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Cheap flights from St. Louis to Greenville from $118

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Greenville departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:53 am - 1:10 pmSTL  Lambert-St Louis-GSP Greenville
5h 17m1 stop Charlotte Douglas
American Airlines Logo
7:24 am - 1:16 pmGSP  Greenville-STL Lambert-St Louis
6h 52m1 stop Chicago O'Hare Intl
$255American Airlines
Thu, Sep 10 - Wed, Sep 16
Southwest Logo
3:45 pm - 9:40 pmSTL  Lambert-St Louis-GSP Greenville
4h 55m1 stop Nashville Intl
Southwest Logo
5:30 pm - 10:15 pmGSP  Greenville-STL Lambert-St Louis
5h 45m1 stop Nashville Intl
$256Southwest
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
5:00 am - 11:03 amSTL  Lambert-St Louis-GSP Greenville
5h 03m1 stop Chicago O'Hare Intl
American Airlines Logo
6:23 pm - 12:27 amGSP  Greenville-STL Lambert-St Louis
7h 04m1 stop Chicago O'Hare Intl
$257American Airlines
Thu, Sep 24 - Mon, Sep 28
Southwest Logo
7:20 am - 12:10 pmSTL  Lambert-St Louis-GSP Greenville
3h 50m1 stop Nashville Intl
Southwest Logo
8:40 pm - 11:35 pmGSP  Greenville-STL Lambert-St Louis
3h 55m1 stop Nashville Intl
$257Southwest
Sat, Oct 3 - Mon, Oct 5
American Airlines Logo
6:54 am - 2:47 pmSTL  Lambert-St Louis-GSP Greenville
6h 53m1 stop Charlotte Douglas
American Airlines Logo
6:34 pm - 12:14 amGSP  Greenville-STL Lambert-St Louis
6h 40m1 stop Chicago O'Hare Intl
$259American Airlines
Sat, Aug 29 - Wed, Sep 2
Southwest Logo
3:45 pm - 9:40 pmSTL  Lambert-St Louis-GSP Greenville
4h 55m1 stop Nashville Intl
Southwest Logo
11:00 am - 5:55 pmGSP  Greenville-STL Lambert-St Louis
7h 55m2 stops Nashville Intl Chicago Midway
$261Southwest
Thu, Sep 10 - Wed, Sep 16
United Airlines Logo
10:53 am - 5:02 pmSTL  Lambert-St Louis-GSP Greenville
5h 09m1 stop Chicago O'Hare Intl
United Airlines Logo
6:30 am - 12:02 pmGSP  Greenville-STL Lambert-St Louis
6h 32m1 stop Chicago O'Hare Intl
$270United Airlines
Wed, Sep 2 - Mon, Sep 7
Delta Logo
5:35 pm - 9:51 pmSTL  Lambert-St Louis-GSP Greenville
3h 16m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:04 pm - 11:54 pmGSP  Greenville-STL Lambert-St Louis
5h 50m1 stop Atlanta Hartsfield-Jackson
$303Delta
Fri, Oct 9 - Mon, Oct 12
Delta Logo
3:44 pm - 8:31 pmSTL  Lambert-St Louis-GSP Greenville
3h 47m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:46 am - 8:09 amGSP  Greenville-STL Lambert-St Louis
3h 23m1 stop Atlanta Hartsfield-Jackson
$338Delta
Sat, Aug 22 - Sun, Aug 23
United Airlines Logo
12:59 pm - 9:07 pmSTL  Lambert-St Louis-GSP Greenville
7h 08m1 stop Chicago O'Hare Intl
United Airlines Logo
7:00 am - 11:22 amGSP  Greenville-STL Lambert-St Louis
5h 22m1 stop Newark
$339United Airlines
Tue, Aug 25 - Sat, Aug 29

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United Airlines flights from St. Louis to Greenville

Our best United Airlines deals on St. Louis to Greenville flight tickets
United Airlines
Sep 2
STL10:53 amLambert-St Louis
5h 09m
1 stop
GSP5:02 pmGreenville
Sep 7
GSP6:30 amGreenville
6h 32m
1 stop
STL12:02 pmLambert-St Louis
$270
United Airlines
Aug 25
STL12:59 pmLambert-St Louis
7h 08m
1 stop
GSP9:07 pmGreenville
Aug 29
GSP7:00 amGreenville
5h 22m
1 stop
STL11:22 amLambert-St Louis
$339
United Airlines
Aug 25
STL7:25 amLambert-St Louis
5h 07m
1 stop
GSP1:32 pmGreenville
Aug 29
GSP7:00 amGreenville
11h 06m
2 stops
STL5:06 pmLambert-St Louis
$344

American Airlines flights from St. Louis to Greenville

Our best American Airlines deals on St. Louis to Greenville flight tickets
American Airlines
Sep 10
STL6:53 amLambert-St Louis
5h 17m
1 stop
GSP1:10 pmGreenville
Sep 16
GSP7:24 amGreenville
6h 52m
1 stop
STL1:16 pmLambert-St Louis
$255
American Airlines
Sep 24
STL5:00 amLambert-St Louis
5h 03m
1 stop
GSP11:03 amGreenville
Sep 28
GSP6:23 pmGreenville
7h 04m
1 stop
STL12:27 amLambert-St Louis
$257
American Airlines
Aug 25
STL8:36 amLambert-St Louis
7h 02m
1 stop
GSP4:38 pmGreenville
Aug 29
GSP7:05 pmGreenville
4h 35m
1 stop
STL10:40 pmLambert-St Louis
$259

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Thu 9/10

6:53 am-1:10 pm

1 stop5h 17m

Greenville

Wed 9/16

7:24 am-1:16 pm

1 stop6h 52m

$255

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Thu 9/10

3:45 pm-9:40 pm

1 stop4h 55m

Greenville

Wed 9/16

5:30 pm-10:15 pm

1 stop5h 45m

$256

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Thu 9/24

5:00 am-11:03 am

1 stop5h 03m

Greenville

Mon 9/28

6:23 pm-12:27 am

1 stop7h 04m

$257

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Sat 10/3

7:20 am-12:10 pm

1 stop3h 50m

Greenville

Mon 10/5

8:40 pm-11:35 pm

1 stop3h 55m

$257

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Sat 8/29

6:54 am-2:47 pm

1 stop6h 53m

Greenville

Wed 9/2

6:34 pm-12:14 am

1 stop6h 40m

$259

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Thu 9/10

3:45 pm-9:40 pm

1 stop4h 55m

Greenville

Wed 9/16

11:00 am-5:55 pm

2 stops7h 55m

$261

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Wed 9/2

10:53 am-5:02 pm

1 stop5h 09m

Greenville

Mon 9/7

6:30 am-12:02 pm

1 stop6h 32m

$270

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Fri 10/9

5:35 pm-9:51 pm

1 stop3h 16m

Greenville

Mon 10/12

7:04 pm-11:54 pm

1 stop5h 50m

$303
Quickest round-trip

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Sat 8/22

3:44 pm-8:31 pm

1 stop3h 47m

Greenville

Sun 8/23

5:46 am-8:09 am

1 stop3h 23m

$338

St. LouisGreenville

STL Lambert-St Louis - GSP Greenville

STLGSP

Lambert-St Louis

Tue 8/25

12:59 pm-9:07 pm

1 stop7h 08m

Greenville

Sat 8/29

7:00 am-11:22 am

1 stop5h 22m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from St. Louis to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of June is another great option to travel to Greenville, with average flight prices from St. Louis averaging around $364.

How have St. Louis to Greenville flight prices changed over time?

When to book flights from St. Louis to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Greenville (STL to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Greenville

Fastest flight time

3h 25m

Direct flights

None
The fastest flight from St. Louis to Greenville takes 3h 25m
There are no direct flights from St. Louis to Greenville. There are no popular flight routes from St. Louis to Greenville.
Search flight deals

Frequently asked questions about flying from St. Louis to Greenville

  • How far is Lambert-St Louis to Greenville by plane?

    Lambert-St Louis and Greenville are 504.1 mi apart from one another. In terms of flight time, this usually takes a little over 3h 25m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Greenville Airport?

    Prices for flights from Lambert-St Louis Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Greenville Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Greenville?

Best airlines flying from St. Louis to Greenville

Compare and see reviews for airlines that fly from St. Louis to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $259Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $307Free CancellationRating
7.1
11,915 reviews
Search American Airlines flights
SouthwestPriceFrom $328Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Greenville for you.

Can I find flights from St. Louis to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from St. Louis.

I’m not ready to book a flight from St. Louis to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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