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Cheap flights from Des Moines to Charleston from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:58 pm - 5:36 pmDSM-CHS
25h 38m1 stop
Multiple Airlines Logo
3:01 pm - 10:19 amCHS-DSM
20h 18m2 stops
$277Multiple Airlines
Find Deal
Sun, Jan 11 - Sun, Jan 18
Delta Logo
10:56 am - 6:15 pmDSM-CHS
6h 19m1 stop
Delta Logo
1:04 pm - 4:27 pmCHS-DSM
4h 23m1 stop
$313Delta
Find Deal
Sat, Feb 14 - Tue, Feb 17
Delta Logo
12:04 pm - 5:43 pmDSM-CHS
4h 39m1 stop
Delta Logo
11:49 am - 5:08 pmCHS-DSM
6h 19m1 stop
$315Delta
Find Deal
Sun, Jan 18 - Sat, Jan 24
American Airlines Logo
5:21 am - 2:25 pmDSM-CHS
8h 04m1 stop
American Airlines Logo
5:24 pm - 11:08 pmCHS-DSM
6h 44m1 stop
$316American Airlines
Find Deal
Wed, Jan 14 - Wed, Jan 21
Delta Logo
12:04 pm - 5:43 pmDSM-CHS
4h 39m1 stop
Delta Logo
10:25 am - 4:28 pmCHS-DSM
7h 03m1 stop
$317Delta
Find Deal
Fri, Jan 9 - Tue, Jan 13
Multiple Airlines Logo
4:30 pm - 4:10 pmDSM-CHS
22h 40m2 stops
Multiple Airlines Logo
6:35 pm - 10:19 amCHS-DSM
16h 44m2 stops
$318Multiple Airlines
Find Deal
Sun, Jan 11 - Sun, Jan 18
American Airlines Logo
11:42 am - 11:07 pmDSM-CHS
10h 25m2 stops
American Airlines Logo
7:32 am - 3:15 pmCHS-DSM
8h 43m1 stop
$320American Airlines
Find Deal
Sun, Jan 18 - Sat, Jan 24
American Airlines Logo
6:00 am - 1:39 pmDSM-CHS
6h 39m2 stops
American Airlines Logo
5:57 pm - 11:23 pmCHS-DSM
6h 26m1 stop
$322American Airlines
Find Deal
Tue, Jan 13 - Tue, Jan 13
American Airlines Logo
11:27 am - 10:23 pmDSM-CHS
9h 56m2 stops
American Airlines Logo
3:54 pm - 10:26 pmCHS-DSM
7h 32m2 stops
$323American Airlines
Find Deal
Sat, Feb 14 - Tue, Feb 17
Multiple Airlines Logo
1:23 pm - 10:37 pmDSM-CHS
8h 14m1 stop
Multiple Airlines Logo
7:00 am - 1:46 pmCHS-DSM
31h 46m2 stops
$324Multiple Airlines
Find Deal
Tue, Mar 24 - Wed, Apr 1

Delta flights from Des Moines to Charleston

Our best Delta deals on Des Moines to Charleston flight tickets
Delta
Feb 14
DSM10:56 amDes Moines
6h 19m
1 stop
CHS6:15 pmCharleston
Feb 17
CHS1:04 pmCharleston
4h 23m
1 stop
DSM4:27 pmDes Moines
$313
Find similar
Delta
Jan 18
DSM10:14 amDes Moines
7h 05m
1 stop
CHS6:19 pmCharleston
Jan 24
CHS9:00 amCharleston
4h 15m
1 stop
DSM12:15 pmDes Moines
$315
Find similar
Delta
Jan 9
DSM7:34 amDes Moines
5h 48m
1 stop
CHS2:22 pmCharleston
Jan 11
CHS5:18 pmCharleston
6h 11m
1 stop
DSM10:29 pmDes Moines
$317
Find similar

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
Jan 14
DSM5:21 amDes Moines
8h 04m
1 stop
CHS2:25 pmCharleston
Jan 21
CHS5:24 pmCharleston
6h 44m
1 stop
DSM11:08 pmDes Moines
$316
Find similar
American Airlines
Jan 18
DSM7:40 amDes Moines
4h 59m
1 stop
CHS1:39 pmCharleston
Jan 24
CHS6:10 amCharleston
7h 36m
2 stops
DSM12:46 pmDes Moines
$320
Find similar
American Airlines
Jan 13
DSM6:00 amDes Moines
6h 39m
2 stops
CHS1:39 pmCharleston
Jan 13
CHS5:57 pmCharleston
6h 26m
1 stop
DSM11:23 pmDes Moines
$322
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/11

2:58 pm-5:36 pm

1 stop25h 38m

Charleston

Sun 1/18

3:01 pm-10:19 am

2 stops20h 18m

$277

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 2/14

10:56 am-6:15 pm

1 stop6h 19m

Charleston

Tue 2/17

1:04 pm-4:27 pm

1 stop4h 23m

$313

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

12:04 pm-5:43 pm

1 stop4h 39m

Charleston

Sat 1/24

11:49 am-5:08 pm

1 stop6h 19m

$315

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 1/14

5:21 am-2:25 pm

1 stop8h 04m

Charleston

Wed 1/21

5:24 pm-11:08 pm

1 stop6h 44m

$316

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 1/9

12:04 pm-5:43 pm

1 stop4h 39m

Charleston

Tue 1/13

10:25 am-4:28 pm

1 stop7h 03m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/11

4:30 pm-4:10 pm

2 stops22h 40m

Charleston

Sun 1/18

6:35 pm-10:19 am

2 stops16h 44m

$318

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

11:42 am-11:07 pm

2 stops10h 25m

Charleston

Sat 1/24

7:32 am-3:15 pm

1 stop8h 43m

$320

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 1/13

6:00 am-1:39 pm

2 stops6h 39m

Charleston

Tue 1/13

5:57 pm-11:23 pm

1 stop6h 26m

$322

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 2/14

11:27 am-10:23 pm

2 stops9h 56m

Charleston

Tue 2/17

3:54 pm-10:26 pm

2 stops7h 32m

$323

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 3/24

1:23 pm-10:37 pm

1 stop8h 14m

Charleston

Wed 4/1

7:00 am-1:46 pm

2 stops31h 46m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $285, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $324.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Des Moines to Charleston is on a Monday. Travelers who choose to depart for Charleston on a Monday will often find tickets for as low as $379. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the afternoon when flights can be purchased for as low as $386. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $405 per ticket.

How far in advance should I book a flight to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $385 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $242 on momondo.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 5% on your flight if you consider stops on a Des Moines to Charleston flight.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Des Moines to Charleston takes 4h 28m
There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.
Search flight deals

  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 13m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $199Free CancellationRating
7.9
8,011 reviews
Search Delta flights
American AirlinesPriceFrom $260Free CancellationRating
7.2
11,039 reviews
Search American Airlines flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
9,056 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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