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Cheap flights from Chicago to Florence from $325

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 4/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:39 am - 3:50 pm
ORD
-
FLO
6h 11m
1 stop
American Airlines Logo
6:15 am - 12:36 pm
FLO
-
ORD
7h 21m
1 stop
$325American Airlines
Thu, Apr 16 - Tue, Apr 21
American Airlines Logo
6:44 pm - 11:57 pm
ORD
-
FLO
4h 13m
1 stop
American Airlines Logo
5:16 am - 9:08 am
FLO
-
ORD
4h 52m
1 stop
$371American Airlines
Sun, Mar 8 - Fri, Mar 13
American Airlines Logo
11:50 am - 5:50 pm
ORD
-
FLO
5h 00m
1 stop
American Airlines Logo
6:20 pm - 12:06 am
FLO
-
ORD
6h 46m
1 stop
$401American Airlines
Wed, Mar 18 - Mon, Mar 23
American Airlines Logo
8:39 am - 3:50 pm
ORD
-
FLO
6h 11m
1 stop
American Airlines Logo
5:24 am - 8:30 am
FLO
-
ORD
4h 06m
1 stop
$413American Airlines
Fri, Apr 10 - Sun, Apr 12
American Airlines Logo
8:39 am - 3:50 pm
ORD
-
FLO
6h 11m
1 stop
American Airlines Logo
2:36 pm - 5:44 pm
FLO
-
ORD
4h 08m
1 stop
$421American Airlines
Wed, May 20 - Mon, May 25
American Airlines Logo
10:28 am - 5:50 pm
ORD
-
FLO
6h 22m
1 stop
American Airlines Logo
5:16 am - 12:16 pm
FLO
-
ORD
8h 00m
2 stops
$440American Airlines
Sun, Mar 8 - Fri, Mar 13
American Airlines Logo
10:28 am - 5:50 pm
ORD
-
FLO
6h 22m
1 stop
American Airlines Logo
6:15 am - 11:03 am
FLO
-
ORD
5h 48m
1 stop
$480American Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
9:48 am - 5:50 pm
ORD
-
FLO
7h 02m
2 stops
American Airlines Logo
6:20 pm - 12:06 am
FLO
-
ORD
6h 46m
1 stop
$482American Airlines
Wed, Mar 18 - Mon, Mar 23
American Airlines Logo
4:04 pm - 11:57 pm
ORD
-
FLO
6h 53m
2 stops
American Airlines Logo
6:15 am - 12:35 pm
FLO
-
ORD
7h 20m
1 stop
$485American Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
4:04 pm - 11:57 pm
ORD
-
FLO
6h 53m
2 stops
American Airlines Logo
6:15 am - 1:05 pm
FLO
-
ORD
7h 50m
2 stops
$491American Airlines
Sat, Feb 21 - Wed, Feb 25

American Airlines flights from Chicago to Florence, South Carolina

Our best American Airlines deals on Chicago to Florence, South Carolina flight tickets
American Airlines
Apr 16
ORD8:39 amChicago O'Hare Intl
6h 11m
1 stop
FLO3:50 pmFlorence
Apr 21
FLO6:15 amFlorence
7h 21m
1 stop
ORD12:36 pmChicago O'Hare Intl
$325
American Airlines
Mar 8
ORD6:44 pmChicago O'Hare Intl
4h 13m
1 stop
FLO11:57 pmFlorence
Mar 13
FLO5:16 amFlorence
4h 52m
1 stop
ORD9:08 amChicago O'Hare Intl
$371
American Airlines
Mar 18
ORD11:50 amChicago O'Hare Intl
5h 00m
1 stop
FLO5:50 pmFlorence
Mar 23
FLO6:20 pmFlorence
6h 46m
1 stop
ORD12:06 amChicago O'Hare Intl
$401

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from Chicago to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 4/16

8:39 am-3:50 pm

1 stop6h 11m

Florence

Tue 4/21

6:15 am-12:36 pm

1 stop7h 21m

$325

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 3/8

6:44 pm-11:57 pm

1 stop4h 13m

Florence

Fri 3/13

5:16 am-9:08 am

1 stop4h 52m

$371

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 3/18

11:50 am-5:50 pm

1 stop5h 00m

Florence

Mon 3/23

6:20 pm-12:06 am

1 stop6h 46m

$401

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 4/10

8:39 am-3:50 pm

1 stop6h 11m

Florence

Sun 4/12

5:24 am-8:30 am

1 stop4h 06m

$413

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 5/20

8:39 am-3:50 pm

1 stop6h 11m

Florence

Mon 5/25

2:36 pm-5:44 pm

1 stop4h 08m

$421

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 3/8

10:28 am-5:50 pm

1 stop6h 22m

Florence

Fri 3/13

5:16 am-12:16 pm

2 stops8h 00m

$440

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 2/21

10:28 am-5:50 pm

1 stop6h 22m

Florence

Wed 2/25

6:15 am-11:03 am

1 stop5h 48m

$480

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 3/18

9:48 am-5:50 pm

2 stops7h 02m

Florence

Mon 3/23

6:20 pm-12:06 am

1 stop6h 46m

$482

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 2/21

4:04 pm-11:57 pm

2 stops6h 53m

Florence

Wed 2/25

6:15 am-12:35 pm

1 stop7h 20m

$485

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 2/21

4:04 pm-11:57 pm

2 stops6h 53m

Florence

Wed 2/25

6:15 am-1:05 pm

2 stops7h 50m

$491

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, South Carolina (CHI to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, South Carolina

Fastest flight time

4h 12m

Direct flights

None
The fastest flight from Chicago to Florence, South Carolina takes 4h 12m
There are no direct flights from Chicago to Florence, South Carolina. There are no popular flight routes from Chicago to Florence, South Carolina.
Search flight deals

  • How far is Chicago to Florence by plane?

    There are 680.6 mi between Chicago and Florence. Flights usually cover this in 4h 12m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago to Florence Airport?

    Prices for flights from Chicago to Florence Airport refresh daily.

  • How old do you have to be to fly from Chicago to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

It is quick and easy to find Chicago to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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