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Cheap flights from Chicago to Florence from $219

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago to Florence

Cheap round-trip flights

American Airlines Logo
5:00 am - 10:45 amORD-FLO
4h 45m1 stop
American Airlines Logo
6:15 am - 10:42 amFLO-ORD
5h 27m1 stop
$393American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 8
American Airlines Logo
5:00 am - 10:45 amORD-FLO
4h 45m1 stop
American Airlines Logo
6:15 am - 1:08 pmFLO-ORD
7h 53m2 stops
$398American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 8
American Airlines Logo
5:08 pm - 11:16 pmORD-FLO
5h 08m1 stop
American Airlines Logo
6:14 am - 10:43 amFLO-ORD
5h 29m1 stop
$437American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
5:08 pm - 11:16 pmORD-FLO
5h 08m1 stop
American Airlines Logo
6:14 am - 1:42 pmFLO-ORD
8h 28m2 stops
$442American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
3:33 pm - 11:16 pmORD-FLO
6h 43m2 stops
American Airlines Logo
6:14 am - 11:06 amFLO-ORD
5h 52m2 stops
$447American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
3:10 pm - 10:45 amORD-FLO
18h 35m2 stops
American Airlines Logo
10:28 am - 4:51 pmFLO-ORD
7h 23m2 stops
$453American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 8
American Airlines Logo
9:20 am - 2:54 pmORD-FLO
4h 34m1 stop
American Airlines Logo
11:11 am - 4:05 pmFLO-ORD
5h 54m1 stop
$463American Airlines
Find Deal
Wed, Oct 15 - Mon, Oct 20
American Airlines Logo
7:10 am - 2:54 pmORD-FLO
6h 44m1 stop
American Airlines Logo
5:14 am - 12:03 pmFLO-ORD
7h 49m2 stops
$468American Airlines
Find Deal
Wed, Oct 15 - Thu, Oct 23
American Airlines Logo
7:00 am - 2:54 pmORD-FLO
6h 54m2 stops
American Airlines Logo
5:14 am - 1:52 pmFLO-ORD
9h 38m2 stops
$473American Airlines
Find Deal
Wed, Oct 15 - Thu, Oct 23
American Airlines Logo
5:22 am - 10:46 amORD-FLO
4h 24m1 stop
American Airlines Logo
3:19 pm - 11:50 pmFLO-ORD
9h 31m2 stops
$490American Airlines
Find Deal
Thu, Oct 16 - Wed, Oct 22

American Airlines flights from Chicago to Florence, South Carolina

Our best American Airlines deals on Chicago to Florence, South Carolina flight tickets
American Airlines
Nov 27
ORD5:00 amChicago O'Hare Intl
4h 45m
1 stop
FLO10:45 amFlorence
Dec 8
FLO6:15 amFlorence
5h 27m
1 stop
ORD10:42 amChicago O'Hare Intl
$393
Find similar
American Airlines
Nov 27
ORD5:00 amChicago O'Hare Intl
4h 45m
1 stop
FLO10:45 amFlorence
Dec 8
FLO6:15 amFlorence
7h 53m
2 stops
ORD1:08 pmChicago O'Hare Intl
$398
Find similar
American Airlines
Sep 30
ORD5:08 pmChicago O'Hare Intl
5h 08m
1 stop
FLO11:16 pmFlorence
Oct 4
FLO6:14 amFlorence
5h 29m
1 stop
ORD10:43 amChicago O'Hare Intl
$437
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Chicago to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

6:15 am-10:42 am

1 stop5h 27m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

6:15 am-1:08 pm

2 stops7h 53m

$398

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/30

5:08 pm-11:16 pm

1 stop5h 08m

Florence

Sat 10/4

6:14 am-10:43 am

1 stop5h 29m

$437

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/30

5:08 pm-11:16 pm

1 stop5h 08m

Florence

Sat 10/4

6:14 am-1:42 pm

2 stops8h 28m

$442

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/30

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sat 10/4

6:14 am-11:06 am

2 stops5h 52m

$447

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

3:10 pm-10:45 am

2 stops18h 35m

Florence

Mon 12/8

10:28 am-4:51 pm

2 stops7h 23m

$453

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 10/15

9:20 am-2:54 pm

1 stop4h 34m

Florence

Mon 10/20

11:11 am-4:05 pm

1 stop5h 54m

$463

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 10/15

7:10 am-2:54 pm

1 stop6h 44m

Florence

Thu 10/23

5:14 am-12:03 pm

2 stops7h 49m

$468

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 10/15

7:00 am-2:54 pm

2 stops6h 54m

Florence

Thu 10/23

5:14 am-1:52 pm

2 stops9h 38m

$473

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 10/16

5:22 am-10:46 am

1 stop4h 24m

Florence

Wed 10/22

3:19 pm-11:50 pm

2 stops9h 31m

$490

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Chicago to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Chicago is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $437. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Monday is the most expensive day to depart from Chicago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $449.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the afternoon. momondo users have found flights departing from Chicago to Florence, South Carolina in the afternoon for as low as $437. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $477 per ticket.

When to book flights from Chicago to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, South Carolina (CHI to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, South Carolina

Direct flights

None
There are no direct flights from Chicago to Florence, South Carolina. There are no popular flight routes from Chicago to Florence, South Carolina.
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  • How far is Chicago to Florence by plane?

    There are 680.6 mi between Chicago and Florence. Flights usually cover this in 4h 24m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago to Florence Airport?

    Prices for flights from Chicago to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Florence Airport?

  • How old do you have to be to fly from Chicago to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Chicago to Florence, South Carolina

Compare and see reviews for airlines that fly from Chicago to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $290Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

It is quick and easy to find Chicago to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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