What is the cheapest airline that flies from Des Moines to North Carolina?

Delta, United Airlines, and Southwest are the most popular carriers operating from Des Moines to North Carolina

What airlines fly to North Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to North Carolina from Des Moines according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to North Carolina. Keep in mind that there are 4 different airlines that fly to North Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Des Moines to North Carolina on average per day?

The number of flights available between Des Moines and North Carolina is 2 per day as of July 2026. The most frequent departure time is 7:00AM, with 50% of daily flights leaving at noon.

How many flights depart from Des Moines to North Carolina on average per week?

18 flights are operational weekly from Des Moines to North Carolina as of July 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.

When did momondo last update prices for flights from Des Moines Airport to North Carolina?

Prices for flights from Des Moines Airport to North Carolina refresh daily.

How many operators does momondo search for flights from Des Moines Airport to North Carolina?

There are 4 operators available for flights from Des Moines Airport to North Carolina as of July 2026.

How old do you have to be to fly from Des Moines Airport to North Carolina?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to North Carolina.

What documentation or ID do you need to fly to North Carolina?

The necessary travel and health documents for your North Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$90 Cheap Flights from Des Moines to North Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to North Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:54 pm - 7:58 am

DSM

MYR

15h 04m

1 stop

8:35 am - 2:42 pm

MYR

DSM

7h 07m

1 stop

$223Multiple Airlines

Sun, Oct 11 - Thu, Oct 15

1:58 pm - 7:34 pm

DSM

TYS

28h 36m

1 stop

4:14 pm - 9:02 am

TYS

DSM

17h 48m

1 stop

$249Allegiant Air

Sun, Sep 27 - Wed, Sep 30

10:30 am - 6:17 pm

DSM

AVL

6h 47m

1 stop

5:34 pm - 11:25 pm

AVL

DSM

6h 51m

1 stop

$285American Airlines

Sat, Sep 5 - Tue, Sep 8

4:14 pm - 11:07 pm

DSM

AVL

5h 53m

1 stop

4:47 pm - 11:12 pm

AVL

DSM

7h 25m

1 stop

$285American Airlines

Sat, Sep 19 - Wed, Sep 23

6:54 pm - 11:55 pm

DSM

TYS

4h 01m

1 stop

11:45 am - 5:19 pm

TYS

DSM

6h 34m

1 stop

$287Delta

Mon, Sep 14 - Mon, Sep 21

6:35 pm - 11:52 pm

DSM

TYS

4h 17m

1 stop

5:00 pm - 10:37 pm

TYS

DSM

6h 37m

1 stop

$287Delta

Tue, Aug 25 - Sat, Aug 29

6:15 am - 1:20 pm

DSM

TYS

6h 05m

1 stop

6:02 pm - 9:23 pm

TYS

DSM

4h 21m

1 stop

$287United Airlines

Tue, Aug 25 - Sat, Aug 29

1:24 pm - 8:49 pm

DSM

TYS

6h 25m

1 stop

9:58 am - 5:23 pm

TYS

DSM

8h 25m

2 stops

$292United Airlines

Wed, Oct 21 - Wed, Oct 28

3:30 pm - 9:20 pm

DSM

CLT

4h 50m

1 stop

8:10 am - 11:30 am

CLT

DSM

4h 20m

1 stop

$321Southwest

Tue, Nov 10 - Thu, Nov 12

5:30 am - 12:20 pm

DSM

CLT

5h 50m

1 stop

8:05 am - 11:50 am

CLT

DSM

4h 45m

1 stop

$321Southwest

Sat, Sep 5 - Wed, Sep 9

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Frontier flights from Des Moines to North Carolina

Our best Frontier deals on Des Moines to North Carolina flight tickets

Frontier

Sep 24

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Oct 1

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$257

Frontier

Sep 24

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Sep 27

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$264

Frontier

Sep 13

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Sep 17

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$265

Southwest flights from Des Moines to North Carolina

Our best Southwest deals on Des Moines to North Carolina flight tickets

Southwest

Aug 25

DSM6:10 amDes Moines

7h 10m

2 stops

TYS2:20 pmKnoxville McGhee Tyson

Aug 29

TYS6:50 amKnoxville McGhee Tyson

8h 20m

2 stops

DSM2:10 pmDes Moines

$297

Southwest

Aug 29

DSM5:30 amDes Moines

5h 50m

1 stop

CLT12:20 pmCharlotte Douglas

Aug 31

CLT6:30 pmCharlotte Douglas

4h 40m

1 stop

DSM10:10 pmDes Moines

$321

Southwest

Aug 11

DSM7:15 amDes Moines

8h 15m

1 stop

TYS4:30 pmKnoxville McGhee Tyson

Aug 19

TYS12:45 pmKnoxville McGhee Tyson

10h 10m

2 stops

DSM9:55 pmDes Moines

$323

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sun 10/11

3:54 pm-7:58 am

1 stop15h 04m

Myrtle Beach Intl

Thu 10/15

8:35 am-2:42 pm

1 stop7h 07m

$223

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 9/27

1:58 pm-7:34 pm

1 stop28h 36m

Knoxville McGhee Tyson

Wed 9/30

4:14 pm-9:02 am

1 stop17h 48m

$249

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Sat 9/5

10:30 am-6:17 pm

1 stop6h 47m

Asheville Regional

Tue 9/8

5:34 pm-11:25 pm

1 stop6h 51m

$285

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Sat 9/19

4:14 pm-11:07 pm

1 stop5h 53m

Asheville Regional

Wed 9/23

4:47 pm-11:12 pm

1 stop7h 25m

$285

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 9/14

6:54 pm-11:55 pm

1 stop4h 01m

Knoxville McGhee Tyson

Mon 9/21

11:45 am-5:19 pm

1 stop6h 34m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:35 pm-11:52 pm

1 stop4h 17m

Knoxville McGhee Tyson

Sat 8/29

5:00 pm-10:37 pm

1 stop6h 37m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:15 am-1:20 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 8/29

6:02 pm-9:23 pm

1 stop4h 21m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 10/21

1:24 pm-8:49 pm

1 stop6h 25m

Knoxville McGhee Tyson

Wed 10/28

9:58 am-5:23 pm

2 stops8h 25m

$292

Quickest round-trip

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 11/10

3:30 pm-9:20 pm

1 stop4h 50m

Charlotte Douglas

Thu 11/12

8:10 am-11:30 am

1 stop4h 20m

$321

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 9/5

5:30 am-12:20 pm

1 stop5h 50m

Charlotte Douglas

Wed 9/9

8:05 am-11:50 am

1 stop4h 45m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to North Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to North Carolina?

If you don’t want to visit North Carolina in September, then you should wait until June to fly from Des Moines, when ticket prices are also cheap, with an average price of $381.

What is the cheapest Des Moines to North Carolina flight route?

Fly from Des Moines to Charlotte Douglas for the best Des Moines - North Carolina flight prices

What cabin class options are available on Des Moines to North Carolina flights?

There are 4 cabin classes available to choose from on Des Moines to North Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to North Carolina flights?

You could potentially save up to 65% on your flight if you consider stops on a Des Moines to North Carolina flight.

Cheap Des Moines to North Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to North Carolina

Best Price Found	$259
Fastest flight time	2h 20m
Direct flights	Every day
Airports in North Carolina	110 airports

The best one-way flight to North Carolina from Des Moines in the past 72 hours is $259. The best round-trip flight deal from Des Moines to North Carolina found on momondo in the last 72 hours is $389.

The fastest flight from Des Moines to North Carolina takes 2h 20m

Direct flights go from Des Moines to North Carolina every day.

There are 110 airports in North Carolina. From Des Moines there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Des Moines to North Carolina

When did momondo last update prices for flights from Des Moines Airport to North Carolina?
Prices for flights from Des Moines Airport to North Carolina refresh daily.
How many operators does momondo search for flights from Des Moines Airport to North Carolina?
There are 4 operators available for flights from Des Moines Airport to North Carolina as of July 2026.
How old do you have to be to fly from Des Moines Airport to North Carolina?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to North Carolina.
What documentation or ID do you need to fly to North Carolina?
The necessary travel and health documents for your North Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to North Carolina?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to North Carolina is Airbus A320-100/200, representing 46.36% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 20.00%, Airbus A319 at 9.09%, and Canadair (Bombardier) Regional Jet 900 at 7.27%.

Best airlines flying from Des Moines to North Carolina

Compare and see reviews for airlines that fly from Des Moines to North Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $236	Free Cancellation	Rating 7.8 8,486 reviews	Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.1 11,839 reviews	Search American Airlines flights
United Airlines	PriceFrom $268	Free Cancellation	Rating 7.4 10,052 reviews	Search United Airlines flights
Southwest	PriceFrom $309	Free Cancellation	Rating 8.0 4,228 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to North Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to North Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to North Carolina with flexible booking policies on momondo?

Yes. All flights to North Carolina from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to North Carolina?

momondo provides multiple filters to help you find the best flight to North Carolina from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to North Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to North Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.