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Cheap flights from Chicago to Florence from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Chicago to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:05 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 04m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 11:00 amFLO  Florence-ORD Chicago O'Hare Intl
5h 36m1 stop Charlotte Douglas
$355American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
1:22 pm - 9:20 pmORD  Chicago O'Hare Intl-FLO Florence
6h 58m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 7:38 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 55m1 stop Charlotte Douglas
$498American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
7:50 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 19m2 stops Washington, D.C. Reagan-National Charlotte Douglas
American Airlines Logo
3:44 pm - 7:35 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 51m1 stop Charlotte Douglas
$584American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
6:00 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
7h 12m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 12:14 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 50m1 stop Charlotte Douglas
$656American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
7:50 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 19m2 stops Washington, D.C. Reagan-National Charlotte Douglas
American Airlines Logo
6:24 am - 12:59 pmFLO  Florence-ORD Chicago O'Hare Intl
7h 35m2 stops Charlotte Douglas Washington, D.C. Reagan-National
$733American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
1:25 pm - 9:20 pmORD  Chicago O'Hare Intl-FLO Florence
6h 55m2 stops Washington, D.C. Reagan-National Charlotte Douglas
American Airlines Logo
6:24 am - 12:50 pmFLO  Florence-ORD Chicago O'Hare Intl
7h 26m2 stops Charlotte Douglas Washington, D.C. Reagan-National
$799American Airlines
Sat, Sep 5 - Fri, Sep 11

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American Airlines flights from Chicago to Florence, South Carolina

Our best American Airlines deals on Chicago to Florence, South Carolina flight tickets
American Airlines
Nov 4
ORD8:05 amChicago O'Hare Intl
6h 04m
1 stop
FLO3:09 pmFlorence
Nov 10
FLO6:24 amFlorence
5h 36m
1 stop
ORD11:00 amChicago O'Hare Intl
$355
American Airlines
Sep 5
ORD1:22 pmChicago O'Hare Intl
6h 58m
1 stop
FLO9:20 pmFlorence
Sep 11
FLO1:43 pmFlorence
6h 55m
1 stop
ORD7:38 pmChicago O'Hare Intl
$498
American Airlines
Nov 4
ORD7:50 amChicago O'Hare Intl
6h 19m
2 stops
FLO3:09 pmFlorence
Nov 10
FLO3:44 pmFlorence
4h 51m
1 stop
ORD7:35 pmChicago O'Hare Intl
$584

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Chicago to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

8:05 am-3:09 pm

1 stop6h 04m

Florence

Tue 11/10

6:24 am-11:00 am

1 stop5h 36m

$355

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

1:22 pm-9:20 pm

1 stop6h 58m

Florence

Fri 9/11

1:43 pm-7:38 pm

1 stop6h 55m

$498
Quickest round-trip

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

7:50 am-3:09 pm

2 stops6h 19m

Florence

Tue 11/10

3:44 pm-7:35 pm

1 stop4h 51m

$584

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:00 am-2:12 pm

2 stops7h 12m

Florence

Fri 9/11

6:24 am-12:14 pm

1 stop6h 50m

$656

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

7:50 am-3:09 pm

2 stops6h 19m

Florence

Tue 11/10

6:24 am-12:59 pm

2 stops7h 35m

$733

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

1:25 pm-9:20 pm

2 stops6h 55m

Florence

Fri 9/11

6:24 am-12:50 pm

2 stops7h 26m

$799
Cheapest one-way

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 8/26

7:30 am-2:56 pm

1 stop6h 26m

$225
Quickest one-way

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sun 8/30

6:49 am-2:12 pm

1 stop6h 23m

$274

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 8/26

6:45 am-2:56 pm

2 stops7h 11m

$520

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sun 8/30

6:45 am-2:12 pm

2 stops6h 27m

$571

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago to Florence?

American Airlines is the most popular carrier operating from Chicago to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, South Carolina (CHI to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, South Carolina

Fastest flight time

6h 04m

Direct flights

None
The fastest flight from Chicago to Florence, South Carolina takes 6h 04m
There are no direct flights from Chicago to Florence, South Carolina. There are no popular flight routes from Chicago to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Chicago to Florence, South Carolina

  • How far is Chicago to Florence by plane?

    There are 680.6 mi between Chicago and Florence. Flights usually cover this in 6h 04m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago to Florence Airport?

    Prices for flights from Chicago to Florence Airport refresh daily.

  • How old do you have to be to fly from Chicago to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

It is quick and easy to find Chicago to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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