What is the cheapest airline that flies from Knoxville McGhee Tyson to Missouri?

Southwest, American Airlines, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Missouri

What airlines fly to Missouri?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Missouri from Knoxville according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 4 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of October 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$109 Cheap Flights from Knoxville to Missouri in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:04 pm - 11:58 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 54m1 stop Charlotte Douglas

6:00 am - 1:25 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

6h 25m1 stop Charlotte Douglas

$217American Airlines

Thu, Nov 19 - Thu, Nov 26

7:22 pm - 11:56 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 34m1 stop Atlanta Hartsfield-Jackson

12:29 pm - 5:22 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 53m1 stop Atlanta Hartsfield-Jackson

$217Delta

Mon, Nov 16 - Mon, Nov 23

1:00 pm - 5:40 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

5h 40m1 stop Orlando

4:30 pm - 8:35 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 05m1 stop Nashville Intl

$220Southwest

Thu, Dec 3 - Sun, Dec 6

2:40 pm - 9:10 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

7h 30m1 stop Dallas Love Field

2:40 pm - 8:35 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 55m2 stops Kansas City Nashville Intl

$225Southwest

Thu, Dec 3 - Sun, Dec 6

4:20 pm - 9:57 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 37m1 stop Charlotte Douglas

8:13 am - 1:41 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 28m1 stop Charlotte Douglas

$245American Airlines

Fri, Feb 5 - Tue, Feb 9

6:17 pm - 12:05 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 48m1 stop Atlanta Hartsfield-Jackson

5:31 pm - 9:56 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 25m1 stop Atlanta Hartsfield-Jackson

$245Delta

Mon, Dec 14 - Fri, Dec 18

5:40 am - 9:01 amTYS Knoxville McGhee Tyson-STL Lambert-St Louis

4h 21m1 stop Atlanta Hartsfield-Jackson

7:15 pm - 11:50 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 35m1 stop Atlanta Hartsfield-Jackson

$245Delta

Fri, Dec 18 - Sat, Dec 19

5:05 pm - 11:52 pmTYS Knoxville McGhee Tyson-MCI Kansas City

7h 47m1 stop Denver Intl

11:18 am - 4:59 pmMCI Kansas City-TYS Knoxville McGhee Tyson

4h 41m1 stop Chicago O'Hare Intl

$246United Airlines

Tue, Nov 10 - Wed, Nov 11

8:50 pm - 12:24 amTYS Knoxville McGhee Tyson-MCI Kansas City

4h 34m1 stop Chicago O'Hare Intl

6:30 am - 1:25 pmMCI Kansas City-TYS Knoxville McGhee Tyson

5h 55m1 stop Charlotte Douglas

$251American Airlines

Wed, Nov 25 - Thu, Nov 26

6:00 am - 10:46 amTYS Knoxville McGhee Tyson-MCI Kansas City

5h 46m1 stop Chicago O'Hare Intl

6:00 am - 2:53 pmMCI Kansas City-TYS Knoxville McGhee Tyson

7h 53m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$256United Airlines

Thu, Nov 26 - Tue, Dec 1

Cheap last minute flights

Enter your travel dates to find the best prices.

5:28 pm - 10:06 amTYS Knoxville McGhee Tyson-MCI Kansas City

17h 38m1 stop Fort Lauderdale

9:16 am - 7:24 pmMCI Kansas City-TYS Knoxville McGhee Tyson

9h 08m1 stop Fort Lauderdale

$409Allegiant Air

Thu, Oct 29 - Mon, Nov 2

8:57 am - 2:44 pmTYS Knoxville McGhee Tyson-SGF Springfield-Branson

6h 47m1 stop Charlotte Douglas

5:26 pm - 11:47 pmSGF Springfield-Branson-TYS Knoxville McGhee Tyson

5h 21m1 stop Chicago O'Hare Intl

$449American Airlines

Fri, Oct 30 - Mon, Nov 2

6:06 pm - 9:46 pmTYS Knoxville McGhee Tyson-SGF Springfield-Branson

4h 40m1 stop Charlotte Douglas

5:26 pm - 11:47 pmSGF Springfield-Branson-TYS Knoxville McGhee Tyson

5h 21m1 stop Chicago O'Hare Intl

$449American Airlines

Fri, Oct 30 - Mon, Nov 2

8:57 am - 2:44 pmTYS Knoxville McGhee Tyson-SGF Springfield-Branson

6h 47m1 stop Charlotte Douglas

5:26 pm - 11:47 pmSGF Springfield-Branson-TYS Knoxville McGhee Tyson

5h 21m1 stop Chicago O'Hare Intl

$464American Airlines

Fri, Oct 30 - Mon, Nov 2

4:29 pm - 8:06 amTYS Knoxville McGhee Tyson-MCI Kansas City

16h 37m1 stop Tampa St. Petersburg

5:29 pm - 6:21 pmMCI Kansas City-TYS Knoxville McGhee Tyson

23h 52m1 stop Punta Gorda

$475Allegiant Air

Wed, Oct 28 - Fri, Oct 30

8:00 am - 7:47 pmTYS Knoxville McGhee Tyson-MCI Kansas City

36h 47m2 stops Orlando Denver Intl

9:16 am - 7:24 pmMCI Kansas City-TYS Knoxville McGhee Tyson

9h 08m1 stop Fort Lauderdale

$510Multiple Airlines

Fri, Oct 30 - Mon, Nov 2

6:23 pm - 11:54 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 31m1 stop Atlanta Hartsfield-Jackson

2:25 pm - 6:47 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

3h 22m1 stop Atlanta Hartsfield-Jackson

$619Delta

Wed, Oct 28 - Fri, Oct 30

6:23 pm - 11:54 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

6h 31m1 stop Atlanta Hartsfield-Jackson

12:00 pm - 5:28 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

4h 28m1 stop Atlanta Hartsfield-Jackson

$619Delta

Wed, Oct 28 - Thu, Oct 29

1:00 pm - 8:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 00m1 stop Orlando

5:00 am - 1:10 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 10m1 stop Orlando

$619Southwest

Wed, Oct 28 - Fri, Oct 30

1:00 pm - 8:00 pmTYS Knoxville McGhee Tyson-STL Lambert-St Louis

8h 00m1 stop Orlando

2:00 pm - 10:45 pmSTL Lambert-St Louis-TYS Knoxville McGhee Tyson

7h 45m2 stops Chicago Midway Nashville Intl

$624Southwest

Wed, Oct 28 - Fri, Oct 30

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United Airlines flights from Knoxville to Missouri

Our best United Airlines deals on Knoxville to Missouri flight tickets

United Airlines

Nov 10

TYS5:05 pmKnoxville McGhee Tyson

7h 47m

1 stop

MCI11:52 pmKansas City

Nov 11

MCI11:18 amKansas City

4h 41m

1 stop

TYS4:59 pmKnoxville McGhee Tyson

$246

United Airlines

Nov 10

TYS1:56 pmKnoxville McGhee Tyson

4h 42m

1 stop

MCI5:38 pmKansas City

Nov 11

MCI6:00 amKansas City

7h 48m

2 stops

TYS2:48 pmKnoxville McGhee Tyson

$256

United Airlines

Nov 20

TYS6:45 amKnoxville McGhee Tyson

6h 25m

1 stop

STL12:10 pmLambert-St Louis

Nov 27

STL12:57 pmLambert-St Louis

6h 57m

1 stop

TYS8:54 pmKnoxville McGhee Tyson

$273

American Airlines flights from Knoxville to Missouri

Our best American Airlines deals on Knoxville to Missouri flight tickets

American Airlines

Nov 25

TYS8:50 pmKnoxville McGhee Tyson

4h 34m

1 stop

MCI12:24 amKansas City

Nov 26

MCI9:00 amKansas City

6h 40m

1 stop

TYS4:40 pmKnoxville McGhee Tyson

$251

American Airlines

Dec 11

TYS5:32 pmKnoxville McGhee Tyson

7h 02m

1 stop

STL11:34 pmLambert-St Louis

Dec 14

STL5:02 amLambert-St Louis

5h 00m

1 stop

TYS11:02 amKnoxville McGhee Tyson

$259

American Airlines

Dec 25

TYS9:16 amKnoxville McGhee Tyson

7h 48m

1 stop

STL4:04 pmLambert-St Louis

Jan 1

STL6:00 amLambert-St Louis

4h 02m

1 stop

TYS11:02 amKnoxville McGhee Tyson

$293

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 11/19

8:04 pm-11:58 pm

1 stop4h 54m

Lambert-St Louis

Thu 11/26

6:00 am-1:25 pm

1 stop6h 25m

$217

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Mon 11/16

7:22 pm-11:56 pm

1 stop5h 34m

Lambert-St Louis

Mon 11/23

12:29 pm-5:22 pm

1 stop3h 53m

$217

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

1:00 pm-5:40 pm

1 stop5h 40m

Lambert-St Louis

Sun 12/6

4:30 pm-8:35 pm

1 stop3h 05m

$220

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Thu 12/3

2:40 pm-9:10 pm

1 stop7h 30m

Lambert-St Louis

Sun 12/6

2:40 pm-8:35 pm

2 stops4h 55m

$225

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 2/5

4:20 pm-9:57 pm

1 stop6h 37m

Lambert-St Louis

Tue 2/9

8:13 am-1:41 pm

1 stop4h 28m

$245

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Mon 12/14

6:17 pm-12:05 am

1 stop6h 48m

Lambert-St Louis

Fri 12/18

5:31 pm-9:56 pm

1 stop3h 25m

$245

Quickest round-trip

KnoxvilleSt. Louis

TYS Knoxville McGhee Tyson - STL Lambert-St Louis

TYSSTL

Knoxville McGhee Tyson

Fri 12/18

5:40 am-9:01 am

1 stop4h 21m

Lambert-St Louis

Sat 12/19

7:15 pm-11:50 pm

1 stop3h 35m

$245

KnoxvilleKansas City

TYS Knoxville McGhee Tyson - MCI Kansas City

TYSMCI

Knoxville McGhee Tyson

Tue 11/10

5:05 pm-11:52 pm

1 stop7h 47m

Kansas City

Wed 11/11

11:18 am-4:59 pm

1 stop4h 41m

$246

KnoxvilleKansas City

TYS Knoxville McGhee Tyson - MCI Kansas City

TYSMCI

Knoxville McGhee Tyson

Wed 11/25

8:50 pm-12:24 am

1 stop4h 34m

Kansas City

Thu 11/26

6:30 am-1:25 pm

1 stop5h 55m

$251

KnoxvilleKansas City

TYS Knoxville McGhee Tyson - MCI Kansas City

TYSMCI

Knoxville McGhee Tyson

Thu 11/26

6:00 am-10:46 am

1 stop5h 46m

Kansas City

Tue 12/1

6:00 am-2:53 pm

2 stops7h 53m

$256

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, January is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $342. If you aren’t able to travel to Missouri during the month of January, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $368.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Best Price Found	$109
Fastest flight time	3h 50m
Direct flights	None

The best one-way flight to Missouri from Knoxville in the past 72 hours is $109. The best round-trip flight deal from Knoxville to Missouri found on momondo in the last 72 hours is $217.

The fastest flight from Knoxville to Missouri takes 3h 50m

There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.

Search flight deals

Frequently asked questions about flying from Knoxville to Missouri

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?
Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Missouri as of October 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $167	Free Cancellation	Rating 7.0 12,189 reviews	Search American Airlines flights
Southwest	PriceFrom $236	Free Cancellation	Rating 7.9 4,221 reviews	Search Southwest flights
Delta	PriceFrom $258	Free Cancellation	Rating 7.8 8,678 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.