Which layover airport offers the lowest fares from Des Moines to Harrisburg?

Flights via Chicago (ORD) offer the lowest average round-trip price of $443.

What is the cheapest airline that flies from Des Moines to Harrisburg?

Delta, United Airlines, and American Airlines are the most popular carriers operating from Des Moines to Harrisburg

Which layover airport has the shortest connection time from Des Moines to Harrisburg?

Detroit (DTW) has the shortest average layover time for this route: 1h 02m.

Which airport is the most popular layover for flights between Des Moines and Harrisburg?

Chicago (ORD) was the most common stop: 86% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Harrisburg?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Harrisburg from Des Moines according to our data. United Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Harrisburg. Keep in mind that there are 4 different airlines that fly to Harrisburg on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from Des Moines to Harrisburg?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 34m.

When did momondo last update prices for flights from Des Moines Airport to Harrisburg Airport?

Prices for flights from Des Moines Airport to Harrisburg Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Harrisburg Airport?

The number of operators available for flights from Des Moines Airport to Harrisburg Airport is 3 as of September 2026.

How old do you have to be to fly from Des Moines Airport to Harrisburg Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Harrisburg Airport.

What documentation or ID do you need to fly to Harrisburg Airport?

The travel and health documents you'll need for your trip to Harrisburg Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Harrisburg Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$274 Cheap Flights from Des Moines to Harrisburg in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Harrisburg

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:00 am - 1:27 pmDSM Des Moines-MDT Harrisburg

4h 27m1 stop Chicago O'Hare Intl

6:25 am - 10:30 amMDT Harrisburg-DSM Des Moines

5h 05m1 stop Chicago O'Hare Intl

$319United Airlines

Sat, Oct 10 - Sun, Oct 11

3:11 pm - 11:29 pmDSM Des Moines-MDT Harrisburg

7h 18m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:25 am - 10:30 amMDT Harrisburg-DSM Des Moines

5h 05m1 stop Chicago O'Hare Intl

$324United Airlines

Sat, Oct 10 - Sun, Oct 11

8:00 am - 1:30 pmDSM Des Moines-MDT Harrisburg

4h 30m1 stop Chicago O'Hare Intl

8:32 am - 12:27 pmMDT Harrisburg-DSM Des Moines

4h 55m1 stop Chicago O'Hare Intl

$399United Airlines

Sat, Jan 30 - Wed, Feb 3

5:50 pm - 10:58 pmDSM Des Moines-MDT Harrisburg

4h 08m1 stop Detroit Metropolitan Wayne County

6:13 am - 9:42 amMDT Harrisburg-DSM Des Moines

4h 29m1 stop Detroit Metropolitan Wayne County

$409Delta

Fri, Oct 9 - Sun, Oct 11

5:50 pm - 10:58 pmDSM Des Moines-MDT Harrisburg

4h 08m1 stop Detroit Metropolitan Wayne County

6:13 am - 9:42 amMDT Harrisburg-DSM Des Moines

4h 29m1 stop Detroit Metropolitan Wayne County

$409Delta

Fri, Oct 9 - Sun, Oct 11

5:50 pm - 10:58 pmDSM Des Moines-MDT Harrisburg

4h 08m1 stop Detroit Metropolitan Wayne County

6:13 am - 9:42 amMDT Harrisburg-DSM Des Moines

4h 29m1 stop Detroit Metropolitan Wayne County

$409Delta

Fri, Oct 9 - Sat, Oct 10

2:01 pm - 7:32 pmDSM Des Moines-MDT Harrisburg

4h 31m1 stop Chicago O'Hare Intl

8:09 pm - 12:14 amMDT Harrisburg-DSM Des Moines

5h 05m1 stop Chicago O'Hare Intl

$485American Airlines

Sat, Oct 10 - Mon, Oct 12

2:01 pm - 10:59 pmDSM Des Moines-MDT Harrisburg

7h 58m2 stops Chicago O'Hare Intl Philadelphia

8:09 pm - 12:14 amMDT Harrisburg-DSM Des Moines

5h 05m1 stop Chicago O'Hare Intl

$490American Airlines

Sat, Oct 10 - Mon, Oct 12

8:28 am - 4:24 pmDSM Des Moines-MDT Harrisburg

6h 56m1 stop Nashville Intl

8:39 pm - 2:26 pmMDT Harrisburg-DSM Des Moines

18h 47m1 stop Orlando Sanford Intl

$648Allegiant Air

Sun, Oct 11 - Sun, Oct 11

6:15 am - 8:26 pmDSM Des Moines-MDT Harrisburg

13h 11m1 stop Tampa St. Petersburg

8:39 pm - 7:30 pmMDT Harrisburg-DSM Des Moines

23h 51m2 stops Orlando Sanford Intl Denver Intl

$704Multiple Airlines

Fri, Oct 9 - Sun, Oct 11

Cheap last minute flights

Enter your travel dates to find the best prices.

6:00 am - 11:35 amDSM Des Moines-MDT Harrisburg

4h 35m1 stop Detroit Metropolitan Wayne County

6:10 am - 9:38 amMDT Harrisburg-DSM Des Moines

4h 28m1 stop Detroit Metropolitan Wayne County

$368Delta

Thu, Sep 10 - Sun, Sep 13

11:32 am - 4:52 pmDSM Des Moines-MDT Harrisburg

4h 20m1 stop Chicago O'Hare Intl

6:30 am - 10:31 amMDT Harrisburg-DSM Des Moines

5h 01m1 stop Chicago O'Hare Intl

$368United Airlines

Sun, Sep 6 - Sun, Sep 13

1:21 pm - 8:58 pmDSM Des Moines-MDT Harrisburg

6h 37m1 stop Chicago O'Hare Intl

6:15 am - 12:16 pmMDT Harrisburg-DSM Des Moines

7h 01m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$373United Airlines

Sun, Sep 6 - Sun, Sep 13

1:18 pm - 8:53 pmDSM Des Moines-MDT Harrisburg

6h 35m1 stop Chicago O'Hare Intl

6:30 am - 10:31 amMDT Harrisburg-DSM Des Moines

5h 01m1 stop Chicago O'Hare Intl

$424United Airlines

Sat, Sep 5 - Sun, Sep 13

6:00 am - 1:32 pmDSM Des Moines-MDT Harrisburg

6h 32m1 stop Chicago O'Hare Intl

6:30 am - 10:31 amMDT Harrisburg-DSM Des Moines

5h 01m1 stop Chicago O'Hare Intl

$424United Airlines

Sun, Sep 6 - Sun, Sep 13

1:18 pm - 8:53 pmDSM Des Moines-MDT Harrisburg

6h 35m1 stop Chicago O'Hare Intl

6:15 am - 2:20 pmMDT Harrisburg-DSM Des Moines

9h 05m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$429United Airlines

Sat, Sep 5 - Sun, Sep 13

1:08 pm - 7:45 pmDSM Des Moines-MDT Harrisburg

5h 37m1 stop Charlotte Douglas

12:59 pm - 7:48 pmMDT Harrisburg-DSM Des Moines

7h 49m1 stop Charlotte Douglas

$823American Airlines

Tue, Sep 8 - Fri, Sep 11

1:07 pm - 7:10 pmDSM Des Moines-MDT Harrisburg

5h 03m1 stop Philadelphia

8:30 am - 12:31 pmMDT Harrisburg-DSM Des Moines

5h 01m1 stop Philadelphia

$823American Airlines

Tue, Sep 8 - Thu, Sep 10

1:07 pm - 7:10 pmDSM Des Moines-MDT Harrisburg

5h 03m1 stop Philadelphia

8:30 am - 12:31 pmMDT Harrisburg-DSM Des Moines

5h 01m1 stop Philadelphia

$823American Airlines

Tue, Sep 8 - Thu, Sep 10

5:41 am - 11:45 amDSM Des Moines-MDT Harrisburg

5h 04m1 stop Philadelphia

7:00 am - 1:43 pmMDT Harrisburg-DSM Des Moines

7h 43m2 stops Boston Logan Intl Washington, D.C. Reagan-National

$828American Airlines

Tue, Sep 8 - Thu, Sep 10

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American Airlines flights from Des Moines to Harrisburg

Our best American Airlines deals on Des Moines to Harrisburg flight tickets

American Airlines

Sep 12

DSM6:00 amDes Moines

7h 10m

1 stop

MDT2:10 pmHarrisburg

Sep 13

MDT5:45 amHarrisburg

7h 46m

1 stop

DSM12:31 pmDes Moines

$454

American Airlines

Nov 15

DSM7:23 amDes Moines

5h 11m

1 stop

MDT1:34 pmHarrisburg

Nov 28

MDT7:55 pmHarrisburg

5h 24m

1 stop

DSM12:19 amDes Moines

$464

American Airlines

Oct 10

DSM2:01 pmDes Moines

4h 31m

1 stop

MDT7:32 pmHarrisburg

Oct 12

MDT8:09 pmHarrisburg

5h 05m

1 stop

DSM12:14 amDes Moines

$485

United Airlines flights from Des Moines to Harrisburg

Our best United Airlines deals on Des Moines to Harrisburg flight tickets

United Airlines

Oct 10

DSM8:00 amDes Moines

4h 27m

1 stop

MDT1:27 pmHarrisburg

Oct 11

MDT6:25 amHarrisburg

5h 05m

1 stop

DSM10:30 amDes Moines

$319

United Airlines

Oct 10

DSM3:11 pmDes Moines

7h 18m

2 stops

MDT11:29 pmHarrisburg

Oct 11

MDT6:25 amHarrisburg

5h 05m

1 stop

DSM10:30 amDes Moines

$324

United Airlines

Sep 6

DSM11:32 amDes Moines

4h 20m

1 stop

MDT4:52 pmHarrisburg

Sep 13

MDT6:30 amHarrisburg

5h 01m

1 stop

DSM10:31 amDes Moines

$368

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sat 10/10

8:00 am-1:27 pm

1 stop4h 27m

Harrisburg

Sun 10/11

6:25 am-10:30 am

1 stop5h 05m

$319

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sat 10/10

3:11 pm-11:29 pm

2 stops7h 18m

Harrisburg

Sun 10/11

6:25 am-10:30 am

1 stop5h 05m

$324

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sat 1/30

8:00 am-1:30 pm

1 stop4h 30m

Harrisburg

Wed 2/3

8:32 am-12:27 pm

1 stop4h 55m

$399

Quickest round-trip

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Fri 10/9

5:50 pm-10:58 pm

1 stop4h 08m

Harrisburg

Sun 10/11

6:13 am-9:42 am

1 stop4h 29m

$409

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Fri 10/9

5:50 pm-10:58 pm

1 stop4h 08m

Harrisburg

Sun 10/11

6:13 am-9:42 am

1 stop4h 29m

$409

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Fri 10/9

5:50 pm-10:58 pm

1 stop4h 08m

Harrisburg

Sat 10/10

6:13 am-9:42 am

1 stop4h 29m

$409

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sat 10/10

2:01 pm-7:32 pm

1 stop4h 31m

Harrisburg

Mon 10/12

8:09 pm-12:14 am

1 stop5h 05m

$485

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sat 10/10

2:01 pm-10:59 pm

2 stops7h 58m

Harrisburg

Mon 10/12

8:09 pm-12:14 am

1 stop5h 05m

$490

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Sun 10/11

8:28 am-4:24 pm

1 stop6h 56m

Harrisburg

Sun 10/11

8:39 pm-2:26 pm

1 stop18h 47m

$648

Des MoinesHarrisburg

DSM Des Moines - MDT Harrisburg

DSMMDT

Des Moines

Fri 10/9

6:15 am-8:26 pm

1 stop13h 11m

Harrisburg

Sun 10/11

8:39 pm-7:30 pm

2 stops23h 51m

$704

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Harrisburg

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Des Moines and Harrisburg?

Prices are currently typical for flights on this route.

Typical prices usually range from $318 to $406.
The lowest price recently found on this route was $319.

What is the cheapest month to fly to Harrisburg?

The month of October is, on average, the cheapest month to fly to Harrisburg from Des Moines, with most prices found around $293. If you aren’t able to travel to Harrisburg during the month of October, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $319.

When to book flights from Des Moines to Harrisburg

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Harrisburg according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Harrisburg (DSM to MDT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Harrisburg

Best Price Found	$274
Fastest flight time	4h 08m
Direct flights	None

The best one-way flight to Harrisburg from Des Moines in the past 72 hours is $274. The best round-trip flight deal from Des Moines to Harrisburg found on momondo in the last 72 hours is $319.

The fastest flight from Des Moines to Harrisburg takes 4h 08m

There are no direct flights from Des Moines to Harrisburg. There are no popular flight routes from Des Moines to Harrisburg.

Search flight deals

Frequently asked questions about flying from Des Moines to Harrisburg

How far is Des Moines to Harrisburg by plane?
The straight-line distance from Des Moines to Harrisburg is 876.7 mi. Flights usually cover this in 4h 08m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Harrisburg Airport?
Prices for flights from Des Moines Airport to Harrisburg Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Harrisburg Airport?
The number of operators available for flights from Des Moines Airport to Harrisburg Airport is 3 as of September 2026.
How old do you have to be to fly from Des Moines Airport to Harrisburg Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Harrisburg Airport.
What documentation or ID do you need to fly to Harrisburg Airport?
The travel and health documents you'll need for your trip to Harrisburg Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Harrisburg Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Harrisburg?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Harrisburg is United Airlines, representing 48% of all bookings. The subsequent popular airlines are American Airlines at 40% and Delta at 12%.

Best airlines flying from Des Moines to Harrisburg

Compare and see reviews for airlines that fly from Des Moines to Harrisburg with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $219	Free Cancellation	Rating 7.4 10,168 reviews	Search United Airlines flights
American Airlines	PriceFrom $246	Free Cancellation	Rating 7.1 12,043 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.8 8,559 reviews	Search Delta flights

Hershey

Carlisle

Mechanicsburg

Camp Hill

Hummelstown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Harrisburg?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Harrisburg from Des Moines.

Can I find flights from Des Moines to Harrisburg with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Harrisburg flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Harrisburg?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Harrisburg from Des Moines.

I’m not ready to book a flight from Des Moines to Harrisburg right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Harrisburg flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.