Which layover airport has the shortest connection time from Des Moines to Charleston?

Atlanta (ATL) has the shortest average layover time for this route: 1h 01m.

What airlines fly to Charleston?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Charleston from Des Moines according to our data. American Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 4 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from Des Moines to Charleston?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 4h 20m.

Which layover airport offers the lowest fares from Des Moines to Charleston?

Flights via Chicago (MDW) offer the lowest average round-trip price of $380.

Which airport is the most popular layover for flights between Des Moines and Charleston?

Chicago (ORD) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

There are 4 operators available for flights from Des Moines Airport to Charleston Airport as of October 2026.

How old do you have to be to fly from Des Moines Airport to Charleston Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

What documentation or ID do you need to fly to Charleston Airport?

The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$141 Cheap Flights from Des Moines to Charleston in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Charleston

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:55 am - 12:31 pmDSM Des Moines-CHS Charleston

24h 36m1 stop Tampa St. Petersburg

1:21 pm - 11:05 amCHS Charleston-DSM Des Moines

22h 44m1 stop Tampa

$276Multiple Airlines

Mon, Jan 11 - Tue, Jan 19

11:12 am - 8:38 amDSM Des Moines-CHS Charleston

20h 26m2 stops Nashville Intl Orlando Sanford Intl

1:21 pm - 11:05 amCHS Charleston-DSM Des Moines

22h 44m1 stop Tampa

$313Multiple Airlines

Mon, Jan 11 - Tue, Jan 19

11:09 am - 6:46 pmDSM Des Moines-CHS Charleston

6h 37m1 stop Charlotte Douglas

7:00 am - 2:35 pmCHS Charleston-DSM Des Moines

8h 35m1 stop Dallas/Fort Worth

$395American Airlines

Tue, Nov 17 - Thu, Nov 19

5:24 am - 12:05 pmDSM Des Moines-CHS Charleston

5h 41m1 stop Washington, D.C. Reagan-National

11:10 am - 5:31 pmCHS Charleston-DSM Des Moines

7h 21m1 stop Charlotte Douglas

$395American Airlines

Tue, Dec 15 - Tue, Jan 5

8:00 am - 5:39 pmDSM Des Moines-CHS Charleston

8h 39m2 stops Chicago O'Hare Intl Newark

12:18 pm - 5:28 pmCHS Charleston-DSM Des Moines

6h 10m1 stop Chicago O'Hare Intl

$400United Airlines

Tue, Nov 17 - Thu, Nov 19

8:00 am - 1:56 pmDSM Des Moines-CHS Charleston

4h 56m1 stop Chicago O'Hare Intl

3:29 pm - 9:55 pmCHS Charleston-DSM Des Moines

7h 26m1 stop Chicago O'Hare Intl

$405United Airlines

Fri, Nov 13 - Fri, Nov 20

5:55 am - 4:20 pmDSM Des Moines-CHS Charleston

9h 25m2 stops Chicago Midway Baltimore/Washington

11:00 am - 8:40 pmCHS Charleston-DSM Des Moines

10h 40m2 stops Nashville Intl Denver Intl

$405Southwest

Mon, Jan 11 - Tue, Jan 19

7:00 am - 7:35 pmDSM Des Moines-CHS Charleston

11h 35m2 stops Denver Intl Nashville Intl

1:30 pm - 10:05 pmCHS Charleston-DSM Des Moines

9h 35m2 stops Baltimore/Washington Chicago Midway

$405Southwest

Tue, Nov 17 - Thu, Nov 19

10:15 am - 6:03 pmDSM Des Moines-CHS Charleston

6h 48m1 stop Detroit Metropolitan Wayne County

6:30 am - 10:18 amCHS Charleston-DSM Des Moines

4h 48m1 stop Atlanta Hartsfield-Jackson

$437Delta

Tue, Mar 16 - Wed, Mar 17

5:35 am - 1:00 pmDSM Des Moines-CHS Charleston

6h 25m1 stop Atlanta Hartsfield-Jackson

7:05 am - 10:42 amCHS Charleston-DSM Des Moines

4h 37m1 stop Atlanta Hartsfield-Jackson

$682Delta

Thu, Oct 29 - Mon, Nov 2

Cheap last minute flights

Enter your travel dates to find the best prices.

2:26 pm - 10:09 pmDSM Des Moines-CHS Charleston

6h 43m1 stop Washington, D.C. Reagan-National

8:08 pm - 11:58 pmCHS Charleston-DSM Des Moines

4h 50m1 stop Charlotte Douglas

$893American Airlines

Thu, Oct 22 - Sun, Oct 25

11:22 am - 6:14 pmDSM Des Moines-CHS Charleston

5h 52m1 stop Charlotte Douglas

8:08 pm - 11:58 pmCHS Charleston-DSM Des Moines

4h 50m1 stop Charlotte Douglas

$932American Airlines

Thu, Oct 22 - Sun, Oct 25

6:54 pm - 11:59 pmDSM Des Moines-CHS Charleston

4h 05m1 stop Atlanta Hartsfield-Jackson

7:05 pm - 10:33 pmCHS Charleston-DSM Des Moines

4h 28m1 stop Atlanta Hartsfield-Jackson

$982Delta

Thu, Oct 22 - Sun, Oct 25

8:00 am - 2:04 pmDSM Des Moines-CHS Charleston

5h 04m1 stop Chicago O'Hare Intl

10:23 am - 9:55 pmCHS Charleston-DSM Des Moines

12h 32m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$1,026United Airlines

Thu, Oct 22 - Sun, Oct 25

1:27 pm - 9:46 pmDSM Des Moines-CHS Charleston

7h 19m1 stop Denver Intl

10:23 am - 7:16 pmCHS Charleston-DSM Des Moines

9h 53m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$1,026United Airlines

Thu, Oct 22 - Sun, Oct 25

1:24 pm - 12:15 amDSM Des Moines-CHS Charleston

9h 51m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

10:23 am - 7:16 pmCHS Charleston-DSM Des Moines

9h 53m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$1,031United Airlines

Thu, Oct 22 - Sun, Oct 25

11:22 am - 6:14 pmDSM Des Moines-CHS Charleston

5h 52m1 stop Charlotte Douglas

8:08 pm - 11:58 pmCHS Charleston-DSM Des Moines

4h 50m1 stop Charlotte Douglas

$1,037American Airlines

Thu, Oct 22 - Sun, Oct 25

1:24 pm - 9:33 pmDSM Des Moines-CHS Charleston

7h 09m1 stop Chicago O'Hare Intl

7:00 am - 5:27 pmCHS Charleston-DSM Des Moines

11h 27m2 stops Newark Chicago O'Hare Intl

$1,108United Airlines

Thu, Oct 22 - Sun, Oct 25

3:11 pm - 12:15 amDSM Des Moines-CHS Charleston

8h 04m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

7:00 am - 5:27 pmCHS Charleston-DSM Des Moines

11h 27m2 stops Newark Chicago O'Hare Intl

$1,113United Airlines

Thu, Oct 22 - Sun, Oct 25

2:26 pm - 10:09 pmDSM Des Moines-CHS Charleston

6h 43m1 stop Washington, D.C. Reagan-National

6:01 am - 1:30 pmCHS Charleston-DSM Des Moines

8h 29m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

$1,201American Airlines

Thu, Oct 22 - Sun, Oct 25

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Southwest flights from Des Moines to Charleston

Our best Southwest deals on Des Moines to Charleston flight tickets

Southwest

Jan 14

DSM5:55 amDes Moines

9h 25m

2 stops

CHS4:20 pmCharleston

Jan 17

CHS1:25 pmCharleston

9h 10m

2 stops

DSM9:35 pmDes Moines

$416

Southwest

Jan 15

DSM5:20 amDes Moines

6h 40m

2 stops

CHS1:00 pmCharleston

Jan 18

CHS6:35 amCharleston

12h 35m

2 stops

DSM6:10 pmDes Moines

$463

Southwest

Nov 13

DSM6:40 amDes Moines

10h 50m

2 stops

CHS6:30 pmCharleston

Nov 20

CHS1:20 pmCharleston

9h 45m

2 stops

DSM10:05 pmDes Moines

$518

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets

American Airlines

Nov 7

DSM6:00 amDes Moines

7h 39m

1 stop

CHS2:39 pmCharleston

Nov 10

CHS12:17 pmCharleston

7h 39m

1 stop

DSM6:56 pmDes Moines

$395

American Airlines

Jan 14

DSM7:36 amDes Moines

6h 51m

1 stop

CHS3:27 pmCharleston

Jan 17

CHS6:05 amCharleston

5h 53m

1 stop

DSM10:58 amDes Moines

$406

American Airlines

Nov 7

DSM7:23 amDes Moines

7h 01m

1 stop

CHS3:24 pmCharleston

Nov 10

CHS2:40 pmCharleston

7h 40m

2 stops

DSM9:20 pmDes Moines

$411

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 1/11

10:55 am-12:31 pm

1 stop24h 36m

Charleston

Tue 1/19

1:21 pm-11:05 am

1 stop22h 44m

$276

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 1/11

11:12 am-8:38 am

2 stops20h 26m

Charleston

Tue 1/19

1:21 pm-11:05 am

1 stop22h 44m

$313

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Tue 11/17

11:09 am-6:46 pm

1 stop6h 37m

Charleston

Thu 11/19

7:00 am-2:35 pm

1 stop8h 35m

$395

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Tue 12/15

5:24 am-12:05 pm

1 stop5h 41m

Charleston

Tue 1/5

11:10 am-5:31 pm

1 stop7h 21m

$395

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Tue 11/17

8:00 am-5:39 pm

2 stops8h 39m

Charleston

Thu 11/19

12:18 pm-5:28 pm

1 stop6h 10m

$400

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Fri 11/13

8:00 am-1:56 pm

1 stop4h 56m

Charleston

Fri 11/20

3:29 pm-9:55 pm

1 stop7h 26m

$405

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 1/11

5:55 am-4:20 pm

2 stops9h 25m

Charleston

Tue 1/19

11:00 am-8:40 pm

2 stops10h 40m

$405

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Tue 11/17

7:00 am-7:35 pm

2 stops11h 35m

Charleston

Thu 11/19

1:30 pm-10:05 pm

2 stops9h 35m

$405

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Tue 3/16

10:15 am-6:03 pm

1 stop6h 48m

Charleston

Wed 3/17

6:30 am-10:18 am

1 stop4h 48m

$437

Quickest round-trip

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Thu 10/29

5:35 am-1:00 pm

1 stop6h 25m

Charleston

Mon 11/2

7:05 am-10:42 am

1 stop4h 37m

$682

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Des Moines and Charleston?

Prices are currently low for flights on this route.

Typical prices usually range from $404 to $588.
The lowest price recently found on this route was $276.

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in January. Flight prices, which tend to average around $392, are often lower during this time because this is during the off-season. The month of February is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $408.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Best Price Found	$141
Fastest flight time	4h 05m
Direct flights	None

The best one-way flight to Charleston from Des Moines in the past 72 hours is $141. The best round-trip flight deal from Des Moines to Charleston found on momondo in the last 72 hours is $276.

The fastest flight from Des Moines to Charleston takes 4h 05m

There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.

Search flight deals

Frequently asked questions about flying from Des Moines to Charleston

How far is Des Moines to Charleston by plane?
The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 05m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?
Prices for flights from Des Moines Airport to Charleston Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?
There are 4 operators available for flights from Des Moines Airport to Charleston Airport as of October 2026.
How old do you have to be to fly from Des Moines Airport to Charleston Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.
What documentation or ID do you need to fly to Charleston Airport?
The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Charleston?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Charleston is American Airlines (47% of total bookings). The next most popular airlines are Delta (26%), United Airlines (19%), and Southwest (7%).

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $305	Free Cancellation	Rating 7.0 12,177 reviews	Search American Airlines flights
United Airlines	PriceFrom $324	Free Cancellation	Rating 7.3 10,388 reviews	Search United Airlines flights
Delta	PriceFrom $324	Free Cancellation	Rating 7.8 8,651 reviews	Search Delta flights
Southwest	PriceFrom $380	Free Cancellation	Rating 7.9 4,210 reviews	Search Southwest flights

Folly Beach

North Charleston

Isle of Palms

Summerville

Mount Pleasant

Kiawah Island

Walterboro

Goose Creek

Santee

Edisto Island

Edisto Beach

Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Des Moines to Charleston from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 11/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Southwest flights from Des Moines to Charleston

Our best Southwest deals on Des Moines to Charleston flight tickets

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets

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How to get the cheapest flight ticket from Des Moines to Charleston

What is the typical price of a round-trip flight between Des Moines and Charleston?

What is the cheapest month to fly to Charleston?

How have Des Moines to Charleston flight prices changed over time?

What airlines fly to Charleston?

Which airport is the most popular layover for flights between Des Moines and Charleston?

Which layover airport offers the lowest fares from Des Moines to Charleston?

Which layover airport has the shortest travel time from Des Moines to Charleston?

Which layover airport has the shortest connection time from Des Moines to Charleston?

When to book flights from Des Moines to Charleston

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Charleston

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo

Traveling to a place near Charleston?

Why use momondo?

An easier way to manage your Charleston trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

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Airports servicing South Carolina

Fly your favorite airline to Charleston

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Charleston

List of cabin classes available on flights landing in Charleston. Availability may vary depending on flight origin and airline.

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