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Cheap flights from Syracuse to Knoxville from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Syracuse to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:44 pm - 9:40 am
SYR
-
TYS
13h 56m
1 stop
Allegiant Air Logo
9:40 pm - 10:41 am
TYS
-
SYR
13h 01m
1 stop
$260Allegiant Air
Mon, May 4 - Sun, May 10
American Airlines Logo
6:15 pm - 10:24 pm
SYR
-
TYS
4h 09m
1 stop
American Airlines Logo
5:11 pm - 11:42 pm
TYS
-
SYR
6h 31m
1 stop
$291American Airlines
Wed, Apr 22 - Wed, Apr 29
United Airlines Logo
5:47 pm - 10:34 pm
SYR
-
TYS
4h 47m
1 stop
United Airlines Logo
7:18 pm - 11:30 pm
TYS
-
SYR
4h 12m
1 stop
$310United Airlines
Sat, Apr 25 - Fri, May 1
American Airlines Logo
6:10 am - 1:11 pm
SYR
-
TYS
7h 01m
1 stop
American Airlines Logo
5:11 pm - 11:42 pm
TYS
-
SYR
6h 31m
1 stop
$315American Airlines
Wed, Apr 15 - Tue, Apr 21
Allegiant Air Logo
8:36 pm - 9:48 pm
SYR
-
TYS
25h 12m
1 stop
Allegiant Air Logo
9:32 pm - 10:41 am
TYS
-
SYR
13h 09m
1 stop
$320Allegiant Air
Thu, Apr 23 - Sun, Apr 26
Delta Logo
6:00 am - 10:51 am
SYR
-
TYS
4h 51m
1 stop
Delta Logo
5:51 pm - 11:09 pm
TYS
-
SYR
5h 18m
1 stop
$329Delta
Sat, Jun 27 - Thu, Jul 2
American Airlines Logo
5:30 am - 11:01 am
SYR
-
TYS
5h 31m
1 stop
American Airlines Logo
4:15 pm - 9:34 pm
TYS
-
SYR
5h 19m
1 stop
$345American Airlines
Thu, Apr 30 - Sat, May 2
United Airlines Logo
6:00 am - 1:13 pm
SYR
-
TYS
7h 13m
2 stops
United Airlines Logo
5:45 am - 9:43 am
TYS
-
SYR
3h 58m
1 stop
$352United Airlines
Wed, Aug 26 - Wed, Sep 2
Multiple Airlines Logo
6:03 pm - 5:30 pm
SYR
-
TYS
23h 27m
2 stops
Multiple Airlines Logo
9:32 pm - 10:41 am
TYS
-
SYR
13h 09m
1 stop
$353Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Allegiant Air Logo
3:46 pm - 3:41 pm
SYR
-
TYS
23h 55m
2 stops
Allegiant Air Logo
4:25 pm - 5:13 pm
TYS
-
SYR
24h 48m
1 stop
$354Allegiant Air
Wed, Apr 22 - Wed, Apr 29

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets
Allegiant Air
May 4
SYR7:44 pmSyracuse Hancock Intl
13h 56m
1 stop
TYS9:40 amKnoxville McGhee Tyson
May 10
TYS9:40 pmKnoxville McGhee Tyson
13h 01m
1 stop
SYR10:41 amSyracuse Hancock Intl
$260
Allegiant Air
Apr 23
SYR8:36 pmSyracuse Hancock Intl
25h 12m
1 stop
TYS9:48 pmKnoxville McGhee Tyson
Apr 26
TYS9:32 pmKnoxville McGhee Tyson
13h 09m
1 stop
SYR10:41 amSyracuse Hancock Intl
$320
Allegiant Air
Apr 22
SYR3:46 pmSyracuse Hancock Intl
23h 55m
2 stops
TYS3:41 pmKnoxville McGhee Tyson
Apr 29
TYS4:25 pmKnoxville McGhee Tyson
24h 48m
1 stop
SYR5:13 pmSyracuse Hancock Intl
$354

United Airlines flights from Syracuse to Knoxville

Our best United Airlines deals on Syracuse to Knoxville flight tickets
United Airlines
Apr 25
SYR5:47 pmSyracuse Hancock Intl
4h 47m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
May 1
TYS7:18 pmKnoxville McGhee Tyson
4h 12m
1 stop
SYR11:30 pmSyracuse Hancock Intl
$310
United Airlines
Aug 26
SYR6:00 amSyracuse Hancock Intl
7h 13m
2 stops
TYS1:13 pmKnoxville McGhee Tyson
Sep 2
TYS5:45 amKnoxville McGhee Tyson
3h 58m
1 stop
SYR9:43 amSyracuse Hancock Intl
$352
United Airlines
Apr 15
SYR6:00 amSyracuse Hancock Intl
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
Apr 21
TYS7:00 amKnoxville McGhee Tyson
7h 08m
2 stops
SYR2:08 pmSyracuse Hancock Intl
$366

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 5/4

7:44 pm-9:40 am

1 stop13h 56m

Knoxville McGhee Tyson

Sun 5/10

9:40 pm-10:41 am

1 stop13h 01m

$260

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/22

6:15 pm-10:24 pm

1 stop4h 09m

Knoxville McGhee Tyson

Wed 4/29

5:11 pm-11:42 pm

1 stop6h 31m

$291
Quickest round-trip

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 4/25

5:47 pm-10:34 pm

1 stop4h 47m

Knoxville McGhee Tyson

Fri 5/1

7:18 pm-11:30 pm

1 stop4h 12m

$310

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/15

6:10 am-1:11 pm

1 stop7h 01m

Knoxville McGhee Tyson

Tue 4/21

5:11 pm-11:42 pm

1 stop6h 31m

$315

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 4/23

8:36 pm-9:48 pm

1 stop25h 12m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-10:41 am

1 stop13h 09m

$320

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Sat 6/27

6:00 am-10:51 am

1 stop4h 51m

Knoxville McGhee Tyson

Thu 7/2

5:51 pm-11:09 pm

1 stop5h 18m

$329

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 4/30

5:30 am-11:01 am

1 stop5h 31m

Knoxville McGhee Tyson

Sat 5/2

4:15 pm-9:34 pm

1 stop5h 19m

$345

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 8/26

6:00 am-1:13 pm

2 stops7h 13m

Knoxville McGhee Tyson

Wed 9/2

5:45 am-9:43 am

1 stop3h 58m

$352

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Thu 4/23

6:03 pm-5:30 pm

2 stops23h 27m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-10:41 am

1 stop13h 09m

$353

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/22

3:46 pm-3:41 pm

2 stops23h 55m

Knoxville McGhee Tyson

Wed 4/29

4:25 pm-5:13 pm

1 stop24h 48m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $248. If you aren’t able to travel during the month of May, then book flights to Knoxville from Syracuse during January instead. Flights to Knoxville in January, while not as cheap as those in May, still average around $260.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $354 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $265 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Syracuse to Knoxville takes 4h 02m
There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.
Search flight deals

  • How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 02m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to Knoxville?

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $232Free CancellationRating
7.9
8,340 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,503 reviews
Search American Airlines flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,491 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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