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Cheap flights from Des Moines to Charleston from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 7/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:53 pm - 8:38 am
DSM
-
CHS
16h 45m
1 stop
Multiple Airlines Logo
3:54 pm - 10:08 pm
CHS
-
DSM
7h 14m
1 stop
$233Multiple Airlines
Mon, Aug 24 - Fri, Sep 4
Multiple Airlines Logo
2:53 pm - 8:38 am
DSM
-
CHS
16h 45m
1 stop
Multiple Airlines Logo
8:20 pm - 6:56 pm
CHS
-
DSM
23h 36m
1 stop
$260Multiple Airlines
Mon, Aug 24 - Thu, Sep 3
Multiple Airlines Logo
2:53 pm - 8:38 am
DSM
-
CHS
16h 45m
1 stop
Multiple Airlines Logo
2:53 pm - 12:58 pm
CHS
-
DSM
23h 05m
1 stop
$264Multiple Airlines
Mon, Aug 24 - Thu, Sep 3
Multiple Airlines Logo
9:28 am - 8:38 am
DSM
-
CHS
46h 10m
2 stops
Multiple Airlines Logo
3:54 pm - 10:08 pm
CHS
-
DSM
7h 14m
1 stop
$273Multiple Airlines
Sun, Aug 23 - Fri, Sep 4
Multiple Airlines Logo
2:53 pm - 8:38 am
DSM
-
CHS
16h 45m
1 stop
Multiple Airlines Logo
2:53 pm - 10:44 am
CHS
-
DSM
20h 51m
1 stop
$292Multiple Airlines
Mon, Aug 24 - Sun, Sep 6
Multiple Airlines Logo
2:19 pm - 12:31 pm
DSM
-
CHS
21h 12m
1 stop
Multiple Airlines Logo
9:39 pm - 7:59 am
CHS
-
DSM
11h 20m
1 stop
$293Multiple Airlines
Mon, Oct 5 - Thu, Oct 8
Multiple Airlines Logo
3:04 pm - 9:29 pm
DSM
-
CHS
29h 25m
1 stop
Multiple Airlines Logo
9:39 pm - 4:05 pm
CHS
-
DSM
19h 26m
1 stop
$306Multiple Airlines
Fri, Sep 4 - Thu, Sep 10
Multiple Airlines Logo
4:40 pm - 6:14 pm
DSM
-
CHS
24h 34m
1 stop
Multiple Airlines Logo
7:47 pm - 3:50 pm
CHS
-
DSM
21h 03m
1 stop
$314Multiple Airlines
Mon, Jul 27 - Sun, Aug 2
Delta Logo
5:40 am - 11:54 am
DSM
-
CHS
5h 14m
1 stop
Delta Logo
3:14 pm - 8:59 pm
CHS
-
DSM
6h 45m
1 stop
$317Delta
Tue, Aug 25 - Wed, Sep 2
Multiple Airlines Logo
4:14 pm - 9:08 am
DSM
-
CHS
15h 54m
1 stop
Multiple Airlines Logo
8:20 pm - 10:15 pm
CHS
-
DSM
26h 55m
1 stop
$323Multiple Airlines
Tue, Jul 21 - Thu, Jul 23

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American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
Sep 30
DSM1:30 pmDes Moines
6h 36m
1 stop
CHS9:06 pmCharleston
Oct 3
CHS8:04 amCharleston
5h 00m
1 stop
DSM12:04 pmDes Moines
$336
American Airlines
Nov 7
DSM4:02 pmDes Moines
6h 54m
2 stops
CHS11:56 pmCharleston
Nov 10
CHS7:30 amCharleston
6h 23m
1 stop
DSM12:53 pmDes Moines
$373
American Airlines
Jul 3
DSM1:41 pmDes Moines
7h 22m
1 stop
CHS10:03 pmCharleston
Jul 9
CHS6:41 amCharleston
7h 15m
1 stop
DSM12:56 pmDes Moines
$391

Southwest flights from Des Moines to Charleston

Our best Southwest deals on Des Moines to Charleston flight tickets
Southwest
Aug 24
DSM3:50 pmDes Moines
4h 35m
1 stop
CHS9:25 pmCharleston
Sep 3
CHS1:15 pmCharleston
9h 55m
2 stops
DSM10:10 pmDes Moines
$360
Southwest
Aug 24
DSM5:40 amDes Moines
8h 45m
2 stops
CHS3:25 pmCharleston
Sep 3
CHS1:15 pmCharleston
9h 55m
2 stops
DSM10:10 pmDes Moines
$366
Southwest
Jul 21
DSM5:20 amDes Moines
9h 50m
2 stops
CHS4:10 pmCharleston
Jul 23
CHS4:45 pmCharleston
7h 50m
2 stops
DSM11:35 pmDes Moines
$372

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/24

2:53 pm-8:38 am

1 stop16h 45m

Charleston

Fri 9/4

3:54 pm-10:08 pm

1 stop7h 14m

$233

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/24

2:53 pm-8:38 am

1 stop16h 45m

Charleston

Thu 9/3

8:20 pm-6:56 pm

1 stop23h 36m

$260

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/24

2:53 pm-8:38 am

1 stop16h 45m

Charleston

Thu 9/3

2:53 pm-12:58 pm

1 stop23h 05m

$264

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 8/23

9:28 am-8:38 am

2 stops46h 10m

Charleston

Fri 9/4

3:54 pm-10:08 pm

1 stop7h 14m

$273

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/24

2:53 pm-8:38 am

1 stop16h 45m

Charleston

Sun 9/6

2:53 pm-10:44 am

1 stop20h 51m

$292

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 10/5

2:19 pm-12:31 pm

1 stop21h 12m

Charleston

Thu 10/8

9:39 pm-7:59 am

1 stop11h 20m

$293

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 9/4

3:04 pm-9:29 pm

1 stop29h 25m

Charleston

Thu 9/10

9:39 pm-4:05 pm

1 stop19h 26m

$306

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 7/27

4:40 pm-6:14 pm

1 stop24h 34m

Charleston

Sun 8/2

7:47 pm-3:50 pm

1 stop21h 03m

$314
Quickest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 8/25

5:40 am-11:54 am

1 stop5h 14m

Charleston

Wed 9/2

3:14 pm-8:59 pm

1 stop6h 45m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 7/21

4:14 pm-9:08 am

1 stop15h 54m

Charleston

Thu 7/23

8:20 pm-10:15 pm

1 stop26h 55m

$323

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $283, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $312.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 49% on your flight if you consider stops on a Des Moines to Charleston flight.

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Fastest flight time

4h 12m

Direct flights

None
The fastest flight from Des Moines to Charleston takes 4h 12m
There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.
Search flight deals

Frequently asked questions about flying from Des Moines to Charleston

  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 12m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $242Free CancellationRating
7.1
11,703 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.8
8,418 reviews
Search Delta flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
9,860 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
North Charleston
Isle of Palms
Summerville
Kiawah Island
Mount Pleasant
Edisto Island
Walterboro
Santee
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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