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Cheap flights from Syracuse to Knoxville from $269

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 8/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:26 pm - 8:36 am
SYR
-
TYS
13h 10m
1 stop
Allegiant Air Logo
1:36 pm - 7:51 pm
TYS
-
SYR
6h 15m
1 stop
$272Allegiant Air
Thu, Aug 6 - Mon, Aug 10
Allegiant Air Logo
5:30 pm - 2:06 pm
SYR
-
TYS
20h 36m
1 stop
Allegiant Air Logo
1:54 pm - 10:58 am
TYS
-
SYR
21h 04m
1 stop
$274Allegiant Air
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
7:34 pm - 11:51 pm
SYR
-
TYS
4h 17m
1 stop
American Airlines Logo
6:10 pm - 10:46 pm
TYS
-
SYR
4h 36m
1 stop
$277American Airlines
Wed, Jul 29 - Sat, Aug 1
Delta Logo
5:10 pm - 9:34 pm
SYR
-
TYS
4h 24m
1 stop
Delta Logo
1:30 pm - 6:21 pm
TYS
-
SYR
4h 51m
1 stop
$293Delta
Sat, Nov 14 - Fri, Nov 20
Allegiant Air Logo
7:26 pm - 8:36 am
SYR
-
TYS
13h 10m
1 stop
Allegiant Air Logo
7:45 am - 6:36 pm
TYS
-
SYR
10h 51m
1 stop
$302Allegiant Air
Thu, Aug 6 - Sun, Aug 9
Delta Logo
6:00 am - 10:58 am
SYR
-
TYS
4h 58m
1 stop
Delta Logo
5:40 am - 11:33 am
TYS
-
SYR
5h 53m
1 stop
$309Delta
Thu, Aug 27 - Sun, Aug 30
United Airlines Logo
6:00 am - 4:58 pm
SYR
-
TYS
10h 58m
2 stops
United Airlines Logo
7:20 pm - 11:46 pm
TYS
-
SYR
4h 26m
1 stop
$314United Airlines
Fri, Aug 28 - Mon, Aug 31
Allegiant Air Logo
6:25 pm - 10:23 pm
SYR
-
TYS
27h 58m
1 stop
Allegiant Air Logo
6:42 pm - 9:48 am
TYS
-
SYR
15h 06m
1 stop
$320Allegiant Air
Sat, Jul 18 - Sat, Jul 25
Allegiant Air Logo
5:45 pm - 5:19 pm
SYR
-
TYS
23h 34m
2 stops
Allegiant Air Logo
1:54 pm - 10:58 am
TYS
-
SYR
21h 04m
1 stop
$333Allegiant Air
Sat, Aug 15 - Sat, Aug 22
Allegiant Air Logo
5:45 pm - 12:51 pm
SYR
-
TYS
43h 06m
2 stops
Allegiant Air Logo
1:54 pm - 10:58 am
TYS
-
SYR
21h 04m
1 stop
$336Allegiant Air
Sat, Aug 15 - Sat, Aug 22

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Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
Aug 6
SYR7:26 pmSyracuse Hancock Intl
13h 10m
1 stop
TYS8:36 amKnoxville McGhee Tyson
Aug 10
TYS1:36 pmKnoxville McGhee Tyson
6h 15m
1 stop
SYR7:51 pmSyracuse Hancock Intl
$272
Allegiant Air
Aug 15
SYR5:30 pmSyracuse Hancock Intl
20h 36m
1 stop
TYS2:06 pmKnoxville McGhee Tyson
Aug 22
TYS1:54 pmKnoxville McGhee Tyson
21h 04m
1 stop
SYR10:58 amSyracuse Hancock Intl
$274
Allegiant Air
Aug 6
SYR7:26 pmSyracuse Hancock Intl
13h 10m
1 stop
TYS8:36 amKnoxville McGhee Tyson
Aug 9
TYS7:45 amKnoxville McGhee Tyson
10h 51m
1 stop
SYR6:36 pmSyracuse Hancock Intl
$302

American Airlines flights from Syracuse to Knoxville

Our best American Airlines deals on Syracuse to Knoxville flight tickets
American Airlines
Jul 29
SYR7:34 pmSyracuse Hancock Intl
4h 17m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Aug 1
TYS6:10 pmKnoxville McGhee Tyson
4h 36m
1 stop
SYR10:46 pmSyracuse Hancock Intl
$277
American Airlines
Jul 11
SYR7:34 pmSyracuse Hancock Intl
4h 17m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Jul 15
TYS7:17 pmKnoxville McGhee Tyson
5h 03m
1 stop
SYR12:20 amSyracuse Hancock Intl
$339
American Airlines
Nov 14
SYR5:30 pmSyracuse Hancock Intl
5h 24m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Nov 20
TYS5:12 pmKnoxville McGhee Tyson
6h 42m
1 stop
SYR11:54 pmSyracuse Hancock Intl
$389

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 8/6

7:26 pm-8:36 am

1 stop13h 10m

Knoxville McGhee Tyson

Mon 8/10

1:36 pm-7:51 pm

1 stop6h 15m

$272

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 8/15

5:30 pm-2:06 pm

1 stop20h 36m

Knoxville McGhee Tyson

Sat 8/22

1:54 pm-10:58 am

1 stop21h 04m

$274
Quickest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 7/29

7:34 pm-11:51 pm

1 stop4h 17m

Knoxville McGhee Tyson

Sat 8/1

6:10 pm-10:46 pm

1 stop4h 36m

$277

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 11/14

5:10 pm-9:34 pm

1 stop4h 24m

Knoxville McGhee Tyson

Fri 11/20

1:30 pm-6:21 pm

1 stop4h 51m

$293

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 8/6

7:26 pm-8:36 am

1 stop13h 10m

Knoxville McGhee Tyson

Sun 8/9

7:45 am-6:36 pm

1 stop10h 51m

$302

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 8/27

6:00 am-10:58 am

1 stop4h 58m

Knoxville McGhee Tyson

Sun 8/30

5:40 am-11:33 am

1 stop5h 53m

$309

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Fri 8/28

6:00 am-4:58 pm

2 stops10h 58m

Knoxville McGhee Tyson

Mon 8/31

7:20 pm-11:46 pm

1 stop4h 26m

$314

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 7/18

6:25 pm-10:23 pm

1 stop27h 58m

Knoxville McGhee Tyson

Sat 7/25

6:42 pm-9:48 am

1 stop15h 06m

$320

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 8/15

5:45 pm-5:19 pm

2 stops23h 34m

Knoxville McGhee Tyson

Sat 8/22

1:54 pm-10:58 am

1 stop21h 04m

$333

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 8/15

5:45 pm-12:51 pm

2 stops43h 06m

Knoxville McGhee Tyson

Sat 8/22

1:54 pm-10:58 am

1 stop21h 04m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $260. If you aren’t able to travel during the month of January, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $333.

How far in advance should I book a flight from Syracuse to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $399 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $317 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

4h 24m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 4h 24m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
Search flight deals

Frequently asked questions about flying from Syracuse to Knoxville

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 24m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,770 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,449 reviews
Search Delta flights
United AirlinesPriceFrom $262Free CancellationRating
7.4
9,894 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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