What airlines fly to Gainesville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. American Airlines is the first choice among our users, with 37% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

American Airlines and Delta are the most popular carriers operating from Des Moines to Gainesville Regional

When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?

As of September 2025, there is 1 operator available to choose from for flights from Des Moines Airport to Gainesville Regional Airport.

How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

What documentation or ID do you need to fly to Gainesville Regional Airport?

The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$264 Cheap Flights from Des Moines to Gainesville in 2025/26

1 adult

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Find the cheapest flights from Des Moines to Gainesville

Round-trip

One-way

Cheap round-trip flights

6:22 pm - 12:17 amDSM-GNV

4h 55m1 stop

1:46 pm - 5:42 pmGNV-DSM

4h 56m1 stop

$447American Airlines

Find Deal

lun., oct. 6 - lun., oct. 13

3:56 pm - 12:17 amDSM-GNV

7h 21m2 stops

1:46 pm - 5:42 pmGNV-DSM

4h 56m1 stop

$452American Airlines

Find Deal

lun., oct. 6 - lun., oct. 13

5:00 am - 1:16 pmDSM-GNV

7h 16m2 stops

1:46 pm - 8:11 pmGNV-DSM

7h 25m2 stops

$526American Airlines

Find Deal

lun., oct. 6 - lun., oct. 13

6:37 pm - 11:53 pmDSM-GNV

4h 16m1 stop

6:00 am - 10:39 amGNV-DSM

5h 39m1 stop

$592Delta

Find Deal

mar., dic. 23 - dom., dic. 28

6:15 am - 2:21 pmDSM-GNV

7h 06m2 stops

6:00 am - 10:39 amGNV-DSM

5h 39m1 stop

$797Delta

Find Deal

mar., dic. 23 - dom., dic. 28

Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets

Delta

Dec 23

DSM6:37 pmDes Moines

4h 16m

1 stop

GNV11:53 pmGainesville Regional

Dec 28

GNV6:00 amGainesville Regional

5h 39m

1 stop

DSM10:39 amDes Moines

$592

Find similar

Delta

Dec 23

DSM6:15 amDes Moines

7h 06m

2 stops

GNV2:21 pmGainesville Regional

Dec 28

GNV6:00 amGainesville Regional

5h 39m

1 stop

DSM10:39 amDes Moines

$797

Find similar

American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets

American Airlines

Oct 6

DSM6:22 pmDes Moines

4h 55m

1 stop

GNV12:17 amGainesville Regional

Oct 13

GNV1:46 pmGainesville Regional

4h 56m

1 stop

DSM5:42 pmDes Moines

$447

Find similar

American Airlines

Oct 6

DSM3:56 pmDes Moines

7h 21m

2 stops

GNV12:17 amGainesville Regional

Oct 13

GNV1:46 pmGainesville Regional

4h 56m

1 stop

DSM5:42 pmDes Moines

$452

Find similar

American Airlines

Oct 6

DSM5:00 amDes Moines

7h 16m

2 stops

GNV1:16 pmGainesville Regional

Oct 13

GNV1:46 pmGainesville Regional

7h 25m

2 stops

DSM8:11 pmDes Moines

$526

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

6:22 pm-12:17 am

1 stop4h 55m

Gainesville Regional

lun. 10/13

1:46 pm-5:42 pm

1 stop4h 56m

$447

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

3:56 pm-12:17 am

2 stops7h 21m

Gainesville Regional

lun. 10/13

1:46 pm-5:42 pm

1 stop4h 56m

$452

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

5:00 am-1:16 pm

2 stops7h 16m

Gainesville Regional

lun. 10/13

1:46 pm-8:11 pm

2 stops7h 25m

$526

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:37 pm-11:53 pm

1 stop4h 16m

Gainesville Regional

dom. 12/28

6:00 am-10:39 am

1 stop5h 39m

$592

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:15 am-2:21 pm

2 stops7h 06m

Gainesville Regional

dom. 12/28

6:00 am-10:39 am

1 stop5h 39m

$797

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

jue. 11/6

2:16 pm-10:26 pm

1 stop7h 10m

$264

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

jue. 11/6

2:19 pm-11:59 pm

2 stops8h 40m

$269

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:37 pm-11:53 pm

1 stop4h 16m

$329

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

vie. 11/7

12:54 pm-11:59 pm

2 stops10h 05m

$334

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:15 am-2:21 pm

2 stops7h 06m

$534

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Gainesville?

The cheapest day to depart on your flight to Gainesville is on a Wednesday when prices can be found for as low as $410. This is often the case because there is less demand to fly during this day of the week. Flights from Des Moines to Gainesville on a Friday will generally be more expensive and average around $651. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Gainesville?

At noon is the cheapest time of day to fly from Des Moines to Gainesville when you can find flight prices for as low as $428. Flying to Gainesville at noon is an ideal time because this is during off-peak travel hours. Flights to Gainesville are more costly in the morning, with an average ticket price of $716. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Direct flights	None

There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.

Search flight deals

How far is Des Moines to Gainesville Regional by plane?
A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 4h 16m.
When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?
Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?
As of September 2025, there is 1 operator available to choose from for flights from Des Moines Airport to Gainesville Regional Airport.
How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.
What documentation or ID do you need to fly to Gainesville Regional Airport?
The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Gainesville?
Based on momondo bookings for flights between Des Moines and Gainesville, the leading airline is Delta, making up 100% of the total bookings.

Best airlines flying from Des Moines to Gainesville

Compare and see reviews for airlines that fly from Des Moines to Gainesville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $422	Free Cancellation	Rating 7.9 7,957 reviews		Search Delta flights

Lake City

Alachua

Trenton

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Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.

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Cheap flights from Des Moines to Gainesville from $264

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 11/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from Des Moines to Gainesville

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American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets

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How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Gainesville?

What is the cheapest time of day to depart on your flight to Gainesville?

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

American Airlines and Delta are the most popular carriers operating from Des Moines to Gainesville Regional

What airlines fly to Gainesville?

When to book flights from Des Moines to Gainesville

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Direct flights

How far is Des Moines to Gainesville Regional by plane?

When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?

How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

What documentation or ID do you need to fly to Gainesville Regional Airport?

What is the most popular airline from Des Moines to Gainesville?

Best airlines flying from Des Moines to Gainesville

Compare and see reviews for airlines that fly from Des Moines to Gainesville with momondo

Traveling to a place near Gainesville?

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Gainesville?

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

An easier way to manage your Gainesville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Florida