What is the cheapest airline that flies from Syracuse Hancock Intl to Knoxville McGhee Tyson?

United Airlines and Delta are the most popular carriers operating from Syracuse Hancock Intl to Knoxville McGhee Tyson

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Syracuse according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.

How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

As of September 2026, there are 3 operators available to choose from for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$162 Cheap Flights from Syracuse to Knoxville in 2026/27

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6:00 am - 10:58 amSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 58m1 stop Washington, D.C. Reagan-National

6:01 am - 12:13 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

6h 12m1 stop Charlotte Douglas

$307American Airlines

Tue, Nov 3 - Sat, Nov 7

6:00 am - 11:12 amSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

5h 12m1 stop Philadelphia

10:10 am - 3:33 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

5h 23m1 stop Charlotte Douglas

$307American Airlines

Wed, Dec 2 - Sat, Dec 5

4:30 pm - 9:49 pmSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

5h 19m1 stop Charlotte Douglas

6:56 am - 11:59 amTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

5h 03m1 stop Charlotte Douglas

$307American Airlines

Sat, Oct 24 - Sat, Oct 31

7:50 pm - 11:59 pmSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 09m1 stop Washington, D.C. Dulles Intl

6:25 am - 2:08 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

7h 43m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$312United Airlines

Wed, Dec 2 - Sat, Dec 5

7:35 pm - 11:59 pmSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 24m1 stop Washington, D.C. Dulles Intl

1:56 pm - 11:43 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

9h 47m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$312United Airlines

Tue, Nov 3 - Sat, Nov 7

6:08 am - 11:02 amSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 54m1 stop New York LaGuardia

5:40 am - 11:09 amTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

5h 29m1 stop Atlanta Hartsfield-Jackson

$323Delta

Mon, Oct 19 - Sat, Oct 24

6:00 am - 10:54 amSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 54m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:21 amTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

5h 21m1 stop New York LaGuardia

$323Delta

Wed, Oct 21 - Wed, Oct 28

7:53 pm - 11:59 pmSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

4h 06m1 stop Washington, D.C. Dulles Intl

4:30 pm - 11:43 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

7h 13m2 stops Newark Washington, D.C. Dulles Intl

$328United Airlines

Wed, Oct 21 - Wed, Oct 28

7:29 pm - 7:45 amSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

12h 16m1 stop Tampa

2:21 pm - 1:53 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

23h 32m2 stops Philadelphia Tampa

$420Multiple Airlines

Thu, Nov 12 - Mon, Nov 16

7:29 pm - 7:24 pmSYR Syracuse Hancock Intl-TYS Knoxville McGhee Tyson

23h 55m2 stops Tampa Fort Lauderdale

9:33 am - 5:52 pmTYS Knoxville McGhee Tyson-SYR Syracuse Hancock Intl

8h 19m1 stop Tampa St. Petersburg

$461Multiple Airlines

Sun, Oct 25 - Sun, Nov 1

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United Airlines flights from Syracuse to Knoxville

Our best United Airlines deals on Syracuse to Knoxville flight tickets

United Airlines

Nov 3

SYR7:35 pmSyracuse Hancock Intl

4h 24m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

Nov 7

TYS1:56 pmKnoxville McGhee Tyson

9h 47m

2 stops

SYR11:43 pmSyracuse Hancock Intl

$312

United Airlines

Oct 21

SYR7:53 pmSyracuse Hancock Intl

4h 06m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

Oct 28

TYS4:30 pmKnoxville McGhee Tyson

7h 13m

2 stops

SYR11:43 pmSyracuse Hancock Intl

$328

United Airlines

Oct 29

SYR5:40 amSyracuse Hancock Intl

5h 50m

1 stop

TYS11:30 amKnoxville McGhee Tyson

Nov 5

TYS4:30 pmKnoxville McGhee Tyson

7h 13m

2 stops

SYR11:43 pmSyracuse Hancock Intl

$344

Allegiant Air flights from Syracuse to Knoxville

Our best Allegiant Air deals on Syracuse to Knoxville flight tickets

Allegiant Air

Oct 9

SYR9:23 amSyracuse Hancock Intl

24h 14m

1 stop

TYS9:37 amKnoxville McGhee Tyson

Oct 15

TYS7:36 pmKnoxville McGhee Tyson

13h 14m

1 stop

SYR8:50 amSyracuse Hancock Intl

$610

Allegiant Air

Oct 9

SYR9:23 amSyracuse Hancock Intl

24h 14m

1 stop

TYS9:37 amKnoxville McGhee Tyson

Oct 12

TYS9:25 pmKnoxville McGhee Tyson

16h 25m

1 stop

SYR1:50 pmSyracuse Hancock Intl

$739

Allegiant Air

Oct 2

SYR9:40 amSyracuse Hancock Intl

13h 18m

1 stop

TYS10:58 pmKnoxville McGhee Tyson

Oct 4

TYS9:53 pmKnoxville McGhee Tyson

13h 22m

1 stop

SYR11:15 amSyracuse Hancock Intl

$768

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Tue 11/3

6:00 am-10:58 am

1 stop4h 58m

Knoxville McGhee Tyson

Sat 11/7

6:01 am-12:13 pm

1 stop6h 12m

$307

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 12/2

6:00 am-11:12 am

1 stop5h 12m

Knoxville McGhee Tyson

Sat 12/5

10:10 am-3:33 pm

1 stop5h 23m

$307

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Sat 10/24

4:30 pm-9:49 pm

1 stop5h 19m

Knoxville McGhee Tyson

Sat 10/31

6:56 am-11:59 am

1 stop5h 03m

$307

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 12/2

7:50 pm-11:59 pm

1 stop4h 09m

Knoxville McGhee Tyson

Sat 12/5

6:25 am-2:08 pm

2 stops7h 43m

$312

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Tue 11/3

7:35 pm-11:59 pm

1 stop4h 24m

Knoxville McGhee Tyson

Sat 11/7

1:56 pm-11:43 pm

2 stops9h 47m

$312

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Mon 10/19

6:08 am-11:02 am

1 stop4h 54m

Knoxville McGhee Tyson

Sat 10/24

5:40 am-11:09 am

1 stop5h 29m

$323

Quickest round-trip

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 10/21

6:00 am-10:54 am

1 stop4h 54m

Knoxville McGhee Tyson

Wed 10/28

6:00 am-11:21 am

1 stop5h 21m

$323

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Wed 10/21

7:53 pm-11:59 pm

1 stop4h 06m

Knoxville McGhee Tyson

Wed 10/28

4:30 pm-11:43 pm

2 stops7h 13m

$328

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Thu 11/12

7:29 pm-7:45 am

1 stop12h 16m

Knoxville McGhee Tyson

Mon 11/16

2:21 pm-1:53 pm

2 stops23h 32m

$420

SyracuseKnoxville

SYR Syracuse Hancock Intl - TYS Knoxville McGhee Tyson

SYRTYS

Syracuse Hancock Intl

Sun 10/25

7:29 pm-7:24 pm

2 stops23h 55m

Knoxville McGhee Tyson

Sun 11/1

9:33 am-5:52 pm

1 stop8h 19m

$461

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Syracuse to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Syracuse and Knoxville?

Prices are currently typical for flights on this route.

Typical prices usually range from $304 to $446.
The lowest price recently found on this route was $307.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Syracuse, with most prices found around $260. If you aren’t able to travel during the month of January, then book flights to Knoxville from Syracuse during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $318.

How far in advance should I book a flight from Syracuse to Knoxville?

You are more likely to see cheaper flights to Knoxville from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $402 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Syracuse for as low as $309 on momondo.

When to book flights from Syracuse to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Knoxville

Best Price Found	$162
Fastest flight time	4h 15m
Direct flights	None

The best one-way flight to Knoxville from Syracuse in the past 72 hours is $162. The best round-trip flight deal from Syracuse to Knoxville found on momondo in the last 72 hours is $307.

The fastest flight from Syracuse to Knoxville takes 4h 15m

There are no direct flights from Syracuse to Knoxville. There are no popular flight routes from Syracuse to Knoxville.

Search flight deals

Frequently asked questions about flying from Syracuse to Knoxville

How far is Syracuse Hancock Intl to Knoxville McGhee Tyson by plane?
Knoxville McGhee Tyson is 640.5 mi away from Syracuse Hancock Intl. A reasonable flight in good conditions will take 4h 15m.
When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport are updated daily.
How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?
As of September 2026, there are 3 operators available to choose from for flights from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Syracuse Hancock Intl Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Syracuse to Knoxville?
Based on momondo bookings for flights between Syracuse and Knoxville, the leading airline is American Airlines, making up 49% of the total bookings. Other popular airlines include Delta with 42% and United Airlines with 9%.

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $253	Free Cancellation	Rating 7.8 8,603 reviews	Search Delta flights
American Airlines	PriceFrom $259	Free Cancellation	Rating 7.0 12,089 reviews	Search American Airlines flights
United Airlines	PriceFrom $309	Free Cancellation	Rating 7.4 10,238 reviews	Search United Airlines flights

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Gatlinburg

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Bryson City

Morristown

Alcoa

Corbin

Maryville

Crossville

Murphy

Oak Ridge

Kodak

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Dandridge

Lenoir City

Clinton

Rockford

Jefferson City

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Why should I use momondo to find a flight deal from Syracuse to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Syracuse to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Syracuse to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Syracuse with this policy.

How can momondo help me find flights from Syracuse to Knoxville?

Once you have performed a search for Syracuse to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cheap flights from Syracuse to Knoxville from $162

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Knoxville departing on 11/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Syracuse to Knoxville

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How to get the cheapest flight ticket from Syracuse to Knoxville

What is the typical price of a round-trip flight between Syracuse and Knoxville?

What is the cheapest month to fly to Knoxville?

How far in advance should I book a flight from Syracuse to Knoxville?

What is the cheapest airline that flies from Syracuse Hancock Intl to Knoxville McGhee Tyson?

What airlines fly to Knoxville?

When to book flights from Syracuse to Knoxville

Cheap Syracuse to Knoxville (SYR to TYS) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Syracuse to Knoxville

Best airlines flying from Syracuse to Knoxville

Compare and see reviews for airlines that fly from Syracuse to Knoxville with momondo

Traveling to a place near Knoxville?

Why use momondo?

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

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