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Cheap flights from Greenville to Panama City from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 11/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:09 pm - 5:33 pmGSP-ECP
6h 24m1 stop
American Airlines Logo
6:03 pm - 11:26 pmECP-GSP
4h 23m1 stop
$263American Airlines
Find Deal
Mon, Jan 19 - Sun, Jan 25
Delta Logo
5:16 pm - 8:32 pmGSP-ECP
4h 16m1 stop
Delta Logo
7:02 am - 1:10 pmECP-GSP
5h 08m1 stop
$291Delta
Find Deal
Mon, Nov 17 - Mon, Nov 24
Southwest Logo
8:20 am - 6:45 pmGSP-ECP
11h 25m2 stops
Southwest Logo
7:35 am - 8:20 pmECP-GSP
11h 45m2 stops
$348Southwest
Find Deal
Mon, Jan 19 - Sun, Jan 25
American Airlines Logo
7:16 am - 5:33 pmGSP-ECP
11h 17m2 stops
American Airlines Logo
6:03 pm - 11:26 pmECP-GSP
4h 23m1 stop
$350American Airlines
Find Deal
Mon, Jan 19 - Sun, Jan 25
Delta Logo
7:55 pm - 10:42 pmGSP-ECP
3h 47m1 stop
Delta Logo
7:45 am - 1:54 pmECP-GSP
5h 09m1 stop
$357Delta
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Fri, Feb 13 - Mon, Feb 16
Delta Logo
5:45 am - 8:20 amGSP-ECP
3h 35m1 stop
Delta Logo
7:05 pm - 11:36 pmECP-GSP
3h 31m1 stop
$408Delta
Find Deal
Thu, Feb 12 - Mon, Feb 16
Delta Logo
5:30 am - 8:44 amGSP-ECP
4h 14m1 stop
Delta Logo
6:00 am - 10:27 amECP-GSP
3h 27m1 stop
$419Delta
Find Deal
Wed, Nov 5 - Sun, Nov 9
Southwest Logo
8:30 am - 10:30 pmGSP-ECP
15h 00m2 stops
Southwest Logo
9:55 am - 9:45 pmECP-GSP
10h 50m2 stops
$529Southwest
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Fri, Feb 13 - Mon, Feb 16
United Airlines Logo
4:17 pm - 1:56 pmGSP-ECP
22h 39m2 stops
United Airlines Logo
5:00 pm - 2:59 pmECP-GSP
20h 59m2 stops
$738United Airlines
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Mon, Nov 17 - Mon, Nov 24
United Airlines Logo
2:55 pm - 4:03 pmGSP-ECP
26h 08m2 stops
United Airlines Logo
3:00 pm - 2:59 pmECP-GSP
22h 59m2 stops
$748United Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10

American Airlines flights from Greenville to Panama City, Florida

Our best American Airlines deals on Greenville to Panama City, Florida flight tickets
American Airlines
Jan 19
GSP12:09 pmGreenville
6h 24m
1 stop
ECP5:33 pmPanama City NW Florida Beaches
Jan 25
ECP6:03 pmPanama City NW Florida Beaches
4h 23m
1 stop
GSP11:26 pmGreenville
$263
Find similar
American Airlines
Jan 19
GSP7:16 amGreenville
11h 17m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Jan 25
ECP6:03 pmPanama City NW Florida Beaches
4h 23m
1 stop
GSP11:26 pmGreenville
$350
Find similar
American Airlines
Nov 17
GSP6:22 amGreenville
11h 53m
2 stops
ECP5:15 pmPanama City NW Florida Beaches
Nov 24
ECP5:55 pmPanama City NW Florida Beaches
4h 16m
1 stop
GSP11:11 pmGreenville
$559
Find similar

Delta flights from Greenville to Panama City, Florida

Our best Delta deals on Greenville to Panama City, Florida flight tickets
Delta
Nov 17
GSP5:16 pmGreenville
4h 16m
1 stop
ECP8:32 pmPanama City NW Florida Beaches
Nov 24
ECP7:02 amPanama City NW Florida Beaches
5h 08m
1 stop
GSP1:10 pmGreenville
$291
Find similar
Delta
Feb 13
GSP7:55 pmGreenville
3h 47m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
Feb 16
ECP7:45 amPanama City NW Florida Beaches
5h 09m
1 stop
GSP1:54 pmGreenville
$357
Find similar
Delta
Feb 12
GSP5:45 amGreenville
3h 35m
1 stop
ECP8:20 amPanama City NW Florida Beaches
Feb 16
ECP7:05 pmPanama City NW Florida Beaches
3h 31m
1 stop
GSP11:36 pmGreenville
$408
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Greenville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 1/19

12:09 pm-5:33 pm

1 stop6h 24m

Panama City NW Florida Beaches

Sun 1/25

6:03 pm-11:26 pm

1 stop4h 23m

$263

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 11/17

5:16 pm-8:32 pm

1 stop4h 16m

Panama City NW Florida Beaches

Mon 11/24

7:02 am-1:10 pm

1 stop5h 08m

$291

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 1/19

8:20 am-6:45 pm

2 stops11h 25m

Panama City NW Florida Beaches

Sun 1/25

7:35 am-8:20 pm

2 stops11h 45m

$348

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 1/19

7:16 am-5:33 pm

2 stops11h 17m

Panama City NW Florida Beaches

Sun 1/25

6:03 pm-11:26 pm

1 stop4h 23m

$350

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 2/13

7:55 pm-10:42 pm

1 stop3h 47m

Panama City NW Florida Beaches

Mon 2/16

7:45 am-1:54 pm

1 stop5h 09m

$357

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Thu 2/12

5:45 am-8:20 am

1 stop3h 35m

Panama City NW Florida Beaches

Mon 2/16

7:05 pm-11:36 pm

1 stop3h 31m

$408

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Wed 11/5

5:30 am-8:44 am

1 stop4h 14m

Panama City NW Florida Beaches

Sun 11/9

6:00 am-10:27 am

1 stop3h 27m

$419

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 2/13

8:30 am-10:30 pm

2 stops15h 00m

Panama City NW Florida Beaches

Mon 2/16

9:55 am-9:45 pm

2 stops10h 50m

$529

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 11/17

4:17 pm-1:56 pm

2 stops22h 39m

Panama City NW Florida Beaches

Mon 11/24

5:00 pm-2:59 pm

2 stops20h 59m

$738

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Thu 11/6

2:55 pm-4:03 pm

2 stops26h 08m

Panama City NW Florida Beaches

Mon 11/10

3:00 pm-2:59 pm

2 stops22h 59m

$748

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Greenville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Greenville and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Greenville is in June. Flight prices, which tend to average around $280, are often lower during this time because this is during the off-season. The month of November is another great option to travel to Panama City, Florida, with average flight prices from Greenville averaging around $286.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $310. On the other hand, Wednesday is the most expensive day to depart from Greenville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $437.

When to book flights from Greenville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Panama City, Florida (GSP to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama City, Florida

Direct flights

None
There are no direct flights from Greenville to Panama City, Florida. There are no popular flight routes from Greenville to Panama City, Florida.
Search flight deals

  • How far is Greenville to Panama City NW Florida Beaches by plane?

    Panama City NW Florida Beaches is 375.7 mi away from Greenville. Flights usually cover this in 3h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Greenville Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Greenville Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Greenville Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Panama City, Florida?

Best airlines flying from Greenville to Panama City, Florida

Compare and see reviews for airlines that fly from Greenville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $256Free CancellationRating
7.9
7,981 reviews
Search Delta flights
SouthwestPriceFrom $301Free CancellationRating
8.0
4,237 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to Panama City for you.

Can I find flights from Greenville to Panama City with flexible booking policies on momondo?

Flights from Greenville to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Greenville to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Greenville to Panama City.

I’m not ready to book a flight from Greenville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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