Cheap flights from Detroit to Missouri from $58

In general, September is the cheapest month to fly from Detroit to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $397. If you aren’t able to travel to Missouri during the month of September, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $399.

The cheapest day to depart from Detroit to Missouri is on a Saturday when prices can be found for as low as $382. Flights from Detroit to Missouri on a Sunday will generally be more expensive and average around $482. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Detroit to Missouri at noon for as low as $352. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $446. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Missouri flight prices

You are more likely to see cheaper flights to Missouri from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Detroit for as low as $279 on momondo.

There are 4 cabin classes available to choose from on Detroit to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Delta, Southwest, and Frontier are the most popular carriers operating from Detroit to Missouri

Delta, Southwest and United Airlines are the top three most popular airlines that fly to Missouri from Detroit according to our data. Delta is the first choice among our users, with 57% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 5 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

As of September 2026, 27 flights take off from Detroit and land in Missouri each day. The most common flight departure time for this route is 7:00PM, with 50% of daily flights taking off in the afternoon.

The number of flights available between Detroit and Missouri is 190 per week as of September 2026. The most frequent departure day is Tue, with 16% of weekly flights leaving on this day.