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Cheap flights from Des Moines to Gainesville from $353

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:30 pm - 9:50 pmDSM  Des Moines-GNV Gainesville Regional
7h 20m1 stop Charlotte Douglas
American Airlines Logo
7:33 am - 12:04 pmGNV  Gainesville Regional-DSM Des Moines
5h 31m1 stop Charlotte Douglas
$387American Airlines
Sat, Sep 19 - Wed, Sep 23
American Airlines Logo
1:30 pm - 9:50 pmDSM  Des Moines-GNV Gainesville Regional
7h 20m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 3:10 pmGNV  Gainesville Regional-DSM Des Moines
10h 10m2 stops Miami Dallas/Fort Worth
$412American Airlines
Sat, Sep 19 - Wed, Sep 23
Delta Logo
5:45 am - 12:39 pmDSM  Des Moines-GNV Gainesville Regional
5h 54m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:18 am - 3:15 pmGNV  Gainesville Regional-DSM Des Moines
5h 57m1 stop Atlanta Hartsfield-Jackson
$432Delta
Thu, Sep 10 - Sat, Sep 19
Delta Logo
5:45 am - 12:39 pmDSM  Des Moines-GNV Gainesville Regional
5h 54m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:05 am - 2:06 pmGNV  Gainesville Regional-DSM Des Moines
9h 01m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$437Delta
Thu, Sep 10 - Sat, Sep 19
Delta Logo
4:07 pm - 9:35 pmDSM  Des Moines-GNV Gainesville Regional
4h 28m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:33 pm - 8:49 pmGNV  Gainesville Regional-DSM Des Moines
8h 16m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County
$447Delta
Sat, Oct 17 - Wed, Oct 21
Delta Logo
12:25 pm - 9:35 pmDSM  Des Moines-GNV Gainesville Regional
8h 10m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson
Delta Logo
1:33 pm - 8:49 pmGNV  Gainesville Regional-DSM Des Moines
8h 16m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County
$452Delta
Sat, Oct 17 - Wed, Oct 21
American Airlines Logo
1:15 pm - 11:59 pmDSM  Des Moines-GNV Gainesville Regional
9h 44m2 stops Philadelphia Miami
American Airlines Logo
6:15 am - 10:42 amGNV  Gainesville Regional-DSM Des Moines
5h 27m1 stop Charlotte Douglas
$492American Airlines
Sat, Oct 17 - Wed, Oct 21
American Airlines Logo
4:14 pm - 11:14 pmDSM  Des Moines-GNV Gainesville Regional
6h 00m1 stop Dallas/Fort Worth
American Airlines Logo
5:18 pm - 11:12 pmGNV  Gainesville Regional-DSM Des Moines
6h 54m1 stop Dallas/Fort Worth
$543American Airlines
Thu, Sep 24 - Mon, Sep 28
American Airlines Logo
10:35 am - 11:25 pmDSM  Des Moines-GNV Gainesville Regional
11h 50m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
7:33 am - 5:27 pmGNV  Gainesville Regional-DSM Des Moines
10h 54m2 stops Charlotte Douglas Chicago O'Hare Intl
$544American Airlines
Thu, Sep 10 - Sat, Sep 19
American Airlines Logo
6:00 am - 3:58 pmDSM  Des Moines-GNV Gainesville Regional
8h 58m2 stops Philadelphia Charlotte Douglas
American Airlines Logo
7:33 am - 7:07 pmGNV  Gainesville Regional-DSM Des Moines
12h 34m2 stops Charlotte Douglas New York LaGuardia
$546American Airlines
Thu, Sep 10 - Sat, Sep 19

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American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets
American Airlines
Sep 19
DSM1:30 pmDes Moines
7h 20m
1 stop
GNV9:50 pmGainesville Regional
Sep 23
GNV7:33 amGainesville Regional
5h 31m
1 stop
DSM12:04 pmDes Moines
$387
American Airlines
Sep 19
DSM1:30 pmDes Moines
7h 20m
1 stop
GNV9:50 pmGainesville Regional
Sep 23
GNV6:00 amGainesville Regional
10h 10m
2 stops
DSM3:10 pmDes Moines
$412
American Airlines
Oct 17
DSM1:15 pmDes Moines
9h 44m
2 stops
GNV11:59 pmGainesville Regional
Oct 21
GNV6:15 amGainesville Regional
5h 27m
1 stop
DSM10:42 amDes Moines
$492

Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets
Delta
Sep 10
DSM5:45 amDes Moines
5h 54m
1 stop
GNV12:39 pmGainesville Regional
Sep 19
GNV10:18 amGainesville Regional
5h 57m
1 stop
DSM3:15 pmDes Moines
$432
Delta
Sep 10
DSM5:45 amDes Moines
5h 54m
1 stop
GNV12:39 pmGainesville Regional
Sep 19
GNV6:05 amGainesville Regional
9h 01m
2 stops
DSM2:06 pmDes Moines
$437
Delta
Oct 17
DSM4:07 pmDes Moines
4h 28m
1 stop
GNV9:35 pmGainesville Regional
Oct 21
GNV1:33 pmGainesville Regional
8h 16m
2 stops
DSM8:49 pmDes Moines
$447

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Sat 9/19

1:30 pm-9:50 pm

1 stop7h 20m

Gainesville Regional

Wed 9/23

7:33 am-12:04 pm

1 stop5h 31m

$387

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Sat 9/19

1:30 pm-9:50 pm

1 stop7h 20m

Gainesville Regional

Wed 9/23

6:00 am-3:10 pm

2 stops10h 10m

$412
Quickest round-trip

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Thu 9/10

5:45 am-12:39 pm

1 stop5h 54m

Gainesville Regional

Sat 9/19

10:18 am-3:15 pm

1 stop5h 57m

$432

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Thu 9/10

5:45 am-12:39 pm

1 stop5h 54m

Gainesville Regional

Sat 9/19

6:05 am-2:06 pm

2 stops9h 01m

$437

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Sat 10/17

4:07 pm-9:35 pm

1 stop4h 28m

Gainesville Regional

Wed 10/21

1:33 pm-8:49 pm

2 stops8h 16m

$447

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Sat 10/17

12:25 pm-9:35 pm

2 stops8h 10m

Gainesville Regional

Wed 10/21

1:33 pm-8:49 pm

2 stops8h 16m

$452

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Sat 10/17

1:15 pm-11:59 pm

2 stops9h 44m

Gainesville Regional

Wed 10/21

6:15 am-10:42 am

1 stop5h 27m

$492

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Thu 9/24

4:14 pm-11:14 pm

1 stop6h 00m

Gainesville Regional

Mon 9/28

5:18 pm-11:12 pm

1 stop6h 54m

$543

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Thu 9/10

10:35 am-11:25 pm

2 stops11h 50m

Gainesville Regional

Sat 9/19

7:33 am-5:27 pm

2 stops10h 54m

$544

Des MoinesGainesville

DSM Des Moines - GNV Gainesville Regional

DSMGNV

Des Moines

Thu 9/10

6:00 am-3:58 pm

2 stops8h 58m

Gainesville Regional

Sat 9/19

7:33 am-7:07 pm

2 stops12h 34m

$546

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

American Airlines is the most popular carrier operating from Des Moines to Gainesville Regional

What airlines fly to Gainesville?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. Allegiant Air is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Des Moines to Gainesville takes 4h 28m
There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.
Search flight deals

Frequently asked questions about flying from Des Moines to Gainesville

  • How far is Des Moines to Gainesville Regional by plane?

    A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 4h 28m.

  • When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

    Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.

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