, September is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $150. If you aren’t able to travel to Missouri during the month of September, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $163.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Fastest flight time	3h 34m
Direct flights	None

The fastest flight from Knoxville to Missouri takes 3h 34m

There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.

Search flight deals

Frequently asked questions about flying from Knoxville to Missouri

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?
Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of June 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.1 11,640 reviews	Search American Airlines flights
Delta	PriceFrom $248	Free Cancellation	Rating 7.9 8,396 reviews	Search Delta flights
Southwest	PriceFrom $302	Free Cancellation	Rating 7.9 4,249 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.