What is the cheapest airline that flies from Islip Long Island to Greenville?

Breeze Airways and Southwest are the most popular carriers operating from Islip Long Island to Greenville

What airlines fly to Greenville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Greenville from Islip, New York according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 7 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Islip Long Island Airport to Greenville Airport?

Prices for flights from Islip Long Island Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Islip Long Island Airport to Greenville Airport?

The number of operators available for flights from Islip Long Island Airport to Greenville Airport is 1 as of August 2026.

How old do you have to be to fly from Islip Long Island Airport to Greenville Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Islip Long Island Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$142 Cheap Flights from Islip, New York to Greenville in 2026

Find the cheapest flights from Islip, New York to Greenville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:30 am - 10:05 amISP Islip Long Island-GSP Greenville

4h 35m1 stop Baltimore/Washington

8:00 am - 11:55 amGSP Greenville-ISP Islip Long Island

3h 55m1 stop Baltimore/Washington

$309Southwest

Sat, Sep 26 - Sat, Oct 3

5:30 am - 2:55 pmISP Islip Long Island-GSP Greenville

9h 25m2 stops Baltimore/Washington Nashville Intl

12:45 pm - 4:10 pmGSP Greenville-ISP Islip Long Island

3h 25m1 stop Baltimore/Washington

$314Southwest

Sat, Sep 26 - Sat, Oct 3

3:10 pm - 9:30 pmISP Islip Long Island-GSP Greenville

6h 20m1 stop Baltimore/Washington

8:25 am - 2:30 pmGSP Greenville-ISP Islip Long Island

6h 05m1 stop Baltimore/Washington

$332Southwest

Thu, Oct 15 - Thu, Oct 22

5:40 pm - 9:30 pmISP Islip Long Island-GSP Greenville

3h 50m1 stop Baltimore/Washington

6:25 am - 2:30 pmGSP Greenville-ISP Islip Long Island

8h 05m2 stops Nashville Intl Baltimore/Washington

$337Southwest

Thu, Oct 15 - Thu, Oct 22

5:28 pm - 8:27 amISP Islip Long Island-GSP Greenville

14h 59m2 stops Wilmington New Hanover County Tampa

6:55 pm - 4:58 pmGSP Greenville-ISP Islip Long Island

22h 03m1 stop Orlando Sanford Intl

$354Multiple Airlines

Thu, Sep 10 - Fri, Sep 18

3:10 pm - 9:30 pmISP Islip Long Island-GSP Greenville

6h 20m1 stop Baltimore/Washington

8:25 am - 2:30 pmGSP Greenville-ISP Islip Long Island

6h 05m1 stop Baltimore/Washington

$355Southwest

Thu, Oct 15 - Thu, Oct 22

5:43 pm - 8:45 amISP Islip Long Island-GSP Greenville

15h 02m1 stop Orlando

6:55 pm - 4:58 pmGSP Greenville-ISP Islip Long Island

22h 03m1 stop Orlando Sanford Intl

$358Multiple Airlines

Thu, Sep 10 - Fri, Sep 18

4:05 pm - 7:50 pmISP Islip Long Island-GSP Greenville

3h 45m1 stop Baltimore/Washington

8:05 am - 4:20 pmGSP Greenville-ISP Islip Long Island

8h 15m1 stop Baltimore/Washington

$358Southwest

Mon, Dec 14 - Mon, Dec 21

12:30 pm - 8:45 pmISP Islip Long Island-GSP Greenville

8h 15m2 stops Baltimore/Washington Nashville Intl

8:05 am - 4:20 pmGSP Greenville-ISP Islip Long Island

8h 15m1 stop Baltimore/Washington

$364Southwest

Mon, Dec 14 - Mon, Dec 21

5:43 pm - 8:45 amISP Islip Long Island-GSP Greenville

15h 02m1 stop Orlando

8:32 pm - 4:58 pmGSP Greenville-ISP Islip Long Island

20h 26m1 stop Orlando

$368Multiple Airlines

Thu, Sep 10 - Mon, Sep 14

Cheap last minute flights

Enter your travel dates to find the best prices.

10:57 am - 3:43 pmISP Islip Long Island-GSP Greenville

28h 46m1 stop Orlando

8:28 pm - 9:53 amGSP Greenville-ISP Islip Long Island

13h 25m1 stop Orlando

$657Multiple Airlines

Thu, Sep 3 - Mon, Sep 7

6:45 am - 4:05 pmISP Islip Long Island-GSP Greenville

9h 20m2 stops Orlando Baltimore/Washington

8:40 am - 12:35 pmGSP Greenville-ISP Islip Long Island

3h 55m1 stop Baltimore/Washington

$672Southwest

Thu, Sep 3 - Mon, Sep 7

10:20 am - 4:05 pmISP Islip Long Island-GSP Greenville

5h 45m1 stop Baltimore/Washington

8:55 am - 12:45 pmGSP Greenville-ISP Islip Long Island

3h 50m1 stop Baltimore/Washington

$802Southwest

Thu, Sep 3 - Sun, Sep 6

6:10 am - 12:30 pmISP Islip Long Island-GSP Greenville

6h 20m2 stops Baltimore/Washington Nashville Intl

8:55 am - 12:45 pmGSP Greenville-ISP Islip Long Island

3h 50m1 stop Baltimore/Washington

$807Southwest

Thu, Sep 3 - Sun, Sep 6

6:10 am - 12:30 pmISP Islip Long Island-GSP Greenville

6h 20m2 stops Baltimore/Washington Nashville Intl

7:45 am - 4:35 pmGSP Greenville-ISP Islip Long Island

8h 50m2 stops Nashville Intl Baltimore/Washington

$812Southwest

Thu, Sep 3 - Sun, Sep 6

6:45 am - 4:05 pmISP Islip Long Island-GSP Greenville

9h 20m2 stops Orlando Baltimore/Washington

1:05 pm - 10:10 pmGSP Greenville-ISP Islip Long Island

9h 05m2 stops Nashville Intl Baltimore/Washington

$1,029Southwest

Thu, Sep 3 - Mon, Sep 7

8:43 pm - 7:11 pmISP Islip Long Island-GSP Greenville

46h 28m2 stops Charleston Pittsburgh

8:13 pm - 1:28 pmGSP Greenville-ISP Islip Long Island

17h 15m2 stops Tampa Wilmington New Hanover County

$1,158Breeze Airways

Fri, Sep 4 - Mon, Sep 7

6:46 pm - 5:39 pmISP Islip Long Island-GSP Greenville

22h 53m3 stops Richmond Byrd Intl Tampa Fort Lauderdale

8:13 pm - 1:28 pmGSP Greenville-ISP Islip Long Island

17h 15m2 stops Tampa Wilmington New Hanover County

$1,219Breeze Airways

Thu, Sep 3 - Mon, Sep 7

6:46 pm - 5:39 pmISP Islip Long Island-GSP Greenville

22h 53m3 stops Richmond Byrd Intl Tampa Fort Lauderdale

12:06 pm - 4:47 pmGSP Greenville-ISP Islip Long Island

28h 41m3 stops Fort Lauderdale Tallahassee Raleigh-Durham

$1,308Breeze Airways

Thu, Sep 3 - Mon, Sep 7

8:43 pm - 7:11 pmISP Islip Long Island-GSP Greenville

46h 28m2 stops Charleston Pittsburgh

12:06 pm - 11:20 amGSP Greenville-ISP Islip Long Island

47h 14m3 stops Fort Lauderdale Tallahassee Raleigh-Durham

$1,313Breeze Airways

Fri, Sep 4 - Mon, Sep 7

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Breeze Airways flights from Islip, New York to Greenville

Our best Breeze Airways deals on Islip, New York to Greenville flight tickets

Breeze Airways

Sep 11

ISP11:08 amIslip Long Island

7h 22m

2 stops

GSP6:30 pmGreenville

Sep 14

GSP8:32 pmGreenville

16h 26m

2 stops

ISP12:58 pmIslip Long Island

$639

Breeze Airways

Sep 10

ISP5:28 pmIslip Long Island

23h 55m

2 stops

GSP5:23 pmGreenville

Sep 14

GSP8:32 pmGreenville

16h 26m

2 stops

ISP12:58 pmIslip Long Island

$699

Breeze Airways

Nov 12

ISP5:28 pmIslip Long Island

26h 39m

2 stops

GSP8:07 pmGreenville

Nov 15

GSP10:07 amGreenville

24h 21m

3 stops

ISP10:28 amIslip Long Island

$704

Southwest flights from Islip, New York to Greenville

Our best Southwest deals on Islip, New York to Greenville flight tickets

Southwest

Sep 26

ISP5:30 amIslip Long Island

4h 35m

1 stop

GSP10:05 amGreenville

Oct 3

GSP8:00 amGreenville

3h 55m

1 stop

ISP11:55 amIslip Long Island

$309

Southwest

Sep 26

ISP5:30 amIslip Long Island

9h 25m

2 stops

GSP2:55 pmGreenville

Oct 3

GSP12:45 pmGreenville

3h 25m

1 stop

ISP4:10 pmIslip Long Island

$314

Southwest

Oct 15

ISP3:10 pmIslip Long Island

6h 20m

1 stop

GSP9:30 pmGreenville

Oct 22

GSP8:25 amGreenville

6h 05m

1 stop

ISP2:30 pmIslip Long Island

$332

momondo Fare Finder

Use the filters below to find and compare flights from Islip, New York to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Sat 9/26

5:30 am-10:05 am

1 stop4h 35m

Greenville

Sat 10/3

8:00 am-11:55 am

1 stop3h 55m

$309

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Sat 9/26

5:30 am-2:55 pm

2 stops9h 25m

Greenville

Sat 10/3

12:45 pm-4:10 pm

1 stop3h 25m

$314

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 10/15

3:10 pm-9:30 pm

1 stop6h 20m

Greenville

Thu 10/22

8:25 am-2:30 pm

1 stop6h 05m

$332

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 10/15

5:40 pm-9:30 pm

1 stop3h 50m

Greenville

Thu 10/22

6:25 am-2:30 pm

2 stops8h 05m

$337

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 9/10

5:28 pm-8:27 am

2 stops14h 59m

Greenville

Fri 9/18

6:55 pm-4:58 pm

1 stop22h 03m

$354

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 10/15

3:10 pm-9:30 pm

1 stop6h 20m

Greenville

Thu 10/22

8:25 am-2:30 pm

1 stop6h 05m

$355

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 9/10

5:43 pm-8:45 am

1 stop15h 02m

Greenville

Fri 9/18

6:55 pm-4:58 pm

1 stop22h 03m

$358

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Mon 12/14

4:05 pm-7:50 pm

1 stop3h 45m

Greenville

Mon 12/21

8:05 am-4:20 pm

1 stop8h 15m

$358

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Mon 12/14

12:30 pm-8:45 pm

2 stops8h 15m

Greenville

Mon 12/21

8:05 am-4:20 pm

1 stop8h 15m

$364

IslipGreenville

ISP Islip Long Island - GSP Greenville

ISPGSP

Islip Long Island

Thu 9/10

5:43 pm-8:45 am

1 stop15h 02m

Greenville

Mon 9/14

8:32 pm-4:58 pm

1 stop20h 26m

$368

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Islip, New York to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Greenville?

The month of March is another great option to travel to Greenville, with average flight prices from Islip, New York averaging around $376.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Islip, New York. The lowest ticket price found for a Saturday departure recently was $329. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $459. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Islip, New York to Greenville during this time can be as low as $338. Flights to Greenville are more costly in the morning, with an average ticket price of $370. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Islip, New York to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip, New York to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Islip, New York to Greenville (ISP to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Greenville

Best Price Found	$142
Fastest flight time	3h 45m
Direct flights	None

The best one-way flight to Greenville from Islip, New York in the past 72 hours is $142. The best round-trip flight deal from Islip, New York to Greenville found on momondo in the last 72 hours is $309.

The fastest flight from Islip, New York to Greenville takes 3h 45m

There are no direct flights from Islip, New York to Greenville. There are no popular flight routes from Islip, New York to Greenville.

Search flight deals

Frequently asked questions about flying from Islip, New York to Greenville

How far is Islip Long Island to Greenville by plane?
There are 644.2 mi between Islip Long Island and Greenville. Typically, this will take 3h 45m by plane in normal conditions.
When did momondo last update prices for flights from Islip Long Island Airport to Greenville Airport?
Prices for flights from Islip Long Island Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Islip Long Island Airport to Greenville Airport?
The number of operators available for flights from Islip Long Island Airport to Greenville Airport is 1 as of August 2026.
How old do you have to be to fly from Islip Long Island Airport to Greenville Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Islip Long Island Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Islip, New York to Greenville?
Based on momondo bookings for flights between Islip, New York and Greenville, the leading airline is Southwest, making up 100% of the total bookings.

Best airlines flying from Islip, New York to Greenville

Compare and see reviews for airlines that fly from Islip, New York to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $302	Free Cancellation	Rating 8.0 4,199 reviews		Search Southwest flights

Anderson

Simpsonville

Greenwood

Greer

Seneca

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Islip to Greenville?

Finding the right flight to Greenville from Islip is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Greenville quick and easy, saving you time and money.

Can I find flights from Islip to Greenville with flexible booking policies on momondo?

All flight searches from Islip to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Greenville?

Once all potential Islip to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Islip to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Islip. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Cheap flights from Islip, New York to Greenville from $142

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Islip, New York to Greenville departing on 9/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Find the cheapest flights from Islip, New York to Greenville

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Big names and deals

Big names and deals

Filter for what you want

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Breeze Airways flights from Islip, New York to Greenville

Our best Breeze Airways deals on Islip, New York to Greenville flight tickets

Southwest flights from Islip, New York to Greenville

Our best Southwest deals on Islip, New York to Greenville flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Islip, New York to Greenville that are best for you.

See travel insights to Greenville from

How to get the cheapest flight ticket from Islip, New York to Greenville

What is the cheapest month to fly to Greenville?

What is the cheapest day to depart on your flight to Greenville?

What is the cheapest time of day to depart on your flight to Greenville?

What is the cheapest airline that flies from Islip Long Island to Greenville?

What airlines fly to Greenville?

When to book flights from Islip, New York to Greenville

Cheap Islip, New York to Greenville (ISP to GSP) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Islip, New York to Greenville

Best airlines flying from Islip, New York to Greenville

Compare and see reviews for airlines that fly from Islip, New York to Greenville with momondo

Traveling to a place near Greenville?

Why use momondo?

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing South Carolina

Fly your favorite airline to Greenville

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Greenville

List of cabin classes available on flights landing in Greenville. Availability may vary depending on flight origin and airline.

Popular cities in the United States

Popular flights according to clicks in the last 7 days on momondo

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According to popular flight searches on momondo this year

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