What airlines fly to Charleston?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Charleston from Des Moines according to our data. American Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 3 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Charleston?

American Airlines, Delta, and Southwest are the most popular carriers operating from Des Moines to Charleston

When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

There are 3 operators available for flights from Des Moines Airport to Charleston Airport as of January 2026.

How old do you have to be to fly from Des Moines Airport to Charleston Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

What documentation or ID do you need to fly to Charleston Airport?

The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$171 Cheap Flights from Des Moines to Charleston in 2026

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Des Moines to Charleston

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:58 pm - 5:39 pm

DSM

CHS

25h 41m

1 stop

6:35 pm - 7:48 pm

CHS

DSM

26h 13m

2 stops

$300Multiple Airlines

Sun, Feb 8 - Thu, Feb 12

6:00 am - 10:33 pm

DSM

CHS

15h 33m

1 stop

8:07 am - 1:46 pm

CHS

DSM

30h 39m

2 stops

$312Multiple Airlines

Thu, Mar 26 - Wed, Apr 1

3:24 pm - 9:27 pm

DSM

CHS

5h 03m

1 stop

5:10 pm - 10:20 pm

CHS

DSM

6h 10m

1 stop

$317United Airlines

Wed, Feb 18 - Wed, Feb 25

6:10 am - 5:35 pm

DSM

CHS

10h 25m

2 stops

1:45 pm - 7:20 pm

CHS

DSM

6h 35m

1 stop

$322Southwest

Wed, Feb 18 - Wed, Feb 25

6:10 am - 5:35 pm

DSM

CHS

10h 25m

2 stops

9:05 am - 7:20 pm

CHS

DSM

11h 15m

2 stops

$328Southwest

Wed, Feb 18 - Wed, Feb 25

5:35 am - 1:21 pm

DSM

CHS

6h 46m

1 stop

6:09 pm - 10:38 pm

CHS

DSM

5h 29m

1 stop

$341Delta

Wed, Mar 25 - Wed, Apr 1

6:00 am - 1:52 pm

DSM

CHS

6h 52m

2 stops

2:49 pm - 9:51 pm

CHS

DSM

8h 02m

1 stop

$346American Airlines

Mon, Feb 23 - Mon, Mar 2

6:00 am - 3:38 pm

DSM

CHS

8h 38m

2 stops

2:59 pm - 11:29 pm

CHS

DSM

9h 30m

2 stops

$352American Airlines

Tue, Apr 21 - Sat, Apr 25

6:25 am - 6:45 pm

DSM

CHS

11h 20m

2 stops

12:55 pm - 10:15 pm

CHS

DSM

10h 20m

2 stops

$357Southwest

Mon, Feb 23 - Mon, Mar 2

5:20 pm - 12:16 am

DSM

CHS

5h 56m

1 stop

5:27 am - 10:48 am

CHS

DSM

6h 21m

1 stop

$364Delta

Fri, Mar 27 - Sat, Mar 28

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets

American Airlines

Feb 23

DSM6:00 amDes Moines

6h 52m

2 stops

CHS1:52 pmCharleston

Mar 2

CHS2:49 pmCharleston

8h 02m

1 stop

DSM9:51 pmDes Moines

$346

American Airlines

Apr 21

DSM6:00 amDes Moines

8h 38m

2 stops

CHS3:38 pmCharleston

Apr 25

CHS2:59 pmCharleston

9h 30m

2 stops

DSM11:29 pmDes Moines

$352

American Airlines

Mar 25

DSM7:45 amDes Moines

7h 33m

1 stop

CHS4:18 pmCharleston

Mar 30

CHS5:25 pmCharleston

7h 23m

1 stop

DSM11:48 pmDes Moines

$411

United Airlines flights from Des Moines to Charleston

Our best United Airlines deals on Des Moines to Charleston flight tickets

United Airlines

Feb 18

DSM3:24 pmDes Moines

5h 03m

1 stop

CHS9:27 pmCharleston

Feb 25

CHS5:10 pmCharleston

6h 10m

1 stop

DSM10:20 pmDes Moines

$317

United Airlines

Apr 17

DSM3:21 pmDes Moines

7h 06m

1 stop

CHS11:27 pmCharleston

Apr 20

CHS5:12 pmCharleston

6h 31m

1 stop

DSM10:43 pmDes Moines

$384

United Airlines

Feb 14

DSM8:00 amDes Moines

4h 52m

1 stop

CHS1:52 pmCharleston

Feb 18

CHS4:00 pmCharleston

8h 43m

1 stop

DSM11:43 pmDes Moines

$387

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 2/8

2:58 pm-5:39 pm

1 stop25h 41m

Charleston

Thu 2/12

6:35 pm-7:48 pm

2 stops26h 13m

$300

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 3/26

6:00 am-10:33 pm

1 stop15h 33m

Charleston

Wed 4/1

8:07 am-1:46 pm

2 stops30h 39m

$312

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 2/18

3:24 pm-9:27 pm

1 stop5h 03m

Charleston

Wed 2/25

5:10 pm-10:20 pm

1 stop6h 10m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 2/18

6:10 am-5:35 pm

2 stops10h 25m

Charleston

Wed 2/25

1:45 pm-7:20 pm

1 stop6h 35m

$322

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 2/18

6:10 am-5:35 pm

2 stops10h 25m

Charleston

Wed 2/25

9:05 am-7:20 pm

2 stops11h 15m

$328

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 3/25

5:35 am-1:21 pm

1 stop6h 46m

Charleston

Wed 4/1

6:09 pm-10:38 pm

1 stop5h 29m

$341

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 2/23

6:00 am-1:52 pm

2 stops6h 52m

Charleston

Mon 3/2

2:49 pm-9:51 pm

1 stop8h 02m

$346

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 4/21

6:00 am-3:38 pm

2 stops8h 38m

Charleston

Sat 4/25

2:59 pm-11:29 pm

2 stops9h 30m

$352

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 2/23

6:25 am-6:45 pm

2 stops11h 20m

Charleston

Mon 3/2

12:55 pm-10:15 pm

2 stops10h 20m

$357

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 3/27

5:20 pm-12:16 am

1 stop5h 56m

Charleston

Sat 3/28

5:27 am-10:48 am

1 stop6h 21m

$364

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $285, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $312.

How far in advance should I book a flight to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $385 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $242 on momondo.

Can stopping save me money on Des Moines to Charleston flights?

You could potentially save up to 66% on your flight if you consider stops on a Des Moines to Charleston flight.

How have Des Moines to Charleston flight prices changed over time?

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Fastest flight time	4h 49m
Direct flights	None

The fastest flight from Des Moines to Charleston takes 4h 49m

There are no direct flights from Des Moines to Charleston. There are no popular flight routes from Des Moines to Charleston.

Search flight deals

How far is Des Moines to Charleston by plane?
The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 49m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?
Prices for flights from Des Moines Airport to Charleston Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?
There are 3 operators available for flights from Des Moines Airport to Charleston Airport as of January 2026.
How old do you have to be to fly from Des Moines Airport to Charleston Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.
What documentation or ID do you need to fly to Charleston Airport?
The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Charleston?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Charleston is American Airlines (68% of total bookings). The next most popular airlines are Delta (25%) and United Airlines (6%).

Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $166	Free Cancellation	Rating 7.9 8,111 reviews	Search Delta flights
American Airlines	PriceFrom $256	Free Cancellation	Rating 7.2 11,197 reviews	Search American Airlines flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 9,198 reviews	Search United Airlines flights

Folly Beach

Isle of Palms

Kiawah Island

North Charleston

Summerville

Mount Pleasant

Edisto Island

Santee

Walterboro

Goose Creek

Edisto Beach

Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.