Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from St. Louis to Florence from $307

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Florence departing on 4/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:34 am - 2:10 pmSTL-FLO
5h 36m1 stop
American Airlines Logo
2:33 pm - 5:13 pmFLO-STL
3h 40m1 stop
$307American Airlines
Find Deal
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
12:03 pm - 11:41 pmSTL-FLO
10h 38m2 stops
American Airlines Logo
5:13 am - 8:05 amFLO-STL
3h 52m1 stop
$312American Airlines
Find Deal
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
6:28 am - 2:10 pmSTL-FLO
6h 42m2 stops
American Airlines Logo
2:33 pm - 10:25 pmFLO-STL
8h 52m2 stops
$317American Airlines
Find Deal
Tue, Apr 14 - Sat, Apr 18

American Airlines flights from St. Louis to Florence, South Carolina

Our best American Airlines deals on St. Louis to Florence, South Carolina flight tickets
American Airlines
Apr 14
STL7:34 amLambert-St Louis
5h 36m
1 stop
FLO2:10 pmFlorence
Apr 18
FLO2:33 pmFlorence
3h 40m
1 stop
STL5:13 pmLambert-St Louis
$307
Find similar
American Airlines
Apr 14
STL12:03 pmLambert-St Louis
10h 38m
2 stops
FLO11:41 pmFlorence
Apr 18
FLO5:13 amFlorence
3h 52m
1 stop
STL8:05 amLambert-St Louis
$312
Find similar
American Airlines
Apr 14
STL6:28 amLambert-St Louis
6h 42m
2 stops
FLO2:10 pmFlorence
Apr 18
FLO2:33 pmFlorence
8h 52m
2 stops
STL10:25 pmLambert-St Louis
$317
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from St. Louis to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/14

7:34 am-2:10 pm

1 stop5h 36m

Florence

Sat 4/18

2:33 pm-5:13 pm

1 stop3h 40m

$307

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/14

12:03 pm-11:41 pm

2 stops10h 38m

Florence

Sat 4/18

5:13 am-8:05 am

1 stop3h 52m

$312

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 4/14

6:28 am-2:10 pm

2 stops6h 42m

Florence

Sat 4/18

2:33 pm-10:25 pm

2 stops8h 52m

$317

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from St. Louis to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Southwest and Delta are the top three most popular airlines that fly to Florence, South Carolina from St. Louis according to our data. American Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from St. Louis to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Florence, South Carolina (STL to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Florence, South Carolina

Direct flights

None
There are no direct flights from St. Louis to Florence, South Carolina. There are no popular flight routes from St. Louis to Florence, South Carolina.
Search flight deals

  • How far is Lambert-St Louis to Florence by plane?

    The distance between Lambert-St Louis and Florence is about 655.0 mi. 5h 36m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Florence Airport?

    Prices for flights from Lambert-St Louis Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Lambert-St Louis Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Florence for you.

Can I find flights from St. Louis to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Florence?

Once you have performed a search for St. Louis to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 11/26
Wed 12/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States