Cheap flights from Arizona to Des Moines from $45

If you’re not able to fly to Des Moines in November, then May is your next best option. Flight prices from Arizona to Des Moines during May average around $330.

The cheapest day to depart from Arizona to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $309. Flights from Arizona to Des Moines on a Sunday will generally be more expensive and average around $458. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Arizona to Des Moines in the afternoon for as low as $273. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $387. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Phoenix Sky Harbor Intl to Des Moines for the best Arizona - Des Moines flight prices

You are more likely to see cheaper flights to Des Moines from Arizona when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $365 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from Arizona for as low as $273 on momondo.

There are 3 cabin classes available to choose from on Arizona to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Southwest, and Delta are the most popular carriers operating from Arizona to Des Moines

American Airlines, Southwest and Allegiant Air are the top three most popular airlines that fly to Des Moines from Arizona according to our data. American Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 6 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

As of March 2026, there are 8 flights per day flying from Arizona to Des Moines. The most common time of day flights depart is 8:00AM, with 45% of flights taking off at noon.

As of March 2026, there are 59 flights per week flying from Arizona to Des Moines. The most common day of the week flights depart is Mon, with 20% of flights taking off on this day.