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Cheap flights from Tyler to Knoxville from $419

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Tyler to Knoxville departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

American Airlines Logo
5:25 am - 1:09 pmTYR-TYS
6h 44m1 stop
American Airlines Logo
6:00 am - 9:49 amTYS-TYR
4h 49m1 stop
$419American Airlines
Find Deal
Thu, Sep 25 - Wed, Oct 1
American Airlines Logo
5:25 am - 5:36 pmTYR-TYS
11h 11m2 stops
American Airlines Logo
4:37 pm - 10:42 pmTYS-TYR
7h 05m1 stop
$425American Airlines
Find Deal
Thu, Sep 25 - Wed, Oct 1
American Airlines Logo
5:25 am - 5:36 pmTYR-TYS
11h 11m2 stops
American Airlines Logo
2:08 pm - 10:42 pmTYS-TYR
9h 34m2 stops
$463American Airlines
Find Deal
Thu, Sep 25 - Wed, Oct 1
American Airlines Logo
6:00 am - 1:36 pmTYR-TYS
6h 36m1 stop
American Airlines Logo
6:24 pm - 10:42 pmTYS-TYR
5h 18m1 stop
$492American Airlines
Find Deal
Mon, Sep 1 - Mon, Sep 8
American Airlines Logo
6:00 am - 1:36 pmTYR-TYS
6h 36m1 stop
American Airlines Logo
3:09 pm - 10:42 pmTYS-TYR
8h 33m2 stops
$579American Airlines
Find Deal
Mon, Sep 1 - Mon, Sep 8
American Airlines Logo
6:00 am - 2:24 pmTYR-TYS
7h 24m2 stops
American Airlines Logo
3:09 pm - 10:42 pmTYS-TYR
8h 33m2 stops
$595American Airlines
Find Deal
Mon, Sep 1 - Mon, Sep 8
American Airlines Logo
6:00 am - 11:30 amTYR-TYS
4h 30m1 stop
American Airlines Logo
6:24 pm - 10:42 pmTYS-TYR
5h 18m1 stop
$782American Airlines
Find Deal
Mon, Sep 1 - Fri, Sep 5
American Airlines Logo
6:00 am - 11:30 amTYR-TYS
4h 30m1 stop
American Airlines Logo
6:00 am - 4:27 pmTYS-TYR
11h 27m2 stops
$788American Airlines
Find Deal
Mon, Sep 1 - Fri, Sep 5
American Airlines Logo
6:00 am - 4:57 pmTYR-TYS
9h 57m2 stops
American Airlines Logo
6:10 am - 4:27 pmTYS-TYR
11h 17m2 stops
$793American Airlines
Find Deal
Mon, Sep 1 - Fri, Sep 5

American Airlines flights from Tyler to Knoxville

Our best American Airlines deals on Tyler to Knoxville flight tickets
American Airlines
Sep 25
TYR5:25 amTyler Pounds Field
6h 44m
1 stop
TYS1:09 pmKnoxville McGhee Tyson
Oct 1
TYS6:00 amKnoxville McGhee Tyson
4h 49m
1 stop
TYR9:49 amTyler Pounds Field
$419
Find similar
American Airlines
Sep 25
TYR5:25 amTyler Pounds Field
11h 11m
2 stops
TYS5:36 pmKnoxville McGhee Tyson
Oct 1
TYS4:37 pmKnoxville McGhee Tyson
7h 05m
1 stop
TYR10:42 pmTyler Pounds Field
$425
Find similar
American Airlines
Sep 25
TYR5:25 amTyler Pounds Field
11h 11m
2 stops
TYS5:36 pmKnoxville McGhee Tyson
Oct 1
TYS2:08 pmKnoxville McGhee Tyson
9h 34m
2 stops
TYR10:42 pmTyler Pounds Field
$463
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Tyler to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Tyler to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Thu 9/25

5:25 am-1:09 pm

1 stop6h 44m

Knoxville McGhee Tyson

Wed 10/1

6:00 am-9:49 am

1 stop4h 49m

$419

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Thu 9/25

5:25 am-5:36 pm

2 stops11h 11m

Knoxville McGhee Tyson

Wed 10/1

4:37 pm-10:42 pm

1 stop7h 05m

$425

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Thu 9/25

5:25 am-5:36 pm

2 stops11h 11m

Knoxville McGhee Tyson

Wed 10/1

2:08 pm-10:42 pm

2 stops9h 34m

$463

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-1:36 pm

1 stop6h 36m

Knoxville McGhee Tyson

Mon 9/8

6:24 pm-10:42 pm

1 stop5h 18m

$492

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-1:36 pm

1 stop6h 36m

Knoxville McGhee Tyson

Mon 9/8

3:09 pm-10:42 pm

2 stops8h 33m

$579

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-2:24 pm

2 stops7h 24m

Knoxville McGhee Tyson

Mon 9/8

3:09 pm-10:42 pm

2 stops8h 33m

$595

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-11:30 am

1 stop4h 30m

Knoxville McGhee Tyson

Fri 9/5

6:24 pm-10:42 pm

1 stop5h 18m

$782

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-11:30 am

1 stop4h 30m

Knoxville McGhee Tyson

Fri 9/5

6:00 am-4:27 pm

2 stops11h 27m

$788

TylerKnoxville

TYR - TYS

TYRTYS

Tyler Pounds Field

Mon 9/1

6:00 am-4:57 pm

2 stops9h 57m

Knoxville McGhee Tyson

Fri 9/5

6:10 am-4:27 pm

2 stops11h 17m

$793

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Tyler to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Tyler to Knoxville flights?

You could potentially save up to 1% on your flight if you consider stops on a Tyler to Knoxville flight.

When to book flights from Tyler to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Tyler to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tyler to Knoxville (TYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tyler to Knoxville

Best Price Found

$419

Fastest flight time

4h 30m

Direct flights

None

Airports in Knoxville

1 airport
The best flight deal from Tyler to Knoxville found on momondo in the last 72 hours is $419
The fastest flight from Tyler to Knoxville takes 4h 30m
There are no direct flights from Tyler to Knoxville. Popular non-direct route for this connection is Tyler Pounds Field Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
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  • How far is Tyler Pounds Field to Knoxville McGhee Tyson by plane?

    The straight-line distance from Tyler Pounds Field to Knoxville McGhee Tyson is 695.8 mi. By plane, this route typically takes 4h 30m.

  • When did momondo last update prices for flights from Tyler Pounds Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Tyler Pounds Field Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Tyler Pounds Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Tyler Pounds Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Tyler Pounds Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Tyler to Knoxville?

Best airlines flying from Tyler to Knoxville

Compare and see reviews for airlines that fly from Tyler to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $403Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Tyler to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Tyler.

Can I find flights from Tyler to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Tyler on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Tyler to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Tyler. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Tyler to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Tyler to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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