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Cheap flights from Des Moines to Gainesville from $314

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:00 pm - 9:28 pm
DSM
-
GNV
6h 28m
1 stop
American Airlines Logo
3:09 pm - 9:59 pm
GNV
-
DSM
7h 50m
1 stop
$337American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
1:48 pm - 11:59 pm
DSM
-
GNV
9h 11m
2 stops
American Airlines Logo
3:09 pm - 9:59 pm
GNV
-
DSM
7h 50m
1 stop
$342American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
6:00 am - 2:41 pm
DSM
-
GNV
7h 41m
2 stops
American Airlines Logo
5:47 pm - 10:18 pm
GNV
-
DSM
5h 31m
1 stop
$426American Airlines
Fri, Apr 17 - Mon, Apr 20
American Airlines Logo
3:26 pm - 11:00 pm
DSM
-
GNV
6h 34m
1 stop
American Airlines Logo
6:24 am - 1:17 pm
GNV
-
DSM
7h 53m
1 stop
$435American Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
1:38 pm - 11:59 pm
DSM
-
GNV
9h 21m
2 stops
American Airlines Logo
6:24 am - 1:17 pm
GNV
-
DSM
7h 53m
1 stop
$440American Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
2:44 pm - 10:39 pm
DSM
-
GNV
6h 55m
1 stop
Delta Logo
7:03 pm - 10:34 pm
GNV
-
DSM
4h 31m
1 stop
$470Delta
Fri, Apr 17 - Mon, Apr 20
American Airlines Logo
1:48 pm - 11:59 pm
DSM
-
GNV
9h 11m
2 stops
American Airlines Logo
6:00 am - 1:05 pm
GNV
-
DSM
8h 05m
2 stops
$472American Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
2:33 pm - 10:44 pm
DSM
-
GNV
7h 11m
1 stop
Delta Logo
6:40 am - 11:03 am
GNV
-
DSM
5h 23m
1 stop
$480Delta
Fri, May 8 - Sun, May 10
American Airlines Logo
11:17 am - 11:59 pm
DSM
-
GNV
11h 42m
2 stops
American Airlines Logo
11:29 am - 9:39 pm
GNV
-
DSM
11h 10m
2 stops
$494American Airlines
Tue, Mar 24 - Sat, Mar 28
Delta Logo
6:19 am - 6:13 pm
DSM
-
GNV
10h 54m
2 stops
Delta Logo
7:00 pm - 10:28 pm
GNV
-
DSM
4h 28m
1 stop
$496Delta
Wed, Feb 25 - Sun, Mar 1

Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets
Delta
Apr 17
DSM2:44 pmDes Moines
6h 55m
1 stop
GNV10:39 pmGainesville Regional
Apr 20
GNV7:03 pmGainesville Regional
4h 31m
1 stop
DSM10:34 pmDes Moines
$470
Delta
May 8
DSM2:33 pmDes Moines
7h 11m
1 stop
GNV10:44 pmGainesville Regional
May 10
GNV6:40 amGainesville Regional
5h 23m
1 stop
DSM11:03 amDes Moines
$480
Delta
Feb 18
DSM5:15 pmDes Moines
4h 19m
1 stop
GNV10:34 pmGainesville Regional
Feb 23
GNV7:00 pmGainesville Regional
4h 28m
1 stop
DSM10:28 pmDes Moines
$481

American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets
American Airlines
Mar 24
DSM2:00 pmDes Moines
6h 28m
1 stop
GNV9:28 pmGainesville Regional
Mar 28
GNV3:09 pmGainesville Regional
7h 50m
1 stop
DSM9:59 pmDes Moines
$337
American Airlines
Mar 24
DSM1:48 pmDes Moines
9h 11m
2 stops
GNV11:59 pmGainesville Regional
Mar 28
GNV3:09 pmGainesville Regional
7h 50m
1 stop
DSM9:59 pmDes Moines
$342
American Airlines
Apr 17
DSM6:00 amDes Moines
7h 41m
2 stops
GNV2:41 pmGainesville Regional
Apr 20
GNV5:47 pmGainesville Regional
5h 31m
1 stop
DSM10:18 pmDes Moines
$426

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 3/24

2:00 pm-9:28 pm

1 stop6h 28m

Gainesville Regional

Sat 3/28

3:09 pm-9:59 pm

1 stop7h 50m

$337

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 3/24

1:48 pm-11:59 pm

2 stops9h 11m

Gainesville Regional

Sat 3/28

3:09 pm-9:59 pm

1 stop7h 50m

$342

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Fri 4/17

6:00 am-2:41 pm

2 stops7h 41m

Gainesville Regional

Mon 4/20

5:47 pm-10:18 pm

1 stop5h 31m

$426

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 2/24

3:26 pm-11:00 pm

1 stop6h 34m

Gainesville Regional

Sat 2/28

6:24 am-1:17 pm

1 stop7h 53m

$435

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 2/24

1:38 pm-11:59 pm

2 stops9h 21m

Gainesville Regional

Sat 2/28

6:24 am-1:17 pm

1 stop7h 53m

$440

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Fri 4/17

2:44 pm-10:39 pm

1 stop6h 55m

Gainesville Regional

Mon 4/20

7:03 pm-10:34 pm

1 stop4h 31m

$470

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 2/24

1:48 pm-11:59 pm

2 stops9h 11m

Gainesville Regional

Sat 2/28

6:00 am-1:05 pm

2 stops8h 05m

$472

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Fri 5/8

2:33 pm-10:44 pm

1 stop7h 11m

Gainesville Regional

Sun 5/10

6:40 am-11:03 am

1 stop5h 23m

$480

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 3/24

11:17 am-11:59 pm

2 stops11h 42m

Gainesville Regional

Sat 3/28

11:29 am-9:39 pm

2 stops11h 10m

$494

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 2/25

6:19 am-6:13 pm

2 stops10h 54m

Gainesville Regional

Sun 3/1

7:00 pm-10:28 pm

1 stop4h 28m

$496

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

American Airlines is the most popular carrier operating from Des Moines to Gainesville Regional

What airlines fly to Gainesville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. American Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Des Moines to Gainesville takes 4h 17m
There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.
Search flight deals

  • How far is Des Moines to Gainesville Regional by plane?

    A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 4h 17m.

  • When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

    Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Gainesville Regional Airport?

  • How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Gainesville?

Best airlines flying from Des Moines to Gainesville

Compare and see reviews for airlines that fly from Des Moines to Gainesville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $253Free CancellationRating
7.9
8,178 reviews
Search Delta flights

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua
Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.

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