What airlines fly to Greenville?

American Airlines, Spirit Airlines and United Airlines are the top three most popular airlines that fly to Greenville from Islip, New York according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 7 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Islip Long Island Airport to Greenville Airport?

Prices for flights from Islip Long Island Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Islip Long Island Airport to Greenville Airport?

The number of operators available for flights from Islip Long Island Airport to Greenville Airport is 1 as of November 2025.

How old do you have to be to fly from Islip Long Island Airport to Greenville Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Islip Long Island Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$146 Cheap Flights from Islip to Greenville in 2025/26

Q: What is the typical price of a round-trip flight between Islip, New York and Greenville?

Prices are currently low for flights on this route. Typical prices usually range from $366 to $471. The lowest price recently found on this route was $226.

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Find the cheapest flights from Islip, New York to Greenville

Round-trip

One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

11:35 am - 3:59 pmISP-GSP

28h 24m1 stop

10:15 am - 1:21 pmGSP-ISP

27h 06m2 stops

$226Multiple Airlines

Find Deal

Sun, Jan 25 - Sun, Feb 1

11:35 am - 3:59 pmISP-GSP

28h 24m1 stop

10:15 am - 1:31 pmGSP-ISP

27h 16m2 stops

$230Multiple Airlines

Find Deal

Sun, Jan 25 - Thu, Feb 5

11:35 am - 3:59 pmISP-GSP

28h 24m1 stop

4:55 pm - 6:40 pmGSP-ISP

25h 45m1 stop

$236Multiple Airlines

Find Deal

Sun, Jan 25 - Thu, Feb 5

7:35 pm - 9:07 pmISP-GSP

25h 32m1 stop

4:55 pm - 6:40 pmGSP-ISP

25h 45m1 stop

$298Breeze Airways

Find Deal

Sat, Jan 24 - Thu, Feb 5

7:35 pm - 9:07 pmISP-GSP

25h 32m1 stop

4:55 pm - 6:40 pmGSP-ISP

25h 45m1 stop

$304Breeze Airways

Find Deal

Sat, Jan 24 - Sun, Feb 1

7:35 pm - 9:07 pmISP-GSP

25h 32m1 stop

4:07 pm - 11:10 amGSP-ISP

19h 03m2 stops

$306Breeze Airways

Find Deal

Sat, Jan 24 - Fri, Jan 30

3:45 pm - 7:50 pmISP-GSP

4h 05m1 stop

10:05 am - 4:15 pmGSP-ISP

6h 10m1 stop

$319Southwest

Find Deal

Mon, Jan 26 - Mon, Feb 2

3:45 pm - 7:50 pmISP-GSP

4h 05m1 stop

11:15 am - 9:55 pmGSP-ISP

10h 40m2 stops

$324Southwest

Find Deal

Mon, Jan 26 - Mon, Feb 2

5:40 am - 10:05 amISP-GSP

4h 25m1 stop

4:45 pm - 10:05 pmGSP-ISP

5h 20m1 stop

$367Southwest

Find Deal

Sun, Dec 21 - Wed, Dec 24

4:30 pm - 8:55 pmISP-GSP

4h 25m1 stop

1:50 pm - 8:25 pmGSP-ISP

6h 35m1 stop

$377Southwest

Find Deal

Fri, May 1 - Mon, May 4

Breeze Airways flights from Islip, New York to Greenville

Our best Breeze Airways deals on Islip, New York to Greenville flight tickets

Breeze Airways

Jan 24

ISP7:35 pmIslip Long Island

25h 32m

1 stop

GSP9:07 pmGreenville

Feb 5

GSP4:55 pmGreenville

25h 45m

1 stop

ISP6:40 pmIslip Long Island

$298

Find similar

Breeze Airways

Jan 24

ISP7:35 pmIslip Long Island

25h 32m

1 stop

GSP9:07 pmGreenville

Feb 1

GSP4:55 pmGreenville

25h 45m

1 stop

ISP6:40 pmIslip Long Island

$304

Find similar

Breeze Airways

Jan 24

ISP7:35 pmIslip Long Island

25h 32m

1 stop

GSP9:07 pmGreenville

Jan 30

GSP4:07 pmGreenville

19h 03m

2 stops

ISP11:10 amIslip Long Island

$306

Find similar

Southwest flights from Islip, New York to Greenville

Our best Southwest deals on Islip, New York to Greenville flight tickets

Southwest

Jan 26

ISP3:45 pmIslip Long Island

4h 05m

1 stop

GSP7:50 pmGreenville

Feb 2

GSP10:05 amGreenville

6h 10m

1 stop

ISP4:15 pmIslip Long Island

$319

Find similar

Southwest

Jan 26

ISP3:45 pmIslip Long Island

4h 05m

1 stop

GSP7:50 pmGreenville

Feb 2

GSP11:15 amGreenville

10h 40m

2 stops

ISP9:55 pmIslip Long Island

$324

Find similar

Southwest

Dec 21

ISP5:40 amIslip Long Island

4h 25m

1 stop

GSP10:05 amGreenville

Dec 24

GSP4:45 pmGreenville

5h 20m

1 stop

ISP10:05 pmIslip Long Island

$367

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Islip, New York to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 1/25

11:35 am-3:59 pm

1 stop28h 24m

Greenville

Sun 2/1

10:15 am-1:21 pm

2 stops27h 06m

$226

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 1/25

11:35 am-3:59 pm

1 stop28h 24m

Greenville

Thu 2/5

10:15 am-1:31 pm

2 stops27h 16m

$230

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 1/25

11:35 am-3:59 pm

1 stop28h 24m

Greenville

Thu 2/5

4:55 pm-6:40 pm

1 stop25h 45m

$236

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sat 1/24

7:35 pm-9:07 pm

1 stop25h 32m

Greenville

Thu 2/5

4:55 pm-6:40 pm

1 stop25h 45m

$298

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sat 1/24

7:35 pm-9:07 pm

1 stop25h 32m

Greenville

Sun 2/1

4:55 pm-6:40 pm

1 stop25h 45m

$304

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sat 1/24

7:35 pm-9:07 pm

1 stop25h 32m

Greenville

Fri 1/30

4:07 pm-11:10 am

2 stops19h 03m

$306

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Mon 1/26

3:45 pm-7:50 pm

1 stop4h 05m

Greenville

Mon 2/2

10:05 am-4:15 pm

1 stop6h 10m

$319

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Mon 1/26

3:45 pm-7:50 pm

1 stop4h 05m

Greenville

Mon 2/2

11:15 am-9:55 pm

2 stops10h 40m

$324

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Sun 12/21

5:40 am-10:05 am

1 stop4h 25m

Greenville

Wed 12/24

4:45 pm-10:05 pm

1 stop5h 20m

$367

IslipGreenville

ISP - GSP

ISPGSP

Islip Long Island

Fri 5/1

4:30 pm-8:55 pm

1 stop4h 25m

Greenville

Mon 5/4

1:50 pm-8:25 pm

1 stop6h 35m

$377

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first

How to get the cheapest flight ticket from Islip, New York to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Islip, New York and Greenville?

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Islip, New York. The lowest ticket price found for a Saturday departure recently was $280. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $339. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Islip, New York to Greenville during this time can be as low as $295. Flights to Greenville are more costly in the afternoon, with an average ticket price of $306. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Islip, New York to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip, New York to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Islip, New York to Greenville (ISP to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Greenville

Direct flights	None

There are no direct flights from Islip, New York to Greenville. There are no popular flight routes from Islip, New York to Greenville.

Search flight deals

How far is Islip Long Island to Greenville by plane?
There are 644.2 mi between Islip Long Island and Greenville. Typically, this will take 4h 05m by plane in normal conditions.
When did momondo last update prices for flights from Islip Long Island Airport to Greenville Airport?
Prices for flights from Islip Long Island Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Islip Long Island Airport to Greenville Airport?
The number of operators available for flights from Islip Long Island Airport to Greenville Airport is 1 as of November 2025.
How old do you have to be to fly from Islip Long Island Airport to Greenville Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Islip Long Island Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Islip, New York to Greenville?
Based on momondo bookings for flights between Islip, New York and Greenville, the leading airline is Southwest, making up 100% of the total bookings.

Best airlines flying from Islip, New York to Greenville

Compare and see reviews for airlines that fly from Islip, New York to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $218	Free Cancellation	Rating 8.0 4,239 reviews		Search Southwest flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Islip to Greenville?

Finding the right flight to Greenville from Islip is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Greenville quick and easy, saving you time and money.

Can I find flights from Islip to Greenville with flexible booking policies on momondo?

All flight searches from Islip to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Greenville?

Once all potential Islip to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Islip to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Islip. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.