What airlines fly to Gainesville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?

As of November 2025, there is 1 operator available to choose from for flights from Des Moines Airport to Gainesville Regional Airport.

How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

What documentation or ID do you need to fly to Gainesville Regional Airport?

The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$273 Cheap Flights from Des Moines to Gainesville in 2025/26

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Find the cheapest flights from Des Moines to Gainesville

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Cheap round-trip flights

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5:35 am - 12:52 pmDSM-GNV

6h 17m1 stop

6:00 am - 12:15 pmGNV-DSM

7h 15m1 stop

$337Delta

Find Deal

Mon, Nov 24 - Thu, Nov 27

2:07 pm - 10:40 pmDSM-GNV

7h 33m1 stop

6:35 am - 4:24 pmGNV-DSM

10h 49m2 stops

$342American Airlines

Find Deal

Wed, Dec 31 - Tue, Jan 6

5:35 am - 12:52 pmDSM-GNV

6h 17m1 stop

6:00 am - 12:15 pmGNV-DSM

7h 15m1 stop

$386Delta

Find Deal

Wed, Nov 19 - Thu, Nov 27

6:17 am - 3:01 pmDSM-GNV

7h 44m2 stops

6:00 am - 12:15 pmGNV-DSM

7h 15m1 stop

$391Delta

Find Deal

Wed, Nov 19 - Thu, Nov 27

6:30 pm - 11:59 pmDSM-GNV

4h 29m1 stop

6:45 am - 12:28 pmGNV-DSM

6h 43m1 stop

$392Delta

Find Deal

Tue, Dec 23 - Thu, Jan 1

1:09 pm - 11:59 pmDSM-GNV

9h 50m2 stops

6:35 am - 5:06 pmGNV-DSM

11h 31m2 stops

$422American Airlines

Find Deal

Wed, Dec 31 - Tue, Jan 6

4:00 pm - 10:53 pmDSM-GNV

5h 53m1 stop

6:00 am - 5:06 pmGNV-DSM

12h 06m2 stops

$426American Airlines

Find Deal

Thu, Jan 15 - Sun, Jan 18

1:16 pm - 11:57 pmDSM-GNV

9h 41m2 stops

6:35 am - 4:24 pmGNV-DSM

10h 49m2 stops

$431American Airlines

Find Deal

Thu, Jan 15 - Sun, Jan 18

11:28 am - 6:19 pmDSM-GNV

5h 51m1 stop

6:00 am - 12:15 pmGNV-DSM

7h 15m1 stop

$432Delta

Find Deal

Sun, Nov 23 - Thu, Nov 27

6:30 pm - 11:59 pmDSM-GNV

4h 29m1 stop

6:00 am - 10:38 amGNV-DSM

5h 38m1 stop

$434Delta

Find Deal

Tue, Dec 23 - Mon, Dec 29

American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets

American Airlines

Dec 31

DSM2:07 pmDes Moines

7h 33m

1 stop

GNV10:40 pmGainesville Regional

Jan 6

GNV6:35 amGainesville Regional

10h 49m

2 stops

DSM4:24 pmDes Moines

$342

Find similar

American Airlines

Dec 31

DSM1:09 pmDes Moines

9h 50m

2 stops

GNV11:59 pmGainesville Regional

Jan 6

GNV6:35 amGainesville Regional

11h 31m

2 stops

DSM5:06 pmDes Moines

$422

Find similar

American Airlines

Jan 15

DSM4:00 pmDes Moines

5h 53m

1 stop

GNV10:53 pmGainesville Regional

Jan 18

GNV6:00 amGainesville Regional

12h 06m

2 stops

DSM5:06 pmDes Moines

$426

Find similar

Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets

Delta

Nov 24

DSM5:35 amDes Moines

6h 17m

1 stop

GNV12:52 pmGainesville Regional

Nov 27

GNV6:00 amGainesville Regional

7h 15m

1 stop

DSM12:15 pmDes Moines

$337

Find similar

Delta

Nov 19

DSM5:35 amDes Moines

6h 17m

1 stop

GNV12:52 pmGainesville Regional

Nov 27

GNV6:00 amGainesville Regional

7h 15m

1 stop

DSM12:15 pmDes Moines

$386

Find similar

Delta

Nov 19

DSM6:17 amDes Moines

7h 44m

2 stops

GNV3:01 pmGainesville Regional

Nov 27

GNV6:00 amGainesville Regional

7h 15m

1 stop

DSM12:15 pmDes Moines

$391

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Mon 11/24

5:35 am-12:52 pm

1 stop6h 17m

Gainesville Regional

Thu 11/27

6:00 am-12:15 pm

1 stop7h 15m

$337

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 12/31

2:07 pm-10:40 pm

1 stop7h 33m

Gainesville Regional

Tue 1/6

6:35 am-4:24 pm

2 stops10h 49m

$342

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 11/19

5:35 am-12:52 pm

1 stop6h 17m

Gainesville Regional

Thu 11/27

6:00 am-12:15 pm

1 stop7h 15m

$386

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 11/19

6:17 am-3:01 pm

2 stops7h 44m

Gainesville Regional

Thu 11/27

6:00 am-12:15 pm

1 stop7h 15m

$391

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 12/23

6:30 pm-11:59 pm

1 stop4h 29m

Gainesville Regional

Thu 1/1

6:45 am-12:28 pm

1 stop6h 43m

$392

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 12/31

1:09 pm-11:59 pm

2 stops9h 50m

Gainesville Regional

Tue 1/6

6:35 am-5:06 pm

2 stops11h 31m

$422

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 1/15

4:00 pm-10:53 pm

1 stop5h 53m

Gainesville Regional

Sun 1/18

6:00 am-5:06 pm

2 stops12h 06m

$426

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 1/15

1:16 pm-11:57 pm

2 stops9h 41m

Gainesville Regional

Sun 1/18

6:35 am-4:24 pm

2 stops10h 49m

$431

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 11/23

11:28 am-6:19 pm

1 stop5h 51m

Gainesville Regional

Thu 11/27

6:00 am-12:15 pm

1 stop7h 15m

$432

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 12/23

6:30 pm-11:59 pm

1 stop4h 29m

Gainesville Regional

Mon 12/29

6:00 am-10:38 am

1 stop5h 38m

$434

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Gainesville?

The cheapest day to depart on your flight to Gainesville is on a Wednesday when prices can be found for as low as $410. This is often the case because there is less demand to fly during this day of the week. Flights from Des Moines to Gainesville on a Friday will generally be more expensive and average around $651. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Gainesville?

At noon is the cheapest time of day to fly from Des Moines to Gainesville when you can find flight prices for as low as $428. Flying to Gainesville at noon is an ideal time because this is during off-peak travel hours. Flights to Gainesville are more costly in the morning, with an average ticket price of $716. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Direct flights	None

There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.

Search flight deals

How far is Des Moines to Gainesville Regional by plane?
A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 4h 29m.
When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?
Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?
As of November 2025, there is 1 operator available to choose from for flights from Des Moines Airport to Gainesville Regional Airport.
How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.
What documentation or ID do you need to fly to Gainesville Regional Airport?
The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Gainesville?
Based on momondo bookings for flights between Des Moines and Gainesville, the leading airline is Delta, making up 100% of the total bookings.

Best airlines flying from Des Moines to Gainesville

Compare and see reviews for airlines that fly from Des Moines to Gainesville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $336	Free Cancellation	Rating 7.9 8,001 reviews		Search Delta flights

Lake City

Alachua

Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.