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Cheap flights from Des Moines to Gainesville from $358

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:45 am - 12:22 pm
DSM
-
GNV
5h 37m
1 stop
Delta Logo
6:00 am - 10:14 am
GNV
-
DSM
5h 14m
1 stop
$419Delta
خ, سبتمبر 10 - س, سبتمبر 19
American Airlines Logo
5:00 am - 1:01 pm
DSM
-
GNV
7h 01m
2 stops
American Airlines Logo
5:18 pm - 11:07 pm
GNV
-
DSM
6h 49m
1 stop
$424American Airlines
خ, سبتمبر 10 - س, سبتمبر 19
American Airlines Logo
5:00 am - 4:22 pm
DSM
-
GNV
10h 22m
2 stops
American Airlines Logo
5:54 pm - 11:28 pm
GNV
-
DSM
6h 34m
2 stops
$429American Airlines
خ, سبتمبر 10 - س, سبتمبر 19
Delta Logo
5:45 am - 12:22 pm
DSM
-
GNV
5h 37m
1 stop
Delta Logo
6:00 am - 10:14 am
GNV
-
DSM
5h 14m
1 stop
$439Delta
خ, سبتمبر 10 - س, سبتمبر 19
Delta Logo
5:45 am - 12:22 pm
DSM
-
GNV
5h 37m
1 stop
Delta Logo
6:00 am - 10:14 am
GNV
-
DSM
5h 14m
1 stop
$458Delta
خ, سبتمبر 10 - س, سبتمبر 19
Delta Logo
5:45 am - 12:22 pm
DSM
-
GNV
5h 37m
1 stop
Delta Logo
4:59 pm - 10:26 pm
GNV
-
DSM
6h 27m
1 stop
$478Delta
خ, سبتمبر 10 - س, سبتمبر 19
American Airlines Logo
9:39 am - 4:49 pm
DSM
-
GNV
6h 10m
1 stop
American Airlines Logo
1:54 pm - 5:39 pm
GNV
-
DSM
4h 45m
1 stop
$481American Airlines
خ, سبتمبر 10 - س, سبتمبر 19
American Airlines Logo
11:09 am - 10:19 pm
DSM
-
GNV
10h 10m
2 stops
American Airlines Logo
5:14 pm - 11:59 pm
GNV
-
DSM
7h 45m
1 stop
$590American Airlines
خ, أبريل 30 - ح, مايو 10
American Airlines Logo
7:05 am - 2:41 pm
DSM
-
GNV
6h 36m
1 stop
American Airlines Logo
6:30 am - 1:11 pm
GNV
-
DSM
7h 41m
1 stop
$610American Airlines
ر, أبريل 22 - ح, أبريل 26
American Airlines Logo
5:44 am - 5:17 pm
DSM
-
GNV
10h 33m
2 stops
American Airlines Logo
6:30 am - 1:11 pm
GNV
-
DSM
7h 41m
1 stop
$615American Airlines
ر, أبريل 22 - ح, أبريل 26

American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets
American Airlines
Sep 10
DSM5:00 amDes Moines
7h 01m
2 stops
GNV1:01 pmGainesville Regional
Sep 19
GNV5:18 pmGainesville Regional
6h 49m
1 stop
DSM11:07 pmDes Moines
$424
American Airlines
Sep 10
DSM5:00 amDes Moines
10h 22m
2 stops
GNV4:22 pmGainesville Regional
Sep 19
GNV5:54 pmGainesville Regional
6h 34m
2 stops
DSM11:28 pmDes Moines
$429
American Airlines
Sep 10
DSM9:39 amDes Moines
6h 10m
1 stop
GNV4:49 pmGainesville Regional
Sep 19
GNV1:54 pmGainesville Regional
4h 45m
1 stop
DSM5:39 pmDes Moines
$481

Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets
Delta
Sep 10
DSM5:45 amDes Moines
5h 37m
1 stop
GNV12:22 pmGainesville Regional
Sep 19
GNV6:00 amGainesville Regional
5h 14m
1 stop
DSM10:14 amDes Moines
$419
Delta
Sep 10
DSM5:45 amDes Moines
5h 37m
1 stop
GNV12:22 pmGainesville Regional
Sep 19
GNV6:00 amGainesville Regional
5h 14m
1 stop
DSM10:14 amDes Moines
$439
Delta
Sep 10
DSM5:45 amDes Moines
5h 37m
1 stop
GNV12:22 pmGainesville Regional
Sep 19
GNV6:00 amGainesville Regional
5h 14m
1 stop
DSM10:14 amDes Moines
$458

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated أبريل 9, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

س 9/19

6:00 am-10:14 am

1 stop5h 14m

$419

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:00 am-1:01 pm

2 stops7h 01m

Gainesville Regional

س 9/19

5:18 pm-11:07 pm

1 stop6h 49m

$424

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:00 am-4:22 pm

2 stops10h 22m

Gainesville Regional

س 9/19

5:54 pm-11:28 pm

2 stops6h 34m

$429

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

س 9/19

6:00 am-10:14 am

1 stop5h 14m

$439

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

س 9/19

6:00 am-10:14 am

1 stop5h 14m

$458

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

س 9/19

4:59 pm-10:26 pm

1 stop6h 27m

$478

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 9/10

9:39 am-4:49 pm

1 stop6h 10m

Gainesville Regional

س 9/19

1:54 pm-5:39 pm

1 stop4h 45m

$481

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

خ 4/30

11:09 am-10:19 pm

2 stops10h 10m

Gainesville Regional

ح 5/10

5:14 pm-11:59 pm

1 stop7h 45m

$590

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

ر 4/22

7:05 am-2:41 pm

1 stop6h 36m

Gainesville Regional

ح 4/26

6:30 am-1:11 pm

1 stop7h 41m

$610

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

ر 4/22

5:44 am-5:17 pm

2 stops10h 33m

Gainesville Regional

ح 4/26

6:30 am-1:11 pm

1 stop7h 41m

$615

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

Delta and American Airlines are the most popular carriers operating from Des Moines to Gainesville Regional

What airlines fly to Gainesville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. American Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Fastest flight time

5h 37m

Direct flights

None
The fastest flight from Des Moines to Gainesville takes 5h 37m
There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.
Search flight deals

Frequently asked questions about flying from Des Moines to Gainesville

  • How far is Des Moines to Gainesville Regional by plane?

    A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 5h 37m.

  • When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

    Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua
Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.

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