Cheap flights from Colorado to Knoxville from $58

The month of October is, on average, the cheapest month to fly to Knoxville from Colorado, with most prices found around $39. If you aren’t able to travel during the month of October, then book flights to Knoxville from Colorado during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $45.

The cheapest day to depart from Colorado to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $196. When flying out on a Wednesday, the most expensive travel day of the week, you can expect to see flight prices from Colorado to Knoxville for around $384.

At noon is the cheapest time of day to fly from Colorado to Knoxville when you can find flight prices for as low as $206. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $324.

Fly from Denver Intl to Knoxville McGhee Tyson for the best Colorado - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Colorado when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $289 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Colorado for as low as $154 on momondo.

There are 2 cabin classes available to choose from on Colorado to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Allegiant Air, American Airlines, and United Airlines are the most popular carriers operating from Colorado to Knoxville McGhee Tyson

United Airlines, American Airlines and Allegiant Air are the top three most popular airlines that fly to Knoxville from Colorado according to our data. United Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 6 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

As of June 2026, there are 2 flights per day flying from Colorado to Knoxville. The most common time of day flights depart is 5:00PM, with 76% of flights taking off in the afternoon.

As of June 2026, 19 flights take off from Colorado and land in Knoxville each week. The most common flight departure day for this route is Thu, with 21% of weekly flights taking off on this day.