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Cheap flights from Syracuse to Knoxville from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
12:31 pm - 3:57 pm
SYR
-
TYS
27h 26m1 stop
Allegiant Air Logo
4:09 pm - 11:54 am
TYS
-
SYR
19h 45m1 stop
$246Allegiant Air
Tue, Jan 27 - Fri, Feb 6
Allegiant Air Logo
12:31 pm - 3:57 pm
SYR
-
TYS
27h 26m1 stop
Allegiant Air Logo
8:30 am - 10:18 am
TYS
-
SYR
25h 48m1 stop
$248Allegiant Air
Tue, Jan 27 - Sat, Feb 7
Multiple Airlines Logo
8:55 pm - 8:39 am
SYR
-
TYS
35h 44m2 stops
Multiple Airlines Logo
4:09 pm - 11:54 am
TYS
-
SYR
19h 45m1 stop
$249Multiple Airlines
Fri, Jan 30 - Fri, Feb 6
Delta Logo
6:00 am - 11:08 am
SYR
-
TYS
5h 08m1 stop
Delta Logo
6:10 am - 11:37 am
TYS
-
SYR
5h 27m1 stop
$251Delta
Wed, Jan 28 - Tue, Feb 10
Multiple Airlines Logo
12:02 pm - 4:36 pm
SYR
-
TYS
28h 34m2 stops
Multiple Airlines Logo
4:09 pm - 11:54 am
TYS
-
SYR
19h 45m1 stop
$254Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
Delta Logo
5:50 am - 12:13 pm
SYR
-
TYS
6h 23m1 stop
Delta Logo
5:26 pm - 10:51 pm
TYS
-
SYR
5h 25m1 stop
$260Delta
Wed, Jan 28 - Thu, Feb 5
Multiple Airlines Logo
3:20 pm - 5:53 pm
SYR
-
TYS
26h 33m2 stops
Multiple Airlines Logo
3:53 pm - 10:18 am
TYS
-
SYR
18h 25m1 stop
$261Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
Multiple Airlines Logo
8:55 pm - 8:39 am
SYR
-
TYS
35h 44m2 stops
Multiple Airlines Logo
8:30 am - 11:41 am
TYS
-
SYR
27h 11m1 stop
$264Multiple Airlines
Fri, Jan 30 - Mon, Feb 9
United Airlines Logo
10:08 am - 2:49 pm
SYR
-
TYS
4h 41m1 stop
United Airlines Logo
6:45 am - 2:07 pm
TYS
-
SYR
7h 22m2 stops
$265United Airlines
Wed, Jan 28 - Mon, Feb 2
Multiple Airlines Logo
12:02 pm - 8:36 pm
SYR
-
TYS
8h 34m2 stops
Multiple Airlines Logo
8:30 am - 10:18 am
TYS
-
SYR
25h 48m1 stop
$266Multiple Airlines
Mon, Feb 2 - Sat, Feb 7

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
Jan 27
SYR12:31 pmSyracuse Hancock Intl
27h 26m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
Feb 6
TYS4:09 pmKnoxville McGhee Tyson
19h 45m
1 stop
SYR11:54 amSyracuse Hancock Intl
$246
Find similar
Allegiant Air
Jan 27
SYR12:31 pmSyracuse Hancock Intl
27h 26m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
Feb 7
TYS8:30 amKnoxville McGhee Tyson
25h 48m
1 stop
SYR10:18 amSyracuse Hancock Intl
$248
Find similar
Allegiant Air
Jan 23
SYR10:26 amSyracuse Hancock Intl
25h 14m
1 stop
TYS11:40 amKnoxville McGhee Tyson
Jan 30
TYS4:09 pmKnoxville McGhee Tyson
19h 45m
1 stop
SYR11:54 amSyracuse Hancock Intl
$268
Find similar

Delta flights from Syracuse to Knoxville

Our best Delta deals on Syracuse to Knoxville flight tickets
Delta
Jan 28
SYR6:15 amSyracuse Hancock Intl
4h 57m
1 stop
TYS11:12 amKnoxville McGhee Tyson
Feb 4
TYS11:55 amKnoxville McGhee Tyson
5h 19m
1 stop
SYR5:14 pmSyracuse Hancock Intl
$251
Find similar
Delta
Jan 28
SYR5:50 amSyracuse Hancock Intl
6h 23m
1 stop
TYS12:13 pmKnoxville McGhee Tyson
Feb 5
TYS5:26 pmKnoxville McGhee Tyson
5h 25m
1 stop
SYR10:51 pmSyracuse Hancock Intl
$260
Find similar
Delta
Jan 29
SYR6:15 amSyracuse Hancock Intl
4h 57m
1 stop
TYS11:12 amKnoxville McGhee Tyson
Feb 6
TYS5:40 amKnoxville McGhee Tyson
5h 25m
1 stop
SYR11:05 amSyracuse Hancock Intl
$269
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 1/27

12:31 pm-3:57 pm

1 stop27h 26m

Knoxville McGhee Tyson

Fri 2/6

4:09 pm-11:54 am

1 stop19h 45m

$246

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 1/27

12:31 pm-3:57 pm

1 stop27h 26m

Knoxville McGhee Tyson

Sat 2/7

8:30 am-10:18 am

1 stop25h 48m

$248

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 1/30

8:55 pm-8:39 am

2 stops35h 44m

Knoxville McGhee Tyson

Fri 2/6

4:09 pm-11:54 am

1 stop19h 45m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 1/28

6:00 am-11:08 am

1 stop5h 08m

Knoxville McGhee Tyson

Tue 2/10

6:10 am-11:37 am

1 stop5h 27m

$251

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 1/23

12:02 pm-4:36 pm

2 stops28h 34m

Knoxville McGhee Tyson

Fri 1/30

4:09 pm-11:54 am

1 stop19h 45m

$254

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 1/28

5:50 am-12:13 pm

1 stop6h 23m

Knoxville McGhee Tyson

Thu 2/5

5:26 pm-10:51 pm

1 stop5h 25m

$260

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 1/10

3:20 pm-5:53 pm

2 stops26h 33m

Knoxville McGhee Tyson

Wed 1/14

3:53 pm-10:18 am

1 stop18h 25m

$261

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 1/30

8:55 pm-8:39 am

2 stops35h 44m

Knoxville McGhee Tyson

Mon 2/9

8:30 am-11:41 am

1 stop27h 11m

$264

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 1/28

10:08 am-2:49 pm

1 stop4h 41m

Knoxville McGhee Tyson

Mon 2/2

6:45 am-2:07 pm

2 stops7h 22m

$265

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 2/2

12:02 pm-8:36 pm

2 stops8h 34m

Knoxville McGhee Tyson

Sat 2/7

8:30 am-10:18 am

1 stop25h 48m

$266

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $273. If you aren’t able to travel during the month of May, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in May, still average around $281.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Syracuse to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $287. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Syracuse to Knoxville for around $458.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $348 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $248 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 4h 06m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
Search flight deals

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 06m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $223Free CancellationRating
7.2
11,072 reviews
Search American Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
8,019 reviews
Search Delta flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,113 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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