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Cheap flights from Syracuse to Knoxville from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 6/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
4:57 pm - 12:09 pm
SYR
-
TYS
19h 12m
1 stop
Allegiant Air Logo
6:42 pm - 9:48 am
TYS
-
SYR
15h 06m
1 stop
$256Allegiant Air
Wed, Jul 29 - Sat, Aug 1
Delta Logo
7:17 pm - 11:52 pm
SYR
-
TYS
4h 35m
1 stop
Delta Logo
7:11 am - 1:00 pm
TYS
-
SYR
5h 49m
1 stop
$277Delta
Tue, Aug 11 - Tue, Aug 25
Allegiant Air Logo
11:38 am - 8:35 am
SYR
-
TYS
20h 57m
1 stop
Allegiant Air Logo
9:19 pm - 10:48 am
TYS
-
SYR
13h 29m
1 stop
$287Allegiant Air
Fri, Jun 5 - Sun, Jun 7
United Airlines Logo
7:52 pm - 11:54 pm
SYR
-
TYS
4h 02m
1 stop
United Airlines Logo
7:19 pm - 11:59 pm
TYS
-
SYR
4h 40m
1 stop
$293United Airlines
Wed, May 27 - Tue, Jun 2
Multiple Airlines Logo
2:44 pm - 10:29 pm
SYR
-
TYS
31h 45m
2 stops
Multiple Airlines Logo
1:02 pm - 6:36 pm
TYS
-
SYR
29h 34m
1 stop
$294Multiple Airlines
Wed, Jun 17 - Wed, Jun 24
Multiple Airlines Logo
7:26 pm - 8:36 am
SYR
-
TYS
13h 10m
1 stop
Multiple Airlines Logo
2:51 pm - 1:44 pm
TYS
-
SYR
46h 53m
2 stops
$295Multiple Airlines
Thu, Aug 13 - Mon, Aug 24
Allegiant Air Logo
7:31 pm - 10:02 am
SYR
-
TYS
14h 31m
1 stop
Allegiant Air Logo
7:04 pm - 5:35 pm
TYS
-
SYR
22h 31m
1 stop
$296Allegiant Air
Fri, Jul 24 - Fri, Jul 31
American Airlines Logo
6:00 am - 10:48 am
SYR
-
TYS
4h 48m
1 stop
American Airlines Logo
6:30 pm - 11:47 pm
TYS
-
SYR
5h 17m
1 stop
$298American Airlines
Wed, May 27 - Tue, Jun 2
Allegiant Air Logo
10:35 am - 10:16 pm
SYR
-
TYS
11h 41m
1 stop
Allegiant Air Logo
9:19 pm - 10:48 am
TYS
-
SYR
13h 29m
1 stop
$300Allegiant Air
Thu, Jun 4 - Sun, Jun 7
American Airlines Logo
6:10 am - 12:35 pm
SYR
-
TYS
6h 25m
2 stops
American Airlines Logo
6:30 pm - 11:47 pm
TYS
-
SYR
5h 17m
1 stop
$303American Airlines
Wed, May 27 - Tue, Jun 2

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
Jul 29
SYR4:57 pmSyracuse Hancock Intl
19h 12m
1 stop
TYS12:09 pmKnoxville McGhee Tyson
Aug 1
TYS6:42 pmKnoxville McGhee Tyson
15h 06m
1 stop
SYR9:48 amSyracuse Hancock Intl
$256
Allegiant Air
Jun 5
SYR11:38 amSyracuse Hancock Intl
20h 57m
1 stop
TYS8:35 amKnoxville McGhee Tyson
Jun 7
TYS9:19 pmKnoxville McGhee Tyson
13h 29m
1 stop
SYR10:48 amSyracuse Hancock Intl
$287
Allegiant Air
Jul 24
SYR7:31 pmSyracuse Hancock Intl
14h 31m
1 stop
TYS10:02 amKnoxville McGhee Tyson
Jul 31
TYS7:04 pmKnoxville McGhee Tyson
22h 31m
1 stop
SYR5:35 pmSyracuse Hancock Intl
$296

American Airlines flights from Syracuse to Knoxville

Our best American Airlines deals on Syracuse to Knoxville flight tickets
American Airlines
May 27
SYR6:00 amSyracuse Hancock Intl
4h 48m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Jun 2
TYS6:30 pmKnoxville McGhee Tyson
5h 17m
1 stop
SYR11:47 pmSyracuse Hancock Intl
$298
American Airlines
May 27
SYR6:10 amSyracuse Hancock Intl
6h 25m
2 stops
TYS12:35 pmKnoxville McGhee Tyson
Jun 2
TYS6:30 pmKnoxville McGhee Tyson
5h 17m
1 stop
SYR11:47 pmSyracuse Hancock Intl
$303
American Airlines
May 27
SYR6:10 amSyracuse Hancock Intl
6h 25m
2 stops
TYS12:35 pmKnoxville McGhee Tyson
Jun 2
TYS6:07 pmKnoxville McGhee Tyson
4h 45m
1 stop
SYR10:52 pmSyracuse Hancock Intl
$336

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 7/29

4:57 pm-12:09 pm

1 stop19h 12m

Knoxville McGhee Tyson

Sat 8/1

6:42 pm-9:48 am

1 stop15h 06m

$256

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 8/11

7:17 pm-11:52 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 8/25

7:11 am-1:00 pm

1 stop5h 49m

$277

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 6/5

11:38 am-8:35 am

1 stop20h 57m

Knoxville McGhee Tyson

Sun 6/7

9:19 pm-10:48 am

1 stop13h 29m

$287
Quickest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 5/27

7:52 pm-11:54 pm

1 stop4h 02m

Knoxville McGhee Tyson

Tue 6/2

7:19 pm-11:59 pm

1 stop4h 40m

$293

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 6/17

2:44 pm-10:29 pm

2 stops31h 45m

Knoxville McGhee Tyson

Wed 6/24

1:02 pm-6:36 pm

1 stop29h 34m

$294

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 8/13

7:26 pm-8:36 am

1 stop13h 10m

Knoxville McGhee Tyson

Mon 8/24

2:51 pm-1:44 pm

2 stops46h 53m

$295

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 7/24

7:31 pm-10:02 am

1 stop14h 31m

Knoxville McGhee Tyson

Fri 7/31

7:04 pm-5:35 pm

1 stop22h 31m

$296

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 5/27

6:00 am-10:48 am

1 stop4h 48m

Knoxville McGhee Tyson

Tue 6/2

6:30 pm-11:47 pm

1 stop5h 17m

$298

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 6/4

10:35 am-10:16 pm

1 stop11h 41m

Knoxville McGhee Tyson

Sun 6/7

9:19 pm-10:48 am

1 stop13h 29m

$300

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 5/27

6:10 am-12:35 pm

2 stops6h 25m

Knoxville McGhee Tyson

Tue 6/2

6:30 pm-11:47 pm

1 stop5h 17m

$303

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $260. If you aren’t able to travel during the month of January, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $298.

How far in advance should I book a flight from Syracuse to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $362 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $270 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

4h 04m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 4h 04m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
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Frequently asked questions about flying from Syracuse to Knoxville

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 04m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,455 reviews
Search Delta flights
United AirlinesPriceFrom $262Free CancellationRating
7.4
9,700 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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