Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Detroit to Florence from $491

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Florence departing on 11/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Detroit to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:50 pm - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
6h 09m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 10:30 amFLO  Florence-DTW Detroit Metropolitan Wayne County
4h 06m1 stop Charlotte Douglas
$491American Airlines
Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
6:43 pm - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 16m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:30 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
3h 47m1 stop Charlotte Douglas
$491American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
10:33 am - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
12h 26m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 10:06 amFLO  Florence-DTW Detroit Metropolitan Wayne County
3h 42m1 stop Charlotte Douglas
$520American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
10:25 am - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
12h 34m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 10:30 amFLO  Florence-DTW Detroit Metropolitan Wayne County
4h 06m1 stop Charlotte Douglas
$525American Airlines
Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
10:25 am - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
12h 34m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 6:52 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
12h 28m2 stops Charlotte Douglas New York LaGuardia
$549American Airlines
Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
10:33 am - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
12h 26m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 7:03 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
12h 39m2 stops Charlotte Douglas New York LaGuardia
$549American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
7:58 pm - 12:15 amDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 17m1 stop Charlotte Douglas
American Airlines Logo
12:51 pm - 4:26 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
3h 35m1 stop Charlotte Douglas
$565American Airlines
Fri, Dec 25 - Mon, Jan 4
American Airlines Logo
6:43 pm - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 16m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:30 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
3h 47m1 stop Charlotte Douglas
$608American Airlines
Fri, Sep 4 - Fri, Sep 11
American Airlines Logo
6:43 pm - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 16m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 4:42 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
10h 18m2 stops Charlotte Douglas Washington, D.C. Reagan-National
$612American Airlines
Fri, Sep 4 - Fri, Sep 11
American Airlines Logo
6:43 pm - 10:59 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 16m1 stop Charlotte Douglas
American Airlines Logo
3:22 pm - 10:30 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
7h 08m1 stop Charlotte Douglas
$649American Airlines
Thu, Aug 20 - Mon, Aug 24

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Detroit to Florence, South Carolina

Our best American Airlines deals on Detroit to Florence, South Carolina flight tickets
American Airlines
Sep 2
DTW6:43 pmDetroit Metropolitan Wayne County
4h 16m
1 stop
FLO10:59 pmFlorence
Sep 9
FLO1:43 pmFlorence
3h 47m
1 stop
DTW5:30 pmDetroit Metropolitan Wayne County
$491
American Airlines
Sep 2
DTW10:33 amDetroit Metropolitan Wayne County
12h 26m
2 stops
FLO10:59 pmFlorence
Sep 9
FLO6:24 amFlorence
3h 42m
1 stop
DTW10:06 amDetroit Metropolitan Wayne County
$520
American Airlines
Nov 11
DTW10:25 amDetroit Metropolitan Wayne County
12h 34m
2 stops
FLO10:59 pmFlorence
Nov 18
FLO6:24 amFlorence
4h 06m
1 stop
DTW10:30 amDetroit Metropolitan Wayne County
$525

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Detroit to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 11/11

4:50 pm-10:59 pm

1 stop6h 09m

Florence

Wed 11/18

6:24 am-10:30 am

1 stop4h 06m

$491

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/2

6:43 pm-10:59 pm

1 stop4h 16m

Florence

Wed 9/9

1:43 pm-5:30 pm

1 stop3h 47m

$491

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/2

10:33 am-10:59 pm

2 stops12h 26m

Florence

Wed 9/9

6:24 am-10:06 am

1 stop3h 42m

$520

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 11/11

10:25 am-10:59 pm

2 stops12h 34m

Florence

Wed 11/18

6:24 am-10:30 am

1 stop4h 06m

$525

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 11/11

10:25 am-10:59 pm

2 stops12h 34m

Florence

Wed 11/18

6:24 am-6:52 pm

2 stops12h 28m

$549

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 9/2

10:33 am-10:59 pm

2 stops12h 26m

Florence

Wed 9/9

6:24 am-7:03 pm

2 stops12h 39m

$549
Quickest round-trip

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/25

7:58 pm-12:15 am

1 stop4h 17m

Florence

Mon 1/4

12:51 pm-4:26 pm

1 stop3h 35m

$565

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Fri 9/4

6:43 pm-10:59 pm

1 stop4h 16m

Florence

Fri 9/11

1:43 pm-5:30 pm

1 stop3h 47m

$608

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Fri 9/4

6:43 pm-10:59 pm

1 stop4h 16m

Florence

Fri 9/11

6:24 am-4:42 pm

2 stops10h 18m

$612

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Thu 8/20

6:43 pm-10:59 pm

1 stop4h 16m

Florence

Mon 8/24

3:22 pm-10:30 pm

1 stop7h 08m

$649

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Detroit to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Detroit to Florence, South Carolina flights?

You could potentially save up to 34% on your flight if you consider stops on a Detroit to Florence, South Carolina flight.

When to book flights from Detroit to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Florence, South Carolina (DTT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Florence, South Carolina

Fastest flight time

4h 16m

Direct flights

None
The fastest flight from Detroit to Florence, South Carolina takes 4h 16m
There are no direct flights from Detroit to Florence, South Carolina. There are no popular flight routes from Detroit to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Detroit to Florence, South Carolina

  • How far is Detroit to Florence by plane?

    The distance between Detroit and Florence is about 589.7 mi. Typically, this will take 4h 16m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit to Florence Airport?

    Prices for flights from Detroit to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Detroit to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Florence?

Once you have performed a search for Detroit to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 9/5
Sat 9/12
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States