Cheap flights from Chicago to Panama City from $172

The cheapest month to fly to Panama City, Florida from Chicago is in February. Flight prices, which tend to average around $284, are often lower during this time because this is during the off-season. The month of November is another great option to travel to Panama City, Florida, with average flight prices from Chicago averaging around $334.

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $331. On the other hand, Thursday is the most expensive day to depart from Chicago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $443.

Fly from Chicago O'Hare Intl to Panama City NW Florida Beaches for the best Chicago - Panama City NW Florida Beaches flight prices

You are more likely to see cheaper flights to Panama City, Florida from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $373 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Chicago for as low as $331 on momondo.

There are 4 cabin classes available to choose from on Chicago to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 14% on your flight if you consider stops on a Chicago to Panama City, Florida flight.

United Airlines, Southwest, and Delta are the most popular carriers operating from Chicago to Panama City NW Florida Beaches

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Panama City, Florida from Chicago according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 5 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

Nashville (BNA) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $228.

Flights connecting via Nashville (BNA) have the shortest average one-way travel time: 3h 50m.

Atlanta (ATL) has the shortest average layover time for this route: 0h 53m.

As of August 2026, 1 flights take off from Chicago and land in Panama City, Florida each day. The most common flight departure time for this route is 10:00AM, with 84% of daily flights taking off at noon.

As of August 2026, 12 flights take off from Chicago and land in Panama City, Florida each week. The most common flight departure day for this route is Mon, with 25% of weekly flights taking off on this day.