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Cheap flights from Des Moines to Charleston from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 11/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:30 am - 6:13 pmDSM-CHS
8h 43m1 stop
Multiple Airlines Logo
7:55 pm - 11:15 amCHS-DSM
40h 20m2 stops
$231Multiple Airlines
Find Deal
Mon, Oct 27 - Wed, Oct 29
Multiple Airlines Logo
10:41 am - 9:01 amDSM-CHS
21h 20m1 stop
Multiple Airlines Logo
9:02 am - 2:50 pmCHS-DSM
6h 48m1 stop
$271Multiple Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
American Airlines Logo
6:00 am - 1:12 pmDSM-CHS
6h 12m1 stop
American Airlines Logo
7:15 am - 11:42 amCHS-DSM
5h 27m1 stop
$282American Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4
Delta Logo
7:25 am - 5:23 pmDSM-CHS
8h 58m1 stop
Delta Logo
10:00 am - 3:48 pmCHS-DSM
6h 48m1 stop
$284Delta
Find Deal
Sun, Jan 18 - Sat, Jan 24
American Airlines Logo
11:42 am - 9:11 pmDSM-CHS
8h 29m2 stops
American Airlines Logo
3:16 pm - 11:23 pmCHS-DSM
9h 07m1 stop
$289American Airlines
Find Deal
Sun, Jan 18 - Sat, Jan 24
Delta Logo
11:28 am - 5:23 pmDSM-CHS
4h 55m1 stop
Delta Logo
3:13 pm - 9:15 pmCHS-DSM
7h 02m1 stop
$315Delta
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Sat, Nov 15 - Wed, Nov 19
United Airlines Logo
11:32 am - 7:23 pmDSM-CHS
6h 51m1 stop
United Airlines Logo
6:15 am - 4:12 pmCHS-DSM
10h 57m2 stops
$320United Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
Southwest Logo
6:10 am - 5:35 pmDSM-CHS
10h 25m2 stops
Southwest Logo
9:05 am - 7:20 pmCHS-DSM
11h 15m2 stops
$323Southwest
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Wed, Feb 25 - Tue, Mar 3
Southwest Logo
5:25 am - 4:50 pmDSM-CHS
10h 25m2 stops
Southwest Logo
8:25 am - 7:55 pmCHS-DSM
12h 30m2 stops
$325Southwest
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Sat, Nov 15 - Wed, Nov 19
United Airlines Logo
8:00 am - 2:02 pmDSM-CHS
5h 02m1 stop
United Airlines Logo
11:00 am - 9:50 pmCHS-DSM
11h 50m2 stops
$347United Airlines
Find Deal
Fri, Jan 30 - Mon, Feb 2

Delta flights from Des Moines to Charleston

Our best Delta deals on Des Moines to Charleston flight tickets
Delta
Jan 18
DSM7:00 amDes Moines
6h 11m
1 stop
CHS2:11 pmCharleston
Jan 24
CHS3:10 pmCharleston
7h 17m
1 stop
DSM9:27 pmDes Moines
$284
Find similar
Delta
Nov 6
DSM6:39 pmDes Moines
4h 20m
1 stop
CHS11:59 pmCharleston
Nov 10
CHS6:28 pmCharleston
5h 05m
1 stop
DSM10:33 pmDes Moines
$334
Find similar
Delta
Nov 9
DSM6:50 amDes Moines
6h 28m
1 stop
CHS2:18 pmCharleston
Nov 15
CHS7:05 amCharleston
4h 37m
1 stop
DSM10:42 amDes Moines
$362
Find similar

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
Nov 27
DSM6:00 amDes Moines
6h 12m
1 stop
CHS1:12 pmCharleston
Dec 4
CHS7:15 amCharleston
5h 27m
1 stop
DSM11:42 amDes Moines
$282
Find similar
American Airlines
Jan 18
DSM11:42 amDes Moines
8h 29m
2 stops
CHS9:11 pmCharleston
Jan 24
CHS3:16 pmCharleston
9h 07m
1 stop
DSM11:23 pmDes Moines
$289
Find similar
American Airlines
Jan 18
DSM11:42 amDes Moines
8h 29m
2 stops
CHS9:11 pmCharleston
Jan 24
CHS6:10 amCharleston
7h 36m
2 stops
DSM12:46 pmDes Moines
$294
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 15, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 10/27

8:30 am-6:13 pm

1 stop8h 43m

Charleston

Wed 10/29

7:55 pm-11:15 am

2 stops40h 20m

$231

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 10/30

10:41 am-9:01 am

1 stop21h 20m

Charleston

Mon 11/3

9:02 am-2:50 pm

1 stop6h 48m

$271

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 11/27

6:00 am-1:12 pm

1 stop6h 12m

Charleston

Thu 12/4

7:15 am-11:42 am

1 stop5h 27m

$282

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

7:25 am-5:23 pm

1 stop8h 58m

Charleston

Sat 1/24

10:00 am-3:48 pm

1 stop6h 48m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

11:42 am-9:11 pm

2 stops8h 29m

Charleston

Sat 1/24

3:16 pm-11:23 pm

1 stop9h 07m

$289

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 11/15

11:28 am-5:23 pm

1 stop4h 55m

Charleston

Wed 11/19

3:13 pm-9:15 pm

1 stop7h 02m

$315

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 11/15

11:32 am-7:23 pm

1 stop6h 51m

Charleston

Wed 11/19

6:15 am-4:12 pm

2 stops10h 57m

$320

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 2/25

6:10 am-5:35 pm

2 stops10h 25m

Charleston

Tue 3/3

9:05 am-7:20 pm

2 stops11h 15m

$323

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 11/15

5:25 am-4:50 pm

2 stops10h 25m

Charleston

Wed 11/19

8:25 am-7:55 pm

2 stops12h 30m

$325

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 1/30

8:00 am-2:02 pm

1 stop5h 02m

Charleston

Mon 2/2

11:00 am-9:50 pm

2 stops11h 50m

$347

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $285, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $331.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Des Moines to Charleston is on a Monday. Travelers who choose to depart for Charleston on a Monday will often find tickets for as low as $379. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the afternoon when flights can be purchased for as low as $386. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $405 per ticket.

How far in advance should I book a flight to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $399 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $286 on momondo.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 44% on your flight if you consider stops on a Des Moines to Charleston flight.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Direct flights

None
There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.
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  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $262Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
8,978 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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