Cheap flights from Indiana to South Carolina from $57

The cheapest month to fly to South Carolina from Indiana is in June. Flight prices, which tend to average around $165, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of June, then book flights to South Carolina from Indiana during July instead. Flights to South Carolina in July, while not as cheap as those in June, still average around $224.

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $45. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $149.

Our data shows that the cheapest Indiana to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $140. Try not to purchase tickets in the afternoon because they tend to be around $155. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Indianapolis to Myrtle Beach Intl for the best Indiana - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Indiana when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $313 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indiana for as low as $181 on momondo.

There is only 1 cabin class available to choose from on Indiana to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Spirit Airlines, and United Airlines are the most popular carriers operating from Indiana to South Carolina

American Airlines, Delta and Allegiant Air are the top three most popular airlines that fly to South Carolina from Indiana according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of February 2026, 631 flights take off from Indiana and land in South Carolina each week. The most common flight departure day for this route is Fri, with 18% of weekly flights taking off on this day.

Flight times vary depending on what airport in Indiana you fly out of and what airport in South Carolina you fly into. For example, flying from Indianapolis to Charleston takes 1h 48m on average. On the other hand, flying from Evansville to Charleston takes 3h 32m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.