Cheap flights from Denver to Knoxville from $52

The month of November is, on average, the cheapest month to fly to Knoxville from Denver, with most prices found around $175. If you aren’t able to travel during the month of November, then book flights to Knoxville from Denver during August instead. Flights to Knoxville in August, while not as cheap as those in November, still average around $189.

The cheapest day to depart from Denver to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $209. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Denver to Knoxville for around $384.

At noon is the cheapest time of day to fly from Denver to Knoxville when you can find flight prices for as low as $239. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $377.

Fly from Denver Intl to Knoxville McGhee Tyson for the best Denver Intl - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $310 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Denver for as low as $170 on momondo.

There are 4 cabin classes available to choose from on Denver to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Delta, and United Airlines are the most popular carriers operating from Denver Intl to Knoxville McGhee Tyson

United Airlines, Allegiant Air and American Airlines are the top three most popular airlines that fly to Knoxville from Denver according to our data. United Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 6 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

The number of flights available between Denver and Knoxville is 2 per day as of September 2026. The most frequent departure time is 11:00AM, with 56% of daily flights leaving at noon.

As of September 2026, there are 18 flights per week flying from Denver to Knoxville. The most common day of the week flights depart is Sun, with 22% of flights taking off on this day.