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Cheap flights from Syracuse to Knoxville from $194

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:54 am - 10:04 amSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
23h 10m1 stop Fort Lauderdale
Allegiant Air Logo
5:38 pm - 5:18 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
23h 40m1 stop Orlando Sanford Intl
$272Allegiant Air
Thu, Sep 10 - Thu, Sep 17
Allegiant Air Logo
10:54 am - 10:04 amSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
23h 10m1 stop Fort Lauderdale
Allegiant Air Logo
5:38 pm - 5:18 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
23h 40m1 stop Orlando Sanford Intl
$286Allegiant Air
Thu, Sep 17 - Thu, Sep 24
American Airlines Logo
5:40 pm - 9:42 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
4h 02m1 stop Washington, D.C. Reagan-National
American Airlines Logo
8:18 am - 12:34 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
4h 16m1 stop Charlotte Douglas
$287American Airlines
Wed, Sep 9 - Wed, Sep 16
Delta Logo
6:00 am - 11:04 amSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
5h 04m1 stop New York LaGuardia
Delta Logo
11:00 am - 5:00 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
6h 00m1 stop New York LaGuardia
$287Delta
Tue, Sep 8 - Tue, Sep 15
United Airlines Logo
5:48 pm - 10:49 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
5h 01m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 2:14 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
8h 14m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$292United Airlines
Wed, Sep 9 - Wed, Sep 16
United Airlines Logo
6:00 am - 1:18 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
7h 18m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 2:14 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
8h 14m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$297United Airlines
Wed, Sep 9 - Wed, Sep 16
American Airlines Logo
4:40 pm - 10:50 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
6h 10m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 10:25 amTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
3h 55m1 stop Philadelphia
$303American Airlines
Wed, Sep 16 - Sun, Sep 20
Delta Logo
1:00 pm - 7:38 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
6h 38m1 stop Detroit Metropolitan Wayne County
Delta Logo
11:00 am - 5:00 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
6h 00m1 stop New York LaGuardia
$303Delta
Tue, Sep 8 - Tue, Sep 15
Delta Logo
1:25 pm - 7:55 pmSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
6h 30m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:09 pm - 11:59 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
5h 50m1 stop Atlanta Hartsfield-Jackson
$303Delta
Sat, Nov 14 - Fri, Nov 20
Multiple Airlines Logo
10:54 am - 10:04 amSYR  Syracuse Hancock Intl-TYS Knoxville McGhee Tyson
23h 10m1 stop Fort Lauderdale
Multiple Airlines Logo
10:54 am - 8:23 pmTYS  Knoxville McGhee Tyson-SYR Syracuse Hancock Intl
9h 29m2 stops Fort Lauderdale Myrtle Beach Intl
$378Multiple Airlines
Thu, Sep 10 - Thu, Sep 17

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American Airlines flights from Syracuse to Knoxville

Our best American Airlines deals on Syracuse to Knoxville flight tickets
American Airlines
Oct 3
SYR4:40 pmSyracuse Hancock Intl
4h 26m
1 stop
TYS9:06 pmKnoxville McGhee Tyson
Oct 12
TYS6:00 amKnoxville McGhee Tyson
4h 24m
1 stop
SYR10:24 amSyracuse Hancock Intl
$334
American Airlines
Sep 18
SYR4:40 pmSyracuse Hancock Intl
6h 10m
1 stop
TYS10:50 pmKnoxville McGhee Tyson
Sep 20
TYS6:30 amKnoxville McGhee Tyson
3h 55m
1 stop
SYR10:25 amSyracuse Hancock Intl
$350
American Airlines
Aug 15
SYR1:03 pmSyracuse Hancock Intl
4h 31m
1 stop
TYS5:34 pmKnoxville McGhee Tyson
Aug 24
TYS7:31 pmKnoxville McGhee Tyson
4h 24m
1 stop
SYR11:55 pmSyracuse Hancock Intl
$356

United Airlines flights from Syracuse to Knoxville

Our best United Airlines deals on Syracuse to Knoxville flight tickets
United Airlines
Sep 9
SYR5:48 pmSyracuse Hancock Intl
5h 01m
1 stop
TYS10:49 pmKnoxville McGhee Tyson
Sep 16
TYS6:00 amKnoxville McGhee Tyson
8h 14m
2 stops
SYR2:14 pmSyracuse Hancock Intl
$292
United Airlines
Sep 9
SYR6:00 amSyracuse Hancock Intl
7h 18m
2 stops
TYS1:18 pmKnoxville McGhee Tyson
Sep 16
TYS6:00 amKnoxville McGhee Tyson
8h 14m
2 stops
SYR2:14 pmSyracuse Hancock Intl
$297
United Airlines
Sep 8
SYR6:00 amSyracuse Hancock Intl
10h 58m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
Sep 15
TYS7:20 pmKnoxville McGhee Tyson
4h 26m
1 stop
SYR11:46 pmSyracuse Hancock Intl
$309

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Thu 9/10

10:54 am-10:04 am

1 stop23h 10m

Knoxville McGhee Tyson

Thu 9/17

5:38 pm-5:18 pm

1 stop23h 40m

$272

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Thu 9/17

10:54 am-10:04 am

1 stop23h 10m

Knoxville McGhee Tyson

Thu 9/24

5:38 pm-5:18 pm

1 stop23h 40m

$286
Quickest round-trip

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 9/9

5:40 pm-9:42 pm

1 stop4h 02m

Knoxville McGhee Tyson

Wed 9/16

8:18 am-12:34 pm

1 stop4h 16m

$287

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Tue 9/8

6:00 am-11:04 am

1 stop5h 04m

Knoxville McGhee Tyson

Tue 9/15

11:00 am-5:00 pm

1 stop6h 00m

$287

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 9/9

5:48 pm-10:49 pm

1 stop5h 01m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-2:14 pm

2 stops8h 14m

$292

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 9/9

6:00 am-1:18 pm

2 stops7h 18m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-2:14 pm

2 stops8h 14m

$297

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 9/16

4:40 pm-10:50 pm

1 stop6h 10m

Knoxville McGhee Tyson

Sun 9/20

6:30 am-10:25 am

1 stop3h 55m

$303

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Tue 9/8

1:00 pm-7:38 pm

1 stop6h 38m

Knoxville McGhee Tyson

Tue 9/15

11:00 am-5:00 pm

1 stop6h 00m

$303

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Sat 11/14

1:25 pm-7:55 pm

1 stop6h 30m

Knoxville McGhee Tyson

Fri 11/20

6:09 pm-11:59 pm

1 stop5h 50m

$303

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Thu 9/10

10:54 am-10:04 am

1 stop23h 10m

Knoxville McGhee Tyson

Thu 9/17

10:54 am-8:23 pm

2 stops9h 29m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $382 to $519.
The lowest price recently found on this route was $272.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $260. If you aren’t able to travel during the month of January, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $293.

How far in advance should I book a flight from Syracuse to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $400 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $313 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

3h 57m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 3h 57m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
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Frequently asked questions about flying from Syracuse to Knoxville

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 3h 57m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights
DeltaPriceFrom $253Free CancellationRating
7.8
8,502 reviews
Search Delta flights
United AirlinesPriceFrom $262Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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