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Cheap flights from Tampa to Des Moines from $69

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Des Moines departing on 9/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Tampa to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:00 am - 7:57 pmTPA  Tampa-DSM Des Moines
10h 57m1 stop Philadelphia
Multiple Airlines Logo
1:58 pm - 8:44 amDSM  Des Moines-TPA Tampa
17h 46m1 stop Philadelphia
$139Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
Multiple Airlines Logo
10:00 am - 7:57 pmTPA  Tampa-DSM Des Moines
10h 57m1 stop Philadelphia
Multiple Airlines Logo
1:58 pm - 7:53 amDSM  Des Moines-TPA Tampa
16h 55m1 stop Philadelphia
$156Multiple Airlines
Thu, Sep 17 - Sun, Sep 20
Multiple Airlines Logo
6:00 am - 7:57 pmTPA  Tampa-DSM Des Moines
14h 57m1 stop Philadelphia
Multiple Airlines Logo
11:29 am - 12:26 amDSM  Des Moines-TPA Tampa
11h 57m1 stop Denver Intl
$170Multiple Airlines
Thu, Sep 24 - Thu, Oct 1
American Airlines Logo
7:22 pm - 12:14 amTPA  Tampa-DSM Des Moines
5h 52m1 stop Chicago O'Hare Intl
American Airlines Logo
11:09 am - 5:42 pmDSM  Des Moines-TPA Tampa
5h 33m1 stop Charlotte Douglas
$237American Airlines
Wed, Nov 4 - Mon, Nov 9
Delta Logo
3:13 pm - 9:11 pmTPA  Tampa-DSM Des Moines
6h 58m1 stop Minneapolis St Paul
Delta Logo
4:10 pm - 9:27 pmDSM  Des Moines-TPA Tampa
4h 17m1 stop Atlanta Hartsfield-Jackson
$237Delta
Wed, Sep 23 - Sat, Sep 26
American Airlines Logo
8:06 am - 3:12 pmTPA  Tampa-DSM Des Moines
8h 06m1 stop Dallas/Fort Worth
American Airlines Logo
7:53 am - 2:32 pmDSM  Des Moines-TPA Tampa
5h 39m1 stop Charlotte Douglas
$265American Airlines
Thu, Sep 3 - Sun, Sep 6
Delta Logo
5:15 am - 10:46 amTPA  Tampa-DSM Des Moines
6h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:10 pm - 9:27 pmDSM  Des Moines-TPA Tampa
4h 17m1 stop Atlanta Hartsfield-Jackson
$281Delta
Sat, Sep 26 - Sat, Sep 26
United Airlines Logo
6:00 pm - 11:35 pmTPA  Tampa-DSM Des Moines
6h 35m1 stop Chicago O'Hare Intl
United Airlines Logo
3:02 pm - 9:28 pmDSM  Des Moines-TPA Tampa
5h 26m1 stop Houston George Bush Intcntl
$281United Airlines
Thu, Sep 24 - Sat, Sep 26
Delta Logo
7:45 am - 2:06 pmTPA  Tampa-DSM Des Moines
7h 21m1 stop Minneapolis St Paul
Delta Logo
12:25 pm - 9:22 pmDSM  Des Moines-TPA Tampa
7h 57m1 stop Detroit Metropolitan Wayne County
$281Delta
Sat, Sep 26 - Sat, Oct 3
United Airlines Logo
6:00 pm - 11:35 pmTPA  Tampa-DSM Des Moines
6h 35m1 stop Chicago O'Hare Intl
United Airlines Logo
1:26 pm - 11:32 pmDSM  Des Moines-TPA Tampa
9h 06m2 stops Chicago O'Hare Intl Newark
$286United Airlines
Thu, Sep 24 - Sat, Sep 26

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Frontier flights from Tampa to Des Moines

Our best Frontier deals on Tampa to Des Moines flight tickets
Frontier
Sep 17
TPA8:01 pmTampa
24h 32m
1 stop
DSM7:33 pmDes Moines
Sep 21
DSM8:30 pmDes Moines
19h 23m
1 stop
TPA4:53 pmTampa
$192
Frontier
Sep 23
TPA6:15 amTampa
29h 29m
1 stop
DSM10:44 amDes Moines
Oct 1
DSM11:29 amDes Moines
11h 57m
1 stop
TPA12:26 amTampa
$213
Frontier
Sep 11
TPA6:15 amTampa
14h 18m
1 stop
DSM7:33 pmDes Moines
Sep 14
DSM8:30 pmDes Moines
19h 23m
1 stop
TPA4:53 pmTampa
$221

American Airlines flights from Tampa to Des Moines

Our best American Airlines deals on Tampa to Des Moines flight tickets
American Airlines
Sep 3
TPA8:06 amTampa
8h 06m
1 stop
DSM3:12 pmDes Moines
Sep 6
DSM7:53 amDes Moines
5h 39m
1 stop
TPA2:32 pmTampa
$265
American Airlines
Sep 24
TPA8:01 amTampa
5h 03m
1 stop
DSM12:04 pmDes Moines
Sep 26
DSM2:44 pmDes Moines
7h 08m
1 stop
TPA10:52 pmTampa
$271
American Airlines
Sep 9
TPA8:31 amTampa
6h 28m
1 stop
DSM1:59 pmDes Moines
Sep 16
DSM1:30 pmDes Moines
6h 30m
1 stop
TPA9:00 pmTampa
$282

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Tampa to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/10

10:00 am-7:57 pm

1 stop10h 57m

Des Moines

Sun 9/13

1:58 pm-8:44 am

1 stop17h 46m

$139

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/17

10:00 am-7:57 pm

1 stop10h 57m

Des Moines

Sun 9/20

1:58 pm-7:53 am

1 stop16h 55m

$156

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/24

6:00 am-7:57 pm

1 stop14h 57m

Des Moines

Thu 10/1

11:29 am-12:26 am

1 stop11h 57m

$170

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Wed 11/4

7:22 pm-12:14 am

1 stop5h 52m

Des Moines

Mon 11/9

11:09 am-5:42 pm

1 stop5h 33m

$237

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Wed 9/23

3:13 pm-9:11 pm

1 stop6h 58m

Des Moines

Sat 9/26

4:10 pm-9:27 pm

1 stop4h 17m

$237

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/3

8:06 am-3:12 pm

1 stop8h 06m

Des Moines

Sun 9/6

7:53 am-2:32 pm

1 stop5h 39m

$265
Quickest round-trip

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Sat 9/26

5:15 am-10:46 am

1 stop6h 31m

Des Moines

Sat 9/26

4:10 pm-9:27 pm

1 stop4h 17m

$281

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/24

6:00 pm-11:35 pm

1 stop6h 35m

Des Moines

Sat 9/26

3:02 pm-9:28 pm

1 stop5h 26m

$281

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Sat 9/26

7:45 am-2:06 pm

1 stop7h 21m

Des Moines

Sat 10/3

12:25 pm-9:22 pm

1 stop7h 57m

$281

TampaDes Moines

TPA Tampa - DSM Des Moines

TPADSM

Tampa

Thu 9/24

6:00 pm-11:35 pm

1 stop6h 35m

Des Moines

Sat 9/26

1:26 pm-11:32 pm

2 stops9h 06m

$286

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Tampa to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Tampa and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $300 to $655.
The lowest price recently found on this route was $139.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then August is your next best option. Flight prices from Tampa to Des Moines during August average around $426.

How have Tampa to Des Moines flight prices changed over time?

As of August 2026, prices for Tampa to Des Moines flights are approximately 17% cheaper when compared to flights at the same time last year.

When to book flights from Tampa to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Des Moines (TPA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Des Moines

Fastest flight time

4h 36m

Direct flights

None
The fastest flight from Tampa to Des Moines takes 4h 36m
There are no direct flights from Tampa to Des Moines. There are no popular flight routes from Tampa to Des Moines.
Search flight deals

Frequently asked questions about flying from Tampa to Des Moines

  • How far is Tampa to Des Moines by plane?

    The distance between Tampa and Des Moines is about 1132.4 mi. Typically, this will take 4h 36m by plane in normal conditions.

  • When did momondo last update prices for flights from Tampa Airport to Des Moines Airport?

    Prices for flights from Tampa Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Tampa Airport to Des Moines Airport?

  • How old do you have to be to fly from Tampa Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tampa Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Tampa to Des Moines?

Best airlines flying from Tampa to Des Moines

Compare and see reviews for airlines that fly from Tampa to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $222Free CancellationRating
7.8
8,502 reviews
Search Delta flights
American AirlinesPriceFrom $250Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights
United AirlinesPriceFrom $635Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Tampa to Des Moines for you.

Can I find flights from Tampa to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Tampa which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Tampa to Des Moines?

Once you have performed a search for Tampa to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Tampa to Des Moines right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Tampa to Des Moines flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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