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Cheap flights from Des Moines to Charleston from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 6/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:40 pm - 6:14 pm
DSM
-
CHS
24h 34m
1 stop
Multiple Airlines Logo
7:47 pm - 3:50 pm
CHS
-
DSM
21h 03m
1 stop
$331Multiple Airlines
Mon, Jul 27 - Sun, Aug 2
Delta Logo
10:26 am - 5:53 pm
DSM
-
CHS
6h 27m
1 stop
Delta Logo
11:27 am - 7:33 pm
CHS
-
DSM
9h 06m
1 stop
$335Delta
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
5:00 am - 2:41 pm
DSM
-
CHS
8h 41m
2 stops
American Airlines Logo
7:47 pm - 11:50 pm
CHS
-
DSM
5h 03m
1 stop
$340American Airlines
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
5:00 am - 2:41 pm
DSM
-
CHS
8h 41m
2 stops
American Airlines Logo
12:58 pm - 7:35 pm
CHS
-
DSM
7h 37m
2 stops
$345American Airlines
Tue, Jun 2 - Tue, Jun 9
Multiple Airlines Logo
4:40 pm - 6:14 pm
DSM
-
CHS
24h 34m
1 stop
Multiple Airlines Logo
6:00 am - 9:58 pm
CHS
-
DSM
16h 58m
2 stops
$352Multiple Airlines
Mon, Jul 27 - Sun, Aug 2
United Airlines Logo
3:01 pm - 10:15 pm
DSM
-
CHS
6h 14m
1 stop
United Airlines Logo
6:50 am - 2:20 pm
CHS
-
DSM
8h 30m
1 stop
$355United Airlines
Wed, Jun 3 - Sat, Jun 6
United Airlines Logo
5:00 am - 2:27 pm
DSM
-
CHS
8h 27m
2 stops
United Airlines Logo
6:00 am - 10:27 am
CHS
-
DSM
5h 27m
1 stop
$360United Airlines
Wed, Jun 3 - Sat, Jun 6
American Airlines Logo
5:00 am - 2:41 pm
DSM
-
CHS
8h 41m
2 stops
American Airlines Logo
6:51 am - 1:21 pm
CHS
-
DSM
7h 30m
2 stops
$365American Airlines
Tue, Jun 2 - Tue, Jun 9
Delta Logo
5:45 am - 11:25 am
DSM
-
CHS
4h 40m
1 stop
Delta Logo
6:30 am - 10:14 am
CHS
-
DSM
4h 44m
1 stop
$371Delta
Wed, Sep 30 - Sat, Oct 3
Multiple Airlines Logo
7:45 am - 9:37 am
DSM
-
CHS
48h 52m
2 stops
Multiple Airlines Logo
4:34 pm - 8:53 am
CHS
-
DSM
17h 19m
1 stop
$374Multiple Airlines
Sun, May 17 - Wed, May 20

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
Jun 2
DSM5:00 amDes Moines
8h 41m
2 stops
CHS2:41 pmCharleston
Jun 9
CHS7:47 pmCharleston
5h 03m
1 stop
DSM11:50 pmDes Moines
$340
American Airlines
Jun 2
DSM5:00 amDes Moines
8h 41m
2 stops
CHS2:41 pmCharleston
Jun 9
CHS12:58 pmCharleston
7h 37m
2 stops
DSM7:35 pmDes Moines
$345
American Airlines
Jun 2
DSM5:00 amDes Moines
8h 41m
2 stops
CHS2:41 pmCharleston
Jun 9
CHS6:51 amCharleston
7h 30m
2 stops
DSM1:21 pmDes Moines
$365

Delta flights from Des Moines to Charleston

Our best Delta deals on Des Moines to Charleston flight tickets
Delta
Jun 2
DSM10:26 amDes Moines
6h 27m
1 stop
CHS5:53 pmCharleston
Jun 9
CHS11:27 amCharleston
9h 06m
1 stop
DSM7:33 pmDes Moines
$335
Delta
Sep 30
DSM5:45 amDes Moines
4h 40m
1 stop
CHS11:25 amCharleston
Oct 3
CHS6:30 amCharleston
4h 44m
1 stop
DSM10:14 amDes Moines
$371
Delta
Sep 17
DSM2:15 pmDes Moines
6h 32m
1 stop
CHS9:47 pmCharleston
Sep 21
CHS5:30 amCharleston
5h 44m
1 stop
DSM10:14 amDes Moines
$407

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 7/27

4:40 pm-6:14 pm

1 stop24h 34m

Charleston

Sun 8/2

7:47 pm-3:50 pm

1 stop21h 03m

$331

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 6/2

10:26 am-5:53 pm

1 stop6h 27m

Charleston

Tue 6/9

11:27 am-7:33 pm

1 stop9h 06m

$335

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 6/2

5:00 am-2:41 pm

2 stops8h 41m

Charleston

Tue 6/9

7:47 pm-11:50 pm

1 stop5h 03m

$340

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 6/2

5:00 am-2:41 pm

2 stops8h 41m

Charleston

Tue 6/9

12:58 pm-7:35 pm

2 stops7h 37m

$345

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 7/27

4:40 pm-6:14 pm

1 stop24h 34m

Charleston

Sun 8/2

6:00 am-9:58 pm

2 stops16h 58m

$352

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 6/3

3:01 pm-10:15 pm

1 stop6h 14m

Charleston

Sat 6/6

6:50 am-2:20 pm

1 stop8h 30m

$355

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 6/3

5:00 am-2:27 pm

2 stops8h 27m

Charleston

Sat 6/6

6:00 am-10:27 am

1 stop5h 27m

$360

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 6/2

5:00 am-2:41 pm

2 stops8h 41m

Charleston

Tue 6/9

6:51 am-1:21 pm

2 stops7h 30m

$365
Quickest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/30

5:45 am-11:25 am

1 stop4h 40m

Charleston

Sat 10/3

6:30 am-10:14 am

1 stop4h 44m

$371

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 5/17

7:45 am-9:37 am

2 stops48h 52m

Charleston

Wed 5/20

4:34 pm-8:53 am

1 stop17h 19m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $281, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $310.

How far in advance should I book a flight from Des Moines to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $399 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $274 on momondo.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 52% on your flight if you consider stops on a Des Moines to Charleston flight.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Des Moines to Charleston takes 4h 17m
There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.
Search flight deals

Frequently asked questions about flying from Des Moines to Charleston

  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
8,460 reviews
Search Delta flights
American AirlinesPriceFrom $242Free CancellationRating
7.1
11,673 reviews
Search American Airlines flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
9,680 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
Summerville
Kiawah Island
North Charleston
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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