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Cheap flights from Knoxville to Lafayette from $259

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Lafayette departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Lafayette

Cheap round-trip flights

American Airlines Logo
6:00 am - 9:38 amTYS-LFT
4h 38m1 stop
American Airlines Logo
6:37 pm - 12:21 amLFT-TYS
4h 44m1 stop
$259American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
4:37 pm - 11:25 pmTYS-LFT
7h 48m1 stop
American Airlines Logo
4:20 pm - 11:51 pmLFT-TYS
6h 31m1 stop
$284American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
5:30 am - 11:42 amTYS-LFT
7h 12m1 stop
American Airlines Logo
5:48 am - 1:09 pmLFT-TYS
6h 21m1 stop
$309American Airlines
Find Deal
Thu, Sep 25 - Sun, Sep 28
American Airlines Logo
3:09 pm - 11:25 pmTYS-LFT
9h 16m2 stops
American Airlines Logo
5:48 am - 1:09 pmLFT-TYS
6h 21m1 stop
$314American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
7:45 pm - 11:26 pmTYS-LFT
4h 41m1 stop
American Airlines Logo
12:12 pm - 11:03 pmLFT-TYS
9h 51m2 stops
$332American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
2:08 pm - 11:25 pmTYS-LFT
10h 17m2 stops
American Airlines Logo
4:20 pm - 11:51 pmLFT-TYS
6h 31m1 stop
$382American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
8:23 am - 6:00 pmTYS-LFT
10h 37m2 stops
American Airlines Logo
12:12 pm - 11:03 pmLFT-TYS
9h 51m2 stops
$405American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
11:17 am - 5:26 pmTYS-LFT
7h 09m2 stops
American Airlines Logo
5:48 am - 1:09 pmLFT-TYS
6h 21m1 stop
$407American Airlines
Find Deal
Thu, Sep 25 - Sun, Sep 28
American Airlines Logo
3:09 pm - 11:25 pmTYS-LFT
9h 16m2 stops
American Airlines Logo
5:48 am - 4:03 pmLFT-TYS
9h 15m2 stops
$570American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
6:30 am - 3:50 pmTYS-LFT
10h 20m2 stops
American Airlines Logo
5:48 am - 4:03 pmLFT-TYS
9h 15m2 stops
$662American Airlines
Find Deal
Thu, Sep 25 - Sun, Sep 28

American Airlines flights from Knoxville to Lafayette

Our best American Airlines deals on Knoxville to Lafayette flight tickets
American Airlines
Sep 30
TYS6:00 amKnoxville McGhee Tyson
4h 38m
1 stop
LFT9:38 amLafayette Regional
Oct 4
LFT6:37 pmLafayette Regional
4h 44m
1 stop
TYS12:21 amKnoxville McGhee Tyson
$259
Find similar
American Airlines
Sep 26
TYS4:37 pmKnoxville McGhee Tyson
7h 48m
1 stop
LFT11:25 pmLafayette Regional
Sep 28
LFT4:20 pmLafayette Regional
6h 31m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$284
Find similar
American Airlines
Sep 25
TYS5:30 amKnoxville McGhee Tyson
7h 12m
1 stop
LFT11:42 amLafayette Regional
Sep 28
LFT5:48 amLafayette Regional
6h 21m
1 stop
TYS1:09 pmKnoxville McGhee Tyson
$309
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Lafayette that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to Lafayette that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Tue 9/30

6:00 am-9:38 am

1 stop4h 38m

Lafayette Regional

Sat 10/4

6:37 pm-12:21 am

1 stop4h 44m

$259

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Fri 9/26

4:37 pm-11:25 pm

1 stop7h 48m

Lafayette Regional

Sun 9/28

4:20 pm-11:51 pm

1 stop6h 31m

$284

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Thu 9/25

5:30 am-11:42 am

1 stop7h 12m

Lafayette Regional

Sun 9/28

5:48 am-1:09 pm

1 stop6h 21m

$309

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Fri 9/26

3:09 pm-11:25 pm

2 stops9h 16m

Lafayette Regional

Sun 9/28

5:48 am-1:09 pm

1 stop6h 21m

$314

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Tue 9/30

7:45 pm-11:26 pm

1 stop4h 41m

Lafayette Regional

Sat 10/4

12:12 pm-11:03 pm

2 stops9h 51m

$332

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Fri 9/26

2:08 pm-11:25 pm

2 stops10h 17m

Lafayette Regional

Sun 9/28

4:20 pm-11:51 pm

1 stop6h 31m

$382

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Tue 9/30

8:23 am-6:00 pm

2 stops10h 37m

Lafayette Regional

Sat 10/4

12:12 pm-11:03 pm

2 stops9h 51m

$405

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Thu 9/25

11:17 am-5:26 pm

2 stops7h 09m

Lafayette Regional

Sun 9/28

5:48 am-1:09 pm

1 stop6h 21m

$407

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Fri 9/26

3:09 pm-11:25 pm

2 stops9h 16m

Lafayette Regional

Sun 9/28

5:48 am-4:03 pm

2 stops9h 15m

$570

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Thu 9/25

6:30 am-3:50 pm

2 stops10h 20m

Lafayette Regional

Sun 9/28

5:48 am-4:03 pm

2 stops9h 15m

$662

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Lafayette from

How to get the cheapest flight ticket from Knoxville to Lafayette

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Lafayette?

The cheapest day to depart from Knoxville to Lafayette is on a Thursday. Travelers who choose to depart for Lafayette on a Thursday will often find tickets for as low as $253. The most expensive day to fly to Lafayette is Friday, with ticket prices averaging around $349.

What is the cheapest time of day to depart on your flight to Lafayette?

In the evening is the cheapest time of day to fly from Knoxville to Lafayette when you can find flight prices for as low as $252. Flying to Lafayette in the evening is an ideal time because this is during off-peak travel hours. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $343 on average. Flights to Lafayette from Knoxville in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Knoxville to Lafayette

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Lafayette according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Lafayette (TYS to LFT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Lafayette

Direct flights

None
There are no direct flights from Knoxville to Lafayette. There are no popular flight routes from Knoxville to Lafayette.
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  • How far is Knoxville McGhee Tyson to Lafayette Regional by plane?

    Lafayette Regional is 613.1 mi away from Knoxville McGhee Tyson. 4h 38m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lafayette Regional Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lafayette Regional Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lafayette Regional Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lafayette Regional Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lafayette Regional Airport.

  • What documentation or ID do you need to fly to Lafayette Regional Airport?

    The required travel and health documents for your Lafayette Regional Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lafayette Regional Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Lafayette?

Best airlines flying from Knoxville to Lafayette

Compare and see reviews for airlines that fly from Knoxville to Lafayette with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Lafayette?

Book flights to Lafayette if you plan to visit one of these locations
Opelousas

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Lafayette?

It is quick and easy to find Knoxville to Lafayette flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Lafayette that suits you.

Can I find flights from Knoxville to Lafayette with flexible booking policies on momondo?

All flight searches from Knoxville to Lafayette on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Lafayette?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Lafayette from Knoxville.

I’m not ready to book a flight from Knoxville to Lafayette right now. Can momondo alert me if prices change?

Price alerts on flights to Lafayette from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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