Which airport is the most popular layover for flights between Des Moines and Charleston?

Atlanta (ATL) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

What is the cheapest airline that flies from Des Moines to Charleston?

Delta, American Airlines, and Southwest are the most popular carriers operating from Des Moines to Charleston

Which layover airport has the shortest connection time from Des Moines to Charleston?

Chicago (ORD) has the shortest average layover time for this route: 1h 11m.

Which layover airport offers the lowest fares from Des Moines to Charleston?

Flights via Chicago (MDW) offer the lowest average round-trip price of $380.

Which layover airport has the shortest travel time from Des Moines to Charleston?

Flights connecting via Chicago (MDW) have the shortest average one-way travel time: 4h 45m.

What airlines fly to Charleston?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Charleston from Des Moines according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 4 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

There are 3 operators available for flights from Des Moines Airport to Charleston Airport as of September 2026.

How old do you have to be to fly from Des Moines Airport to Charleston Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

What documentation or ID do you need to fly to Charleston Airport?

The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$171 Cheap Flights from Des Moines to Charleston in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Charleston

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:25 am - 2:38 pmDSM Des Moines-CHS Charleston

31h 13m2 stops Nashville Intl Orlando

2:13 pm - 8:25 amCHS Charleston-DSM Des Moines

19h 12m1 stop Orlando

$286Multiple Airlines

Mon, Oct 19 - Thu, Oct 22

1:24 pm - 9:33 pmDSM Des Moines-CHS Charleston

7h 09m1 stop Chicago O'Hare Intl

6:50 pm - 11:35 pmCHS Charleston-DSM Des Moines

5h 45m1 stop Chicago O'Hare Intl

$325United Airlines

Mon, Oct 19 - Thu, Oct 22

1:30 pm - 9:06 pmDSM Des Moines-CHS Charleston

6h 36m1 stop Charlotte Douglas

7:18 am - 1:59 pmCHS Charleston-DSM Des Moines

7h 41m1 stop Chicago O'Hare Intl

$325American Airlines

Wed, Sep 30 - Sat, Oct 3

2:59 pm - 9:10 pmDSM Des Moines-CHS Charleston

5h 11m1 stop Atlanta Hartsfield-Jackson

4:11 pm - 10:35 pmCHS Charleston-DSM Des Moines

7h 24m1 stop Atlanta Hartsfield-Jackson

$325Delta

Wed, Nov 18 - Mon, Nov 23

2:59 pm - 8:13 pmDSM Des Moines-CHS Charleston

4h 14m1 stop Atlanta Hartsfield-Jackson

7:04 pm - 10:35 pmCHS Charleston-DSM Des Moines

4h 31m1 stop Atlanta Hartsfield-Jackson

$325Delta

Mon, Nov 9 - Thu, Nov 12

3:01 pm - 9:59 pmDSM Des Moines-CHS Charleston

5h 58m1 stop Houston George Bush Intcntl

2:52 pm - 9:55 pmCHS Charleston-DSM Des Moines

8h 03m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$330United Airlines

Mon, Nov 9 - Thu, Nov 12

5:25 am - 6:30 pmDSM Des Moines-CHS Charleston

12h 05m2 stops Chicago Midway Nashville Intl

4:00 pm - 11:00 pmCHS Charleston-DSM Des Moines

8h 00m2 stops Baltimore/Washington Chicago Midway

$341Southwest

Mon, Nov 9 - Thu, Nov 12

5:10 am - 6:00 pmDSM Des Moines-CHS Charleston

11h 50m2 stops Chicago Midway Baltimore/Washington

1:25 pm - 11:15 pmCHS Charleston-DSM Des Moines

10h 50m2 stops Lambert-St Louis Chicago Midway

$341Southwest

Mon, Oct 19 - Thu, Oct 22

4:12 pm - 10:33 pmDSM Des Moines-CHS Charleston

5h 21m1 stop Dallas/Fort Worth

7:04 pm - 11:58 pmCHS Charleston-DSM Des Moines

5h 54m1 stop Charlotte Douglas

$345American Airlines

Mon, Oct 5 - Fri, Oct 9

8:00 am - 1:56 pmDSM Des Moines-CHS Charleston

4h 56m1 stop Chicago O'Hare Intl

2:52 pm - 9:55 pmCHS Charleston-DSM Des Moines

8h 03m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$376United Airlines

Sun, Nov 8 - Wed, Nov 11

Cheap last minute flights

Enter your travel dates to find the best prices.

5:40 am - 3:53 pmDSM Des Moines-CHS Charleston

9h 13m1 stop Philadelphia

1:58 pm - 11:44 pmCHS Charleston-DSM Des Moines

10h 46m1 stop Washington, D.C. Reagan-National

$856American Airlines

Sat, Sep 5 - Tue, Sep 8

3:20 pm - 9:34 pmDSM Des Moines-CHS Charleston

5h 14m1 stop Chicago O'Hare Intl

6:30 am - 12:20 pmCHS Charleston-DSM Des Moines

6h 50m1 stop Chicago O'Hare Intl

$892United Airlines

Fri, Sep 4 - Mon, Sep 7

1:55 pm - 9:51 pmDSM Des Moines-CHS Charleston

6h 56m2 stops Chicago O'Hare Intl Charlotte Douglas

7:00 am - 1:25 pmCHS Charleston-DSM Des Moines

7h 25m1 stop Chicago O'Hare Intl

$897American Airlines

Sat, Sep 5 - Tue, Sep 8

9:13 am - 9:34 pmDSM Des Moines-CHS Charleston

11h 21m2 stops Denver Intl Chicago O'Hare Intl

10:19 am - 9:28 pmCHS Charleston-DSM Des Moines

12h 09m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$902United Airlines

Sat, Sep 5 - Tue, Sep 8

3:04 pm - 9:29 pmDSM Des Moines-CHS Charleston

29h 25m1 stop Fort Myers SW Florida Intl

3:54 pm - 9:55 pmCHS Charleston-DSM Des Moines

7h 01m1 stop Fort Myers SW Florida Intl

$915Multiple Airlines

Fri, Sep 4 - Mon, Sep 7

5:40 am - 5:25 pmDSM Des Moines-CHS Charleston

10h 45m2 stops Chicago Midway Dallas Love Field

6:30 pm - 10:15 pmCHS Charleston-DSM Des Moines

4h 45m1 stop Chicago Midway

$927Southwest

Fri, Sep 4 - Mon, Sep 7

12:00 pm - 9:29 pmDSM Des Moines-CHS Charleston

32h 29m2 stops Las Vegas Harry Reid Intl Fort Myers SW Florida Intl

3:54 pm - 9:55 pmCHS Charleston-DSM Des Moines

7h 01m1 stop Fort Myers SW Florida Intl

$959Multiple Airlines

Fri, Sep 4 - Mon, Sep 7

1:55 pm - 11:00 pmDSM Des Moines-CHS Charleston

8h 05m2 stops Chicago O'Hare Intl Charlotte Douglas

6:15 am - 1:25 pmCHS Charleston-DSM Des Moines

8h 10m2 stops Charlotte Douglas Chicago O'Hare Intl

$1,054American Airlines

Fri, Sep 4 - Mon, Sep 7

5:40 am - 5:25 pmDSM Des Moines-CHS Charleston

10h 45m2 stops Chicago Midway Dallas Love Field

1:15 pm - 10:15 pmCHS Charleston-DSM Des Moines

10h 00m2 stops Baltimore/Washington Chicago Midway

$1,131Southwest

Fri, Sep 4 - Mon, Sep 7

6:00 am - 11:59 pmDSM Des Moines-CHS Charleston

16h 59m3 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl Newark

2:54 pm - 11:33 pmCHS Charleston-DSM Des Moines

9h 39m2 stops Washington, D.C. Dulles Intl Denver Intl

$1,288United Airlines

Sat, Sep 5 - Tue, Sep 8

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Southwest flights from Des Moines to Charleston

Our best Southwest deals on Des Moines to Charleston flight tickets

Southwest

Oct 19

DSM5:10 amDes Moines

11h 50m

2 stops

CHS6:00 pmCharleston

Oct 22

CHS1:25 pmCharleston

10h 50m

2 stops

DSM11:15 pmDes Moines

$341

Southwest

Oct 10

DSM5:50 amDes Moines

4h 30m

1 stop

CHS11:20 amCharleston

Oct 14

CHS1:55 pmCharleston

9h 05m

2 stops

DSM10:00 pmDes Moines

$350

Southwest

Oct 10

DSM5:50 amDes Moines

11h 55m

2 stops

CHS6:45 pmCharleston

Oct 14

CHS1:55 pmCharleston

9h 05m

2 stops

DSM10:00 pmDes Moines

$374

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets

American Airlines

Oct 5

DSM7:29 amDes Moines

6h 33m

1 stop

CHS3:02 pmCharleston

Oct 9

CHS7:04 pmCharleston

5h 54m

1 stop

DSM11:58 pmDes Moines

$345

American Airlines

Nov 8

DSM7:23 amDes Moines

7h 01m

1 stop

CHS3:24 pmCharleston

Nov 11

CHS7:13 amCharleston

7h 15m

1 stop

DSM1:28 pmDes Moines

$371

American Airlines

Sep 30

DSM6:00 amDes Moines

6h 34m

1 stop

CHS1:34 pmCharleston

Oct 3

CHS10:27 amCharleston

8h 00m

2 stops

DSM5:27 pmDes Moines

$376

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 10/19

6:25 am-2:38 pm

2 stops31h 13m

Charleston

Thu 10/22

2:13 pm-8:25 am

1 stop19h 12m

$286

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 10/19

1:24 pm-9:33 pm

1 stop7h 09m

Charleston

Thu 10/22

6:50 pm-11:35 pm

1 stop5h 45m

$325

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Wed 9/30

1:30 pm-9:06 pm

1 stop6h 36m

Charleston

Sat 10/3

7:18 am-1:59 pm

1 stop7h 41m

$325

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Wed 11/18

2:59 pm-9:10 pm

1 stop5h 11m

Charleston

Mon 11/23

4:11 pm-10:35 pm

1 stop7h 24m

$325

Quickest round-trip

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 11/9

2:59 pm-8:13 pm

1 stop4h 14m

Charleston

Thu 11/12

7:04 pm-10:35 pm

1 stop4h 31m

$325

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 11/9

3:01 pm-9:59 pm

1 stop5h 58m

Charleston

Thu 11/12

2:52 pm-9:55 pm

2 stops8h 03m

$330

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 11/9

5:25 am-6:30 pm

2 stops12h 05m

Charleston

Thu 11/12

4:00 pm-11:00 pm

2 stops8h 00m

$341

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 10/19

5:10 am-6:00 pm

2 stops11h 50m

Charleston

Thu 10/22

1:25 pm-11:15 pm

2 stops10h 50m

$341

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 10/5

4:12 pm-10:33 pm

1 stop5h 21m

Charleston

Fri 10/9

7:04 pm-11:58 pm

1 stop5h 54m

$345

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Sun 11/8

8:00 am-1:56 pm

1 stop4h 56m

Charleston

Wed 11/11

2:52 pm-9:55 pm

2 stops8h 03m

$376

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Des Moines and Charleston?

Prices are currently low for flights on this route.

Typical prices usually range from $410 to $578.
The lowest price recently found on this route was $325.

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in April. Flight prices, which tend to average around $380, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $392.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to Charleston flight.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Best Price Found	$171
Fastest flight time	4h 00m
Direct flights	None

The best one-way flight to Charleston from Des Moines in the past 72 hours is $171. The best round-trip flight deal from Des Moines to Charleston found on momondo in the last 72 hours is $286.

The fastest flight from Des Moines to Charleston takes 4h 00m

There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.

Search flight deals

Frequently asked questions about flying from Des Moines to Charleston

How far is Des Moines to Charleston by plane?
The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 00m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?
Prices for flights from Des Moines Airport to Charleston Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?
There are 3 operators available for flights from Des Moines Airport to Charleston Airport as of September 2026.
How old do you have to be to fly from Des Moines Airport to Charleston Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.
What documentation or ID do you need to fly to Charleston Airport?
The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Charleston?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Charleston is American Airlines (50% of total bookings). The next most popular airlines are Delta (27%) and United Airlines (23%).

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 10,157 reviews	Search United Airlines flights
American Airlines	PriceFrom $302	Free Cancellation	Rating 7.1 12,023 reviews	Search American Airlines flights
Delta	PriceFrom $356	Free Cancellation	Rating 7.8 8,538 reviews	Search Delta flights

Folly Beach

North Charleston

Summerville

Isle of Palms

Mount Pleasant

Kiawah Island

Walterboro

Goose Creek

Santee

Edisto Island

Edisto Beach

Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Des Moines to Charleston from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Southwest flights from Des Moines to Charleston

Our best Southwest deals on Des Moines to Charleston flight tickets

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets

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How to get the cheapest flight ticket from Des Moines to Charleston

What is the typical price of a round-trip flight between Des Moines and Charleston?

What is the cheapest month to fly to Charleston?

Can stopping save me money on Des Moines to Charleston flights?

How have Des Moines to Charleston flight prices changed over time?

What is the cheapest airline that flies from Des Moines to Charleston?

What airlines fly to Charleston?

Which airport is the most popular layover for flights between Des Moines and Charleston?

Which layover airport offers the lowest fares from Des Moines to Charleston?

Which layover airport has the shortest travel time from Des Moines to Charleston?

Which layover airport has the shortest connection time from Des Moines to Charleston?

When to book flights from Des Moines to Charleston

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Charleston

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo

Traveling to a place near Charleston?

Why use momondo?

An easier way to manage your Charleston trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing South Carolina

Fly your favorite airline to Charleston

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Charleston

List of cabin classes available on flights landing in Charleston. Availability may vary depending on flight origin and airline.

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Popular flights according to clicks in the last 7 days on momondo

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