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Cheap flights from Knoxville to Missouri from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Missouri departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to Missouri

Cheap round-trip flights

Multiple Airlines Logo
4:32 pm - 11:01 amTYS-STL
19h 29m1 stop
Multiple Airlines Logo
7:45 pm - 1:44 pmSTL-TYS
16h 59m1 stop
$241Multiple Airlines
Find Deal
Wed, Nov 5 - Sat, Nov 8
Frontier Logo
8:17 pm - 9:07 amTYS-STL
13h 50m1 stop
Frontier Logo
7:52 pm - 7:32 pmSTL-TYS
22h 40m1 stop
$243Frontier
Find Deal
Fri, Oct 24 - Sun, Oct 26
American Airlines Logo
8:15 am - 11:25 amTYS-SGF
4h 10m1 stop
American Airlines Logo
5:53 am - 2:05 pmSGF-TYS
7h 12m1 stop
$249American Airlines
Find Deal
Wed, Mar 18 - Wed, Mar 25
Delta Logo
10:05 am - 2:43 pmTYS-STL
5h 38m1 stop
Delta Logo
5:15 pm - 11:46 pmSTL-TYS
5h 31m1 stop
$249Delta
Find Deal
Fri, Oct 17 - Mon, Oct 20
Delta Logo
3:48 pm - 7:01 pmTYS-MCI
4h 13m1 stop
Delta Logo
5:55 am - 10:28 amMCI-TYS
3h 33m1 stop
$267Delta
Find Deal
Wed, Oct 29 - Sat, Nov 1
American Airlines Logo
8:37 pm - 11:58 pmTYS-STL
4h 21m1 stop
American Airlines Logo
4:25 pm - 11:50 pmSTL-TYS
6h 25m1 stop
$269American Airlines
Find Deal
Mon, Oct 20 - Mon, Oct 27
United Airlines Logo
7:00 am - 10:37 amTYS-MCI
4h 37m1 stop
United Airlines Logo
1:47 pm - 10:30 pmMCI-TYS
7h 43m1 stop
$299United Airlines
Find Deal
Tue, Oct 14 - Sat, Nov 1
United Airlines Logo
7:05 am - 12:01 pmTYS-MCI
5h 56m1 stop
United Airlines Logo
11:36 am - 11:44 pmMCI-TYS
11h 08m2 stops
$342United Airlines
Find Deal
Wed, Oct 29 - Sat, Nov 1
Allegiant Air Logo
5:14 pm - 9:25 amTYS-SGF
17h 11m1 stop
Allegiant Air Logo
3:04 pm - 8:36 pmSGF-TYS
28h 32m1 stop
$418Allegiant Air
Find Deal
Wed, Oct 8 - Sun, Oct 12
Allegiant Air Logo
9:26 pm - 2:38 pmTYS-SGF
18h 12m1 stop
Allegiant Air Logo
3:11 pm - 6:59 pmSGF-TYS
26h 48m1 stop
$469Allegiant Air
Find Deal
Mon, Oct 6 - Fri, Oct 10

Delta flights from Knoxville to Missouri

Our best Delta deals on Knoxville to Missouri flight tickets
Delta
Oct 17
TYS10:05 amKnoxville McGhee Tyson
5h 38m
1 stop
STL2:43 pmLambert-St Louis
Oct 20
STL5:15 pmLambert-St Louis
5h 31m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
$249
Find similar
Delta
Oct 29
TYS3:48 pmKnoxville McGhee Tyson
4h 13m
1 stop
MCI7:01 pmKansas City
Nov 1
MCI5:55 amKansas City
3h 33m
1 stop
TYS10:28 amKnoxville McGhee Tyson
$267
Find similar
Delta
Sep 25
TYS11:49 amKnoxville McGhee Tyson
3h 46m
1 stop
STL2:35 pmLambert-St Louis
Sep 28
STL6:01 amLambert-St Louis
3h 55m
1 stop
TYS10:56 amKnoxville McGhee Tyson
$299
Find similar

Frontier flights from Knoxville to Missouri

Our best Frontier deals on Knoxville to Missouri flight tickets
Frontier
Oct 24
TYS8:17 pmKnoxville McGhee Tyson
13h 50m
1 stop
STL9:07 amLambert-St Louis
Oct 26
STL7:52 pmLambert-St Louis
22h 40m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
$243
Find similar
Frontier
Oct 23
TYS8:17 pmKnoxville McGhee Tyson
13h 50m
1 stop
STL9:07 amLambert-St Louis
Oct 26
STL7:52 pmLambert-St Louis
22h 40m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
$247
Find similar
Frontier
Oct 10
TYS8:17 pmKnoxville McGhee Tyson
13h 50m
1 stop
STL9:07 amLambert-St Louis
Oct 12
STL7:52 pmLambert-St Louis
22h 40m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
$355
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 23, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 11/5

4:32 pm-11:01 am

1 stop19h 29m

Lambert-St Louis

Sat 11/8

7:45 pm-1:44 pm

1 stop16h 59m

$241

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 10/24

8:17 pm-9:07 am

1 stop13h 50m

Lambert-St Louis

Sun 10/26

7:52 pm-7:32 pm

1 stop22h 40m

$243

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 3/18

8:15 am-11:25 am

1 stop4h 10m

Springfield-Branson

Wed 3/25

5:53 am-2:05 pm

1 stop7h 12m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 10/17

10:05 am-2:43 pm

1 stop5h 38m

Lambert-St Louis

Mon 10/20

5:15 pm-11:46 pm

1 stop5h 31m

$249

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 10/29

3:48 pm-7:01 pm

1 stop4h 13m

Kansas City

Sat 11/1

5:55 am-10:28 am

1 stop3h 33m

$267

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 10/20

8:37 pm-11:58 pm

1 stop4h 21m

Lambert-St Louis

Mon 10/27

4:25 pm-11:50 pm

1 stop6h 25m

$269

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Tue 10/14

7:00 am-10:37 am

1 stop4h 37m

Kansas City

Sat 11/1

1:47 pm-10:30 pm

1 stop7h 43m

$299

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 10/29

7:05 am-12:01 pm

1 stop5h 56m

Kansas City

Sat 11/1

11:36 am-11:44 pm

2 stops11h 08m

$342

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 10/8

5:14 pm-9:25 am

1 stop17h 11m

Springfield-Branson

Sun 10/12

3:04 pm-8:36 pm

1 stop28h 32m

$418

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Mon 10/6

9:26 pm-2:38 pm

1 stop18h 12m

Springfield-Branson

Fri 10/10

3:11 pm-6:59 pm

1 stop26h 48m

$469

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Knoxville to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, April is the cheapest month to fly from Knoxville to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $284. If you aren’t able to travel to Missouri during the month of April, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $288.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Knoxville to Missouri is on a Wednesday when prices can be found for as low as $259. Flights from Knoxville to Missouri on a Monday will generally be more expensive and average around $539. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Knoxville to Missouri at noon for as low as $265. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $288. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Cheap Knoxville to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Missouri

Direct flights

None
There are no direct flights from Knoxville to Missouri. There are no popular flight routes from Knoxville to Missouri.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Missouri?

    Prices for flights from Knoxville McGhee Tyson Airport to Missouri were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Missouri?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Missouri?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Missouri

Compare and see reviews for airlines that fly from Knoxville to Missouri with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $213Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
7,974 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Missouri?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Missouri. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Missouri?

momondo helps you find the best flight between Knoxville and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Missouri right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Missouri, momondo offers a useful price alert feature which will track prices for flights to Missouri from Knoxville and alert you when they change.

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