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Cheap flights from Tampa to Des Moines from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Des Moines departing on 5/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Tampa to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:40 am - 1:09 pm
TPA
-
DSM
7h 29m
1 stop
Frontier Logo
2:16 pm - 12:06 pm
DSM
-
TPA
20h 50m
1 stop
$181Frontier
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
12:00 pm - 11:24 pm
TPA
-
DSM
12h 24m
1 stop
Multiple Airlines Logo
5:02 pm - 11:23 am
DSM
-
TPA
17h 21m
1 stop
$216Multiple Airlines
Mon, Jun 1 - Sun, Jun 7
Multiple Airlines Logo
10:31 pm - 9:27 pm
TPA
-
DSM
23h 56m
1 stop
Multiple Airlines Logo
4:40 pm - 8:08 am
DSM
-
TPA
14h 28m
1 stop
$221Multiple Airlines
Wed, Jul 22 - Mon, Jul 27
Multiple Airlines Logo
6:00 am - 10:31 pm
TPA
-
DSM
17h 31m
1 stop
Multiple Airlines Logo
3:57 pm - 7:30 am
DSM
-
TPA
14h 33m
1 stop
$227Multiple Airlines
Thu, May 21 - Mon, May 25
Southwest Logo
6:15 am - 2:05 pm
TPA
-
DSM
8h 50m
1 stop
Southwest Logo
5:30 am - 2:20 pm
DSM
-
TPA
7h 50m
2 stops
$242Southwest
Tue, May 12 - Wed, May 20
Multiple Airlines Logo
8:25 am - 3:15 pm
TPA
-
DSM
7h 50m
1 stop
Multiple Airlines Logo
7:45 am - 2:58 pm
DSM
-
TPA
6h 13m
1 stop
$246Multiple Airlines
Thu, May 14 - Sun, May 17
Southwest Logo
4:20 pm - 10:10 pm
TPA
-
DSM
6h 50m
2 stops
Southwest Logo
5:30 am - 12:30 pm
DSM
-
TPA
6h 00m
2 stops
$247Southwest
Tue, May 12 - Wed, May 20
Multiple Airlines Logo
8:25 am - 3:15 pm
TPA
-
DSM
7h 50m
1 stop
Multiple Airlines Logo
10:23 am - 12:35 pm
DSM
-
TPA
25h 12m
2 stops
$249Multiple Airlines
Thu, May 7 - Fri, May 8
Multiple Airlines Logo
9:46 pm - 10:31 pm
TPA
-
DSM
25h 45m
2 stops
Multiple Airlines Logo
3:57 pm - 7:30 am
DSM
-
TPA
14h 33m
1 stop
$250Multiple Airlines
Wed, May 27 - Mon, Jun 1
Multiple Airlines Logo
6:00 am - 10:31 pm
TPA
-
DSM
17h 31m
1 stop
Multiple Airlines Logo
3:57 pm - 1:01 pm
DSM
-
TPA
20h 04m
1 stop
$251Multiple Airlines
Thu, May 21 - Mon, May 25

Delta flights from Tampa to Des Moines

Our best Delta deals on Tampa to Des Moines flight tickets
Delta
Jun 16
TPA7:20 amTampa
7h 41m
1 stop
DSM2:01 pmDes Moines
Jun 22
DSM6:39 pmDes Moines
4h 53m
1 stop
TPA12:32 amTampa
$352
Delta
May 14
TPA7:02 amTampa
6h 22m
1 stop
DSM12:24 pmDes Moines
May 18
DSM2:33 pmDes Moines
7h 24m
1 stop
TPA10:57 pmTampa
$365
Delta
May 4
TPA5:55 pmTampa
5h 39m
1 stop
DSM10:34 pmDes Moines
May 7
DSM6:41 pmDes Moines
4h 48m
1 stop
TPA12:29 amTampa
$376

Southwest flights from Tampa to Des Moines

Our best Southwest deals on Tampa to Des Moines flight tickets
Southwest
May 12
TPA6:15 amTampa
8h 50m
1 stop
DSM2:05 pmDes Moines
May 20
DSM5:30 amDes Moines
7h 50m
2 stops
TPA2:20 pmTampa
$242
Southwest
May 12
TPA4:20 pmTampa
6h 50m
2 stops
DSM10:10 pmDes Moines
May 20
DSM5:30 amDes Moines
6h 00m
2 stops
TPA12:30 pmTampa
$247
Southwest
May 11
TPA4:20 pmTampa
7h 45m
1 stop
DSM11:05 pmDes Moines
May 20
DSM5:30 amDes Moines
7h 50m
2 stops
TPA2:20 pmTampa
$289

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from Tampa to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Fri 5/1

6:40 am-1:09 pm

1 stop7h 29m

Des Moines

Fri 5/8

2:16 pm-12:06 pm

1 stop20h 50m

$181

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Mon 6/1

12:00 pm-11:24 pm

1 stop12h 24m

Des Moines

Sun 6/7

5:02 pm-11:23 am

1 stop17h 21m

$216

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 7/22

10:31 pm-9:27 pm

1 stop23h 56m

Des Moines

Mon 7/27

4:40 pm-8:08 am

1 stop14h 28m

$221

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 5/21

6:00 am-10:31 pm

1 stop17h 31m

Des Moines

Mon 5/25

3:57 pm-7:30 am

1 stop14h 33m

$227

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Tue 5/12

6:15 am-2:05 pm

1 stop8h 50m

Des Moines

Wed 5/20

5:30 am-2:20 pm

2 stops7h 50m

$242

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 5/14

8:25 am-3:15 pm

1 stop7h 50m

Des Moines

Sun 5/17

7:45 am-2:58 pm

1 stop6h 13m

$246
Quickest round-trip

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Tue 5/12

4:20 pm-10:10 pm

2 stops6h 50m

Des Moines

Wed 5/20

5:30 am-12:30 pm

2 stops6h 00m

$247

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 5/7

8:25 am-3:15 pm

1 stop7h 50m

Des Moines

Fri 5/8

10:23 am-12:35 pm

2 stops25h 12m

$249

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Wed 5/27

9:46 pm-10:31 pm

2 stops25h 45m

Des Moines

Mon 6/1

3:57 pm-7:30 am

1 stop14h 33m

$250

TampaDes Moines

TPA - DSM

TPADSM

Tampa

Thu 5/21

6:00 am-10:31 pm

1 stop17h 31m

Des Moines

Mon 5/25

3:57 pm-1:01 pm

1 stop20h 04m

$251

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Tampa to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Tampa and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then November is your next best option. Flight prices from Tampa to Des Moines during November average around $310.

How have Tampa to Des Moines flight prices changed over time?

When to book flights from Tampa to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Des Moines (TPA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Des Moines

Fastest flight time

5h 10m

Direct flights

None
The fastest flight from Tampa to Des Moines takes 5h 10m
There are no direct flights from Tampa to Des Moines. There are no popular flight routes from Tampa to Des Moines.
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Frequently asked questions about flying from Tampa to Des Moines

  • How far is Tampa to Des Moines by plane?

    The distance between Tampa and Des Moines is about 1132.4 mi. Typically, this will take 5h 10m by plane in normal conditions.

  • When did momondo last update prices for flights from Tampa Airport to Des Moines Airport?

    Prices for flights from Tampa Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Tampa Airport to Des Moines Airport?

  • How old do you have to be to fly from Tampa Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tampa Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Tampa to Des Moines?

Best airlines flying from Tampa to Des Moines

Compare and see reviews for airlines that fly from Tampa to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
8,391 reviews
Search Delta flights
American AirlinesPriceFrom $250Free CancellationRating
7.1
11,554 reviews
Search American Airlines flights
SouthwestPriceFrom $252Free CancellationRating
8.0
4,338 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Tampa to Des Moines for you.

Can I find flights from Tampa to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Tampa which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Tampa to Des Moines?

Once you have performed a search for Tampa to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Tampa to Des Moines right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Tampa to Des Moines flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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