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Cheap flights from St. Louis to Greenville from $234

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Greenville departing on 4/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
2:30 pm - 9:40 pm
STL
-
GSP
6h 10m
1 stop
Southwest Logo
5:05 pm - 10:00 pm
GSP
-
STL
5h 55m
1 stop
$297Southwest
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
12:40 pm - 9:40 pm
STL
-
GSP
8h 00m
2 stops
Southwest Logo
8:20 am - 3:15 pm
GSP
-
STL
7h 55m
1 stop
$302Southwest
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
1:15 pm - 9:40 pm
STL
-
GSP
7h 25m
2 stops
Southwest Logo
12:50 pm - 8:00 pm
GSP
-
STL
8h 10m
2 stops
$307Southwest
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
2:56 pm - 10:38 pm
STL
-
GSP
6h 42m
1 stop
American Airlines Logo
10:33 am - 4:59 pm
GSP
-
STL
7h 26m
1 stop
$319American Airlines
Wed, Jun 3 - Tue, Jun 23
American Airlines Logo
2:56 pm - 10:38 pm
STL
-
GSP
6h 42m
1 stop
American Airlines Logo
7:32 pm - 11:44 pm
GSP
-
STL
5h 12m
1 stop
$342American Airlines
Wed, Jun 3 - Tue, Jun 23
Delta Logo
6:00 am - 12:18 pm
STL
-
GSP
5h 18m
1 stop
Delta Logo
7:47 pm - 11:56 pm
GSP
-
STL
5h 09m
1 stop
$345Delta
Thu, Jun 11 - Thu, Jun 18
United Airlines Logo
11:15 am - 4:57 pm
STL
-
GSP
4h 42m
1 stop
United Airlines Logo
5:45 pm - 9:13 pm
GSP
-
STL
4h 28m
1 stop
$350United Airlines
Sat, May 2 - Wed, May 6
United Airlines Logo
10:25 am - 11:05 pm
STL
-
GSP
11h 40m
2 stops
United Airlines Logo
5:45 pm - 9:13 pm
GSP
-
STL
4h 28m
1 stop
$355United Airlines
Sat, May 2 - Wed, May 6
American Airlines Logo
3:42 pm - 10:19 pm
STL
-
GSP
5h 37m
1 stop
American Airlines Logo
5:20 am - 8:30 am
GSP
-
STL
4h 10m
1 stop
$363American Airlines
Thu, Apr 23 - Sun, Apr 26
Southwest Logo
7:35 am - 12:00 pm
STL
-
GSP
3h 25m
1 stop
Southwest Logo
6:25 pm - 11:15 pm
GSP
-
STL
5h 50m
1 stop
$370Southwest
Mon, May 25 - Fri, May 29

United Airlines flights from St. Louis to Greenville

Our best United Airlines deals on St. Louis to Greenville flight tickets
United Airlines
May 2
STL11:15 amLambert-St Louis
4h 42m
1 stop
GSP4:57 pmGreenville
May 6
GSP5:45 pmGreenville
4h 28m
1 stop
STL9:13 pmLambert-St Louis
$350
United Airlines
May 2
STL10:25 amLambert-St Louis
11h 40m
2 stops
GSP11:05 pmGreenville
May 6
GSP5:45 pmGreenville
4h 28m
1 stop
STL9:13 pmLambert-St Louis
$355
United Airlines
May 2
STL7:45 amLambert-St Louis
5h 25m
1 stop
GSP2:10 pmGreenville
May 5
GSP6:27 pmGreenville
6h 30m
1 stop
STL11:57 pmLambert-St Louis
$377

Southwest flights from St. Louis to Greenville

Our best Southwest deals on St. Louis to Greenville flight tickets
Southwest
Apr 15
STL2:30 pmLambert-St Louis
6h 10m
1 stop
GSP9:40 pmGreenville
Apr 22
GSP5:05 pmGreenville
5h 55m
1 stop
STL10:00 pmLambert-St Louis
$297
Southwest
Apr 15
STL12:40 pmLambert-St Louis
8h 00m
2 stops
GSP9:40 pmGreenville
Apr 22
GSP8:20 amGreenville
7h 55m
1 stop
STL3:15 pmLambert-St Louis
$302
Southwest
Apr 15
STL1:15 pmLambert-St Louis
7h 25m
2 stops
GSP9:40 pmGreenville
Apr 22
GSP12:50 pmGreenville
8h 10m
2 stops
STL8:00 pmLambert-St Louis
$307

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 4/15

2:30 pm-9:40 pm

1 stop6h 10m

Greenville

Wed 4/22

5:05 pm-10:00 pm

1 stop5h 55m

$297

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 4/15

12:40 pm-9:40 pm

2 stops8h 00m

Greenville

Wed 4/22

8:20 am-3:15 pm

1 stop7h 55m

$302

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 4/15

1:15 pm-9:40 pm

2 stops7h 25m

Greenville

Wed 4/22

12:50 pm-8:00 pm

2 stops8h 10m

$307

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 6/3

2:56 pm-10:38 pm

1 stop6h 42m

Greenville

Tue 6/23

10:33 am-4:59 pm

1 stop7h 26m

$319

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 6/3

2:56 pm-10:38 pm

1 stop6h 42m

Greenville

Tue 6/23

7:32 pm-11:44 pm

1 stop5h 12m

$342

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 6/11

6:00 am-12:18 pm

1 stop5h 18m

Greenville

Thu 6/18

7:47 pm-11:56 pm

1 stop5h 09m

$345
Quickest round-trip

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 5/2

11:15 am-4:57 pm

1 stop4h 42m

Greenville

Wed 5/6

5:45 pm-9:13 pm

1 stop4h 28m

$350

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 5/2

10:25 am-11:05 pm

2 stops11h 40m

Greenville

Wed 5/6

5:45 pm-9:13 pm

1 stop4h 28m

$355

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 4/23

3:42 pm-10:19 pm

1 stop5h 37m

Greenville

Sun 4/26

5:20 am-8:30 am

1 stop4h 10m

$363

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Mon 5/25

7:35 am-12:00 pm

1 stop3h 25m

Greenville

Fri 5/29

6:25 pm-11:15 pm

1 stop5h 50m

$370

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

See travel insights to Greenville from

How to get the cheapest flight ticket from St. Louis to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from St. Louis averaging around $297.

How have St. Louis to Greenville flight prices changed over time?

When to book flights from St. Louis to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Greenville (STL to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Greenville

Fastest flight time

3h 10m

Direct flights

None
The fastest flight from St. Louis to Greenville takes 3h 10m
There are no direct flights from St. Louis to Greenville. There are no popular flight routes from St. Louis to Greenville.
Search flight deals

  • How far is Lambert-St Louis to Greenville by plane?

    Lambert-St Louis and Greenville are 504.1 mi apart from one another. In terms of flight time, this usually takes a little over 3h 10m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Greenville Airport?

    Prices for flights from Lambert-St Louis Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Greenville Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Greenville?

Best airlines flying from St. Louis to Greenville

Compare and see reviews for airlines that fly from St. Louis to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,491 reviews
Search American Airlines flights
DeltaPriceFrom $253Free CancellationRating
7.9
8,320 reviews
Search Delta flights
SouthwestPriceFrom $326Free CancellationRating
8.0
4,331 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Greenville for you.

Can I find flights from St. Louis to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from St. Louis.

I’m not ready to book a flight from St. Louis to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

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