Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Chicago to Florence from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 10/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Chicago to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:47 pm - 11:37 pm
ORD
-
FLO
3h 50m
1 stop
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
$379American Airlines
Mon, Jul 27 - Sun, Aug 2
American Airlines Logo
5:45 pm - 11:37 pm
ORD
-
FLO
4h 52m
1 stop
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
$390American Airlines
Tue, Jul 21 - Tue, Jul 28
American Airlines Logo
5:36 pm - 11:37 pm
ORD
-
FLO
5h 01m
1 stop
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
$424American Airlines
Sat, Jul 25 - Sun, Jul 26
American Airlines Logo
6:30 am - 2:10 pm
ORD
-
FLO
6h 40m
1 stop
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
$439American Airlines
Sat, Jul 11 - Wed, Jul 15
American Airlines Logo
9:00 am - 2:10 pm
ORD
-
FLO
4h 10m
1 stop
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
$458American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
6:47 pm - 11:37 pm
ORD
-
FLO
3h 50m
1 stop
American Airlines Logo
5:17 am - 9:02 am
FLO
-
ORD
4h 45m
1 stop
$477American Airlines
Thu, Jul 9 - Sun, Jul 12
American Airlines Logo
8:00 am - 2:10 pm
ORD
-
FLO
5h 10m
1 stop
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
$515American Airlines
Wed, Jul 15 - Tue, Jul 21
American Airlines Logo
4:45 pm - 11:37 pm
ORD
-
FLO
5h 52m
1 stop
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
$517American Airlines
Tue, Jul 14 - Sun, Jul 19
American Airlines Logo
5:45 pm - 11:37 pm
ORD
-
FLO
4h 52m
1 stop
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
$536American Airlines
Mon, Jul 13 - Tue, Jul 21
American Airlines Logo
3:29 pm - 11:37 pm
ORD
-
FLO
7h 08m
2 stops
American Airlines Logo
5:17 am - 9:02 am
FLO
-
ORD
4h 45m
1 stop
$574American Airlines
Tue, Jul 21 - Tue, Jul 28

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Chicago to Florence, South Carolina

Our best American Airlines deals on Chicago to Florence, South Carolina flight tickets
American Airlines
Jul 27
ORD6:47 pmChicago O'Hare Intl
3h 50m
1 stop
FLO11:37 pmFlorence
Aug 2
FLO5:17 amFlorence
6h 43m
1 stop
ORD11:00 amChicago O'Hare Intl
$379
American Airlines
Jul 21
ORD5:45 pmChicago O'Hare Intl
4h 52m
1 stop
FLO11:37 pmFlorence
Jul 28
FLO2:35 pmFlorence
6h 16m
1 stop
ORD7:51 pmChicago O'Hare Intl
$390
American Airlines
Jul 25
ORD5:36 pmChicago O'Hare Intl
5h 01m
1 stop
FLO11:37 pmFlorence
Jul 26
FLO2:35 pmFlorence
6h 16m
1 stop
ORD7:51 pmChicago O'Hare Intl
$424

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Chicago to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 7/27

6:47 pm-11:37 pm

1 stop3h 50m

Florence

Sun 8/2

5:17 am-11:00 am

1 stop6h 43m

$379

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 7/21

5:45 pm-11:37 pm

1 stop4h 52m

Florence

Tue 7/28

2:35 pm-7:51 pm

1 stop6h 16m

$390

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 7/25

5:36 pm-11:37 pm

1 stop5h 01m

Florence

Sun 7/26

2:35 pm-7:51 pm

1 stop6h 16m

$424

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 7/11

6:30 am-2:10 pm

1 stop6h 40m

Florence

Wed 7/15

2:35 pm-7:51 pm

1 stop6h 16m

$439

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 7/10

9:00 am-2:10 pm

1 stop4h 10m

Florence

Tue 7/14

2:35 pm-7:51 pm

1 stop6h 16m

$458
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 7/9

6:47 pm-11:37 pm

1 stop3h 50m

Florence

Sun 7/12

5:17 am-9:02 am

1 stop4h 45m

$477

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 7/15

8:00 am-2:10 pm

1 stop5h 10m

Florence

Tue 7/21

5:17 am-11:00 am

1 stop6h 43m

$515

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 7/14

4:45 pm-11:37 pm

1 stop5h 52m

Florence

Sun 7/19

5:17 am-11:00 am

1 stop6h 43m

$517

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 7/13

5:45 pm-11:37 pm

1 stop4h 52m

Florence

Tue 7/21

5:17 am-11:00 am

1 stop6h 43m

$536

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 7/21

3:29 pm-11:37 pm

2 stops7h 08m

Florence

Tue 7/28

5:17 am-9:02 am

1 stop4h 45m

$574

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago to Florence?

American Airlines is the most popular carrier operating from Chicago to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, South Carolina (CHI to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, South Carolina

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Chicago to Florence, South Carolina takes 3h 50m
There are no direct flights from Chicago to Florence, South Carolina. There are no popular flight routes from Chicago to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Chicago to Florence, South Carolina

  • How far is Chicago to Florence by plane?

    There are 680.6 mi between Chicago and Florence. Flights usually cover this in 3h 50m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago to Florence Airport?

    Prices for flights from Chicago to Florence Airport refresh daily.

  • How old do you have to be to fly from Chicago to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

It is quick and easy to find Chicago to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 7/27
Mon 8/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States