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Cheap flights from St. Louis to Florence from $348

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Florence departing on 7/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:12 pm - 11:37 pm
STL
-
FLO
4h 25m
1 stop
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$348American Airlines
Sat, Jul 18 - Sun, Jul 26
American Airlines Logo
9:25 am - 2:10 pm
STL
-
FLO
3h 45m
1 stop
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$381American Airlines
Thu, Jul 9 - Sun, Jul 12
American Airlines Logo
9:08 am - 11:37 pm
STL
-
FLO
13h 29m
2 stops
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$488American Airlines
Sat, Jul 18 - Sun, Jul 26
American Airlines Logo
7:30 am - 2:10 pm
STL
-
FLO
5h 40m
1 stop
American Airlines Logo
2:35 pm - 7:00 pm
FLO
-
STL
5h 25m
1 stop
$509American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
9:08 am - 11:37 pm
STL
-
FLO
13h 29m
2 stops
American Airlines Logo
5:17 am - 8:33 am
FLO
-
STL
4h 16m
1 stop
$521American Airlines
Thu, Jul 9 - Sun, Jul 12
American Airlines Logo
7:30 am - 2:10 pm
STL
-
FLO
5h 40m
1 stop
American Airlines Logo
5:05 am - 8:32 am
FLO
-
STL
4h 27m
1 stop
$543American Airlines
Fri, Jun 19 - Fri, Jun 26
American Airlines Logo
9:25 am - 2:10 pm
STL
-
FLO
3h 45m
1 stop
American Airlines Logo
5:05 am - 8:32 am
FLO
-
STL
4h 27m
1 stop
$591American Airlines
Thu, Jun 18 - Mon, Jun 22
American Airlines Logo
9:42 am - 10:00 pm
STL
-
FLO
11h 18m
2 stops
American Airlines Logo
2:35 pm - 7:00 pm
FLO
-
STL
5h 25m
1 stop
$619American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
9:08 am - 11:37 pm
STL
-
FLO
13h 29m
2 stops
American Airlines Logo
5:17 am - 5:13 pm
FLO
-
STL
12h 56m
2 stops
$672American Airlines
Sat, Jul 18 - Sun, Jul 26
American Airlines Logo
9:08 am - 11:37 pm
STL
-
FLO
13h 29m
2 stops
American Airlines Logo
5:17 am - 5:13 pm
FLO
-
STL
12h 56m
2 stops
$704American Airlines
Thu, Jul 9 - Sun, Jul 12

American Airlines flights from St. Louis to Florence, South Carolina

Our best American Airlines deals on St. Louis to Florence, South Carolina flight tickets
American Airlines
Jul 18
STL6:12 pmLambert-St Louis
4h 25m
1 stop
FLO11:37 pmFlorence
Jul 26
FLO5:17 amFlorence
4h 16m
1 stop
STL8:33 amLambert-St Louis
$348
American Airlines
Jul 9
STL9:25 amLambert-St Louis
3h 45m
1 stop
FLO2:10 pmFlorence
Jul 12
FLO5:17 amFlorence
4h 16m
1 stop
STL8:33 amLambert-St Louis
$381
American Airlines
Jun 13
STL9:09 amLambert-St Louis
4h 01m
1 stop
FLO2:10 pmFlorence
Jun 15
FLO5:05 amFlorence
4h 27m
1 stop
STL8:32 amLambert-St Louis
$419

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 6, 2026.
Use the filters below to find and compare flights from St. Louis to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 7/18

6:12 pm-11:37 pm

1 stop4h 25m

Florence

Sun 7/26

5:17 am-8:33 am

1 stop4h 16m

$348
Quickest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 7/9

9:25 am-2:10 pm

1 stop3h 45m

Florence

Sun 7/12

5:17 am-8:33 am

1 stop4h 16m

$381

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 7/18

9:08 am-11:37 pm

2 stops13h 29m

Florence

Sun 7/26

5:17 am-8:33 am

1 stop4h 16m

$488

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 6/20

7:30 am-2:10 pm

1 stop5h 40m

Florence

Fri 6/26

2:35 pm-7:00 pm

1 stop5h 25m

$509

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 7/9

9:08 am-11:37 pm

2 stops13h 29m

Florence

Sun 7/12

5:17 am-8:33 am

1 stop4h 16m

$521

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 6/19

7:30 am-2:10 pm

1 stop5h 40m

Florence

Fri 6/26

5:05 am-8:32 am

1 stop4h 27m

$543

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 6/18

9:25 am-2:10 pm

1 stop3h 45m

Florence

Mon 6/22

5:05 am-8:32 am

1 stop4h 27m

$591

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 6/20

9:42 am-10:00 pm

2 stops11h 18m

Florence

Fri 6/26

2:35 pm-7:00 pm

1 stop5h 25m

$619

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 7/18

9:08 am-11:37 pm

2 stops13h 29m

Florence

Sun 7/26

5:17 am-5:13 pm

2 stops12h 56m

$672

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 7/9

9:08 am-11:37 pm

2 stops13h 29m

Florence

Sun 7/12

5:17 am-5:13 pm

2 stops12h 56m

$704

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from St. Louis to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Southwest and Delta are the top three most popular airlines that fly to Florence, South Carolina from St. Louis according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from St. Louis to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Florence, South Carolina (STL to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Florence, South Carolina

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from St. Louis to Florence, South Carolina takes 3h 45m
There are no direct flights from St. Louis to Florence, South Carolina. There are no popular flight routes from St. Louis to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from St. Louis to Florence, South Carolina

  • How far is Lambert-St Louis to Florence by plane?

    The distance between Lambert-St Louis and Florence is about 655.0 mi. 3h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Florence Airport?

    Prices for flights from Lambert-St Louis Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Florence Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Florence, South Carolina?

Best airlines flying from St. Louis to Florence, South Carolina

Compare and see reviews for airlines that fly from St. Louis to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $408Free CancellationRating
7.1
11,649 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Florence for you.

Can I find flights from St. Louis to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Florence?

Once you have performed a search for St. Louis to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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