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Cheap flights from Syracuse to Knoxville from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 11/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
12:19 pm - 4:44 pmSYR-TYS
4h 25m1 stop
Delta Logo
7:30 am - 12:08 pmTYS-SYR
4h 38m1 stop
$249Delta
Find Deal
Thu, Dec 4 - Sat, Dec 6
American Airlines Logo
7:25 am - 2:27 pmSYR-TYS
7h 02m1 stop
American Airlines Logo
2:55 pm - 10:42 pmTYS-SYR
7h 47m2 stops
$254American Airlines
Find Deal
Thu, Dec 4 - Sat, Dec 6
American Airlines Logo
3:24 pm - 10:55 pmSYR-TYS
7h 31m2 stops
American Airlines Logo
6:29 pm - 11:39 pmTYS-SYR
5h 10m1 stop
$269American Airlines
Find Deal
Fri, Dec 5 - Mon, Dec 8
American Airlines Logo
5:30 am - 10:52 amSYR-TYS
5h 22m1 stop
American Airlines Logo
7:35 am - 11:40 amTYS-SYR
4h 05m1 stop
$279American Airlines
Find Deal
Thu, Nov 20 - Mon, Nov 24
Delta Logo
6:34 pm - 11:50 pmSYR-TYS
5h 16m1 stop
Delta Logo
7:30 am - 12:02 pmTYS-SYR
4h 32m1 stop
$294Delta
Find Deal
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
6:17 am - 11:59 amSYR-TYS
5h 42m1 stop
American Airlines Logo
8:44 pm - 11:59 pmTYS-SYR
3h 15m1 stop
$304American Airlines
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Wed, Apr 15 - Mon, Apr 20
Allegiant Air Logo
10:44 am - 7:04 pmSYR-TYS
8h 20m1 stop
Allegiant Air Logo
5:56 pm - 9:44 amTYS-SYR
15h 48m1 stop
$320Allegiant Air
Find Deal
Sat, Dec 20 - Mon, Dec 29
United Airlines Logo
6:00 am - 5:11 pmSYR-TYS
11h 11m2 stops
United Airlines Logo
10:50 am - 11:00 pmTYS-SYR
12h 10m2 stops
$329United Airlines
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Thu, Dec 4 - Sat, Dec 6
United Airlines Logo
6:00 am - 5:11 pmSYR-TYS
11h 11m2 stops
United Airlines Logo
10:50 am - 11:00 pmTYS-SYR
12h 10m2 stops
$344United Airlines
Find Deal
Thu, Dec 4 - Sat, Dec 6
Allegiant Air Logo
11:43 am - 11:00 amSYR-TYS
23h 17m1 stop
Allegiant Air Logo
6:40 pm - 5:31 pmTYS-SYR
22h 51m1 stop
$346Allegiant Air
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Mon, Nov 24 - Tue, Nov 25

Delta flights from Syracuse to Knoxville

Our best Delta deals on Syracuse to Knoxville flight tickets
Delta
Dec 4
SYR12:19 pmSyracuse Hancock Intl
4h 25m
1 stop
TYS4:44 pmKnoxville McGhee Tyson
Dec 6
TYS7:30 amKnoxville McGhee Tyson
4h 38m
1 stop
SYR12:08 pmSyracuse Hancock Intl
$249
Find similar
Delta
Feb 24
SYR6:34 pmSyracuse Hancock Intl
5h 16m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Feb 28
TYS7:30 amKnoxville McGhee Tyson
4h 32m
1 stop
SYR12:02 pmSyracuse Hancock Intl
$294
Find similar
Delta
Dec 18
SYR6:12 amSyracuse Hancock Intl
5h 58m
1 stop
TYS12:10 pmKnoxville McGhee Tyson
Dec 20
TYS7:30 amKnoxville McGhee Tyson
4h 09m
1 stop
SYR11:39 amSyracuse Hancock Intl
$318
Find similar

American Airlines flights from Syracuse to Knoxville

Our best American Airlines deals on Syracuse to Knoxville flight tickets
American Airlines
Dec 4
SYR7:25 amSyracuse Hancock Intl
7h 02m
1 stop
TYS2:27 pmKnoxville McGhee Tyson
Dec 6
TYS2:55 pmKnoxville McGhee Tyson
7h 47m
2 stops
SYR10:42 pmSyracuse Hancock Intl
$254
Find similar
American Airlines
Dec 5
SYR3:24 pmSyracuse Hancock Intl
7h 31m
2 stops
TYS10:55 pmKnoxville McGhee Tyson
Dec 8
TYS6:29 pmKnoxville McGhee Tyson
5h 10m
1 stop
SYR11:39 pmSyracuse Hancock Intl
$269
Find similar
American Airlines
Nov 20
SYR5:30 amSyracuse Hancock Intl
5h 22m
1 stop
TYS10:52 amKnoxville McGhee Tyson
Nov 24
TYS7:35 amKnoxville McGhee Tyson
4h 05m
1 stop
SYR11:40 amSyracuse Hancock Intl
$279
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 12/4

12:19 pm-4:44 pm

1 stop4h 25m

Knoxville McGhee Tyson

Sat 12/6

7:30 am-12:08 pm

1 stop4h 38m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 12/4

7:25 am-2:27 pm

1 stop7h 02m

Knoxville McGhee Tyson

Sat 12/6

2:55 pm-10:42 pm

2 stops7h 47m

$254

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 12/5

3:24 pm-10:55 pm

2 stops7h 31m

Knoxville McGhee Tyson

Mon 12/8

6:29 pm-11:39 pm

1 stop5h 10m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 11/20

5:30 am-10:52 am

1 stop5h 22m

Knoxville McGhee Tyson

Mon 11/24

7:35 am-11:40 am

1 stop4h 05m

$279

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

6:34 pm-11:50 pm

1 stop5h 16m

Knoxville McGhee Tyson

Sat 2/28

7:30 am-12:02 pm

1 stop4h 32m

$294

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/15

6:17 am-11:59 am

1 stop5h 42m

Knoxville McGhee Tyson

Mon 4/20

8:44 pm-11:59 pm

1 stop3h 15m

$304

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 12/20

10:44 am-7:04 pm

1 stop8h 20m

Knoxville McGhee Tyson

Mon 12/29

5:56 pm-9:44 am

1 stop15h 48m

$320

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 12/4

6:00 am-5:11 pm

2 stops11h 11m

Knoxville McGhee Tyson

Sat 12/6

10:50 am-11:00 pm

2 stops12h 10m

$329

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 12/4

6:00 am-5:11 pm

2 stops11h 11m

Knoxville McGhee Tyson

Sat 12/6

10:50 am-11:00 pm

2 stops12h 10m

$344

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 11/24

11:43 am-11:00 am

1 stop23h 17m

Knoxville McGhee Tyson

Tue 11/25

6:40 pm-5:31 pm

1 stop22h 51m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $261. If you aren’t able to travel during the month of May, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in May, still average around $281.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Syracuse to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $287. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Syracuse to Knoxville for around $458.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Syracuse to Knoxville when you can find flight prices for as low as $306. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $397.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $342 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $248 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Direct flights

None
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
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  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 00m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $223Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
8,001 reviews
Search Delta flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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