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Cheap flights from Detroit to Florence from $271

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Florence departing on 6/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Detroit to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:41 am - 11:37 pm
DTW
-
FLO
12h 56m
2 stops
American Airlines Logo
2:35 pm - 7:18 pm
FLO
-
DTW
4h 43m
1 stop
$463American Airlines
Sat, Jul 18 - Sat, Jul 25
American Airlines Logo
7:58 pm - 11:37 pm
DTW
-
FLO
3h 39m
1 stop
American Airlines Logo
5:17 am - 9:17 am
FLO
-
DTW
4h 00m
1 stop
$511American Airlines
Sat, Jul 18 - Sat, Jul 25
American Airlines Logo
10:38 am - 11:37 pm
DTW
-
FLO
12h 59m
2 stops
American Airlines Logo
2:35 pm - 7:18 pm
FLO
-
DTW
4h 43m
1 stop
$540American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
9:30 am - 2:10 pm
DTW
-
FLO
4h 40m
1 stop
American Airlines Logo
5:17 am - 9:17 am
FLO
-
DTW
4h 00m
1 stop
$541American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
10:41 am - 11:37 pm
DTW
-
FLO
12h 56m
2 stops
American Airlines Logo
5:17 am - 5:35 pm
FLO
-
DTW
12h 18m
2 stops
$576American Airlines
Sat, Jul 18 - Sat, Jul 25
American Airlines Logo
10:00 am - 2:10 pm
DTW
-
FLO
4h 10m
1 stop
American Airlines Logo
3:22 pm - 10:30 pm
FLO
-
DTW
7h 08m
1 stop
$601American Airlines
Sun, Aug 2 - Wed, Aug 5
American Airlines Logo
10:38 am - 11:37 pm
DTW
-
FLO
12h 59m
2 stops
American Airlines Logo
3:22 pm - 10:30 pm
FLO
-
DTW
7h 08m
1 stop
$612American Airlines
Mon, Aug 3 - Wed, Aug 5
American Airlines Logo
7:58 pm - 11:37 pm
DTW
-
FLO
3h 39m
1 stop
American Airlines Logo
5:17 am - 9:17 am
FLO
-
DTW
4h 00m
1 stop
$619American Airlines
Sat, Jul 11 - Thu, Jul 16
American Airlines Logo
10:00 am - 2:10 pm
DTW
-
FLO
4h 10m
1 stop
American Airlines Logo
3:22 pm - 9:09 am
FLO
-
DTW
17h 47m
2 stops
$663American Airlines
Sun, Aug 2 - Wed, Aug 5
American Airlines Logo
6:49 am - 11:37 pm
DTW
-
FLO
16h 48m
2 stops
American Airlines Logo
5:17 am - 4:46 pm
FLO
-
DTW
11h 29m
2 stops
$667American Airlines
Sat, Jul 11 - Fri, Jul 17

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American Airlines flights from Detroit to Florence, South Carolina

Our best American Airlines deals on Detroit to Florence, South Carolina flight tickets
American Airlines
Jul 18
DTW10:41 amDetroit Metropolitan Wayne County
12h 56m
2 stops
FLO11:37 pmFlorence
Jul 25
FLO2:35 pmFlorence
4h 43m
1 stop
DTW7:18 pmDetroit Metropolitan Wayne County
$463
American Airlines
Jul 18
DTW7:58 pmDetroit Metropolitan Wayne County
3h 39m
1 stop
FLO11:37 pmFlorence
Jul 25
FLO5:17 amFlorence
4h 00m
1 stop
DTW9:17 amDetroit Metropolitan Wayne County
$511
American Airlines
Jul 7
DTW10:38 amDetroit Metropolitan Wayne County
12h 59m
2 stops
FLO11:37 pmFlorence
Jul 11
FLO2:35 pmFlorence
4h 43m
1 stop
DTW7:18 pmDetroit Metropolitan Wayne County
$540

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from Detroit to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 7/18

10:41 am-11:37 pm

2 stops12h 56m

Florence

Sat 7/25

2:35 pm-7:18 pm

1 stop4h 43m

$463
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 7/18

7:58 pm-11:37 pm

1 stop3h 39m

Florence

Sat 7/25

5:17 am-9:17 am

1 stop4h 00m

$511

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 7/7

10:38 am-11:37 pm

2 stops12h 59m

Florence

Sat 7/11

2:35 pm-7:18 pm

1 stop4h 43m

$540

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 7/7

9:30 am-2:10 pm

1 stop4h 40m

Florence

Sat 7/11

5:17 am-9:17 am

1 stop4h 00m

$541

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 7/18

10:41 am-11:37 pm

2 stops12h 56m

Florence

Sat 7/25

5:17 am-5:35 pm

2 stops12h 18m

$576

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 8/2

10:00 am-2:10 pm

1 stop4h 10m

Florence

Wed 8/5

3:22 pm-10:30 pm

1 stop7h 08m

$601

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 8/3

10:38 am-11:37 pm

2 stops12h 59m

Florence

Wed 8/5

3:22 pm-10:30 pm

1 stop7h 08m

$612

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 7/11

7:58 pm-11:37 pm

1 stop3h 39m

Florence

Thu 7/16

5:17 am-9:17 am

1 stop4h 00m

$619

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 8/2

10:00 am-2:10 pm

1 stop4h 10m

Florence

Wed 8/5

3:22 pm-9:09 am

2 stops17h 47m

$663

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 7/11

6:49 am-11:37 pm

2 stops16h 48m

Florence

Fri 7/17

5:17 am-4:46 pm

2 stops11h 29m

$667

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Detroit to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Detroit to Florence, South Carolina flights?

You could potentially save up to 34% on your flight if you consider stops on a Detroit to Florence, South Carolina flight.

When to book flights from Detroit to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Florence, South Carolina (DTT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Florence, South Carolina

Fastest flight time

4h 10m

Direct flights

None
The fastest flight from Detroit to Florence, South Carolina takes 4h 10m
There are no direct flights from Detroit to Florence, South Carolina. There are no popular flight routes from Detroit to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Detroit to Florence, South Carolina

  • How far is Detroit to Florence by plane?

    The distance between Detroit and Florence is about 589.7 mi. Typically, this will take 4h 10m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit to Florence Airport?

    Prices for flights from Detroit to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Detroit to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Florence?

Once you have performed a search for Detroit to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Florence, South Carolina trip

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