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Cheap flights from Syracuse to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 3/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:15 am - 10:48 am
SYR
-
TYS
5h 33m
1 stop
American Airlines Logo
5:06 pm - 11:05 pm
TYS
-
SYR
5h 59m
1 stop
$251American Airlines
Wed, Apr 1 - Wed, Apr 8
Allegiant Air Logo
10:21 am - 1:32 pm
SYR
-
TYS
27h 11m
1 stop
Allegiant Air Logo
6:03 pm - 9:31 am
TYS
-
SYR
15h 28m
1 stop
$265Allegiant Air
Mon, May 25 - Sun, May 31
United Airlines Logo
6:00 am - 10:49 am
SYR
-
TYS
4h 49m
1 stop
United Airlines Logo
9:40 am - 2:08 pm
TYS
-
SYR
4h 28m
1 stop
$274United Airlines
Mon, Mar 2 - Tue, Mar 10
United Airlines Logo
6:25 am - 1:15 pm
SYR
-
TYS
6h 50m
1 stop
United Airlines Logo
2:21 pm - 8:14 pm
TYS
-
SYR
5h 53m
1 stop
$279United Airlines
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
10:23 am - 8:37 pm
SYR
-
TYS
10h 14m
2 stops
United Airlines Logo
2:21 pm - 8:14 pm
TYS
-
SYR
5h 53m
1 stop
$284United Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
12:19 pm - 8:40 pm
SYR
-
TYS
8h 21m
2 stops
American Airlines Logo
7:02 am - 2:59 pm
TYS
-
SYR
7h 57m
2 stops
$289American Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
6:17 pm - 11:57 pm
SYR
-
TYS
5h 40m
1 stop
Delta Logo
6:05 am - 12:00 pm
TYS
-
SYR
5h 55m
1 stop
$300Delta
Fri, Apr 3 - Tue, Apr 7
United Airlines Logo
6:00 am - 10:49 am
SYR
-
TYS
4h 49m
1 stop
United Airlines Logo
9:40 am - 2:12 pm
TYS
-
SYR
4h 32m
1 stop
$309United Airlines
Fri, Feb 20 - Tue, Feb 24
United Airlines Logo
6:00 am - 10:49 am
SYR
-
TYS
4h 49m
1 stop
United Airlines Logo
6:45 am - 2:12 pm
TYS
-
SYR
7h 27m
2 stops
$314United Airlines
Fri, Feb 20 - Tue, Feb 24
Allegiant Air Logo
7:33 pm - 11:38 pm
SYR
-
TYS
28h 05m
1 stop
Allegiant Air Logo
3:25 pm - 10:53 am
TYS
-
SYR
19h 28m
1 stop
$324Allegiant Air
Sun, Feb 22 - Thu, Feb 26

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
May 25
SYR10:21 amSyracuse Hancock Intl
27h 11m
1 stop
TYS1:32 pmKnoxville McGhee Tyson
May 31
TYS6:03 pmKnoxville McGhee Tyson
15h 28m
1 stop
SYR9:31 amSyracuse Hancock Intl
$265
Allegiant Air
Feb 22
SYR7:33 pmSyracuse Hancock Intl
28h 05m
1 stop
TYS11:38 pmKnoxville McGhee Tyson
Feb 26
TYS3:25 pmKnoxville McGhee Tyson
19h 28m
1 stop
SYR10:53 amSyracuse Hancock Intl
$324
Allegiant Air
May 8
SYR11:31 amSyracuse Hancock Intl
23h 35m
1 stop
TYS11:06 amKnoxville McGhee Tyson
May 10
TYS9:40 pmKnoxville McGhee Tyson
13h 01m
1 stop
SYR10:41 amSyracuse Hancock Intl
$359

United Airlines flights from Syracuse to Knoxville

Our best United Airlines deals on Syracuse to Knoxville flight tickets
United Airlines
Mar 2
SYR6:00 amSyracuse Hancock Intl
4h 49m
1 stop
TYS10:49 amKnoxville McGhee Tyson
Mar 10
TYS9:40 amKnoxville McGhee Tyson
4h 28m
1 stop
SYR2:08 pmSyracuse Hancock Intl
$274
United Airlines
Feb 24
SYR6:25 amSyracuse Hancock Intl
6h 50m
1 stop
TYS1:15 pmKnoxville McGhee Tyson
Feb 28
TYS2:21 pmKnoxville McGhee Tyson
5h 53m
1 stop
SYR8:14 pmSyracuse Hancock Intl
$279
United Airlines
Feb 24
SYR10:23 amSyracuse Hancock Intl
10h 14m
2 stops
TYS8:37 pmKnoxville McGhee Tyson
Feb 28
TYS2:21 pmKnoxville McGhee Tyson
5h 53m
1 stop
SYR8:14 pmSyracuse Hancock Intl
$284

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/1

5:15 am-10:48 am

1 stop5h 33m

Knoxville McGhee Tyson

Wed 4/8

5:06 pm-11:05 pm

1 stop5h 59m

$251

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 5/25

10:21 am-1:32 pm

1 stop27h 11m

Knoxville McGhee Tyson

Sun 5/31

6:03 pm-9:31 am

1 stop15h 28m

$265

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 3/2

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Tue 3/10

9:40 am-2:08 pm

1 stop4h 28m

$274

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

6:25 am-1:15 pm

1 stop6h 50m

Knoxville McGhee Tyson

Sat 2/28

2:21 pm-8:14 pm

1 stop5h 53m

$279

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

10:23 am-8:37 pm

2 stops10h 14m

Knoxville McGhee Tyson

Sat 2/28

2:21 pm-8:14 pm

1 stop5h 53m

$284

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 2/24

12:19 pm-8:40 pm

2 stops8h 21m

Knoxville McGhee Tyson

Sat 2/28

7:02 am-2:59 pm

2 stops7h 57m

$289

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 4/3

6:17 pm-11:57 pm

1 stop5h 40m

Knoxville McGhee Tyson

Tue 4/7

6:05 am-12:00 pm

1 stop5h 55m

$300

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 2/20

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Tue 2/24

9:40 am-2:12 pm

1 stop4h 32m

$309

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 2/20

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Tue 2/24

6:45 am-2:12 pm

2 stops7h 27m

$314

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sun 2/22

7:33 pm-11:38 pm

1 stop28h 05m

Knoxville McGhee Tyson

Thu 2/26

3:25 pm-10:53 am

1 stop19h 28m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $248. If you aren’t able to travel during the month of May, then book flights to Knoxville from Syracuse during January instead. Flights to Knoxville in January, while not as cheap as those in May, still average around $260.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $347 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $265 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

4h 41m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 4h 41m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
Search flight deals

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 41m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $232Free CancellationRating
7.9
8,178 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,262 reviews
Search American Airlines flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,269 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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