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Cheap flights from Syracuse to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Allegiant Air Logo
6:01 pm - 8:25 pmSYR-TYS
26h 24m1 stop
Allegiant Air Logo
10:17 am - 11:17 amTYS-SYR
25h 00m1 stop
$245Allegiant Air
Find Deal
Sat, Oct 25 - Sat, Nov 1
Delta Logo
12:16 pm - 4:46 pmSYR-TYS
4h 30m1 stop
Delta Logo
8:45 am - 1:18 pmTYS-SYR
4h 33m1 stop
$249Delta
Find Deal
Tue, Nov 11 - Sat, Nov 15
American Airlines Logo
2:35 pm - 9:29 pmSYR-TYS
6h 54m2 stops
American Airlines Logo
6:06 am - 11:41 amTYS-SYR
5h 35m1 stop
$254American Airlines
Find Deal
Tue, Nov 11 - Sat, Nov 15
United Airlines Logo
6:10 am - 10:29 amSYR-TYS
4h 19m1 stop
United Airlines Logo
7:00 am - 2:14 pmTYS-SYR
7h 14m2 stops
$259United Airlines
Find Deal
Tue, Sep 30 - Tue, Oct 7
United Airlines Logo
6:10 am - 1:25 pmSYR-TYS
7h 15m2 stops
United Airlines Logo
7:00 am - 2:14 pmTYS-SYR
7h 14m2 stops
$264United Airlines
Find Deal
Tue, Sep 30 - Tue, Oct 7
Delta Logo
6:00 am - 11:07 amSYR-TYS
5h 07m1 stop
Delta Logo
7:30 am - 12:04 pmTYS-SYR
4h 34m1 stop
$274Delta
Find Deal
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
5:29 pm - 11:50 pmSYR-TYS
6h 21m1 stop
American Airlines Logo
1:01 pm - 8:07 pmTYS-SYR
7h 06m2 stops
$284American Airlines
Find Deal
Sat, Oct 25 - Sat, Nov 1
American Airlines Logo
2:35 pm - 9:29 pmSYR-TYS
6h 54m2 stops
American Airlines Logo
5:05 am - 11:41 amTYS-SYR
6h 36m2 stops
$289American Airlines
Find Deal
Tue, Nov 11 - Sat, Nov 15
Multiple Airlines Logo
6:13 pm - 7:50 amSYR-TYS
13h 37m2 stops
Multiple Airlines Logo
9:50 pm - 8:56 amTYS-SYR
11h 06m1 stop
$365Multiple Airlines
Find Deal
Fri, Oct 17 - Sun, Oct 19
Multiple Airlines Logo
7:58 pm - 5:06 pmSYR-TYS
21h 08m2 stops
Multiple Airlines Logo
9:58 pm - 10:17 amTYS-SYR
12h 19m1 stop
$466Multiple Airlines
Find Deal
Thu, Oct 2 - Sat, Oct 4

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
Oct 25
SYR6:01 pmSyracuse Hancock Intl
26h 24m
1 stop
TYS8:25 pmKnoxville McGhee Tyson
Nov 1
TYS10:17 amKnoxville McGhee Tyson
25h 00m
1 stop
SYR11:17 amSyracuse Hancock Intl
$245
Find similar
Allegiant Air
Oct 9
SYR11:07 amSyracuse Hancock Intl
9h 28m
1 stop
TYS8:35 pmKnoxville McGhee Tyson
Oct 13
TYS9:26 pmKnoxville McGhee Tyson
12h 51m
1 stop
SYR10:17 amSyracuse Hancock Intl
$524
Find similar

American Airlines flights from Syracuse to Knoxville

Our best American Airlines deals on Syracuse to Knoxville flight tickets
American Airlines
Nov 11
SYR2:35 pmSyracuse Hancock Intl
6h 54m
2 stops
TYS9:29 pmKnoxville McGhee Tyson
Nov 15
TYS6:06 amKnoxville McGhee Tyson
5h 35m
1 stop
SYR11:41 amSyracuse Hancock Intl
$254
Find similar
American Airlines
Oct 25
SYR5:29 pmSyracuse Hancock Intl
6h 21m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Nov 1
TYS1:01 pmKnoxville McGhee Tyson
7h 06m
2 stops
SYR8:07 pmSyracuse Hancock Intl
$284
Find similar
American Airlines
Nov 11
SYR2:35 pmSyracuse Hancock Intl
6h 54m
2 stops
TYS9:29 pmKnoxville McGhee Tyson
Nov 15
TYS5:05 amKnoxville McGhee Tyson
6h 36m
2 stops
SYR11:41 amSyracuse Hancock Intl
$289
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 10/25

6:01 pm-8:25 pm

1 stop26h 24m

Knoxville McGhee Tyson

Sat 11/1

10:17 am-11:17 am

1 stop25h 00m

$245

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 11/11

12:16 pm-4:46 pm

1 stop4h 30m

Knoxville McGhee Tyson

Sat 11/15

8:45 am-1:18 pm

1 stop4h 33m

$249

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 11/11

2:35 pm-9:29 pm

2 stops6h 54m

Knoxville McGhee Tyson

Sat 11/15

6:06 am-11:41 am

1 stop5h 35m

$254

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 9/30

6:10 am-10:29 am

1 stop4h 19m

Knoxville McGhee Tyson

Tue 10/7

7:00 am-2:14 pm

2 stops7h 14m

$259

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 9/30

6:10 am-1:25 pm

2 stops7h 15m

Knoxville McGhee Tyson

Tue 10/7

7:00 am-2:14 pm

2 stops7h 14m

$264

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

6:00 am-11:07 am

1 stop5h 07m

Knoxville McGhee Tyson

Sat 2/28

7:30 am-12:04 pm

1 stop4h 34m

$274

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 10/25

5:29 pm-11:50 pm

1 stop6h 21m

Knoxville McGhee Tyson

Sat 11/1

1:01 pm-8:07 pm

2 stops7h 06m

$284

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 11/11

2:35 pm-9:29 pm

2 stops6h 54m

Knoxville McGhee Tyson

Sat 11/15

5:05 am-11:41 am

2 stops6h 36m

$289

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 10/17

6:13 pm-7:50 am

2 stops13h 37m

Knoxville McGhee Tyson

Sun 10/19

9:50 pm-8:56 am

1 stop11h 06m

$365

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 10/2

7:58 pm-5:06 pm

2 stops21h 08m

Knoxville McGhee Tyson

Sat 10/4

9:58 pm-10:17 am

1 stop12h 19m

$466

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $261. If you aren’t able to travel during the month of May, then book flights to Knoxville from Syracuse during January instead. Flights to Knoxville in January, while not as cheap as those in May, still average around $303.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Syracuse to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $287. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Syracuse to Knoxville for around $458.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Syracuse to Knoxville when you can find flight prices for as low as $306. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $397.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $356 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $248 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Direct flights

None
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
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  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 02m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $218Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
7,961 reviews
Search Delta flights
United AirlinesPriceFrom $318Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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