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Cheap flights from Tampa to Des Moines from $114

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Des Moines departing on 5/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Tampa to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:32 pm - 9:27 pm
TPA
-
DSM
23h 55m
1 stop
Multiple Airlines Logo
6:44 pm - 11:49 am
DSM
-
TPA
16h 05m
2 stops
$258Multiple Airlines
Wed, Jun 10 - Mon, Jun 15
Multiple Airlines Logo
8:25 am - 11:24 pm
TPA
-
DSM
15h 59m
1 stop
Multiple Airlines Logo
3:37 pm - 7:30 am
DSM
-
TPA
14h 53m
2 stops
$261Multiple Airlines
Mon, Jun 1 - Thu, Jun 4
Multiple Airlines Logo
12:00 pm - 11:24 pm
TPA
-
DSM
12h 24m
1 stop
Multiple Airlines Logo
3:37 pm - 7:30 am
DSM
-
TPA
14h 53m
2 stops
$263Multiple Airlines
Mon, Jun 1 - Thu, Jun 4
Multiple Airlines Logo
7:05 am - 11:07 pm
TPA
-
DSM
17h 02m
2 stops
Multiple Airlines Logo
4:40 pm - 8:08 am
DSM
-
TPA
14h 28m
1 stop
$266Multiple Airlines
Thu, Jul 9 - Mon, Jul 13
Multiple Airlines Logo
10:32 pm - 9:27 pm
TPA
-
DSM
23h 55m
1 stop
Multiple Airlines Logo
9:56 pm - 7:00 am
DSM
-
TPA
32h 04m
1 stop
$267Multiple Airlines
Wed, Jun 10 - Mon, Jun 15
Multiple Airlines Logo
10:32 pm - 9:27 pm
TPA
-
DSM
23h 55m
1 stop
Multiple Airlines Logo
9:56 pm - 7:00 am
DSM
-
TPA
32h 04m
1 stop
$272Multiple Airlines
Wed, Jun 10 - Mon, Jun 15
Multiple Airlines Logo
10:32 pm - 9:27 pm
TPA
-
DSM
23h 55m
1 stop
Multiple Airlines Logo
2:26 pm - 4:38 pm
DSM
-
TPA
25h 12m
2 stops
$279Multiple Airlines
Wed, Jun 10 - Mon, Jun 15
Multiple Airlines Logo
2:01 pm - 4:40 pm
TPA
-
DSM
27h 39m
2 stops
Multiple Airlines Logo
4:40 pm - 8:08 am
DSM
-
TPA
14h 28m
1 stop
$286Multiple Airlines
Thu, Jul 9 - Mon, Jul 13
Multiple Airlines Logo
10:32 pm - 9:47 pm
TPA
-
DSM
24h 15m
1 stop
Multiple Airlines Logo
4:01 pm - 12:23 pm
DSM
-
TPA
19h 22m
2 stops
$294Multiple Airlines
Wed, Jun 17 - Sun, Jun 21
Multiple Airlines Logo
12:31 pm - 9:27 pm
TPA
-
DSM
9h 56m
1 stop
Multiple Airlines Logo
4:40 pm - 8:08 am
DSM
-
TPA
14h 28m
1 stop
$299Multiple Airlines
Thu, Jul 9 - Mon, Jul 13

American Airlines flights from Tampa to Des Moines

Our best American Airlines deals on Tampa to Des Moines flight tickets
American Airlines
Jun 11
TPA12:12 pmTampa
9h 31m
1 stop
DSM8:43 pmDes Moines
Jun 24
DSM6:02 amDes Moines
8h 14m
1 stop
TPA3:16 pmTampa
$332
American Airlines
Jun 1
TPA12:11 pmTampa
9h 32m
1 stop
DSM8:43 pmDes Moines
Jun 4
DSM4:48 pmDes Moines
6h 09m
1 stop
TPA11:57 pmTampa
$339
American Airlines
Jun 1
TPA12:11 pmTampa
9h 32m
1 stop
DSM8:43 pmDes Moines
Jun 8
DSM4:48 pmDes Moines
6h 09m
1 stop
TPA11:57 pmTampa
$340

Southwest flights from Tampa to Des Moines

Our best Southwest deals on Tampa to Des Moines flight tickets
Southwest
Jun 10
TPA4:40 pmTampa
7h 05m
2 stops
DSM10:45 pmDes Moines
Jun 15
DSM4:40 pmDes Moines
6h 35m
2 stops
TPA12:15 amTampa
$342
Southwest
Jun 1
TPA7:00 amTampa
5h 45m
1 stop
DSM11:45 amDes Moines
Jun 8
DSM4:40 pmDes Moines
6h 35m
2 stops
TPA12:15 amTampa
$381
Southwest
Jun 1
TPA4:35 pmTampa
7h 30m
2 stops
DSM11:05 pmDes Moines
Jun 8
DSM4:40 pmDes Moines
6h 35m
2 stops
TPA12:15 amTampa
$396

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Tampa to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 6/10

10:32 pm-9:27 pm

1 stop23h 55m

Des Moines

Mon 6/15

6:44 pm-11:49 am

2 stops16h 05m

$258

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Mon 6/1

8:25 am-11:24 pm

1 stop15h 59m

Des Moines

Thu 6/4

3:37 pm-7:30 am

2 stops14h 53m

$261

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Mon 6/1

12:00 pm-11:24 pm

1 stop12h 24m

Des Moines

Thu 6/4

3:37 pm-7:30 am

2 stops14h 53m

$263

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 7/9

7:05 am-11:07 pm

2 stops17h 02m

Des Moines

Mon 7/13

4:40 pm-8:08 am

1 stop14h 28m

$266

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 6/10

10:32 pm-9:27 pm

1 stop23h 55m

Des Moines

Mon 6/15

9:56 pm-7:00 am

1 stop32h 04m

$267

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 6/10

10:32 pm-9:27 pm

1 stop23h 55m

Des Moines

Mon 6/15

9:56 pm-7:00 am

1 stop32h 04m

$272

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 6/10

10:32 pm-9:27 pm

1 stop23h 55m

Des Moines

Mon 6/15

2:26 pm-4:38 pm

2 stops25h 12m

$279

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 7/9

2:01 pm-4:40 pm

2 stops27h 39m

Des Moines

Mon 7/13

4:40 pm-8:08 am

1 stop14h 28m

$286

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 6/17

10:32 pm-9:47 pm

1 stop24h 15m

Des Moines

Sun 6/21

4:01 pm-12:23 pm

2 stops19h 22m

$294
Quickest round-trip

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 7/9

12:31 pm-9:27 pm

1 stop9h 56m

Des Moines

Mon 7/13

4:40 pm-8:08 am

1 stop14h 28m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Tampa to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Tampa and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then July is your next best option. Flight prices from Tampa to Des Moines during July average around $300.

How have Tampa to Des Moines flight prices changed over time?

As of May 2026, prices for Tampa to Des Moines flights are approximately 35% more expensive when compared to flights at the same time last year.

When to book flights from Tampa to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Des Moines (TPA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Des Moines

Fastest flight time

6h 41m

Direct flights

None
The fastest flight from Tampa to Des Moines takes 6h 41m
There are no direct flights from Tampa to Des Moines. There are no popular flight routes from Tampa to Des Moines.
Search flight deals

Frequently asked questions about flying from Tampa to Des Moines

  • How far is Tampa to Des Moines by plane?

    The distance between Tampa and Des Moines is about 1132.4 mi. Typically, this will take 6h 41m by plane in normal conditions.

  • When did momondo last update prices for flights from Tampa Airport to Des Moines Airport?

    Prices for flights from Tampa Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Tampa Airport to Des Moines Airport?

  • How old do you have to be to fly from Tampa Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tampa Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Tampa to Des Moines?

Best airlines flying from Tampa to Des Moines

Compare and see reviews for airlines that fly from Tampa to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
8,460 reviews
Search Delta flights
American AirlinesPriceFrom $250Free CancellationRating
7.1
11,671 reviews
Search American Airlines flights
SouthwestPriceFrom $252Free CancellationRating
7.9
4,307 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Tampa to Des Moines for you.

Can I find flights from Tampa to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Tampa which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Tampa to Des Moines?

Once you have performed a search for Tampa to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Tampa to Des Moines right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Tampa to Des Moines flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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