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Cheap flights from Knoxville to Iowa from $215

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Iowa departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to Iowa

Cheap round-trip flights

Allegiant Air Logo
9:00 am - 10:19 pmTYS-DSM
14h 19m1 stop
Allegiant Air Logo
6:30 am - 6:45 pmDSM-TYS
11h 15m1 stop
$215Allegiant Air
Find Deal
Sun, Aug 31 - Thu, Sep 4
Logo
9:00 am - 10:19 pmTYS-DSM
14h 19m1 stop
Logo
5:49 pm - 5:34 pmDSM-TYS
22h 45m2 stops
$279
Find Deal
Sun, Aug 31 - Thu, Sep 4
American Airlines Logo
6:56 am - 12:43 pmTYS-OMA
6h 47m1 stop
American Airlines Logo
6:06 pm - 11:41 pmOMA-TYS
4h 35m1 stop
$279American Airlines
Find Deal
Fri, Feb 13 - Sun, Feb 15
American Airlines Logo
4:37 pm - 11:22 pmTYS-OMA
7h 45m1 stop
American Airlines Logo
6:00 pm - 12:07 amOMA-TYS
5h 07m1 stop
$284American Airlines
Find Deal
Fri, Sep 19 - Sun, Sep 21
Delta Logo
11:54 am - 5:45 pmTYS-DSM
6h 51m1 stop
Delta Logo
3:30 pm - 10:27 pmDSM-TYS
5h 57m1 stop
$284Delta
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Thu, Aug 28 - Sat, Aug 30
American Airlines Logo
2:16 pm - 6:40 pmTYS-DSM
5h 24m1 stop
American Airlines Logo
6:00 am - 3:35 pmDSM-TYS
8h 35m2 stops
$289American Airlines
Find Deal
Thu, Aug 28 - Sat, Aug 30
Delta Logo
11:54 am - 5:45 pmTYS-DSM
6h 51m1 stop
Delta Logo
6:00 am - 11:34 amDSM-TYS
4h 34m1 stop
$290Delta
Find Deal
Thu, Aug 28 - Sat, Aug 30
United Airlines Logo
5:45 am - 2:10 pmTYS-DSM
9h 25m2 stops
United Airlines Logo
11:35 am - 8:56 pmDSM-TYS
8h 21m2 stops
$305United Airlines
Find Deal
Sun, Aug 31 - Thu, Sep 4
Allegiant Air Logo
7:35 pm - 10:29 pmTYS-DSM
27h 54m2 stops
Allegiant Air Logo
6:30 am - 6:45 pmDSM-TYS
11h 15m1 stop
$308Allegiant Air
Find Deal
Sun, Sep 14 - Sun, Sep 21
United Airlines Logo
10:54 am - 5:14 pmTYS-DSM
7h 20m1 stop
United Airlines Logo
3:25 pm - 10:45 pmDSM-TYS
6h 20m1 stop
$365United Airlines
Find Deal
Sun, Aug 31 - Thu, Sep 4

American Airlines flights from Knoxville to Iowa

Our best American Airlines deals on Knoxville to Iowa flight tickets
American Airlines
Feb 13
TYS6:56 amKnoxville McGhee Tyson
6h 47m
1 stop
OMA12:43 pmOmaha Eppley Airfield
Feb 15
OMA6:06 pmOmaha Eppley Airfield
4h 35m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$279
Find similar
American Airlines
Sep 19
TYS4:37 pmKnoxville McGhee Tyson
7h 45m
1 stop
OMA11:22 pmOmaha Eppley Airfield
Sep 21
OMA6:00 pmOmaha Eppley Airfield
5h 07m
1 stop
TYS12:07 amKnoxville McGhee Tyson
$284
Find similar
American Airlines
Aug 28
TYS2:16 pmKnoxville McGhee Tyson
5h 24m
1 stop
DSM6:40 pmDes Moines
Aug 30
DSM6:00 amDes Moines
8h 35m
2 stops
TYS3:35 pmKnoxville McGhee Tyson
$289
Find similar

United Airlines flights from Knoxville to Iowa

Our best United Airlines deals on Knoxville to Iowa flight tickets
United Airlines
Aug 31
TYS5:45 amKnoxville McGhee Tyson
9h 25m
2 stops
DSM2:10 pmDes Moines
Sep 4
DSM11:35 amDes Moines
8h 21m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
$305
Find similar
United Airlines
Aug 31
TYS10:54 amKnoxville McGhee Tyson
7h 20m
1 stop
DSM5:14 pmDes Moines
Sep 4
DSM3:25 pmDes Moines
6h 20m
1 stop
TYS10:45 pmKnoxville McGhee Tyson
$365
Find similar
United Airlines
Aug 31
TYS7:00 amKnoxville McGhee Tyson
4h 39m
1 stop
DSM10:39 amDes Moines
Sep 4
DSM11:35 amDes Moines
8h 21m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
$370
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/31

9:00 am-10:19 pm

1 stop14h 19m

Des Moines

Thu 9/4

6:30 am-6:45 pm

1 stop11h 15m

$215

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/31

9:00 am-10:19 pm

1 stop14h 19m

Des Moines

Thu 9/4

5:49 pm-5:34 pm

2 stops22h 45m

$279

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 2/13

6:56 am-12:43 pm

1 stop6h 47m

Omaha Eppley Airfield

Sun 2/15

6:06 pm-11:41 pm

1 stop4h 35m

$279

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 9/19

4:37 pm-11:22 pm

1 stop7h 45m

Omaha Eppley Airfield

Sun 9/21

6:00 pm-12:07 am

1 stop5h 07m

$284

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/28

11:54 am-5:45 pm

1 stop6h 51m

Des Moines

Sat 8/30

3:30 pm-10:27 pm

1 stop5h 57m

$284

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/28

2:16 pm-6:40 pm

1 stop5h 24m

Des Moines

Sat 8/30

6:00 am-3:35 pm

2 stops8h 35m

$289

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/28

11:54 am-5:45 pm

1 stop6h 51m

Des Moines

Sat 8/30

6:00 am-11:34 am

1 stop4h 34m

$290

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/31

5:45 am-2:10 pm

2 stops9h 25m

Des Moines

Thu 9/4

11:35 am-8:56 pm

2 stops8h 21m

$305

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 9/14

7:35 pm-10:29 pm

2 stops27h 54m

Des Moines

Sun 9/21

6:30 am-6:45 pm

1 stop11h 15m

$308

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/31

10:54 am-5:14 pm

1 stop7h 20m

Des Moines

Thu 9/4

3:25 pm-10:45 pm

1 stop6h 20m

$365

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Iowa from

How to get the cheapest flight ticket from Knoxville to Iowa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Iowa?

The month of February is another great option to travel to Iowa, with average flight prices from Knoxville averaging around $278.

What is the cheapest day to depart on your flight to Iowa?

The cheapest day to depart from Knoxville to Iowa is on a Thursday when prices can be found for as low as $262. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $581. These prices are subject to change though, so be sure to set up a Price Alert for flights to Iowa.

What is the cheapest time of day to depart on your flight to Iowa?

Our most recent data shows that the best time of day to fly to Iowa is in the morning. Flights from Knoxville to Iowa during this time can be as low as $320. Try not to purchase tickets in the evening because they tend to be around $338. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Knoxville to Iowa flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Iowa

Best Price Found

$260

Fastest flight time

4h 22m

Direct flights

None

Airports in Iowa

2 airports
The best one-way flight to Iowa from Knoxville in the past 72 hours is $260. The best round-trip flight deal from Knoxville to Iowa found on momondo in the last 72 hours is $215.
The fastest flight from Knoxville to Iowa takes 4h 22m
There are no direct flights from Knoxville to Iowa. Popular non-direct routes for this connection are Knoxville McGhee Tyson Airport - Des Moines Airport and Knoxville McGhee Tyson Airport - Omaha Eppley Airfield Airport.
There are 2 airports near Iowa: Omaha Eppley Airfield (OMA), Des Moines (DSM)
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Iowa?

    Prices for flights from Knoxville McGhee Tyson Airport to Iowa are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Iowa?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Iowa?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Iowa.

  • What documentation or ID do you need to fly to Iowa?

    The travel and health documents required for your trip to Iowa can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Iowa. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Iowa

Compare and see reviews for airlines that fly from Knoxville to Iowa with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $222Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $238Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
8,925 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Iowa?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Iowa. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Iowa with flexible booking policies on momondo?

Flights from Knoxville to Iowa with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Iowa?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Iowa.

I’m not ready to book a flight from Knoxville to Iowa right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Iowa flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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