What airlines fly to Iowa?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Iowa from Knoxville according to our data. American Airlines is the first choice among our users, with 57% of people opting to fly with this airline when traveling to Iowa. Keep in mind that there are 3 different airlines that fly to Iowa on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Iowa?

United Airlines, Delta, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Iowa

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Iowa?

Prices for flights from Knoxville McGhee Tyson Airport to Iowa are updated daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Iowa?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to Iowa as of October 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Iowa?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Iowa.

What documentation or ID do you need to fly to Iowa?

The travel and health documents required for your trip to Iowa can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Iowa. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$126 Cheap Flights from Knoxville to Iowa in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Iowa

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:32 pm - 11:05 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 33m1 stop Dallas/Fort Worth

11:09 am - 4:43 pmDSM Des Moines-TYS Knoxville McGhee Tyson

4h 34m1 stop Charlotte Douglas

$251American Airlines

Thu, Dec 3 - Mon, Dec 7

6:05 pm - 12:26 amTYS Knoxville McGhee Tyson-DSM Des Moines

7h 21m1 stop Charlotte Douglas

6:00 am - 3:13 pmDSM Des Moines-TYS Knoxville McGhee Tyson

8h 13m1 stop Washington, D.C. Reagan-National

$251American Airlines

Thu, Nov 19 - Thu, Nov 26

6:50 am - 10:58 amTYS Knoxville McGhee Tyson-DSM Des Moines

5h 08m1 stop Charlotte Douglas

8:00 am - 3:26 pmDSM Des Moines-TYS Knoxville McGhee Tyson

6h 26m1 stop Charlotte Douglas

$251American Airlines

Thu, Dec 3 - Mon, Dec 7

6:45 am - 10:32 amTYS Knoxville McGhee Tyson-DSM Des Moines

4h 47m1 stop Chicago O'Hare Intl

6:05 am - 2:48 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 43m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$256United Airlines

Thu, Nov 19 - Thu, Nov 26

6:00 am - 10:37 amTYS Knoxville McGhee Tyson-DSM Des Moines

5h 37m1 stop Chicago O'Hare Intl

3:20 pm - 11:59 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 39m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$256United Airlines

Thu, Dec 3 - Mon, Dec 7

1:00 pm - 10:05 pmTYS Knoxville McGhee Tyson-DSM Des Moines

10h 05m2 stops Orlando Chicago Midway

5:10 am - 3:25 pmDSM Des Moines-TYS Knoxville McGhee Tyson

9h 15m2 stops Chicago Midway Nashville Intl

$261Southwest

Thu, Nov 19 - Thu, Nov 26

2:40 pm - 10:05 pmTYS Knoxville McGhee Tyson-DSM Des Moines

8h 25m2 stops Dallas Love Field Chicago Midway

6:00 am - 7:50 pmDSM Des Moines-TYS Knoxville McGhee Tyson

12h 50m2 stops Chicago Midway Nashville Intl

$274Southwest

Thu, Dec 3 - Mon, Dec 7

6:50 am - 10:48 amTYS Knoxville McGhee Tyson-DSM Des Moines

4h 58m1 stop Charlotte Douglas

7:06 am - 3:18 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 12m1 stop Charlotte Douglas

$302American Airlines

Thu, Nov 12 - Sun, Nov 15

6:45 am - 12:20 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 35m1 stop Chicago O'Hare Intl

1:27 pm - 10:32 pmDSM Des Moines-TYS Knoxville McGhee Tyson

8h 05m1 stop Denver Intl

$319United Airlines

Sat, Nov 7 - Wed, Nov 11

8:04 am - 2:08 pmTYS Knoxville McGhee Tyson-DSM Des Moines

7h 04m1 stop Minneapolis St Paul

5:30 am - 11:28 amDSM Des Moines-TYS Knoxville McGhee Tyson

4h 58m1 stop Atlanta Hartsfield-Jackson

$329Delta

Thu, Nov 26 - Sat, Nov 28

Cheap last minute flights

Enter your travel dates to find the best prices.

7:16 pm - 11:00 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

4h 44m1 stop Minneapolis St Paul

5:30 am - 10:45 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

4h 15m1 stop Atlanta Hartsfield-Jackson

$429Delta

Fri, Oct 30 - Sun, Nov 1

6:23 pm - 9:19 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

3h 56m1 stop Atlanta Hartsfield-Jackson

5:30 am - 10:45 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

4h 15m1 stop Atlanta Hartsfield-Jackson

$429Delta

Fri, Oct 30 - Sun, Nov 1

4:11 pm - 9:19 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

6h 08m1 stop Atlanta Hartsfield-Jackson

5:05 pm - 11:02 pmCID Cedar Rapids-TYS Knoxville McGhee Tyson

4h 57m1 stop Minneapolis St Paul

$429Delta

Fri, Oct 30 - Sun, Nov 1

6:23 pm - 9:19 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

3h 56m1 stop Atlanta Hartsfield-Jackson

5:30 am - 10:45 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

4h 15m1 stop Atlanta Hartsfield-Jackson

$449Delta

Fri, Oct 30 - Sun, Nov 1

7:58 pm - 11:58 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

5h 00m1 stop Charlotte Douglas

6:15 am - 1:17 pmCID Cedar Rapids-TYS Knoxville McGhee Tyson

6h 02m1 stop Charlotte Douglas

$491American Airlines

Fri, Oct 30 - Sun, Nov 1

10:00 am - 5:28 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

8h 28m2 stops Charlotte Douglas Chicago O'Hare Intl

5:00 am - 11:04 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

5h 04m1 stop Chicago O'Hare Intl

$501American Airlines

Fri, Oct 30 - Sun, Nov 1

2:38 pm - 11:00 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

9h 22m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul

5:30 am - 10:45 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

4h 15m1 stop Atlanta Hartsfield-Jackson

$529Delta

Fri, Oct 30 - Sun, Nov 1

10:00 am - 5:28 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

8h 28m2 stops Charlotte Douglas Chicago O'Hare Intl

5:00 am - 11:04 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

5h 04m1 stop Chicago O'Hare Intl

$544American Airlines

Fri, Oct 30 - Sun, Nov 1

10:00 am - 5:28 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

8h 28m2 stops Charlotte Douglas Chicago O'Hare Intl

5:00 am - 11:04 amCID Cedar Rapids-TYS Knoxville McGhee Tyson

5h 04m1 stop Chicago O'Hare Intl

$614American Airlines

Fri, Oct 30 - Sun, Nov 1

10:55 am - 1:28 pmTYS Knoxville McGhee Tyson-DSM Des Moines

27h 33m1 stop Punta Gorda

8:00 am - 9:44 pmDSM Des Moines-TYS Knoxville McGhee Tyson

36h 44m2 stops Philadelphia Orlando

$637Multiple Airlines

Wed, Oct 28 - Sun, Nov 1

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American Airlines flights from Knoxville to Iowa

Our best American Airlines deals on Knoxville to Iowa flight tickets

American Airlines

Dec 3

TYS6:50 amKnoxville McGhee Tyson

5h 08m

1 stop

DSM10:58 amDes Moines

Dec 7

DSM8:00 amDes Moines

6h 26m

1 stop

TYS3:26 pmKnoxville McGhee Tyson

$251

American Airlines

Nov 12

TYS6:50 amKnoxville McGhee Tyson

4h 58m

1 stop

DSM10:48 amDes Moines

Nov 15

DSM7:06 amDes Moines

7h 12m

1 stop

TYS3:18 pmKnoxville McGhee Tyson

$302

American Airlines

Dec 3

TYS6:50 amKnoxville McGhee Tyson

5h 08m

1 stop

DSM10:58 amDes Moines

Dec 7

DSM8:00 amDes Moines

6h 26m

1 stop

TYS3:26 pmKnoxville McGhee Tyson

$317

United Airlines flights from Knoxville to Iowa

Our best United Airlines deals on Knoxville to Iowa flight tickets

United Airlines

Nov 19

TYS6:45 amKnoxville McGhee Tyson

4h 47m

1 stop

DSM10:32 amDes Moines

Nov 26

DSM6:05 amDes Moines

7h 43m

2 stops

TYS2:48 pmKnoxville McGhee Tyson

$256

United Airlines

Nov 7

TYS6:45 amKnoxville McGhee Tyson

6h 35m

1 stop

DSM12:20 pmDes Moines

Nov 11

DSM1:27 pmDes Moines

8h 05m

1 stop

TYS10:32 pmKnoxville McGhee Tyson

$319

United Airlines

Nov 7

TYS5:45 amKnoxville McGhee Tyson

7h 35m

2 stops

DSM12:20 pmDes Moines

Nov 11

DSM9:55 amDes Moines

6h 04m

1 stop

TYS4:59 pmKnoxville McGhee Tyson

$324

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/3

5:32 pm-11:05 pm

1 stop6h 33m

Des Moines

Mon 12/7

11:09 am-4:43 pm

1 stop4h 34m

$251

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 11/19

6:05 pm-12:26 am

1 stop7h 21m

Des Moines

Thu 11/26

6:00 am-3:13 pm

1 stop8h 13m

$251

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/3

6:50 am-10:58 am

1 stop5h 08m

Des Moines

Mon 12/7

8:00 am-3:26 pm

1 stop6h 26m

$251

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 11/19

6:45 am-10:32 am

1 stop4h 47m

Des Moines

Thu 11/26

6:05 am-2:48 pm

2 stops7h 43m

$256

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/3

6:00 am-10:37 am

1 stop5h 37m

Des Moines

Mon 12/7

3:20 pm-11:59 pm

2 stops7h 39m

$256

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 11/19

1:00 pm-10:05 pm

2 stops10h 05m

Des Moines

Thu 11/26

5:10 am-3:25 pm

2 stops9h 15m

$261

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/3

2:40 pm-10:05 pm

2 stops8h 25m

Des Moines

Mon 12/7

6:00 am-7:50 pm

2 stops12h 50m

$274

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 11/12

6:50 am-10:48 am

1 stop4h 58m

Des Moines

Sun 11/15

7:06 am-3:18 pm

1 stop7h 12m

$302

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 11/7

6:45 am-12:20 pm

1 stop6h 35m

Des Moines

Wed 11/11

1:27 pm-10:32 pm

1 stop8h 05m

$319

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 11/26

8:04 am-2:08 pm

1 stop7h 04m

Des Moines

Sat 11/28

5:30 am-11:28 am

1 stop4h 58m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Iowa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Iowa?

The month of December is another great option to travel to Iowa, with average flight prices from Knoxville averaging around $263.

Can stopping save me money on Knoxville to Iowa flights?

You could potentially save up to 73% on your flight if you consider stops on a Knoxville to Iowa flight.

Cheap Knoxville to Iowa flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Iowa

Best Price Found	$126
Fastest flight time	3h 59m
Direct flights	None

The best one-way flight to Iowa from Knoxville in the past 72 hours is $126. The best round-trip flight deal from Knoxville to Iowa found on momondo in the last 72 hours is $251.

The fastest flight from Knoxville to Iowa takes 3h 59m

There are no direct flights from Knoxville to Iowa. There are no popular flight routes from Knoxville to Iowa.

Search flight deals

Frequently asked questions about flying from Knoxville to Iowa

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Iowa?
Prices for flights from Knoxville McGhee Tyson Airport to Iowa are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Iowa?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to Iowa as of October 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Iowa?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Iowa.
What documentation or ID do you need to fly to Iowa?
The travel and health documents required for your trip to Iowa can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Iowa. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Iowa

Compare and see reviews for airlines that fly from Knoxville to Iowa with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $226	Free Cancellation	Rating 7.0 12,194 reviews		Search American Airlines flights
United Airlines	PriceFrom $284	Free Cancellation	Rating 7.3 10,436 reviews		Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Iowa?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Iowa. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Iowa with flexible booking policies on momondo?

Flights from Knoxville to Iowa with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Iowa?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Iowa.

I’m not ready to book a flight from Knoxville to Iowa right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Iowa flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.