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Cheap flights from Greenville to Panama City from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:45 am - 8:17 am
GSP
-
ECP
3h 32m1 stop
Delta Logo
7:45 am - 1:56 pm
ECP
-
GSP
5h 11m1 stop
$322Delta
Sat, May 2 - Tue, May 5
Delta Logo
5:40 am - 8:39 am
GSP
-
ECP
3h 59m1 stop
Delta Logo
4:23 pm - 9:52 pm
ECP
-
GSP
4h 29m1 stop
$327Delta
Sun, Apr 5 - Thu, Apr 9
Southwest Logo
6:25 am - 1:00 pm
GSP
-
ECP
7h 35m2 stops
Southwest Logo
10:10 am - 9:40 pm
ECP
-
GSP
10h 30m2 stops
$332Southwest
Sat, May 2 - Tue, May 5
Southwest Logo
10:30 am - 2:45 pm
GSP
-
ECP
5h 15m1 stop
Southwest Logo
7:50 am - 3:35 pm
ECP
-
GSP
6h 45m1 stop
$358Southwest
Sat, Jan 3 - Sat, Jan 10
Southwest Logo
7:45 am - 5:25 pm
GSP
-
ECP
10h 40m2 stops
Southwest Logo
7:50 am - 3:35 pm
ECP
-
GSP
6h 45m1 stop
$364Southwest
Sat, Jan 3 - Sat, Jan 10
Southwest Logo
7:45 am - 5:25 pm
GSP
-
ECP
10h 40m2 stops
Southwest Logo
7:50 am - 7:50 pm
ECP
-
GSP
11h 00m2 stops
$369Southwest
Sat, Jan 3 - Sat, Jan 10
Southwest Logo
11:15 am - 6:10 pm
GSP
-
ECP
7h 55m1 stop
Southwest Logo
7:35 am - 11:55 am
ECP
-
GSP
3h 20m1 stop
$377Southwest
Fri, Jan 23 - Sun, Jan 25
Southwest Logo
11:15 am - 6:10 pm
GSP
-
ECP
7h 55m1 stop
Southwest Logo
10:10 am - 6:00 pm
ECP
-
GSP
6h 50m2 stops
$383Southwest
Fri, Jan 23 - Sun, Jan 25
Southwest Logo
6:25 am - 2:15 pm
GSP
-
ECP
8h 50m2 stops
Southwest Logo
9:55 am - 8:55 pm
ECP
-
GSP
10h 00m2 stops
$387Southwest
Sun, Apr 5 - Thu, Apr 9
United Airlines Logo
6:50 am - 12:04 pm
GSP
-
ECP
6h 14m1 stop
United Airlines Logo
6:30 am - 3:36 pm
ECP
-
GSP
8h 06m1 stop
$434United Airlines
Sat, Feb 21 - Wed, Feb 25

Delta flights from Greenville to Panama City, Florida

Our best Delta deals on Greenville to Panama City, Florida flight tickets
Delta
May 2
GSP5:45 amGreenville
3h 32m
1 stop
ECP8:17 amPanama City NW Florida Beaches
May 5
ECP7:45 amPanama City NW Florida Beaches
5h 11m
1 stop
GSP1:56 pmGreenville
$322
Find similar
Delta
Apr 5
GSP5:40 amGreenville
3h 59m
1 stop
ECP8:39 amPanama City NW Florida Beaches
Apr 9
ECP4:23 pmPanama City NW Florida Beaches
4h 29m
1 stop
GSP9:52 pmGreenville
$327
Find similar
Delta
Dec 18
GSP5:35 amGreenville
4h 39m
1 stop
ECP9:14 amPanama City NW Florida Beaches
Dec 21
ECP8:02 amPanama City NW Florida Beaches
2h 56m
1 stop
GSP11:58 amGreenville
$557
Find similar

United Airlines flights from Greenville to Panama City, Florida

Our best United Airlines deals on Greenville to Panama City, Florida flight tickets
United Airlines
Feb 21
GSP6:50 amGreenville
6h 14m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
Feb 25
ECP6:30 amPanama City NW Florida Beaches
8h 06m
1 stop
GSP3:36 pmGreenville
$434
Find similar
United Airlines
Feb 21
GSP6:50 amGreenville
6h 14m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
Feb 25
ECP1:01 pmPanama City NW Florida Beaches
24h 15m
2 stops
GSP2:16 pmGreenville
$593
Find similar
United Airlines
Dec 18
GSP8:34 amGreenville
5h 53m
1 stop
ECP1:27 pmPanama City NW Florida Beaches
Dec 21
ECP6:15 amPanama City NW Florida Beaches
13h 32m
2 stops
GSP8:47 pmGreenville
$756
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Greenville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 5/2

5:45 am-8:17 am

1 stop3h 32m

Panama City NW Florida Beaches

Tue 5/5

7:45 am-1:56 pm

1 stop5h 11m

$322

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 4/5

5:40 am-8:39 am

1 stop3h 59m

Panama City NW Florida Beaches

Thu 4/9

4:23 pm-9:52 pm

1 stop4h 29m

$327

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 5/2

6:25 am-1:00 pm

2 stops7h 35m

Panama City NW Florida Beaches

Tue 5/5

10:10 am-9:40 pm

2 stops10h 30m

$332

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 1/3

10:30 am-2:45 pm

1 stop5h 15m

Panama City NW Florida Beaches

Sat 1/10

7:50 am-3:35 pm

1 stop6h 45m

$358

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 1/3

7:45 am-5:25 pm

2 stops10h 40m

Panama City NW Florida Beaches

Sat 1/10

7:50 am-3:35 pm

1 stop6h 45m

$364

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 1/3

7:45 am-5:25 pm

2 stops10h 40m

Panama City NW Florida Beaches

Sat 1/10

7:50 am-7:50 pm

2 stops11h 00m

$369

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 1/23

11:15 am-6:10 pm

1 stop7h 55m

Panama City NW Florida Beaches

Sun 1/25

7:35 am-11:55 am

1 stop3h 20m

$377

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 1/23

11:15 am-6:10 pm

1 stop7h 55m

Panama City NW Florida Beaches

Sun 1/25

10:10 am-6:00 pm

2 stops6h 50m

$383

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 4/5

6:25 am-2:15 pm

2 stops8h 50m

Panama City NW Florida Beaches

Thu 4/9

9:55 am-8:55 pm

2 stops10h 00m

$387

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 2/21

6:50 am-12:04 pm

1 stop6h 14m

Panama City NW Florida Beaches

Wed 2/25

6:30 am-3:36 pm

1 stop8h 06m

$434

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Greenville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Greenville is in June. Flight prices, which tend to average around $280, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from Greenville averaging around $306.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $310. On the other hand, Wednesday is the most expensive day to depart from Greenville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $437.

When to book flights from Greenville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Panama City, Florida (GSP to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama City, Florida

Fastest flight time

3h 59m

Direct flights

None
The fastest flight from Greenville to Panama City, Florida takes 3h 59m
There are no direct flights from Greenville to Panama City, Florida. There are no popular flight routes from Greenville to Panama City, Florida.
Search flight deals

  • How far is Greenville to Panama City NW Florida Beaches by plane?

    Panama City NW Florida Beaches is 375.7 mi away from Greenville. Flights usually cover this in 3h 32m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Greenville Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Greenville Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Greenville Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Panama City, Florida?

Best airlines flying from Greenville to Panama City, Florida

Compare and see reviews for airlines that fly from Greenville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $266Free CancellationRating
7.9
8,011 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to Panama City for you.

Can I find flights from Greenville to Panama City with flexible booking policies on momondo?

Flights from Greenville to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Greenville to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Greenville to Panama City.

I’m not ready to book a flight from Greenville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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