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Cheap flights from Detroit to Florence from $303

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Florence departing on 2/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:13 pm - 11:58 pm
DTW
-
FLO
6h 45m1 stop
American Airlines Logo
6:18 pm - 12:43 am
FLO
-
DTW
6h 25m1 stop
$303American Airlines
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
4:30 pm - 11:58 pm
DTW
-
FLO
7h 28m2 stops
American Airlines Logo
6:18 pm - 10:52 pm
FLO
-
DTW
4h 34m1 stop
$308American Airlines
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
7:58 pm - 12:15 am
DTW
-
FLO
4h 17m1 stop
American Airlines Logo
6:30 pm - 10:34 pm
FLO
-
DTW
4h 04m1 stop
$335American Airlines
Tue, Dec 23 - Sat, Dec 27
American Airlines Logo
10:20 am - 5:45 pm
DTW
-
FLO
7h 25m2 stops
American Airlines Logo
5:15 am - 3:56 pm
FLO
-
DTW
10h 41m2 stops
$381American Airlines
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
12:48 pm - 12:15 am
DTW
-
FLO
11h 27m2 stops
American Airlines Logo
6:30 pm - 10:34 pm
FLO
-
DTW
4h 04m1 stop
$413American Airlines
Tue, Dec 23 - Sat, Dec 27
American Airlines Logo
6:00 am - 12:26 pm
DTW
-
FLO
6h 26m1 stop
American Airlines Logo
5:15 am - 9:21 am
FLO
-
DTW
4h 06m1 stop
$432American Airlines
Fri, Dec 19 - Tue, Dec 23
American Airlines Logo
11:12 am - 6:05 pm
DTW
-
FLO
6h 53m2 stops
American Airlines Logo
5:15 am - 9:21 am
FLO
-
DTW
4h 06m1 stop
$437American Airlines
Fri, Dec 19 - Tue, Dec 23
American Airlines Logo
5:11 pm - 12:15 am
DTW
-
FLO
7h 04m1 stop
American Airlines Logo
1:07 pm - 7:17 pm
FLO
-
DTW
6h 10m1 stop
$459American Airlines
Fri, Dec 19 - Fri, Dec 26
American Airlines Logo
7:58 pm - 12:15 am
DTW
-
FLO
4h 17m1 stop
American Airlines Logo
1:07 pm - 11:59 pm
FLO
-
DTW
10h 52m2 stops
$464American Airlines
Fri, Dec 19 - Fri, Dec 26
American Airlines Logo
12:48 pm - 12:15 am
DTW
-
FLO
11h 27m2 stops
American Airlines Logo
1:07 pm - 11:59 pm
FLO
-
DTW
10h 52m2 stops
$469American Airlines
Fri, Dec 19 - Fri, Dec 26

American Airlines flights from Detroit to Florence, South Carolina

Our best American Airlines deals on Detroit to Florence, South Carolina flight tickets
American Airlines
Feb 19
DTW5:13 pmDetroit Metropolitan Wayne County
6h 45m
1 stop
FLO11:58 pmFlorence
Feb 23
FLO6:18 pmFlorence
6h 25m
1 stop
DTW12:43 amDetroit Metropolitan Wayne County
$303
Find similar
American Airlines
Feb 19
DTW4:30 pmDetroit Metropolitan Wayne County
7h 28m
2 stops
FLO11:58 pmFlorence
Feb 23
FLO6:18 pmFlorence
4h 34m
1 stop
DTW10:52 pmDetroit Metropolitan Wayne County
$308
Find similar
American Airlines
Dec 23
DTW7:58 pmDetroit Metropolitan Wayne County
4h 17m
1 stop
FLO12:15 amFlorence
Dec 27
FLO6:30 pmFlorence
4h 04m
1 stop
DTW10:34 pmDetroit Metropolitan Wayne County
$335
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Detroit to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

5:13 pm-11:58 pm

1 stop6h 45m

Florence

Mon 2/23

6:18 pm-12:43 am

1 stop6h 25m

$303

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

4:30 pm-11:58 pm

2 stops7h 28m

Florence

Mon 2/23

6:18 pm-10:52 pm

1 stop4h 34m

$308

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 12/23

7:58 pm-12:15 am

1 stop4h 17m

Florence

Sat 12/27

6:30 pm-10:34 pm

1 stop4h 04m

$335

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

10:20 am-5:45 pm

2 stops7h 25m

Florence

Mon 2/23

5:15 am-3:56 pm

2 stops10h 41m

$381

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 12/23

12:48 pm-12:15 am

2 stops11h 27m

Florence

Sat 12/27

6:30 pm-10:34 pm

1 stop4h 04m

$413

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/19

6:00 am-12:26 pm

1 stop6h 26m

Florence

Tue 12/23

5:15 am-9:21 am

1 stop4h 06m

$432

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/19

11:12 am-6:05 pm

2 stops6h 53m

Florence

Tue 12/23

5:15 am-9:21 am

1 stop4h 06m

$437

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/19

5:11 pm-12:15 am

1 stop7h 04m

Florence

Fri 12/26

1:07 pm-7:17 pm

1 stop6h 10m

$459

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/19

7:58 pm-12:15 am

1 stop4h 17m

Florence

Fri 12/26

1:07 pm-11:59 pm

2 stops10h 52m

$464

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 12/19

12:48 pm-12:15 am

2 stops11h 27m

Florence

Fri 12/26

1:07 pm-11:59 pm

2 stops10h 52m

$469

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Detroit to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Detroit is on a Thursday. momondo users have found tickets for Thursday departures for as low as $360. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Detroit because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $387.

When to book flights from Detroit to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Florence, South Carolina (DTT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Florence, South Carolina

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Detroit to Florence, South Carolina takes 4h 17m
There are no direct flights from Detroit to Florence, South Carolina. There are no popular flight routes from Detroit to Florence, South Carolina.
Search flight deals

  • How far is Detroit to Florence by plane?

    The distance between Detroit and Florence is about 589.7 mi. Typically, this will take 4h 17m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit to Florence Airport?

    Prices for flights from Detroit to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Detroit to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Florence?

Once you have performed a search for Detroit to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Florence, South Carolina trip

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