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Cheap flights from Des Moines to North Carolina from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to North Carolina departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to North Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:19 pm - 9:09 amDSM-CLT
11h 50m2 stops
Frontier Logo
5:49 pm - 7:03 pmCLT-DSM
26h 14m1 stop
$221Frontier
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Sun, Nov 23 - Thu, Dec 4
Frontier Logo
2:00 pm - 5:14 pmDSM-CLT
26h 14m2 stops
Frontier Logo
5:49 pm - 7:03 pmCLT-DSM
26h 14m1 stop
$227Frontier
Find Deal
Wed, Nov 26 - Thu, Dec 4
American Airlines Logo
2:38 pm - 9:42 pmDSM-AVL
6h 04m1 stop
American Airlines Logo
2:09 pm - 6:44 pmAVL-DSM
5h 35m1 stop
$249American Airlines
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Tue, Apr 28 - Sat, May 2
American Airlines Logo
2:38 pm - 9:42 pmDSM-AVL
6h 04m1 stop
American Airlines Logo
7:23 am - 1:04 pmAVL-DSM
6h 41m2 stops
$254American Airlines
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Tue, Apr 28 - Sat, May 2
Delta Logo
7:25 am - 4:28 pmDSM-ILM
8h 03m1 stop
Delta Logo
4:30 pm - 10:29 pmILM-DSM
6h 59m1 stop
$259Delta
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Tue, Apr 14 - Sat, Apr 18
Delta Logo
7:34 am - 4:19 pmDSM-TYS
7h 45m1 stop
Delta Logo
6:20 am - 10:17 amTYS-DSM
4h 57m1 stop
$271Delta
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Wed, Feb 18 - Sat, Feb 21
United Airlines Logo
8:00 am - 7:27 pmDSM-TYS
10h 27m2 stops
United Airlines Logo
6:45 am - 10:55 amTYS-DSM
5h 10m1 stop
$334United Airlines
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Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
1:35 pm - 11:15 pmDSM-RDU
8h 40m1 stop
United Airlines Logo
4:44 pm - 10:30 pmRDU-DSM
6h 46m1 stop
$341United Airlines
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Thu, Jan 15 - Mon, Jan 19
Southwest Logo
5:20 am - 12:50 pmDSM-RDU
6h 30m2 stops
Southwest Logo
11:55 am - 10:15 pmRDU-DSM
11h 20m2 stops
$357Southwest
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Thu, Jan 15 - Mon, Jan 19
Southwest Logo
5:20 am - 1:10 pmDSM-TYS
6h 50m2 stops
Southwest Logo
6:40 am - 1:30 pmTYS-DSM
7h 50m2 stops
$363Southwest
Find Deal
Sat, Apr 4 - Sat, Apr 11

Southwest flights from Des Moines to North Carolina

Our best Southwest deals on Des Moines to North Carolina flight tickets
Southwest
Jan 15
DSM5:20 amDes Moines
6h 30m
2 stops
RDU12:50 pmRaleigh-Durham
Jan 19
RDU11:55 amRaleigh-Durham
11h 20m
2 stops
DSM10:15 pmDes Moines
$357
Find similar
Southwest
Apr 4
DSM5:20 amDes Moines
6h 50m
2 stops
TYS1:10 pmKnoxville McGhee Tyson
Apr 11
TYS6:40 amKnoxville McGhee Tyson
7h 50m
2 stops
DSM1:30 pmDes Moines
$363
Find similar
Southwest
Dec 9
DSM8:20 amDes Moines
8h 20m
2 stops
CLT5:40 pmCharlotte Douglas
Dec 16
CLT8:30 amCharlotte Douglas
12h 25m
2 stops
DSM7:55 pmDes Moines
$371
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Frontier flights from Des Moines to North Carolina

Our best Frontier deals on Des Moines to North Carolina flight tickets
Frontier
Nov 23
DSM8:19 pmDes Moines
11h 50m
2 stops
CLT9:09 amCharlotte Douglas
Dec 4
CLT5:49 pmCharlotte Douglas
26h 14m
1 stop
DSM7:03 pmDes Moines
$221
Find similar
Frontier
Nov 26
DSM2:00 pmDes Moines
26h 14m
2 stops
CLT5:14 pmCharlotte Douglas
Dec 4
CLT5:49 pmCharlotte Douglas
26h 14m
1 stop
DSM7:03 pmDes Moines
$227
Find similar
Frontier
Nov 23
DSM8:19 pmDes Moines
11h 05m
2 stops
RDU8:24 amRaleigh-Durham
Nov 27
RDU5:20 pmRaleigh-Durham
26h 41m
1 stop
DSM7:01 pmDes Moines
$278
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sun 11/23

8:19 pm-9:09 am

2 stops11h 50m

Charlotte Douglas

Thu 12/4

5:49 pm-7:03 pm

1 stop26h 14m

$221

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 11/26

2:00 pm-5:14 pm

2 stops26h 14m

Charlotte Douglas

Thu 12/4

5:49 pm-7:03 pm

1 stop26h 14m

$227

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Tue 4/28

2:38 pm-9:42 pm

1 stop6h 04m

Asheville Regional

Sat 5/2

2:09 pm-6:44 pm

1 stop5h 35m

$249

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Tue 4/28

2:38 pm-9:42 pm

1 stop6h 04m

Asheville Regional

Sat 5/2

7:23 am-1:04 pm

2 stops6h 41m

$254

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Tue 4/14

7:25 am-4:28 pm

1 stop8h 03m

Wilmington New Hanover County

Sat 4/18

4:30 pm-10:29 pm

1 stop6h 59m

$259

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 2/18

7:34 am-4:19 pm

1 stop7h 45m

Knoxville McGhee Tyson

Sat 2/21

6:20 am-10:17 am

1 stop4h 57m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 1/23

8:00 am-7:27 pm

2 stops10h 27m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-10:55 am

1 stop5h 10m

$334

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 1/15

1:35 pm-11:15 pm

1 stop8h 40m

Raleigh-Durham

Mon 1/19

4:44 pm-10:30 pm

1 stop6h 46m

$341

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 1/15

5:20 am-12:50 pm

2 stops6h 30m

Raleigh-Durham

Mon 1/19

11:55 am-10:15 pm

2 stops11h 20m

$357

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 4/4

5:20 am-1:10 pm

2 stops6h 50m

Knoxville McGhee Tyson

Sat 4/11

6:40 am-1:30 pm

2 stops7h 50m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to North Carolina from

How to get the cheapest flight ticket from Des Moines to North Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to North Carolina?

If you don’t want to visit North Carolina in September, then you should wait until May to fly from Des Moines, when ticket prices are also cheap, with an average price of $330.

What is the cheapest day to depart on your flight to North Carolina?

The cheapest day to depart from Des Moines to North Carolina is on a Wednesday when prices can be found for as low as $327. The most expensive day to fly to North Carolina is Sunday, with ticket prices averaging around $461.

What is the cheapest time of day to depart on your flight to North Carolina?

The cheapest time of day to fly to North Carolina is in the morning when flights can be purchased for as low as $352. Try not to purchase tickets in the afternoon because they tend to be around $382. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to North Carolina flight route?

Fly from Des Moines to Charlotte Douglas for the best Des Moines - North Carolina flight prices

How far in advance should I book a flight to North Carolina?

You are more likely to see cheaper flights to North Carolina from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to North Carolina for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to North Carolina from Des Moines for as low as $299 on momondo.

What cabin class options are available on Des Moines to North Carolina flights?

There are 3 cabin classes available to choose from on Des Moines to North Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to North Carolina flights?

You could potentially save up to 35% on your flight if you consider stops on a Des Moines to North Carolina flight.

Cheap Des Moines to North Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to North Carolina

Best Price Found

$175

Fastest flight time

2h 16m

Direct flights

Every day

Airports in North Carolina

1 airport
The best one-way flight to North Carolina from Des Moines in the past 72 hours is $175. The best round-trip flight deal from Des Moines to North Carolina found on momondo in the last 72 hours is $348.
The fastest flight from Des Moines to North Carolina takes 2h 16m
Direct flights go from Des Moines to North Carolina every day.
There is 1 airport near North Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to North Carolina?

    Prices for flights from Des Moines Airport to North Carolina refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to North Carolina?

  • How old do you have to be to fly from Des Moines Airport to North Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to North Carolina.

  • What documentation or ID do you need to fly to North Carolina?

    The necessary travel and health documents for your North Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to North Carolina?

Best airlines flying from Des Moines to North Carolina

Compare and see reviews for airlines that fly from Des Moines to North Carolina with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $216Free CancellationRating
8.0
4,238 reviews
Search Southwest flights
DeltaPriceFrom $216Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
9,012 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to North Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to North Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to North Carolina with flexible booking policies on momondo?

Yes. All flights to North Carolina from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to North Carolina?

momondo provides multiple filters to help you find the best flight to North Carolina from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to North Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to North Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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