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Cheap flights from Detroit to Florence from $304

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Florence departing on 2/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 5:50 pm
DTW
-
FLO
11h 35m
2 stops
American Airlines Logo
6:15 am - 12:16 pm
FLO
-
DTW
6h 01m
1 stop
$304American Airlines
Thu, Feb 19 - Tue, Feb 24
American Airlines Logo
6:15 am - 5:50 pm
DTW
-
FLO
11h 35m
2 stops
American Airlines Logo
6:15 am - 6:11 pm
FLO
-
DTW
11h 56m
2 stops
$310American Airlines
Thu, Feb 19 - Tue, Feb 24
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
6:15 am - 12:16 pm
FLO
-
DTW
6h 01m
1 stop
$346American Airlines
Thu, Feb 19 - Tue, Feb 24
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m
1 stop
American Airlines Logo
5:36 pm - 9:58 pm
FLO
-
DTW
4h 22m
1 stop
$409American Airlines
Fri, Feb 6 - Sun, Feb 8
American Airlines Logo
5:03 pm - 10:43 pm
DTW
-
FLO
5h 40m
1 stop
American Airlines Logo
6:15 am - 3:52 pm
FLO
-
DTW
9h 37m
2 stops
$414American Airlines
Fri, Feb 6 - Sun, Feb 8
American Airlines Logo
6:00 am - 5:09 pm
DTW
-
FLO
11h 09m
2 stops
American Airlines Logo
6:15 am - 3:31 pm
FLO
-
DTW
9h 16m
2 stops
$420American Airlines
Fri, Feb 6 - Sun, Feb 8
American Airlines Logo
1:08 pm - 5:09 pm
DTW
-
FLO
4h 01m
1 stop
American Airlines Logo
6:20 pm - 9:25 am
FLO
-
DTW
15h 05m
1 stop
$797American Airlines
Mon, Feb 9 - Fri, Feb 13
American Airlines Logo
10:46 am - 5:09 pm
DTW
-
FLO
6h 23m
2 stops
American Airlines Logo
6:20 pm - 9:25 am
FLO
-
DTW
15h 05m
1 stop
$802American Airlines
Mon, Feb 9 - Fri, Feb 13
American Airlines Logo
10:46 am - 5:09 pm
DTW
-
FLO
6h 23m
2 stops
American Airlines Logo
6:20 pm - 10:10 am
FLO
-
DTW
15h 50m
2 stops
$820American Airlines
Mon, Feb 9 - Fri, Feb 13

American Airlines flights from Detroit to Florence, South Carolina

Our best American Airlines deals on Detroit to Florence, South Carolina flight tickets
American Airlines
Feb 19
DTW6:15 amDetroit Metropolitan Wayne County
11h 35m
2 stops
FLO5:50 pmFlorence
Feb 24
FLO6:15 amFlorence
6h 01m
1 stop
DTW12:16 pmDetroit Metropolitan Wayne County
$304
American Airlines
Feb 19
DTW6:15 amDetroit Metropolitan Wayne County
11h 35m
2 stops
FLO5:50 pmFlorence
Feb 24
FLO6:15 amFlorence
11h 56m
2 stops
DTW6:11 pmDetroit Metropolitan Wayne County
$310
American Airlines
Feb 19
DTW11:55 amDetroit Metropolitan Wayne County
5h 55m
1 stop
FLO5:50 pmFlorence
Feb 24
FLO6:15 amFlorence
6h 01m
1 stop
DTW12:16 pmDetroit Metropolitan Wayne County
$346

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Detroit to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

6:15 am-5:50 pm

2 stops11h 35m

Florence

Tue 2/24

6:15 am-12:16 pm

1 stop6h 01m

$304

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

6:15 am-5:50 pm

2 stops11h 35m

Florence

Tue 2/24

6:15 am-6:11 pm

2 stops11h 56m

$310

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

11:55 am-5:50 pm

1 stop5h 55m

Florence

Tue 2/24

6:15 am-12:16 pm

1 stop6h 01m

$346

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 2/6

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Sun 2/8

5:36 pm-9:58 pm

1 stop4h 22m

$409

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 2/6

5:03 pm-10:43 pm

1 stop5h 40m

Florence

Sun 2/8

6:15 am-3:52 pm

2 stops9h 37m

$414

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 2/6

6:00 am-5:09 pm

2 stops11h 09m

Florence

Sun 2/8

6:15 am-3:31 pm

2 stops9h 16m

$420

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 2/9

1:08 pm-5:09 pm

1 stop4h 01m

Florence

Fri 2/13

6:20 pm-9:25 am

1 stop15h 05m

$797

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 2/9

10:46 am-5:09 pm

2 stops6h 23m

Florence

Fri 2/13

6:20 pm-9:25 am

1 stop15h 05m

$802

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 2/9

10:46 am-5:09 pm

2 stops6h 23m

Florence

Fri 2/13

6:20 pm-10:10 am

2 stops15h 50m

$820

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Detroit to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Detroit according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Detroit to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Florence, South Carolina (DTT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Florence, South Carolina

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Detroit to Florence, South Carolina takes 4h 02m
There are no direct flights from Detroit to Florence, South Carolina. There are no popular flight routes from Detroit to Florence, South Carolina.
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  • How far is Detroit to Florence by plane?

    The distance between Detroit and Florence is about 589.7 mi. Typically, this will take 4h 02m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit to Florence Airport?

    Prices for flights from Detroit to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Detroit to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Florence?

Once you have performed a search for Detroit to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Florence, South Carolina trip

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