What is the cheapest airline that flies from South Carolina to Missouri?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from South Carolina to Missouri

How many flights depart from South Carolina to Missouri on average per week?

As of December 2025, 92 flights take off from South Carolina and land in Missouri each week. The most common flight departure day for this route is Thu, with 20% of weekly flights taking off on this day.

What airlines fly to Missouri?

Delta, American Airlines and Southwest are the top three most popular airlines that fly to Missouri from South Carolina according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 5 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

How long is the flight from South Carolina to Missouri?

The flight from South Carolina to Missouri depends on which airports you’re departing and arriving from and whether or not you have a layover. If you fly from Charleston (a popular airport in South Carolina) to St. Louis (the most popular airport in Missouri), then the flight time is 2h 15m on average. If you fly from Columbia (another popular airport in South Carolina) to St. Louis, then the average flight time is 3h 44m.

When did momondo last update prices for flights from South Carolina to Missouri?

Prices for flights from South Carolina to Missouri are updated daily.

How many operators does momondo search for flights from South Carolina to Missouri?

As of December 2025, there are 5 operators available to choose from for flights from South Carolina to Missouri.

How old do you have to be to fly from South Carolina to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$64 Cheap Flights from South Carolina to Missouri in 2025/26

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Find the cheapest flights from South Carolina to Missouri

Round-trip

One-way

Last minute

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Cheap round-trip flights

Enter your travel dates to find the best prices.

9:59 pm - 11:33 pm

CLT

STL

26h 34m1 stop

10:16 am - 1:51 pm

STL

CLT

26h 35m1 stop

$128Frontier

Fri, Feb 6 - Mon, Feb 9

11:35 am - 11:33 pm

CLT

STL

12h 58m1 stop

5:42 pm - 1:51 pm

STL

CLT

19h 09m1 stop

$133Frontier

Tue, Feb 3 - Mon, Feb 9

9:00 am - 5:10 pm

CLT

MCI

9h 10m1 stop

11:26 am - 12:40 am

MCI

CLT

12h 14m1 stop

$162Spirit Airlines

Wed, Jan 7 - Fri, Jan 9

11:12 am - 4:09 pm

CLT

MCI

5h 57m1 stop

11:26 am - 6:48 pm

MCI

CLT

6h 22m1 stop

$189Spirit Airlines

Fri, Jan 23 - Mon, Jan 26

7:00 am - 12:54 pm

SAV

STL

6h 54m1 stop

7:05 pm - 12:04 am

STL

SAV

3h 59m1 stop

$237Delta

Fri, May 1 - Mon, May 4

6:00 am - 11:41 am

SAV

STL

6h 41m1 stop

6:00 am - 2:24 pm

STL

SAV

7h 24m2 stops

$242American Airlines

Thu, Jan 22 - Wed, Jan 28

3:05 pm - 9:51 pm

SAV

STL

7h 46m2 stops

6:00 am - 2:24 pm

STL

SAV

7h 24m2 stops

$247American Airlines

Thu, Jan 22 - Wed, Jan 28

4:45 pm - 9:25 pm

GSP

MCI

5h 40m1 stop

5:45 am - 2:25 pm

MCI

GSP

7h 40m1 stop

$269Southwest

Thu, Dec 25 - Wed, Dec 31

10:56 am - 3:12 pm

CAE

MCI

5h 16m1 stop

5:50 am - 11:58 am

MCI

CAE

5h 08m1 stop

$277Delta

Thu, Jan 1 - Wed, Jan 7

4:45 pm - 9:25 pm

GSP

MCI

5h 40m1 stop

6:15 am - 4:05 pm

MCI

GSP

8h 50m2 stops

$359Southwest

Thu, Dec 25 - Wed, Dec 31

American Airlines flights from South Carolina to Missouri

Our best American Airlines deals on South Carolina to Missouri flight tickets

American Airlines

Jan 14

CLT1:59 pmCharlotte Douglas

2h 05m

STL3:04 pmLambert-St Louis

Jan 21

STL6:52 amLambert-St Louis

1h 58m

CLT9:50 amCharlotte Douglas

$217

Find similar

American Airlines

Jan 14

CLT8:25 amCharlotte Douglas

2h 15m

STL9:40 amLambert-St Louis

Jan 21

STL7:15 amLambert-St Louis

6h 14m

1 stop

CLT2:29 pmCharlotte Douglas

$238

Find similar

American Airlines

Jan 7

CLT10:09 pmCharlotte Douglas

2h 03m

STL11:12 pmLambert-St Louis

Jan 11

STL8:13 amLambert-St Louis

1h 58m

CLT11:11 amCharlotte Douglas

$240

Find similar

Southwest flights from South Carolina to Missouri

Our best Southwest deals on South Carolina to Missouri flight tickets

Southwest

Jan 6

CLT8:25 amCharlotte Douglas

2h 10m

STL9:35 amLambert-St Louis

Jan 14

STL8:20 amLambert-St Louis

7h 00m

1 stop

CLT4:20 pmCharlotte Douglas

$227

Find similar

Southwest

Jan 6

CLT8:25 amCharlotte Douglas

2h 10m

STL9:35 amLambert-St Louis

Jan 8

STL2:30 pmLambert-St Louis

1h 45m

CLT5:15 pmCharlotte Douglas

$228

Find similar

Southwest

Jan 27

CLT8:25 amCharlotte Douglas

2h 10m

STL9:35 amLambert-St Louis

Jan 29

STL2:30 pmLambert-St Louis

1h 45m

CLT5:15 pmCharlotte Douglas

$239

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 2/6

9:59 pm-11:33 pm

1 stop26h 34m

Lambert-St Louis

Mon 2/9

10:16 am-1:51 pm

1 stop26h 35m

$128

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 2/3

11:35 am-11:33 pm

1 stop12h 58m

Lambert-St Louis

Mon 2/9

5:42 pm-1:51 pm

1 stop19h 09m

$133

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Wed 1/7

9:00 am-5:10 pm

1 stop9h 10m

Kansas City

Fri 1/9

11:26 am-12:40 am

1 stop12h 14m

$162

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Fri 1/23

11:12 am-4:09 pm

1 stop5h 57m

Kansas City

Mon 1/26

11:26 am-6:48 pm

1 stop6h 22m

$189

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Fri 5/1

7:00 am-12:54 pm

1 stop6h 54m

Lambert-St Louis

Mon 5/4

7:05 pm-12:04 am

1 stop3h 59m

$237

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Thu 1/22

6:00 am-11:41 am

1 stop6h 41m

Lambert-St Louis

Wed 1/28

6:00 am-2:24 pm

2 stops7h 24m

$242

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Thu 1/22

3:05 pm-9:51 pm

2 stops7h 46m

Lambert-St Louis

Wed 1/28

6:00 am-2:24 pm

2 stops7h 24m

$247

GreenvilleKansas City

GSP - MCI

GSPMCI

Greenville

Thu 12/25

4:45 pm-9:25 pm

1 stop5h 40m

Kansas City

Wed 12/31

5:45 am-2:25 pm

1 stop7h 40m

$269

ColumbiaKansas City

CAE - MCI

CAEMCI

Columbia Metropolitan

Thu 1/1

10:56 am-3:12 pm

1 stop5h 16m

Kansas City

Wed 1/7

5:50 am-11:58 am

1 stop5h 08m

$277

GreenvilleKansas City

GSP - MCI

GSPMCI

Greenville

Thu 12/25

4:45 pm-9:25 pm

1 stop5h 40m

Kansas City

Wed 12/31

6:15 am-4:05 pm

2 stops8h 50m

$359

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Missouri?

In general, September is the cheapest month to fly from South Carolina to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $308. If you aren’t able to travel to Missouri during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $342.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from South Carolina to Missouri is on a Thursday when prices can be found for as low as $336. Flights from South Carolina to Missouri on a Saturday will generally be more expensive and average around $646. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from South Carolina to Missouri in the afternoon for as low as $388. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly at noon, with an average ticket price of $606. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest South Carolina to Missouri flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Missouri flight prices

What cabin class options are available on South Carolina to Missouri flights?

There is only 1 cabin class available to choose from on South Carolina to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Missouri flights?

You could potentially save up to 21% on your flight if you consider stops on a South Carolina to Missouri flight.

Cheap South Carolina to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Missouri

Fastest flight time	2h 09m
Direct flights	Every day
Airports in Missouri	55 airports

The fastest flight from South Carolina to Missouri takes 2h 09m

Direct flights go from South Carolina to Missouri every day.

There are 55 airports in Missouri. From South Carolina there are direct flights to Kansas City (MCI), Springfield-Branson (SGF), Lambert-St Louis (STL).

Search flight deals

When did momondo last update prices for flights from South Carolina to Missouri?
Prices for flights from South Carolina to Missouri are updated daily.
How many operators does momondo search for flights from South Carolina to Missouri?
As of December 2025, there are 5 operators available to choose from for flights from South Carolina to Missouri.
How old do you have to be to fly from South Carolina to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from South Carolina to Missouri?
Based on momondo bookings for flights between South Carolina and Missouri, the leading plane model is Boeing 737 MAX 8, making up 14.29% of the total bookings. Other popular models include Boeing 737-900 Passenger/BBJ3 (winglets) with 14.29%, Embraer 175 (Enhanced Winglets) with 7.14%, and Boeing 737 MAX 9 with 7.14%.

Best airlines flying from South Carolina to Missouri

Compare and see reviews for airlines that fly from South Carolina to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $139	Free Cancellation	Rating 7.9 8,008 reviews	Search Delta flights
United Airlines	PriceFrom $174	Free Cancellation	Rating 7.4 9,095 reviews	Search United Airlines flights
Spirit Airlines	PriceFrom $199	Free Cancellation	Rating 6.3 8,179 reviews	Search Spirit Airlines flights
American Airlines	PriceFrom $204	Free Cancellation	Rating 7.2 11,050 reviews	Search American Airlines flights
Southwest	PriceFrom $226	Free Cancellation	Rating 7.9 4,253 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Missouri?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Missouri from South Carolina.

Can I find flights from South Carolina to Missouri with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Missouri from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Missouri?

Once you have performed a search for South Carolina to Missouri flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Find better results for your trip to Missouri

Popular cities in Missouri

Flights to New Yorkfrom $34

Flights to Los Angelesfrom $49

Flights to Miamifrom $49

Flights to Chicagofrom $49

Flights to Orlandofrom $41

Flights to San Franciscofrom $53

Flights to Las Vegasfrom $40

Flights to Washington, D.C.from $49

Flights to Bostonfrom $55

Flights to Atlantafrom $49

Flights to Dallasfrom $52

Flights to Seattlefrom $58

Cheap flights from South Carolina to Missouri from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Missouri departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

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Trusted and free

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Find the cheapest flights from South Carolina to Missouri

Cheap round-trip flights

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Cheap last minute flights

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American Airlines flights from South Carolina to Missouri

Our best American Airlines deals on South Carolina to Missouri flight tickets

Southwest flights from South Carolina to Missouri

Our best Southwest deals on South Carolina to Missouri flight tickets

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Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

See travel insights to Missouri from

How to get the cheapest flight ticket from South Carolina to Missouri

What is the cheapest month to fly to Missouri?

What is the cheapest day to depart on your flight to Missouri?

What is the cheapest time of day to depart on your flight to Missouri?

What is the cheapest South Carolina to Missouri flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Missouri flight prices

What cabin class options are available on South Carolina to Missouri flights?

There is only 1 cabin class available to choose from on South Carolina to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Missouri flights?

You could potentially save up to 21% on your flight if you consider stops on a South Carolina to Missouri flight.

What is the cheapest airline that flies from South Carolina to Missouri?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from South Carolina to Missouri

What airlines fly to Missouri?

How many flights depart from South Carolina to Missouri on average per week?

As of December 2025, 92 flights take off from South Carolina and land in Missouri each week. The most common flight departure day for this route is Thu, with 20% of weekly flights taking off on this day.

How long is the flight from South Carolina to Missouri?

Cheap South Carolina to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Missouri

Fastest flight time

Direct flights

Airports in Missouri

When did momondo last update prices for flights from South Carolina to Missouri?

How many operators does momondo search for flights from South Carolina to Missouri?

How old do you have to be to fly from South Carolina to Missouri?

What documentation or ID do you need to fly to Missouri?

What is the most popular plane model from South Carolina to Missouri?

Best airlines flying from South Carolina to Missouri

Compare and see reviews for airlines that fly from South Carolina to Missouri with momondo

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Missouri?

Can I find flights from South Carolina to Missouri with flexible booking policies on momondo?

How can momondo help me find flights from South Carolina to Missouri?

I’m not ready to book a flight from South Carolina to Missouri right now. Can momondo alert me if prices change?

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Missouri

Popular cities in Missouri

Popular flights according to clicks in the last 7 days on momondo