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Cheap flights from Detroit to Florence from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Florence departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:01 am - 2:10 pm
DTW
-
FLO
4h 09m
1 stop
American Airlines Logo
2:35 pm - 7:18 pm
FLO
-
DTW
4h 43m
1 stop
$303American Airlines
Sat, May 23 - Wed, Jun 3
American Airlines Logo
4:32 pm - 10:00 pm
DTW
-
FLO
5h 28m
1 stop
American Airlines Logo
2:35 pm - 10:34 pm
FLO
-
DTW
7h 59m
2 stops
$308American Airlines
Sat, May 23 - Wed, Jun 3
American Airlines Logo
12:57 pm - 10:00 pm
DTW
-
FLO
9h 03m
2 stops
American Airlines Logo
2:35 pm - 10:34 pm
FLO
-
DTW
7h 59m
2 stops
$313American Airlines
Sat, May 23 - Wed, Jun 3
American Airlines Logo
1:06 pm - 5:21 pm
DTW
-
FLO
4h 15m
1 stop
American Airlines Logo
6:25 pm - 12:38 am
FLO
-
DTW
6h 13m
1 stop
$375American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
11:11 am - 5:21 pm
DTW
-
FLO
6h 10m
2 stops
American Airlines Logo
6:25 pm - 11:03 pm
FLO
-
DTW
4h 38m
1 stop
$380American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
2:06 pm - 11:08 pm
DTW
-
FLO
9h 02m
2 stops
American Airlines Logo
5:16 am - 12:32 pm
FLO
-
DTW
7h 16m
2 stops
$386American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
11:36 am - 5:50 pm
DTW
-
FLO
6h 14m
1 stop
American Airlines Logo
5:20 am - 9:27 am
FLO
-
DTW
4h 07m
1 stop
$551American Airlines
Sat, Apr 4 - Sat, Apr 11
American Airlines Logo
6:10 am - 5:50 pm
DTW
-
FLO
11h 40m
2 stops
American Airlines Logo
6:15 am - 10:32 am
FLO
-
DTW
4h 17m
1 stop
$556American Airlines
Sat, Apr 4 - Tue, Apr 14
American Airlines Logo
2:48 pm - 11:57 pm
DTW
-
FLO
9h 09m
2 stops
American Airlines Logo
4:02 pm - 10:16 pm
FLO
-
DTW
6h 14m
2 stops
$561American Airlines
Sat, Apr 4 - Tue, Apr 14
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
6:15 am - 10:32 am
FLO
-
DTW
4h 17m
1 stop
$567American Airlines
Fri, Apr 3 - Tue, Apr 14

American Airlines flights from Detroit to Florence, South Carolina

Our best American Airlines deals on Detroit to Florence, South Carolina flight tickets
American Airlines
May 23
DTW10:01 amDetroit Metropolitan Wayne County
4h 09m
1 stop
FLO2:10 pmFlorence
Jun 3
FLO2:35 pmFlorence
4h 43m
1 stop
DTW7:18 pmDetroit Metropolitan Wayne County
$303
American Airlines
May 23
DTW4:32 pmDetroit Metropolitan Wayne County
5h 28m
1 stop
FLO10:00 pmFlorence
Jun 3
FLO2:35 pmFlorence
7h 59m
2 stops
DTW10:34 pmDetroit Metropolitan Wayne County
$308
American Airlines
May 23
DTW12:57 pmDetroit Metropolitan Wayne County
9h 03m
2 stops
FLO10:00 pmFlorence
Jun 3
FLO2:35 pmFlorence
7h 59m
2 stops
DTW10:34 pmDetroit Metropolitan Wayne County
$313

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Detroit to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 5/23

10:01 am-2:10 pm

1 stop4h 09m

Florence

Wed 6/3

2:35 pm-7:18 pm

1 stop4h 43m

$303

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 5/23

4:32 pm-10:00 pm

1 stop5h 28m

Florence

Wed 6/3

2:35 pm-10:34 pm

2 stops7h 59m

$308

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 5/23

12:57 pm-10:00 pm

2 stops9h 03m

Florence

Wed 6/3

2:35 pm-10:34 pm

2 stops7h 59m

$313

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/24

1:06 pm-5:21 pm

1 stop4h 15m

Florence

Sat 3/28

6:25 pm-12:38 am

1 stop6h 13m

$375

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/24

11:11 am-5:21 pm

2 stops6h 10m

Florence

Sat 3/28

6:25 pm-11:03 pm

1 stop4h 38m

$380

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 3/24

2:06 pm-11:08 pm

2 stops9h 02m

Florence

Sat 3/28

5:16 am-12:32 pm

2 stops7h 16m

$386

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 4/4

11:36 am-5:50 pm

1 stop6h 14m

Florence

Sat 4/11

5:20 am-9:27 am

1 stop4h 07m

$551

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 4/4

6:10 am-5:50 pm

2 stops11h 40m

Florence

Tue 4/14

6:15 am-10:32 am

1 stop4h 17m

$556

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 4/4

2:48 pm-11:57 pm

2 stops9h 09m

Florence

Tue 4/14

4:02 pm-10:16 pm

2 stops6h 14m

$561

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 4/3

11:55 am-5:50 pm

1 stop5h 55m

Florence

Tue 4/14

6:15 am-10:32 am

1 stop4h 17m

$567

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Detroit to Florence?

American Airlines is the most popular carrier operating from Detroit to Florence

What airlines fly to Florence, South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Detroit according to our data. Delta is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Detroit to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Florence, South Carolina (DTT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Florence, South Carolina

Fastest flight time

6h 14m

Direct flights

None
The fastest flight from Detroit to Florence, South Carolina takes 6h 14m
There are no direct flights from Detroit to Florence, South Carolina. There are no popular flight routes from Detroit to Florence, South Carolina.
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  • How far is Detroit to Florence by plane?

    The distance between Detroit and Florence is about 589.7 mi. Typically, this will take 6h 14m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit to Florence Airport?

    Prices for flights from Detroit to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Detroit to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Florence?

Once you have performed a search for Detroit to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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