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Cheap flights from Des Moines to Gainesville from $348

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 7/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:40 am - 12:23 pm
DSM
-
GNV
5h 43m
1 stop
Delta Logo
5:35 pm - 10:37 pm
GNV
-
DSM
6h 02m
1 stop
$418Delta
Wed, Aug 5 - Sat, Aug 8
American Airlines Logo
4:13 pm - 10:42 pm
DSM
-
GNV
5h 29m
1 stop
American Airlines Logo
6:39 pm - 11:10 pm
GNV
-
DSM
5h 31m
1 stop
$426American Airlines
Wed, Aug 5 - Sat, Aug 8
American Airlines Logo
4:14 pm - 11:14 pm
DSM
-
GNV
6h 00m
1 stop
American Airlines Logo
5:18 pm - 11:13 pm
GNV
-
DSM
6h 55m
1 stop
$429American Airlines
Thu, Sep 10 - Sat, Sep 19
Delta Logo
5:40 am - 12:23 pm
DSM
-
GNV
5h 43m
1 stop
Delta Logo
1:37 pm - 5:50 pm
GNV
-
DSM
5h 13m
1 stop
$458Delta
Wed, Aug 5 - Sun, Aug 9
Delta Logo
5:35 am - 12:25 pm
DSM
-
GNV
5h 50m
1 stop
Delta Logo
10:17 am - 1:34 pm
GNV
-
DSM
4h 17m
1 stop
$477Delta
Mon, Jul 6 - Sun, Jul 12
American Airlines Logo
4:13 pm - 10:42 pm
DSM
-
GNV
5h 29m
1 stop
American Airlines Logo
6:15 am - 3:12 pm
GNV
-
DSM
9h 57m
2 stops
$504American Airlines
Wed, Aug 5 - Sat, Aug 8
American Airlines Logo
1:08 pm - 9:51 pm
DSM
-
GNV
7h 43m
1 stop
American Airlines Logo
5:45 am - 12:49 pm
GNV
-
DSM
8h 04m
1 stop
$510American Airlines
Thu, Aug 6 - Sun, Aug 9
American Airlines Logo
10:26 am - 11:59 pm
DSM
-
GNV
12h 33m
2 stops
American Airlines Logo
6:39 pm - 11:10 pm
GNV
-
DSM
5h 31m
1 stop
$531American Airlines
Wed, Aug 5 - Sat, Aug 8
American Airlines Logo
11:00 am - 6:52 pm
DSM
-
GNV
6h 52m
1 stop
American Airlines Logo
6:00 am - 1:59 pm
GNV
-
DSM
8h 59m
2 stops
$534American Airlines
Thu, Sep 10 - Sat, Sep 19
American Airlines Logo
6:00 am - 6:08 pm
DSM
-
GNV
11h 08m
2 stops
American Airlines Logo
5:45 am - 12:49 pm
GNV
-
DSM
8h 04m
1 stop
$563American Airlines
Wed, Aug 5 - Sun, Aug 9

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Delta flights from Des Moines to Gainesville

Our best Delta deals on Des Moines to Gainesville flight tickets
Delta
Aug 5
DSM5:40 amDes Moines
5h 43m
1 stop
GNV12:23 pmGainesville Regional
Aug 8
GNV5:35 pmGainesville Regional
6h 02m
1 stop
DSM10:37 pmDes Moines
$418
Delta
Aug 5
DSM5:40 amDes Moines
5h 43m
1 stop
GNV12:23 pmGainesville Regional
Aug 9
GNV1:37 pmGainesville Regional
5h 13m
1 stop
DSM5:50 pmDes Moines
$458
Delta
Jul 6
DSM5:35 amDes Moines
5h 50m
1 stop
GNV12:25 pmGainesville Regional
Jul 12
GNV10:17 amGainesville Regional
4h 17m
1 stop
DSM1:34 pmDes Moines
$477

American Airlines flights from Des Moines to Gainesville

Our best American Airlines deals on Des Moines to Gainesville flight tickets
American Airlines
Aug 5
DSM4:13 pmDes Moines
5h 29m
1 stop
GNV10:42 pmGainesville Regional
Aug 8
GNV6:39 pmGainesville Regional
5h 31m
1 stop
DSM11:10 pmDes Moines
$426
American Airlines
Sep 10
DSM4:14 pmDes Moines
6h 00m
1 stop
GNV11:14 pmGainesville Regional
Sep 19
GNV5:18 pmGainesville Regional
6h 55m
1 stop
DSM11:13 pmDes Moines
$429
American Airlines
Aug 5
DSM4:13 pmDes Moines
5h 29m
1 stop
GNV10:42 pmGainesville Regional
Aug 8
GNV6:15 amGainesville Regional
9h 57m
2 stops
DSM3:12 pmDes Moines
$504

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

5:40 am-12:23 pm

1 stop5h 43m

Gainesville Regional

Sat 8/8

5:35 pm-10:37 pm

1 stop6h 02m

$418

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

4:13 pm-10:42 pm

1 stop5h 29m

Gainesville Regional

Sat 8/8

6:39 pm-11:10 pm

1 stop5h 31m

$426

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 9/10

4:14 pm-11:14 pm

1 stop6h 00m

Gainesville Regional

Sat 9/19

5:18 pm-11:13 pm

1 stop6h 55m

$429

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

5:40 am-12:23 pm

1 stop5h 43m

Gainesville Regional

Sun 8/9

1:37 pm-5:50 pm

1 stop5h 13m

$458
Quickest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Mon 7/6

5:35 am-12:25 pm

1 stop5h 50m

Gainesville Regional

Sun 7/12

10:17 am-1:34 pm

1 stop4h 17m

$477

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

4:13 pm-10:42 pm

1 stop5h 29m

Gainesville Regional

Sat 8/8

6:15 am-3:12 pm

2 stops9h 57m

$504

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 8/6

1:08 pm-9:51 pm

1 stop7h 43m

Gainesville Regional

Sun 8/9

5:45 am-12:49 pm

1 stop8h 04m

$510

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

10:26 am-11:59 pm

2 stops12h 33m

Gainesville Regional

Sat 8/8

6:39 pm-11:10 pm

1 stop5h 31m

$531

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 9/10

11:00 am-6:52 pm

1 stop6h 52m

Gainesville Regional

Sat 9/19

6:00 am-1:59 pm

2 stops8h 59m

$534

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

6:00 am-6:08 pm

2 stops11h 08m

Gainesville Regional

Sun 8/9

5:45 am-12:49 pm

1 stop8h 04m

$563

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Des Moines to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Gainesville Regional?

Delta is the most popular carrier operating from Des Moines to Gainesville Regional

What airlines fly to Gainesville?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Gainesville from Des Moines according to our data. Allegiant Air is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Gainesville (DSM to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Gainesville

Fastest flight time

5h 37m

Direct flights

None
The fastest flight from Des Moines to Gainesville takes 5h 37m
There are no direct flights from Des Moines to Gainesville. There are no popular flight routes from Des Moines to Gainesville.
Search flight deals

Frequently asked questions about flying from Des Moines to Gainesville

  • How far is Des Moines to Gainesville Regional by plane?

    A flight from Des Moines to Gainesville Regional will travel around 1037.9 mi. In terms of flight time, this usually takes a little over 5h 37m.

  • When did momondo last update prices for flights from Des Moines Airport to Gainesville Regional Airport?

    Prices for flights from Des Moines Airport to Gainesville Regional Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Gainesville Regional Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The travel and health documents required for your trip to Gainesville Regional Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Gainesville Regional Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua
Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Gainesville?

Finding the right flight to Gainesville from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Gainesville quick and easy, saving you time and money.

Can I find flights from Des Moines to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Gainesville?

Once you have performed a search for Des Moines to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Gainesville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Gainesville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Gainesville and let you know when they change.

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