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Cheap flights from Detroit to Missouri from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Missouri departing on 8/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Missouri

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
5:38 pm - 8:57 am
DTW
-
STL
16h 19m
1 stop
Frontier Logo
5:33 pm - 12:42 am
STL
-
DTW
6h 09m
1 stop
$121Frontier
Fri, Aug 14 - Wed, Aug 19
Frontier Logo
5:38 pm - 8:57 am
DTW
-
STL
16h 19m
1 stop
Frontier Logo
6:33 pm - 12:42 am
STL
-
DTW
5h 09m
1 stop
$123Frontier
Fri, Aug 14 - Thu, Aug 20
Frontier Logo
6:50 am - 5:33 pm
DTW
-
STL
11h 43m
1 stop
Frontier Logo
6:31 pm - 4:53 pm
STL
-
DTW
21h 22m
1 stop
$124Frontier
Tue, Jun 2 - Tue, Jun 9
Frontier Logo
1:59 pm - 8:55 am
DTW
-
STL
19h 56m
1 stop
Frontier Logo
5:27 pm - 5:59 pm
STL
-
DTW
23h 32m
1 stop
$125Frontier
Thu, Jun 4 - Mon, Jun 8
Delta Logo
9:30 am - 2:45 pm
DTW
-
SGF
6h 15m
1 stop
Delta Logo
3:30 pm - 9:20 pm
SGF
-
DTW
4h 50m
1 stop
$277Delta
Sat, Sep 5 - Wed, Sep 9
Delta Logo
7:29 am - 11:27 am
DTW
-
SGF
4h 58m
1 stop
Delta Logo
6:57 pm - 12:59 am
SGF
-
DTW
5h 02m
1 stop
$293Delta
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
5:37 am - 11:14 am
DTW
-
COU
6h 37m
1 stop
American Airlines Logo
5:19 pm - 11:41 pm
COU
-
DTW
5h 22m
1 stop
$298American Airlines
Thu, Jun 4 - Sun, Jun 7
American Airlines Logo
1:43 pm - 9:36 pm
DTW
-
COU
8h 53m
2 stops
American Airlines Logo
5:19 pm - 11:41 pm
COU
-
DTW
5h 22m
1 stop
$304American Airlines
Thu, Jun 4 - Sun, Jun 7
United Airlines Logo
6:00 am - 8:58 am
DTW
-
COU
3h 58m
1 stop
United Airlines Logo
3:25 pm - 10:19 pm
COU
-
DTW
5h 54m
1 stop
$307United Airlines
Sat, Jun 6 - Fri, Jun 12
United Airlines Logo
7:05 am - 1:22 pm
DTW
-
JLN
7h 17m
1 stop
United Airlines Logo
1:57 pm - 11:57 pm
JLN
-
DTW
9h 00m
2 stops
$320United Airlines
Fri, Jun 5 - Fri, Jun 12

Delta flights from Detroit to Missouri

Our best Delta deals on Detroit to Missouri flight tickets
Delta
Jun 2
DTW12:31 pmDetroit Metropolitan Wayne County
1h 39m
STL1:10 pmLambert-St Louis
Jun 16
STL10:20 amLambert-St Louis
1h 35m
DTW12:55 pmDetroit Metropolitan Wayne County
$209
Delta
Jun 2
DTW8:45 amDetroit Metropolitan Wayne County
1h 44m
STL9:29 amLambert-St Louis
Jun 23
STL6:30 amLambert-St Louis
1h 34m
DTW9:04 amDetroit Metropolitan Wayne County
$219
Delta
Aug 26
DTW4:59 pmDetroit Metropolitan Wayne County
1h 39m
STL5:38 pmLambert-St Louis
Aug 31
STL6:45 amLambert-St Louis
1h 31m
DTW9:16 amDetroit Metropolitan Wayne County
$222

Southwest flights from Detroit to Missouri

Our best Southwest deals on Detroit to Missouri flight tickets
Southwest
Jun 1
DTW8:15 pmDetroit Metropolitan Wayne County
1h 40m
STL8:55 pmLambert-St Louis
Jun 2
STL6:45 pmLambert-St Louis
1h 30m
DTW9:15 pmDetroit Metropolitan Wayne County
$211
Southwest
Jun 4
DTW8:15 pmDetroit Metropolitan Wayne County
1h 35m
STL8:50 pmLambert-St Louis
Jun 8
STL7:55 pmLambert-St Louis
1h 30m
DTW10:25 pmDetroit Metropolitan Wayne County
$213
Southwest
Jun 1
DTW5:35 amDetroit Metropolitan Wayne County
6h 15m
1 stop
STL10:50 amLambert-St Louis
Jun 2
STL10:30 amLambert-St Louis
1h 30m
DTW1:00 pmDetroit Metropolitan Wayne County
$221

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Detroit to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 8/14

5:38 pm-8:57 am

1 stop16h 19m

Lambert-St Louis

Wed 8/19

5:33 pm-12:42 am

1 stop6h 09m

$121

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 8/14

5:38 pm-8:57 am

1 stop16h 19m

Lambert-St Louis

Thu 8/20

6:33 pm-12:42 am

1 stop5h 09m

$123

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 6/2

6:50 am-5:33 pm

1 stop11h 43m

Lambert-St Louis

Tue 6/9

6:31 pm-4:53 pm

1 stop21h 22m

$124

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 6/4

1:59 pm-8:55 am

1 stop19h 56m

Lambert-St Louis

Mon 6/8

5:27 pm-5:59 pm

1 stop23h 32m

$125

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Sat 9/5

9:30 am-2:45 pm

1 stop6h 15m

Springfield-Branson

Wed 9/9

3:30 pm-9:20 pm

1 stop4h 50m

$277

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Wed 6/3

7:29 am-11:27 am

1 stop4h 58m

Springfield-Branson

Wed 6/10

6:57 pm-12:59 am

1 stop5h 02m

$293

DetroitColumbia

DTW - COU

DTWCOU

Detroit Metropolitan Wayne County

Thu 6/4

5:37 am-11:14 am

1 stop6h 37m

Columbia Regional

Sun 6/7

5:19 pm-11:41 pm

1 stop5h 22m

$298

DetroitColumbia

DTW - COU

DTWCOU

Detroit Metropolitan Wayne County

Thu 6/4

1:43 pm-9:36 pm

2 stops8h 53m

Columbia Regional

Sun 6/7

5:19 pm-11:41 pm

1 stop5h 22m

$304
Quickest round-trip

DetroitColumbia

DTW - COU

DTWCOU

Detroit Metropolitan Wayne County

Sat 6/6

6:00 am-8:58 am

1 stop3h 58m

Columbia Regional

Fri 6/12

3:25 pm-10:19 pm

1 stop5h 54m

$307

DetroitJoplin

DTW - JLN

DTWJLN

Detroit Metropolitan Wayne County

Fri 6/5

7:05 am-1:22 pm

1 stop7h 17m

Joplin

Fri 6/12

1:57 pm-11:57 pm

2 stops9h 00m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Detroit to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, June is the cheapest month to fly from Detroit to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $26. If you aren’t able to travel to Missouri during the month of June, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $27.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Detroit to Missouri is on a Thursday when prices can be found for as low as $328. Flights from Detroit to Missouri on a Monday will generally be more expensive and average around $412. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Detroit to Missouri at noon for as low as $270. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $366. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit to Missouri flight route?

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Missouri flight prices

How far in advance should I book a flight from Detroit to Missouri?

You are more likely to see cheaper flights to Missouri from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $305 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Detroit for as low as $69 on momondo.

Can stopping save me money on Detroit to Missouri flights?

You could potentially save up to 37% on your flight if you consider stops on a Detroit to Missouri flight.

Cheap Detroit to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Missouri

Best Price Found

$199

Fastest flight time

1h 30m

Direct flights

Every day

Airports in Missouri

55 airports
The best one-way flight to Missouri from Detroit in the past 72 hours is $199. The best round-trip flight deal from Detroit to Missouri found on momondo in the last 72 hours is $361.
The fastest flight from Detroit to Missouri takes 1h 30m
Direct flights go from Detroit to Missouri every day.
There are 55 airports in Missouri. From Detroit there are direct flights to Kansas City (MCI), Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from Detroit to Missouri

  • When did momondo last update prices for flights from Detroit to Missouri?

    Prices for flights from Detroit to Missouri were last updated today.

  • How many operators does momondo search for flights from Detroit to Missouri?

  • How old do you have to be to fly from Detroit to Missouri?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The required travel and health documents for your Missouri trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Missouri. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Detroit to Missouri?

Best airlines flying from Detroit to Missouri

Compare and see reviews for airlines that fly from Detroit to Missouri with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $28Free CancellationRating
6.3
8,636 reviews
Search Spirit Airlines flights
FrontierPriceFrom $111Free CancellationRating
5.6
2,957 reviews
Search Frontier flights
DeltaPriceFrom $120Free CancellationRating
7.9
8,455 reviews
Search Delta flights
SouthwestPriceFrom $149Free CancellationRating
8.0
4,306 reviews
Search Southwest flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights
American AirlinesPriceFrom $292Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Missouri?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Missouri from Detroit.

Can I find flights from Detroit to Missouri with flexible booking policies on momondo?

Flights from Detroit to Missouri with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Missouri?

momondo helps you find the best flight between Detroit and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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