Which airport is the most popular layover for flights between Des Moines and Harrisburg?

Chicago (ORD) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to Harrisburg?

Flights via Detroit (DTW) offer the lowest average round-trip price of $248.

What airlines fly to Harrisburg?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Harrisburg from Des Moines according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Harrisburg. Keep in mind that there are 4 different airlines that fly to Harrisburg on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from Des Moines to Harrisburg?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 21m.

What is the cheapest airline that flies from Des Moines to Harrisburg?

United Airlines, Delta, and American Airlines are the most popular carriers operating from Des Moines to Harrisburg

Which layover airport has the shortest connection time from Des Moines to Harrisburg?

Chicago (ORD) has the shortest average layover time for this route: 0h 56m.

When did momondo last update prices for flights from Des Moines Airport to Harrisburg Airport?

Prices for flights from Des Moines Airport to Harrisburg Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Harrisburg Airport?

The number of operators available for flights from Des Moines Airport to Harrisburg Airport is 3 as of February 2026.

How old do you have to be to fly from Des Moines Airport to Harrisburg Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Harrisburg Airport.

What documentation or ID do you need to fly to Harrisburg Airport?

The travel and health documents you'll need for your trip to Harrisburg Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Harrisburg Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$268 Cheap Flights from Des Moines to Harrisburg in 2026

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Find the cheapest flights from Des Moines to Harrisburg

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:22 pm - 9:29 pm

DSM

MDT

5h 07m

1 stop

8:30 pm - 12:33 am

MDT

DSM

5h 03m

1 stop

$269United Airlines

Sat, Jun 13 - Mon, Jun 15

5:01 pm - 11:52 pm

DSM

MDT

5h 51m

1 stop

5:38 am - 10:26 am

MDT

DSM

5h 48m

1 stop

$289American Airlines

Sun, Apr 12 - Sun, Apr 19

8:00 am - 1:27 pm

DSM

MDT

4h 27m

1 stop

6:29 am - 10:53 am

MDT

DSM

5h 24m

1 stop

$349United Airlines

Sat, Feb 28 - Wed, Mar 4

8:00 am - 1:27 pm

DSM

MDT

4h 27m

1 stop

6:15 am - 2:27 pm

MDT

DSM

9h 12m

2 stops

$354United Airlines

Sat, Feb 28 - Wed, Mar 4

5:30 am - 4:44 pm

DSM

MDT

10h 14m

2 stops

6:15 am - 2:27 pm

MDT

DSM

9h 12m

2 stops

$359United Airlines

Sat, Feb 28 - Wed, Mar 4

1:10 pm - 9:18 pm

DSM

MDT

7h 08m

1 stop

6:15 am - 12:29 pm

MDT

DSM

7h 14m

1 stop

$389United Airlines

Sun, Mar 29 - Sun, Apr 5

3:24 pm - 8:56 pm

DSM

MDT

4h 32m

1 stop

5:40 pm - 9:41 pm

MDT

DSM

5h 01m

1 stop

$394United Airlines

Fri, Feb 27 - Tue, Mar 3

3:24 pm - 8:56 pm

DSM

MDT

4h 32m

1 stop

6:15 am - 4:22 pm

MDT

DSM

11h 07m

2 stops

$399United Airlines

Fri, Feb 27 - Tue, Mar 3

1:10 pm - 9:18 pm

DSM

MDT

7h 08m

1 stop

8:00 pm - 9:27 pm

MDT

DSM

26h 27m

1 stop

$419United Airlines

Tue, Apr 21 - Fri, Apr 24

1:10 pm - 11:28 pm

DSM

MDT

9h 18m

2 stops

8:00 pm - 9:27 pm

MDT

DSM

26h 27m

1 stop

$424United Airlines

Tue, Apr 21 - Fri, Apr 24

United Airlines flights from Des Moines to Harrisburg

Our best United Airlines deals on Des Moines to Harrisburg flight tickets

United Airlines

Jun 13

DSM3:22 pmDes Moines

5h 07m

1 stop

MDT9:29 pmHarrisburg

Jun 15

MDT8:30 pmHarrisburg

5h 03m

1 stop

DSM12:33 amDes Moines

$269

United Airlines

Feb 28

DSM8:00 amDes Moines

4h 27m

1 stop

MDT1:27 pmHarrisburg

Mar 4

MDT6:29 amHarrisburg

5h 24m

1 stop

DSM10:53 amDes Moines

$349

United Airlines

Feb 28

DSM8:00 amDes Moines

4h 27m

1 stop

MDT1:27 pmHarrisburg

Mar 4

MDT6:15 amHarrisburg

9h 12m

2 stops

DSM2:27 pmDes Moines

$354

Delta flights from Des Moines to Harrisburg

Our best Delta deals on Des Moines to Harrisburg flight tickets

Delta

Apr 21

DSM7:00 amDes Moines

9h 33m

2 stops

MDT5:33 pmHarrisburg

Apr 24

MDT12:13 pmHarrisburg

9h 36m

2 stops

DSM8:49 pmDes Moines

$1,565

Delta

Apr 21

DSM7:00 amDes Moines

7h 38m

2 stops

MDT3:38 pmHarrisburg

Apr 24

MDT12:13 pmHarrisburg

9h 36m

2 stops

DSM8:49 pmDes Moines

$1,749

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 6/13

3:22 pm-9:29 pm

1 stop5h 07m

Harrisburg

Mon 6/15

8:30 pm-12:33 am

1 stop5h 03m

$269

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sun 4/12

5:01 pm-11:52 pm

1 stop5h 51m

Harrisburg

Sun 4/19

5:38 am-10:26 am

1 stop5h 48m

$289

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 2/28

8:00 am-1:27 pm

1 stop4h 27m

Harrisburg

Wed 3/4

6:29 am-10:53 am

1 stop5h 24m

$349

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 2/28

8:00 am-1:27 pm

1 stop4h 27m

Harrisburg

Wed 3/4

6:15 am-2:27 pm

2 stops9h 12m

$354

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 2/28

5:30 am-4:44 pm

2 stops10h 14m

Harrisburg

Wed 3/4

6:15 am-2:27 pm

2 stops9h 12m

$359

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sun 3/29

1:10 pm-9:18 pm

1 stop7h 08m

Harrisburg

Sun 4/5

6:15 am-12:29 pm

1 stop7h 14m

$389

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 2/27

3:24 pm-8:56 pm

1 stop4h 32m

Harrisburg

Tue 3/3

5:40 pm-9:41 pm

1 stop5h 01m

$394

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 2/27

3:24 pm-8:56 pm

1 stop4h 32m

Harrisburg

Tue 3/3

6:15 am-4:22 pm

2 stops11h 07m

$399

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 4/21

1:10 pm-9:18 pm

1 stop7h 08m

Harrisburg

Fri 4/24

8:00 pm-9:27 pm

1 stop26h 27m

$419

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 4/21

1:10 pm-11:28 pm

2 stops9h 18m

Harrisburg

Fri 4/24

8:00 pm-9:27 pm

1 stop26h 27m

$424

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Harrisburg

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Harrisburg?

The month of October is, on average, the cheapest month to fly to Harrisburg from Des Moines, with most prices found around $248. If you aren’t able to travel to Harrisburg during the month of October, then flying in June is also cheap. Prices for this month can be found on momondo for an average of $278.

Can stopping save me money on Des Moines to Harrisburg flights?

You could potentially save up to 45% on your flight if you consider stops on a Des Moines to Harrisburg flight.

When to book flights from Des Moines to Harrisburg

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Harrisburg according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Harrisburg (DSM to MDT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Harrisburg

Fastest flight time	4h 23m
Direct flights	None

The fastest flight from Des Moines to Harrisburg takes 4h 23m

There are no direct flights from Des Moines to Harrisburg. There are no popular flight routes from Des Moines to Harrisburg.

Search flight deals

How far is Des Moines to Harrisburg by plane?
The straight-line distance from Des Moines to Harrisburg is 876.7 mi. Flights usually cover this in 4h 23m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Harrisburg Airport?
Prices for flights from Des Moines Airport to Harrisburg Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Harrisburg Airport?
The number of operators available for flights from Des Moines Airport to Harrisburg Airport is 3 as of February 2026.
How old do you have to be to fly from Des Moines Airport to Harrisburg Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Harrisburg Airport.
What documentation or ID do you need to fly to Harrisburg Airport?
The travel and health documents you'll need for your trip to Harrisburg Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Harrisburg Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Harrisburg?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Harrisburg is American Airlines, representing 42% of all bookings. The subsequent popular airlines are United Airlines at 32% and Delta at 26%.

Best airlines flying from Des Moines to Harrisburg

Compare and see reviews for airlines that fly from Des Moines to Harrisburg with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $219	Free Cancellation	Rating 7.4 9,289 reviews	Search United Airlines flights
American Airlines	PriceFrom $226	Free Cancellation	Rating 7.2 11,288 reviews	Search American Airlines flights
Delta	PriceFrom $248	Free Cancellation	Rating 7.9 8,203 reviews	Search Delta flights

Hershey

Carlisle

Mechanicsburg

Camp Hill

Hummelstown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Harrisburg?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Harrisburg from Des Moines.

Can I find flights from Des Moines to Harrisburg with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Harrisburg flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Harrisburg?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Harrisburg from Des Moines.

I’m not ready to book a flight from Des Moines to Harrisburg right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Harrisburg flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.