What is the cheapest airline that flies from Knoxville McGhee Tyson to Missouri?

Southwest, American Airlines, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Missouri

What airlines fly to Missouri?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Missouri from Knoxville according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 3 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of April 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$99 Cheap Flights from Knoxville to Missouri in 2026

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Knoxville to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:55 pm - 9:15 pm

TYS

STL

7h 20m

1 stop

10:15 am - 5:10 pm

STL

TYS

5h 55m

1 stop

$249Southwest

Wed, May 13 - Wed, May 20

12:50 pm - 7:15 pm

TYS

STL

7h 25m

2 stops

8:25 am - 2:20 pm

STL

TYS

4h 55m

1 stop

$254Southwest

Tue, May 12 - Tue, May 19

7:33 pm - 11:59 pm

TYS

STL

5h 26m

1 stop

6:57 pm - 11:56 pm

STL

TYS

3h 59m

1 stop

$265Delta

Tue, May 19 - Tue, May 26

1:15 pm - 5:33 pm

TYS

STL

29h 18m

2 stops

8:08 pm - 1:59 pm

STL

TYS

16h 51m

1 stop

$270Multiple Airlines

Mon, May 18 - Sat, May 23

1:15 pm - 6:04 pm

TYS

STL

29h 49m

2 stops

8:08 pm - 1:59 pm

STL

TYS

16h 51m

1 stop

$271Multiple Airlines

Fri, May 15 - Sat, May 23

12:45 pm - 7:33 pm

TYS

SGF

7h 48m

1 stop

8:23 pm - 9:40 am

SGF

TYS

12h 17m

1 stop

$308Allegiant Air

Fri, May 8 - Mon, May 11

5:36 am - 10:30 am

TYS

SGF

5h 54m

1 stop

6:12 pm - 11:47 pm

SGF

TYS

4h 35m

1 stop

$309American Airlines

Tue, Jun 2 - Tue, Jun 9

1:41 pm - 7:15 pm

TYS

SGF

6h 34m

1 stop

7:09 pm - 11:12 pm

SGF

TYS

27h 03m

1 stop

$313Allegiant Air

Fri, Jun 26 - Sun, Jun 28

5:40 am - 11:16 am

TYS

MCI

6h 36m

1 stop

6:38 pm - 11:56 pm

MCI

TYS

4h 18m

1 stop

$327Delta

Thu, May 28 - Mon, Jun 1

5:09 pm - 9:05 pm

TYS

SGF

4h 56m

1 stop

6:24 pm - 11:55 pm

SGF

TYS

4h 31m

1 stop

$329American Airlines

Fri, May 8 - Mon, May 11

Southwest flights from Knoxville to Missouri

Our best Southwest deals on Knoxville to Missouri flight tickets

Southwest

May 13

TYS2:55 pmKnoxville McGhee Tyson

7h 20m

1 stop

STL9:15 pmLambert-St Louis

May 20

STL10:15 amLambert-St Louis

5h 55m

1 stop

TYS5:10 pmKnoxville McGhee Tyson

$249

Southwest

May 12

TYS12:50 pmKnoxville McGhee Tyson

7h 25m

2 stops

STL7:15 pmLambert-St Louis

May 19

STL8:25 amLambert-St Louis

4h 55m

1 stop

TYS2:20 pmKnoxville McGhee Tyson

$254

Southwest

May 12

TYS12:50 pmKnoxville McGhee Tyson

7h 25m

2 stops

STL7:15 pmLambert-St Louis

May 19

STL10:15 amLambert-St Louis

8h 25m

2 stops

TYS7:40 pmKnoxville McGhee Tyson

$259

American Airlines flights from Knoxville to Missouri

Our best American Airlines deals on Knoxville to Missouri flight tickets

American Airlines

Jun 2

TYS5:36 amKnoxville McGhee Tyson

5h 54m

1 stop

SGF10:30 amSpringfield-Branson

Jun 9

SGF6:12 pmSpringfield-Branson

4h 35m

1 stop

TYS11:47 pmKnoxville McGhee Tyson

$309

American Airlines

May 8

TYS5:09 pmKnoxville McGhee Tyson

4h 56m

1 stop

SGF9:05 pmSpringfield-Branson

May 11

SGF6:24 pmSpringfield-Branson

4h 31m

1 stop

TYS11:55 pmKnoxville McGhee Tyson

$329

American Airlines

May 16

TYS6:54 pmKnoxville McGhee Tyson

5h 05m

1 stop

STL10:59 pmLambert-St Louis

May 26

STL6:00 amLambert-St Louis

3h 59m

1 stop

TYS10:59 amKnoxville McGhee Tyson

$365

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/13

2:55 pm-9:15 pm

1 stop7h 20m

Lambert-St Louis

Wed 5/20

10:15 am-5:10 pm

1 stop5h 55m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-7:15 pm

2 stops7h 25m

Lambert-St Louis

Tue 5/19

8:25 am-2:20 pm

1 stop4h 55m

$254

Quickest round-trip

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 5/19

7:33 pm-11:59 pm

1 stop5h 26m

Lambert-St Louis

Tue 5/26

6:57 pm-11:56 pm

1 stop3h 59m

$265

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 5/18

1:15 pm-5:33 pm

2 stops29h 18m

Lambert-St Louis

Sat 5/23

8:08 pm-1:59 pm

1 stop16h 51m

$270

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/15

1:15 pm-6:04 pm

2 stops29h 49m

Lambert-St Louis

Sat 5/23

8:08 pm-1:59 pm

1 stop16h 51m

$271

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 5/8

12:45 pm-7:33 pm

1 stop7h 48m

Springfield-Branson

Mon 5/11

8:23 pm-9:40 am

1 stop12h 17m

$308

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Tue 6/2

5:36 am-10:30 am

1 stop5h 54m

Springfield-Branson

Tue 6/9

6:12 pm-11:47 pm

1 stop4h 35m

$309

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 6/26

1:41 pm-7:15 pm

1 stop6h 34m

Springfield-Branson

Sun 6/28

7:09 pm-11:12 pm

1 stop27h 03m

$313

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Thu 5/28

5:40 am-11:16 am

1 stop6h 36m

Kansas City

Mon 6/1

6:38 pm-11:56 pm

1 stop4h 18m

$327

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 5/8

5:09 pm-9:05 pm

1 stop4h 56m

Springfield-Branson

Mon 5/11

6:24 pm-11:55 pm

1 stop4h 31m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, May is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you aren’t able to travel to Missouri during the month of May, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $294.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Fastest flight time	3h 10m
Direct flights	None

The fastest flight from Knoxville to Missouri takes 3h 10m

There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.

Search flight deals

Frequently asked questions about flying from Knoxville to Missouri

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?
Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of April 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.1 11,604 reviews		Search American Airlines flights
Delta	PriceFrom $228	Free Cancellation	Rating 7.9 8,424 reviews		Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.