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Cheap flights from St. Louis to Greenville from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Greenville departing on 11/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 1:03 pmSTL-GSP
6h 03m1 stop
American Airlines Logo
6:00 am - 3:02 pmGSP-STL
10h 02m1 stop
$280American Airlines
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Thu, Oct 30 - Tue, Nov 4
Multiple Airlines Logo
12:20 pm - 2:10 pmSTL-GSP
24h 50m1 stop
Multiple Airlines Logo
8:03 pm - 10:46 pmGSP-STL
27h 43m1 stop
$291Multiple Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15
Southwest Logo
5:45 am - 2:30 pmSTL-GSP
7h 45m1 stop
Southwest Logo
3:05 pm - 9:35 pmGSP-STL
7h 30m2 stops
$302Southwest
Find Deal
Thu, Dec 11 - Mon, Dec 15
Southwest Logo
7:00 am - 4:05 pmSTL-GSP
8h 05m2 stops
Southwest Logo
10:35 am - 6:30 pmGSP-STL
8h 55m2 stops
$307Southwest
Find Deal
Thu, Dec 11 - Mon, Dec 15
Southwest Logo
5:30 am - 1:15 pmSTL-GSP
6h 45m1 stop
Southwest Logo
3:05 pm - 9:35 pmGSP-STL
7h 30m2 stops
$313Southwest
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Thu, Oct 30 - Tue, Nov 4
Delta Logo
6:00 am - 10:09 amSTL-GSP
3h 09m1 stop
Delta Logo
5:35 am - 10:43 amGSP-STL
6h 08m1 stop
$332Delta
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Wed, Nov 5 - Sun, Nov 9
American Airlines Logo
1:50 pm - 10:31 pmSTL-GSP
7h 41m1 stop
American Airlines Logo
6:00 am - 10:28 amGSP-STL
5h 28m1 stop
$355American Airlines
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Fri, Nov 7 - Sun, Nov 9
Delta Logo
4:00 pm - 9:22 pmSTL-GSP
4h 22m1 stop
Delta Logo
5:45 am - 9:04 amGSP-STL
4h 19m1 stop
$387Delta
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Tue, Apr 7 - Wed, Apr 8
United Airlines Logo
8:00 am - 1:36 pmSTL-GSP
4h 36m1 stop
United Airlines Logo
10:05 am - 6:17 pmGSP-STL
9h 12m2 stops
$468United Airlines
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Wed, Oct 22 - Sat, Oct 25
United Airlines Logo
5:00 am - 2:11 pmSTL-GSP
8h 11m2 stops
United Airlines Logo
10:05 am - 6:17 pmGSP-STL
9h 12m2 stops
$543United Airlines
Find Deal
Wed, Oct 22 - Sat, Oct 25

American Airlines flights from St. Louis to Greenville

Our best American Airlines deals on St. Louis to Greenville flight tickets
American Airlines
Oct 30
STL6:00 amLambert-St Louis
6h 03m
1 stop
GSP1:03 pmGreenville
Nov 4
GSP6:00 amGreenville
10h 02m
1 stop
STL3:02 pmLambert-St Louis
$280
Find similar
American Airlines
Nov 7
STL1:50 pmLambert-St Louis
7h 41m
1 stop
GSP10:31 pmGreenville
Nov 9
GSP6:00 amGreenville
5h 28m
1 stop
STL10:28 amLambert-St Louis
$355
Find similar
American Airlines
Dec 29
STL6:35 pmLambert-St Louis
4h 23m
1 stop
GSP11:58 pmGreenville
Jan 2
GSP10:43 amGreenville
6h 43m
1 stop
STL4:26 pmLambert-St Louis
$367
Find similar

Delta flights from St. Louis to Greenville

Our best Delta deals on St. Louis to Greenville flight tickets
Delta
Nov 5
STL6:00 amLambert-St Louis
3h 09m
1 stop
GSP10:09 amGreenville
Nov 9
GSP5:35 amGreenville
6h 08m
1 stop
STL10:43 amLambert-St Louis
$332
Find similar
Delta
Apr 7
STL4:00 pmLambert-St Louis
4h 22m
1 stop
GSP9:22 pmGreenville
Apr 8
GSP5:45 amGreenville
4h 19m
1 stop
STL9:04 amLambert-St Louis
$387
Find similar
Delta
Dec 22
STL7:02 pmLambert-St Louis
3h 30m
1 stop
GSP11:32 pmGreenville
Dec 27
GSP7:59 pmGreenville
4h 43m
1 stop
STL11:42 pmLambert-St Louis
$423
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 9, 2025.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 10/30

6:00 am-1:03 pm

1 stop6h 03m

Greenville

Tue 11/4

6:00 am-3:02 pm

1 stop10h 02m

$280

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 12/11

12:20 pm-2:10 pm

1 stop24h 50m

Greenville

Mon 12/15

8:03 pm-10:46 pm

1 stop27h 43m

$291

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 12/11

5:45 am-2:30 pm

1 stop7h 45m

Greenville

Mon 12/15

3:05 pm-9:35 pm

2 stops7h 30m

$302

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 12/11

7:00 am-4:05 pm

2 stops8h 05m

Greenville

Mon 12/15

10:35 am-6:30 pm

2 stops8h 55m

$307

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 10/30

5:30 am-1:15 pm

1 stop6h 45m

Greenville

Tue 11/4

3:05 pm-9:35 pm

2 stops7h 30m

$313

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 11/5

6:00 am-10:09 am

1 stop3h 09m

Greenville

Sun 11/9

5:35 am-10:43 am

1 stop6h 08m

$332

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 11/7

1:50 pm-10:31 pm

1 stop7h 41m

Greenville

Sun 11/9

6:00 am-10:28 am

1 stop5h 28m

$355

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 4/7

4:00 pm-9:22 pm

1 stop4h 22m

Greenville

Wed 4/8

5:45 am-9:04 am

1 stop4h 19m

$387

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 10/22

8:00 am-1:36 pm

1 stop4h 36m

Greenville

Sat 10/25

10:05 am-6:17 pm

2 stops9h 12m

$468

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 10/22

5:00 am-2:11 pm

2 stops8h 11m

Greenville

Sat 10/25

10:05 am-6:17 pm

2 stops9h 12m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from St. Louis to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from St. Louis averaging around $296.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Wednesday is the cheapest day to fly to Greenville from St. Louis. The lowest ticket price found for a Wednesday departure recently was $322. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $537. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is at noon. Flights from St. Louis to Greenville during this time can be as low as $326. Flights to Greenville are more costly in the afternoon, with an average ticket price of $401. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How have St. Louis to Greenville flight prices changed over time?

As of October 2025, prices for St. Louis to Greenville flights are approximately 27% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Greenville (STL to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Greenville

Direct flights

None
There are no direct flights from St. Louis to Greenville. There are no popular flight routes from St. Louis to Greenville.
Search flight deals

  • How far is Lambert-St Louis to Greenville by plane?

    Lambert-St Louis and Greenville are 504.1 mi apart from one another. In terms of flight time, this usually takes a little over 3h 09m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Greenville Airport?

    Prices for flights from Lambert-St Louis Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Greenville Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Greenville?

Best airlines flying from St. Louis to Greenville

Compare and see reviews for airlines that fly from St. Louis to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $259Free CancellationRating
7.9
7,969 reviews
Search Delta flights
American AirlinesPriceFrom $271Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Greenville for you.

Can I find flights from St. Louis to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from St. Louis.

I’m not ready to book a flight from St. Louis to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

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