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Cheap flights from St. Louis to Greenville from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Greenville departing on 7/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:56 pm - 10:38 pm
STL
-
GSP
6h 42m
1 stop
American Airlines Logo
5:25 pm - 11:59 pm
GSP
-
STL
7h 34m
1 stop
$247American Airlines
Wed, Jun 3 - Tue, Jun 23
Southwest Logo
10:15 am - 8:15 pm
STL
-
GSP
9h 00m
2 stops
Southwest Logo
1:50 pm - 7:15 pm
GSP
-
STL
6h 25m
1 stop
$252Southwest
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
9:23 am - 5:28 pm
STL
-
GSP
7h 05m
1 stop
American Airlines Logo
6:38 pm - 12:16 am
GSP
-
STL
6h 38m
1 stop
$267American Airlines
Wed, Jun 3 - Tue, Jun 23
Southwest Logo
1:45 pm - 9:40 pm
STL
-
GSP
6h 55m
2 stops
Southwest Logo
5:05 pm - 10:00 pm
GSP
-
STL
5h 55m
1 stop
$272Southwest
Tue, Jun 2 - Wed, Jun 3
Multiple Airlines Logo
4:17 pm - 7:29 am
STL
-
GSP
14h 12m
1 stop
Multiple Airlines Logo
3:48 pm - 5:30 pm
GSP
-
STL
26h 42m
2 stops
$273Multiple Airlines
Sat, Jun 13 - Wed, Jun 17
Southwest Logo
10:15 am - 4:45 pm
STL
-
GSP
5h 30m
1 stop
Southwest Logo
11:05 am - 6:10 pm
GSP
-
STL
8h 05m
2 stops
$277Southwest
Wed, Aug 26 - Sat, Aug 29
Southwest Logo
1:45 pm - 9:40 pm
STL
-
GSP
6h 55m
2 stops
Southwest Logo
6:45 am - 1:00 pm
GSP
-
STL
7h 15m
2 stops
$278Southwest
Tue, Jun 2 - Wed, Jun 3
Southwest Logo
5:40 am - 1:10 pm
STL
-
GSP
6h 30m
2 stops
Southwest Logo
7:00 am - 2:50 pm
GSP
-
STL
8h 50m
2 stops
$282Southwest
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
2:56 pm - 10:38 pm
STL
-
GSP
6h 42m
1 stop
American Airlines Logo
7:32 pm - 11:44 pm
GSP
-
STL
5h 12m
1 stop
$295American Airlines
Wed, Jun 17 - Sat, Jun 20
Delta Logo
6:30 am - 12:06 pm
STL
-
GSP
4h 36m
1 stop
Delta Logo
1:09 pm - 6:07 pm
GSP
-
STL
5h 58m
1 stop
$300Delta
Sat, Jun 13 - Wed, Jun 17

United Airlines flights from St. Louis to Greenville

Our best United Airlines deals on St. Louis to Greenville flight tickets
United Airlines
Aug 18
STL6:00 amLambert-St Louis
6h 38m
1 stop
GSP1:38 pmGreenville
Aug 19
GSP6:30 amGreenville
6h 43m
1 stop
STL12:13 pmLambert-St Louis
$327
United Airlines
Aug 18
STL5:00 amLambert-St Louis
8h 19m
2 stops
GSP2:19 pmGreenville
Aug 19
GSP5:43 pmGreenville
4h 39m
1 stop
STL9:22 pmLambert-St Louis
$332
United Airlines
Aug 18
STL5:00 amLambert-St Louis
8h 19m
2 stops
GSP2:19 pmGreenville
Aug 19
GSP7:00 amGreenville
9h 38m
2 stops
STL3:38 pmLambert-St Louis
$337

Southwest flights from St. Louis to Greenville

Our best Southwest deals on St. Louis to Greenville flight tickets
Southwest
Jun 9
STL10:15 amLambert-St Louis
9h 00m
2 stops
GSP8:15 pmGreenville
Jun 16
GSP1:50 pmGreenville
6h 25m
1 stop
STL7:15 pmLambert-St Louis
$252
Southwest
Aug 26
STL10:15 amLambert-St Louis
5h 30m
1 stop
GSP4:45 pmGreenville
Aug 29
GSP11:05 amGreenville
8h 05m
2 stops
STL6:10 pmLambert-St Louis
$277
Southwest
Jun 9
STL5:40 amLambert-St Louis
6h 30m
2 stops
GSP1:10 pmGreenville
Jun 16
GSP7:00 amGreenville
8h 50m
2 stops
STL2:50 pmLambert-St Louis
$282

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 6/3

2:56 pm-10:38 pm

1 stop6h 42m

Greenville

Tue 6/23

5:25 pm-11:59 pm

1 stop7h 34m

$247

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 6/9

10:15 am-8:15 pm

2 stops9h 00m

Greenville

Tue 6/16

1:50 pm-7:15 pm

1 stop6h 25m

$252

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 6/3

9:23 am-5:28 pm

1 stop7h 05m

Greenville

Tue 6/23

6:38 pm-12:16 am

1 stop6h 38m

$267

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 6/2

1:45 pm-9:40 pm

2 stops6h 55m

Greenville

Wed 6/3

5:05 pm-10:00 pm

1 stop5h 55m

$272

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 6/13

4:17 pm-7:29 am

1 stop14h 12m

Greenville

Wed 6/17

3:48 pm-5:30 pm

2 stops26h 42m

$273

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 8/26

10:15 am-4:45 pm

1 stop5h 30m

Greenville

Sat 8/29

11:05 am-6:10 pm

2 stops8h 05m

$277

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 6/2

1:45 pm-9:40 pm

2 stops6h 55m

Greenville

Wed 6/3

6:45 am-1:00 pm

2 stops7h 15m

$278

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 6/9

5:40 am-1:10 pm

2 stops6h 30m

Greenville

Tue 6/16

7:00 am-2:50 pm

2 stops8h 50m

$282

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 6/17

2:56 pm-10:38 pm

1 stop6h 42m

Greenville

Sat 6/20

7:32 pm-11:44 pm

1 stop5h 12m

$295
Quickest round-trip

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 6/13

6:30 am-12:06 pm

1 stop4h 36m

Greenville

Wed 6/17

1:09 pm-6:07 pm

1 stop5h 58m

$300

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Greenville from

How to get the cheapest flight ticket from St. Louis to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Greenville?

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from St. Louis averaging around $297.

How have St. Louis to Greenville flight prices changed over time?

As of May 2026, prices for St. Louis to Greenville flights are approximately 20% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Greenville (STL to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Greenville

Fastest flight time

3h 47m

Direct flights

None
The fastest flight from St. Louis to Greenville takes 3h 47m
There are no direct flights from St. Louis to Greenville. There are no popular flight routes from St. Louis to Greenville.
Search flight deals

Frequently asked questions about flying from St. Louis to Greenville

  • How far is Lambert-St Louis to Greenville by plane?

    Lambert-St Louis and Greenville are 504.1 mi apart from one another. In terms of flight time, this usually takes a little over 3h 47m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Greenville Airport?

    Prices for flights from Lambert-St Louis Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Greenville Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Greenville?

Best airlines flying from St. Louis to Greenville

Compare and see reviews for airlines that fly from St. Louis to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights
DeltaPriceFrom $253Free CancellationRating
7.9
8,458 reviews
Search Delta flights
SouthwestPriceFrom $326Free CancellationRating
7.9
4,305 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Greenville for you.

Can I find flights from St. Louis to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from St. Louis.

I’m not ready to book a flight from St. Louis to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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