What is the cheapest airline that flies from Indiana to South Carolina?

Delta, United Airlines, and Southwest are the most popular carriers operating from Indiana to South Carolina

How long is the flight from Indiana to South Carolina?

Flight times vary depending on what airport in Indiana you fly out of and what airport in South Carolina you fly into. For example, flying from Indianapolis to Charleston takes 3h 34m on average. On the other hand, flying from Fort Wayne to Charleston takes 3h 55m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What airlines fly to South Carolina?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to South Carolina from Indiana according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Indiana to South Carolina?

Prices for flights from Indiana to South Carolina are updated daily.

How many operators does momondo search for flights from Indiana to South Carolina?

As of October 2026, there are 5 operators available to choose from for flights from Indiana to South Carolina.

How old do you have to be to fly from Indiana to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Indiana to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$83 Cheap Flights from Indiana to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Indiana to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

12:38 pm - 7:54 amIND Indianapolis-GSP Greenville

19h 16m1 stop Fort Lauderdale

2:42 pm - 5:20 pmGSP Greenville-IND Indianapolis

26h 38m1 stop Fort Lauderdale

$160Multiple Airlines

Wed, Nov 18 - Mon, Nov 23

12:38 pm - 7:14 pmIND Indianapolis-CHS Charleston

6h 36m1 stop Fort Lauderdale

8:58 pm - 11:53 amCHS Charleston-IND Indianapolis

14h 55m2 stops Tampa Fort Lauderdale

$195Multiple Airlines

Wed, Nov 11 - Fri, Nov 13

6:39 am - 11:26 amIND Indianapolis-CHS Charleston

4h 47m1 stop Chicago O'Hare Intl

7:09 am - 3:02 pmCHS Charleston-IND Indianapolis

7h 53m1 stop Chicago O'Hare Intl

$233American Airlines

Thu, Nov 19 - Tue, Nov 24

7:41 am - 1:36 pmIND Indianapolis-CHS Charleston

5h 55m1 stop Washington, D.C. Reagan-National

12:17 pm - 7:18 pmCHS Charleston-IND Indianapolis

7h 01m1 stop Chicago O'Hare Intl

$233American Airlines

Wed, Nov 18 - Tue, Dec 1

2:06 pm - 8:06 pmIND Indianapolis-CHS Charleston

6h 00m1 stop Atlanta Hartsfield-Jackson

6:00 am - 9:47 amCHS Charleston-IND Indianapolis

3h 47m1 stop Atlanta Hartsfield-Jackson

$233Delta

Mon, Dec 7 - Sat, Jan 16

8:08 pm - 11:59 pmIND Indianapolis-CHS Charleston

3h 51m1 stop Atlanta Hartsfield-Jackson

5:20 am - 9:08 amCHS Charleston-IND Indianapolis

3h 48m1 stop Atlanta Hartsfield-Jackson

$233Delta

Mon, Nov 9 - Wed, Nov 11

5:50 am - 10:15 amIND Indianapolis-CHS Charleston

4h 25m1 stop Baltimore/Washington

6:35 am - 10:30 amCHS Charleston-IND Indianapolis

3h 55m1 stop Nashville Intl

$233Southwest

Wed, Jan 27 - Sat, Jan 30

7:15 am - 2:00 pmIND Indianapolis-CHS Charleston

6h 45m1 stop Chicago O'Hare Intl

2:42 pm - 9:59 pmCHS Charleston-IND Indianapolis

7h 17m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$238United Airlines

Mon, Dec 7 - Sat, Jan 16

5:40 am - 10:05 amIND Indianapolis-CHS Charleston

4h 25m1 stop Baltimore/Washington

8:00 am - 6:00 pmCHS Charleston-IND Indianapolis

10h 00m2 stops Baltimore/Washington Atlanta Hartsfield-Jackson

$238Southwest

Mon, Feb 22 - Wed, Feb 24

4:38 pm - 8:59 pmIND Indianapolis-CHS Charleston

4h 21m1 stop Chicago O'Hare Intl

6:00 am - 2:02 pmCHS Charleston-IND Indianapolis

8h 02m1 stop Newark

$258United Airlines

Fri, Feb 19 - Sat, Feb 20

Cheap last minute flights

Enter your travel dates to find the best prices.

7:45 pm - 9:13 amSBN South Bend/Michiana-MYR Myrtle Beach Intl

13h 28m1 stop Fort Lauderdale

8:10 pm - 6:55 pmMYR Myrtle Beach Intl-SBN South Bend/Michiana

22h 45m1 stop Fort Lauderdale

$309Multiple Airlines

Fri, Oct 23 - Thu, Oct 29

7:48 pm - 9:55 amSBN South Bend/Michiana-MYR Myrtle Beach Intl

14h 07m1 stop Fort Lauderdale

8:10 pm - 6:55 pmMYR Myrtle Beach Intl-SBN South Bend/Michiana

22h 45m1 stop Fort Lauderdale

$316Multiple Airlines

Mon, Oct 26 - Thu, Oct 29

5:50 pm - 2:28 pmSBN South Bend/Michiana-GSP Greenville

20h 38m1 stop Orlando Sanford Intl

6:08 pm - 6:55 pmGSP Greenville-SBN South Bend/Michiana

24h 47m1 stop Fort Lauderdale

$382Allegiant Air

Sat, Oct 24 - Thu, Oct 29

6:00 am - 10:07 amFWA Fort Wayne-MYR Myrtle Beach Intl

4h 07m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:57 amMYR Myrtle Beach Intl-FWA Fort Wayne

4h 57m1 stop Atlanta Hartsfield-Jackson

$391Delta

Tue, Oct 27 - Wed, May 26

6:00 am - 10:07 amFWA Fort Wayne-MYR Myrtle Beach Intl

4h 07m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:57 amMYR Myrtle Beach Intl-FWA Fort Wayne

4h 57m1 stop Atlanta Hartsfield-Jackson

$391Delta

Tue, Oct 27 - Tue, May 25

11:09 am - 2:52 pmIND Indianapolis-CHS Charleston

3h 43m1 stop Charlotte Douglas

7:13 am - 12:08 pmCHS Charleston-IND Indianapolis

4h 55m1 stop Chicago O'Hare Intl

$395American Airlines

Tue, Oct 27 - Tue, Nov 10

1:49 pm - 9:09 pmIND Indianapolis-CAE Columbia Metropolitan

7h 20m1 stop Chicago O'Hare Intl

7:54 pm - 11:59 pmCAE Columbia Metropolitan-IND Indianapolis

4h 05m1 stop Washington, D.C. Dulles Intl

$399United Airlines

Fri, Oct 23 - Fri, Oct 30

4:06 pm - 9:51 pmIND Indianapolis-CAE Columbia Metropolitan

5h 45m1 stop Charlotte Douglas

8:30 pm - 12:37 amCAE Columbia Metropolitan-IND Indianapolis

4h 07m1 stop Charlotte Douglas

$409American Airlines

Fri, Oct 23 - Mon, Oct 26

5:25 am - 11:19 amFWA Fort Wayne-CHS Charleston

5h 54m1 stop Chicago O'Hare Intl

11:12 am - 10:15 pmCHS Charleston-FWA Fort Wayne

11h 03m2 stops Newark Chicago O'Hare Intl

$419United Airlines

Sun, Oct 25 - Tue, Nov 3

6:50 am - 1:15 pmIND Indianapolis-CHS Charleston

6h 25m2 stops Chicago Midway Nashville Intl

4:00 pm - 11:25 pmCHS Charleston-IND Indianapolis

7h 25m2 stops Baltimore/Washington Chicago Midway

$547Southwest

Tue, Oct 27 - Sun, Nov 1

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Southwest flights from Indiana to South Carolina

Our best Southwest deals on Indiana to South Carolina flight tickets

Southwest

Jan 27

IND10:25 amIndianapolis

9h 25m

2 stops

CHS7:50 pmCharleston

Jan 30

CHS6:35 amCharleston

3h 55m

1 stop

IND10:30 amIndianapolis

$239

Southwest

Jan 27

IND6:35 amIndianapolis

8h 15m

2 stops

CHS2:50 pmCharleston

Jan 30

CHS8:05 amCharleston

10h 25m

2 stops

IND6:30 pmIndianapolis

$244

Southwest

Feb 20

IND5:30 amIndianapolis

4h 50m

1 stop

GSP10:20 amGreenville

Feb 24

GSP7:05 amGreenville

5h 35m

1 stop

IND12:40 pmIndianapolis

$246

Breeze Airways flights from Indiana to South Carolina

Our best Breeze Airways deals on Indiana to South Carolina flight tickets

Breeze Airways

Dec 2

SBN3:29 pmSouth Bend/Michiana

7h 04m

1 stop

CHS10:33 pmCharleston

Dec 4

CHS2:49 pmCharleston

24h 00m

1 stop

SBN2:49 pmSouth Bend/Michiana

$292

Breeze Airways

Dec 2

SBN3:29 pmSouth Bend/Michiana

7h 04m

1 stop

CHS10:33 pmCharleston

Dec 4

CHS9:38 pmCharleston

17h 11m

2 stops

SBN2:49 pmSouth Bend/Michiana

$434

Breeze Airways

Oct 25

SBN8:46 pmSouth Bend/Michiana

12h 02m

1 stop

CHS8:48 amCharleston

Oct 28

CHS3:42 pmCharleston

28h 24m

1 stop

SBN8:06 pmSouth Bend/Michiana

$496

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisGreenville

IND Indianapolis - GSP Greenville

INDGSP

Indianapolis

Wed 11/18

12:38 pm-7:54 am

1 stop19h 16m

Greenville

Mon 11/23

2:42 pm-5:20 pm

1 stop26h 38m

$160

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Wed 11/11

12:38 pm-7:14 pm

1 stop6h 36m

Charleston

Fri 11/13

8:58 pm-11:53 am

2 stops14h 55m

$195

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Thu 11/19

6:39 am-11:26 am

1 stop4h 47m

Charleston

Tue 11/24

7:09 am-3:02 pm

1 stop7h 53m

$233

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Wed 11/18

7:41 am-1:36 pm

1 stop5h 55m

Charleston

Tue 12/1

12:17 pm-7:18 pm

1 stop7h 01m

$233

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 12/7

2:06 pm-8:06 pm

1 stop6h 00m

Charleston

Sat 1/16

6:00 am-9:47 am

1 stop3h 47m

$233

Quickest round-trip

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 11/9

8:08 pm-11:59 pm

1 stop3h 51m

Charleston

Wed 11/11

5:20 am-9:08 am

1 stop3h 48m

$233

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Wed 1/27

5:50 am-10:15 am

1 stop4h 25m

Charleston

Sat 1/30

6:35 am-10:30 am

1 stop3h 55m

$233

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 12/7

7:15 am-2:00 pm

1 stop6h 45m

Charleston

Sat 1/16

2:42 pm-9:59 pm

2 stops7h 17m

$238

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 2/22

5:40 am-10:05 am

1 stop4h 25m

Charleston

Wed 2/24

8:00 am-6:00 pm

2 stops10h 00m

$238

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Fri 2/19

4:38 pm-8:59 pm

1 stop4h 21m

Charleston

Sat 2/20

6:00 am-2:02 pm

1 stop8h 02m

$258

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Indiana to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indiana is in July. Flight prices, which tend to average around $259, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to South Carolina from Indiana during June instead. Flights to South Carolina in June, while not as cheap as those in July, still average around $281.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $92. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $138.

What is the cheapest Indiana to South Carolina flight route?

Fly from Indianapolis to Myrtle Beach Intl for the best Indiana - South Carolina flight prices

How far in advance should I book a flight from Indiana to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indiana when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $341 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indiana for as low as $219 on momondo.

What cabin class options are available on Indiana to South Carolina flights?

There is only 1 cabin class available to choose from on Indiana to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indiana to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indiana to South Carolina.

Cheap Indiana to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indiana to South Carolina

Best Price Found	$83
Fastest flight time	1h 28m
Direct flights	None

The best one-way flight to South Carolina from Indiana in the past 72 hours is $83. The best round-trip flight deal from Indiana to South Carolina found on momondo in the last 72 hours is $160.

The fastest flight from Indiana to South Carolina takes 1h 28m

There are no direct flights from Indiana to South Carolina. There are no popular flight routes from Indiana to South Carolina.

Search flight deals

Frequently asked questions about flying from Indiana to South Carolina

When did momondo last update prices for flights from Indiana to South Carolina?
Prices for flights from Indiana to South Carolina are updated daily.
How many operators does momondo search for flights from Indiana to South Carolina?
As of October 2026, there are 5 operators available to choose from for flights from Indiana to South Carolina.
How old do you have to be to fly from Indiana to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Indiana to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Indiana to South Carolina?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Indiana to South Carolina is Airbus A320-100/200 (73.33% of total bookings). The next most popular plane models are Boeing 737 MAX 8 (10.00%), Airbus A319 (6.67%), and Embraer 175 (Enhanced Winglets) (3.33%).

Best airlines flying from Indiana to South Carolina

Compare and see reviews for airlines that fly from Indiana to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $74	Free Cancellation	Rating 7.3 677 reviews	Search Allegiant Air flights
Delta	PriceFrom $210	Free Cancellation	Rating 7.8 8,661 reviews	Search Delta flights
United Airlines	PriceFrom $221	Free Cancellation	Rating 7.3 10,400 reviews	Search United Airlines flights
American Airlines	PriceFrom $230	Free Cancellation	Rating 7.0 12,184 reviews	Search American Airlines flights
Southwest	PriceFrom $278	Free Cancellation	Rating 7.9 4,209 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indiana to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Indiana to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Indiana to South Carolina with flexible booking policies on momondo?

Flights from Indiana to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Indiana to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Indiana to South Carolina.

I’m not ready to book a flight from Indiana to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Indiana and alert you when they change.