Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Charleston from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 9/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Charleston (DSM-CHS)

Cheap round-trip flights

Logo
8:30 am - 5:12 pmDSM-CHS
7h 42m1 stop
Logo
5:40 pm - 10:00 amCHS-DSM
17h 20m1 stop
$226
Find Deal
Mon, Nov 3 - Sat, Nov 8
Logo
8:30 am - 8:15 pmDSM-CHS
10h 45m1 stop
Logo
11:40 am - 10:00 amCHS-DSM
23h 20m2 stops
$255
Find Deal
Mon, Nov 3 - Sat, Nov 8
American Airlines Logo
3:56 pm - 9:48 pmDSM-CHS
4h 52m1 stop
American Airlines Logo
3:30 pm - 10:20 pmCHS-DSM
7h 50m1 stop
$277American Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
United Airlines Logo
11:35 am - 7:08 pmDSM-CHS
6h 33m1 stop
United Airlines Logo
2:48 pm - 9:50 pmCHS-DSM
8h 02m2 stops
$282United Airlines
Find Deal
Wed, Sep 24 - Wed, Oct 1
Delta Logo
5:44 am - 1:49 pmDSM-CHS
7h 05m1 stop
Delta Logo
10:21 am - 1:20 pmCHS-DSM
3h 59m1 stop
$287Delta
Find Deal
Sat, Sep 20 - Tue, Sep 23
Delta Logo
12:32 pm - 5:57 pmDSM-CHS
4h 25m1 stop
Delta Logo
5:10 am - 2:03 pmCHS-DSM
9h 53m2 stops
$292Delta
Find Deal
Sat, Sep 20 - Tue, Sep 23
United Airlines Logo
1:10 pm - 7:08 pmDSM-CHS
4h 58m1 stop
United Airlines Logo
4:15 pm - 9:50 pmCHS-DSM
6h 35m1 stop
$304United Airlines
Find Deal
Wed, Sep 24 - Fri, Sep 26
American Airlines Logo
7:03 am - 6:42 pmDSM-CHS
10h 39m2 stops
American Airlines Logo
7:28 pm - 11:06 pmCHS-DSM
4h 38m1 stop
$309American Airlines
Find Deal
Wed, Sep 24 - Fri, Sep 26
Southwest Logo
6:10 am - 12:50 pmDSM-CHS
5h 40m2 stops
Southwest Logo
7:35 am - 2:55 pmCHS-DSM
8h 20m2 stops
$342Southwest
Find Deal
Sun, Jan 18 - Sat, Jan 24
Southwest Logo
6:10 am - 12:50 pmDSM-CHS
5h 40m2 stops
Southwest Logo
1:45 pm - 7:20 pmCHS-DSM
6h 35m1 stop
$354Southwest
Find Deal
Sun, Jan 18 - Fri, Jan 23

Delta flights from Des Moines to Charleston

Our best Delta deals on Des Moines to Charleston flight tickets
Delta
Sep 20
DSM5:44 amDes Moines
7h 05m
1 stop
CHS1:49 pmCharleston
Sep 23
CHS10:21 amCharleston
3h 59m
1 stop
DSM1:20 pmDes Moines
$287
Find similar
Delta
Sep 20
DSM12:32 pmDes Moines
4h 25m
1 stop
CHS5:57 pmCharleston
Sep 23
CHS5:10 amCharleston
9h 53m
2 stops
DSM2:03 pmDes Moines
$292
Find similar
Delta
Sep 20
DSM11:25 amDes Moines
11h 22m
2 stops
CHS11:47 pmCharleston
Sep 23
CHS11:29 amCharleston
10h 32m
2 stops
DSM9:01 pmDes Moines
$297
Find similar

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
Oct 8
DSM3:56 pmDes Moines
4h 52m
1 stop
CHS9:48 pmCharleston
Oct 15
CHS3:30 pmCharleston
7h 50m
1 stop
DSM10:20 pmDes Moines
$277
Find similar
American Airlines
Sep 24
DSM7:03 amDes Moines
10h 39m
2 stops
CHS6:42 pmCharleston
Sep 26
CHS7:28 pmCharleston
4h 38m
1 stop
DSM11:06 pmDes Moines
$309
Find similar
American Airlines
Oct 10
DSM6:22 pmDes Moines
4h 43m
1 stop
CHS12:05 amCharleston
Oct 17
CHS7:54 pmCharleston
5h 05m
1 stop
DSM11:59 pmDes Moines
$330
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/3

8:30 am-5:12 pm

1 stop7h 42m

Charleston

Sat 11/8

5:40 pm-10:00 am

1 stop17h 20m

$226

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/3

8:30 am-8:15 pm

1 stop10h 45m

Charleston

Sat 11/8

11:40 am-10:00 am

2 stops23h 20m

$255

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 10/8

3:56 pm-9:48 pm

1 stop4h 52m

Charleston

Wed 10/15

3:30 pm-10:20 pm

1 stop7h 50m

$277

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/24

11:35 am-7:08 pm

1 stop6h 33m

Charleston

Wed 10/1

2:48 pm-9:50 pm

2 stops8h 02m

$282

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 9/20

5:44 am-1:49 pm

1 stop7h 05m

Charleston

Tue 9/23

10:21 am-1:20 pm

1 stop3h 59m

$287

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 9/20

12:32 pm-5:57 pm

1 stop4h 25m

Charleston

Tue 9/23

5:10 am-2:03 pm

2 stops9h 53m

$292

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/24

1:10 pm-7:08 pm

1 stop4h 58m

Charleston

Fri 9/26

4:15 pm-9:50 pm

1 stop6h 35m

$304

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/24

7:03 am-6:42 pm

2 stops10h 39m

Charleston

Fri 9/26

7:28 pm-11:06 pm

1 stop4h 38m

$309

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

6:10 am-12:50 pm

2 stops5h 40m

Charleston

Sat 1/24

7:35 am-2:55 pm

2 stops8h 20m

$342

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

6:10 am-12:50 pm

2 stops5h 40m

Charleston

Fri 1/23

1:45 pm-7:20 pm

1 stop6h 35m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in October. Flight prices, which tend to average around $331, are often lower during this time because this is during the off-season. The month of September is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $334.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Des Moines to Charleston is on a Monday. Travelers who choose to depart for Charleston on a Monday will often find tickets for as low as $379. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the afternoon when flights can be purchased for as low as $386. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $405 per ticket.

How far in advance should I book a flight to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $385 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $335 on momondo.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Direct flights

None
There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.
Search flight deals

  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 3h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $315Free CancellationRating
7.4
8,945 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Walterboro
Santee
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Charleston trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 9/1
Mon 9/8
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States