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Cheap flights from Islip, New York to Greenville from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Islip, New York to Greenville departing on 3/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Islip, New York to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:08 pm - 7:38 pm
ISP
-
GSP
26h 30m
1 stop
Multiple Airlines Logo
2:12 pm - 9:48 am
GSP
-
ISP
19h 36m
1 stop
$291Multiple Airlines
Sun, Mar 8 - Thu, Mar 12
Southwest Logo
4:40 pm - 8:30 pm
ISP
-
GSP
3h 50m
1 stop
Southwest Logo
1:55 pm - 11:35 pm
GSP
-
ISP
9h 40m
1 stop
$319Southwest
Tue, Mar 17 - Sat, Mar 21
Southwest Logo
5:55 pm - 9:50 pm
ISP
-
GSP
3h 55m
1 stop
Southwest Logo
1:55 pm - 5:20 pm
GSP
-
ISP
3h 25m
1 stop
$325Southwest
Mon, Mar 23 - Mon, Mar 30
Multiple Airlines Logo
7:26 pm - 7:38 pm
ISP
-
GSP
24h 12m
2 stops
Multiple Airlines Logo
2:12 pm - 9:48 am
GSP
-
ISP
19h 36m
1 stop
$336Multiple Airlines
Sun, Mar 8 - Thu, Mar 12
Southwest Logo
5:55 pm - 9:50 pm
ISP
-
GSP
3h 55m
1 stop
Southwest Logo
8:00 am - 11:40 am
GSP
-
ISP
3h 40m
1 stop
$355Southwest
Thu, Mar 26 - Tue, Mar 31
Southwest Logo
5:55 pm - 9:50 pm
ISP
-
GSP
3h 55m
1 stop
Southwest Logo
6:20 am - 4:05 pm
GSP
-
ISP
9h 45m
2 stops
$360Southwest
Thu, Mar 26 - Tue, Mar 31
Multiple Airlines Logo
10:31 am - 5:18 pm
ISP
-
GSP
6h 47m
1 stop
Multiple Airlines Logo
2:12 pm - 10:13 am
GSP
-
ISP
20h 01m
1 stop
$364Multiple Airlines
Thu, Mar 26 - Sun, Mar 29
Southwest Logo
11:45 am - 9:45 pm
ISP
-
GSP
10h 00m
1 stop
Southwest Logo
1:50 pm - 10:50 pm
GSP
-
ISP
9h 00m
1 stop
$366Southwest
Sun, Mar 15 - Wed, Mar 18
Southwest Logo
6:10 am - 5:45 pm
ISP
-
GSP
11h 35m
2 stops
Southwest Logo
1:55 pm - 11:35 pm
GSP
-
ISP
9h 40m
1 stop
$367Southwest
Tue, Mar 17 - Sat, Mar 21
Southwest Logo
5:40 am - 1:15 pm
ISP
-
GSP
7h 35m
1 stop
Southwest Logo
12:35 pm - 10:50 pm
GSP
-
ISP
10h 15m
2 stops
$371Southwest
Sun, Mar 15 - Wed, Mar 18

Southwest flights from Islip, New York to Greenville

Our best Southwest deals on Islip, New York to Greenville flight tickets
Southwest
Mar 17
ISP4:40 pmIslip Long Island
3h 50m
1 stop
GSP8:30 pmGreenville
Mar 21
GSP1:55 pmGreenville
9h 40m
1 stop
ISP11:35 pmIslip Long Island
$319
Southwest
Mar 23
ISP5:55 pmIslip Long Island
3h 55m
1 stop
GSP9:50 pmGreenville
Mar 30
GSP1:55 pmGreenville
3h 25m
1 stop
ISP5:20 pmIslip Long Island
$325
Southwest
Mar 26
ISP5:55 pmIslip Long Island
3h 55m
1 stop
GSP9:50 pmGreenville
Mar 31
GSP8:00 amGreenville
3h 40m
1 stop
ISP11:40 amIslip Long Island
$355

Breeze Airways flights from Islip, New York to Greenville

Our best Breeze Airways deals on Islip, New York to Greenville flight tickets
Breeze Airways
May 29
ISP8:43 pmIslip Long Island
46h 56m
2 stops
GSP7:39 pmGreenville
Jun 1
GSP9:20 pmGreenville
37h 57m
3 stops
ISP11:17 amIslip Long Island
$749
Breeze Airways
Mar 8
ISP7:26 pmIslip Long Island
24h 12m
3 stops
GSP7:38 pmGreenville
Mar 12
GSP2:12 pmGreenville
23h 19m
2 stops
ISP1:31 pmIslip Long Island
$795
Breeze Airways
Mar 8
ISP7:26 pmIslip Long Island
24h 12m
3 stops
GSP7:38 pmGreenville
Mar 12
GSP2:12 pmGreenville
23h 19m
2 stops
ISP1:31 pmIslip Long Island
$809

momondo Fare Finder

 
Customize your flight search to find flights from Islip, New York to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Islip, New York to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 3/8

5:08 pm-7:38 pm

1 stop26h 30m

Greenville

Thu 3/12

2:12 pm-9:48 am

1 stop19h 36m

$291

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Tue 3/17

4:40 pm-8:30 pm

1 stop3h 50m

Greenville

Sat 3/21

1:55 pm-11:35 pm

1 stop9h 40m

$319

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Mon 3/23

5:55 pm-9:50 pm

1 stop3h 55m

Greenville

Mon 3/30

1:55 pm-5:20 pm

1 stop3h 25m

$325

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 3/8

7:26 pm-7:38 pm

2 stops24h 12m

Greenville

Thu 3/12

2:12 pm-9:48 am

1 stop19h 36m

$336

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Thu 3/26

5:55 pm-9:50 pm

1 stop3h 55m

Greenville

Tue 3/31

8:00 am-11:40 am

1 stop3h 40m

$355

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Thu 3/26

5:55 pm-9:50 pm

1 stop3h 55m

Greenville

Tue 3/31

6:20 am-4:05 pm

2 stops9h 45m

$360

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Thu 3/26

10:31 am-5:18 pm

1 stop6h 47m

Greenville

Sun 3/29

2:12 pm-10:13 am

1 stop20h 01m

$364

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 3/15

11:45 am-9:45 pm

1 stop10h 00m

Greenville

Wed 3/18

1:50 pm-10:50 pm

1 stop9h 00m

$366

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Tue 3/17

6:10 am-5:45 pm

2 stops11h 35m

Greenville

Sat 3/21

1:55 pm-11:35 pm

1 stop9h 40m

$367

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 3/15

5:40 am-1:15 pm

1 stop7h 35m

Greenville

Wed 3/18

12:35 pm-10:50 pm

2 stops10h 15m

$371

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Islip, New York to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Islip, New York. The lowest ticket price found for a Saturday departure recently was $287. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $334. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Islip, New York to Greenville during this time can be as low as $295. Flights to Greenville are more costly in the morning, with an average ticket price of $307. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Islip, New York to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip, New York to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Islip, New York to Greenville (ISP to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Greenville

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Islip, New York to Greenville takes 3h 50m
There are no direct flights from Islip, New York to Greenville. There are no popular flight routes from Islip, New York to Greenville.
Search flight deals

  • How far is Islip Long Island to Greenville by plane?

    There are 644.2 mi between Islip Long Island and Greenville. Typically, this will take 3h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Islip Long Island Airport to Greenville Airport?

    Prices for flights from Islip Long Island Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Islip Long Island Airport to Greenville Airport?

  • How old do you have to be to fly from Islip Long Island Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Islip Long Island Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Islip, New York to Greenville?

Best airlines flying from Islip, New York to Greenville

Compare and see reviews for airlines that fly from Islip, New York to Greenville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $256Free CancellationRating
8.0
4,299 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Islip to Greenville?

Finding the right flight to Greenville from Islip is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Greenville quick and easy, saving you time and money.

Can I find flights from Islip to Greenville with flexible booking policies on momondo?

All flight searches from Islip to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Greenville?

Once all potential Islip to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Islip to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Islip. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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