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Cheap flights from Chicago to Florence from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Chicago to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:45 pm - 10:00 pm
ORD
-
FLO
4h 15m
1 stop
American Airlines Logo
2:35 pm - 7:48 pm
FLO
-
ORD
6h 13m
1 stop
$279American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
6:00 am - 2:09 pm
ORD
-
FLO
7h 09m
2 stops
American Airlines Logo
11:20 am - 3:38 pm
FLO
-
ORD
5h 18m
1 stop
$284American Airlines
Tue, Sep 1 - Tue, Sep 15
American Airlines Logo
3:32 pm - 12:02 am
ORD
-
FLO
7h 30m
2 stops
American Airlines Logo
5:31 am - 12:02 pm
FLO
-
ORD
7h 31m
2 stops
$289American Airlines
Tue, Sep 1 - Tue, Sep 15
American Airlines Logo
3:26 pm - 9:47 pm
ORD
-
FLO
5h 21m
1 stop
American Airlines Logo
6:15 am - 10:11 am
FLO
-
ORD
4h 56m
1 stop
$375American Airlines
Fri, Apr 10 - Tue, Apr 14
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
$412American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
8:48 am - 2:10 pm
ORD
-
FLO
4h 22m
1 stop
American Airlines Logo
5:05 am - 10:47 am
FLO
-
ORD
6h 42m
1 stop
$474American Airlines
Sat, Jun 20 - Tue, Jun 23
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
American Airlines Logo
5:05 am - 10:47 am
FLO
-
ORD
6h 42m
1 stop
$479American Airlines
Sat, Jun 20 - Tue, Jun 23
American Airlines Logo
1:25 pm - 10:00 pm
ORD
-
FLO
7h 35m
2 stops
American Airlines Logo
5:05 am - 11:32 am
FLO
-
ORD
7h 27m
2 stops
$567American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
12:42 pm - 9:47 pm
ORD
-
FLO
8h 05m
2 stops
American Airlines Logo
6:15 am - 12:36 pm
FLO
-
ORD
7h 21m
1 stop
$658American Airlines
Fri, Apr 10 - Tue, Apr 14
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
American Airlines Logo
5:05 am - 11:32 am
FLO
-
ORD
7h 27m
2 stops
$736American Airlines
Sat, Jun 20 - Tue, Jun 23

American Airlines flights from Chicago to Florence, South Carolina

Our best American Airlines deals on Chicago to Florence, South Carolina flight tickets
American Airlines
May 23
ORD4:45 pmChicago O'Hare Intl
4h 15m
1 stop
FLO10:00 pmFlorence
May 30
FLO2:35 pmFlorence
6h 13m
1 stop
ORD7:48 pmChicago O'Hare Intl
$279
American Airlines
Sep 1
ORD6:00 amChicago O'Hare Intl
7h 09m
2 stops
FLO2:09 pmFlorence
Sep 15
FLO11:20 amFlorence
5h 18m
1 stop
ORD3:38 pmChicago O'Hare Intl
$284
American Airlines
Sep 1
ORD3:32 pmChicago O'Hare Intl
7h 30m
2 stops
FLO12:02 amFlorence
Sep 15
FLO5:31 amFlorence
7h 31m
2 stops
ORD12:02 pmChicago O'Hare Intl
$289

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Chicago to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/23

4:45 pm-10:00 pm

1 stop4h 15m

Florence

Sat 5/30

2:35 pm-7:48 pm

1 stop6h 13m

$279

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/1

6:00 am-2:09 pm

2 stops7h 09m

Florence

Tue 9/15

11:20 am-3:38 pm

1 stop5h 18m

$284

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/1

3:32 pm-12:02 am

2 stops7h 30m

Florence

Tue 9/15

5:31 am-12:02 pm

2 stops7h 31m

$289
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 4/10

3:26 pm-9:47 pm

1 stop5h 21m

Florence

Tue 4/14

6:15 am-10:11 am

1 stop4h 56m

$375

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/23

5:00 am-2:10 pm

2 stops8h 10m

Florence

Sat 5/30

5:05 am-9:02 am

1 stop4h 57m

$412

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/20

8:48 am-2:10 pm

1 stop4h 22m

Florence

Tue 6/23

5:05 am-10:47 am

1 stop6h 42m

$474

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/20

5:00 am-2:10 pm

2 stops8h 10m

Florence

Tue 6/23

5:05 am-10:47 am

1 stop6h 42m

$479

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/23

1:25 pm-10:00 pm

2 stops7h 35m

Florence

Sat 5/30

5:05 am-11:32 am

2 stops7h 27m

$567

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 4/10

12:42 pm-9:47 pm

2 stops8h 05m

Florence

Tue 4/14

6:15 am-12:36 pm

1 stop7h 21m

$658

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/20

5:00 am-2:10 pm

2 stops8h 10m

Florence

Tue 6/23

5:05 am-11:32 am

2 stops7h 27m

$736

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago to Florence?

American Airlines is the most popular carrier operating from Chicago to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, South Carolina (CHI to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, South Carolina

Fastest flight time

5h 21m

Direct flights

None
The fastest flight from Chicago to Florence, South Carolina takes 5h 21m
There are no direct flights from Chicago to Florence, South Carolina. There are no popular flight routes from Chicago to Florence, South Carolina.
Search flight deals

  • How far is Chicago to Florence by plane?

    There are 680.6 mi between Chicago and Florence. Flights usually cover this in 5h 21m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago to Florence Airport?

    Prices for flights from Chicago to Florence Airport refresh daily.

  • How old do you have to be to fly from Chicago to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

It is quick and easy to find Chicago to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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