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Cheap flights from South Carolina to Missouri from $70

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Missouri departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Missouri

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:09 pm - 11:19 pm
CLT
-
STL
28h 10m
1 stop
Frontier Logo
8:39 am - 4:13 pm
STL
-
CLT
6h 34m
1 stop
$151Frontier
Mon, Apr 20 - Fri, Apr 24
Frontier Logo
7:49 pm - 9:48 am
CLT
-
STL
14h 59m
1 stop
Frontier Logo
4:59 pm - 9:27 am
STL
-
CLT
15h 28m
1 stop
$163Frontier
Sun, Apr 12 - Sun, Apr 26
American Airlines Logo
7:26 am - 8:30 am
CLT
-
STL
2h 04mnonstop
American Airlines Logo
6:54 pm - 9:54 pm
STL
-
CLT
2h 00mnonstop
$189American Airlines
Wed, Apr 29 - Wed, May 13
American Airlines Logo
7:26 am - 8:30 am
CLT
-
STL
2h 04mnonstop
American Airlines Logo
6:53 pm - 9:50 pm
STL
-
CLT
1h 57mnonstop
$190American Airlines
Sat, Apr 25 - Sat, May 2
Southwest Logo
8:00 am - 11:50 am
CLT
-
MCI
4h 50m
1 stop
Southwest Logo
4:15 pm - 9:40 pm
MCI
-
CLT
4h 25m
1 stop
$213Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
7:35 am - 11:35 am
CLT
-
MCI
5h 00m
1 stop
Southwest Logo
4:15 pm - 9:40 pm
MCI
-
CLT
4h 25m
1 stop
$218Southwest
Tue, Apr 21 - Tue, Apr 28
Delta Logo
5:30 am - 8:10 am
SAV
-
STL
3h 40m
1 stop
Delta Logo
10:19 am - 5:53 pm
STL
-
SAV
6h 34m
1 stop
$231Delta
Wed, May 13 - Wed, May 20
Delta Logo
11:00 am - 3:40 pm
MYR
-
STL
5h 40m
1 stop
Delta Logo
6:57 pm - 11:58 pm
STL
-
MYR
4h 01m
1 stop
$272Delta
Thu, May 7 - Tue, May 12
United Airlines Logo
2:58 pm - 7:48 pm
CHS
-
MCI
5h 50m
1 stop
United Airlines Logo
3:00 pm - 9:59 pm
MCI
-
CHS
5h 59m
1 stop
$281United Airlines
Tue, Apr 14 - Tue, Apr 21
United Airlines Logo
3:14 pm - 10:04 pm
MYR
-
MCI
7h 50m
1 stop
United Airlines Logo
6:17 am - 2:18 pm
MCI
-
MYR
7h 01m
1 stop
$310United Airlines
Thu, May 7 - Tue, May 12

Frontier flights from South Carolina to Missouri

Our best Frontier deals on South Carolina to Missouri flight tickets
Frontier
Apr 20
CLT8:09 pmCharlotte Douglas
28h 10m
1 stop
STL11:19 pmLambert-St Louis
Apr 24
STL8:39 amLambert-St Louis
6h 34m
1 stop
CLT4:13 pmCharlotte Douglas
$151
Frontier
Apr 12
CLT7:49 pmCharlotte Douglas
14h 59m
1 stop
STL9:48 amLambert-St Louis
Apr 26
STL4:59 pmLambert-St Louis
15h 28m
1 stop
CLT9:27 amCharlotte Douglas
$163
Frontier
Apr 21
CLT5:30 pmCharlotte Douglas
6h 49m
1 stop
STL11:19 pmLambert-St Louis
Apr 28
STL4:59 pmLambert-St Louis
22h 36m
1 stop
CLT4:35 pmCharlotte Douglas
$170

Southwest flights from South Carolina to Missouri

Our best Southwest deals on South Carolina to Missouri flight tickets
Southwest
Apr 25
CLT4:00 pmCharlotte Douglas
4h 45m
1 stop
STL7:45 pmLambert-St Louis
May 2
STL5:40 amLambert-St Louis
4h 55m
1 stop
CLT11:35 amCharlotte Douglas
$209
Southwest
May 5
CLT8:00 amCharlotte Douglas
4h 50m
1 stop
MCI11:50 amKansas City
May 12
MCI4:15 pmKansas City
4h 25m
1 stop
CLT9:40 pmCharlotte Douglas
$213
Southwest
Apr 25
CLT12:15 pmCharlotte Douglas
5h 10m
1 stop
STL4:25 pmLambert-St Louis
May 2
STL6:10 amLambert-St Louis
8h 00m
2 stops
CLT3:10 pmCharlotte Douglas
$214

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Mon 4/20

8:09 pm-11:19 pm

1 stop28h 10m

Lambert-St Louis

Fri 4/24

8:39 am-4:13 pm

1 stop6h 34m

$151

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sun 4/12

7:49 pm-9:48 am

1 stop14h 59m

Lambert-St Louis

Sun 4/26

4:59 pm-9:27 am

1 stop15h 28m

$163

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/29

7:26 am-8:30 am

Nonstop2h 04m

Lambert-St Louis

Wed 5/13

6:54 pm-9:54 pm

Nonstop2h 00m

$189
Quickest round-trip

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 4/25

7:26 am-8:30 am

Nonstop2h 04m

Lambert-St Louis

Sat 5/2

6:53 pm-9:50 pm

Nonstop1h 57m

$190

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Tue 5/5

8:00 am-11:50 am

1 stop4h 50m

Kansas City

Tue 5/12

4:15 pm-9:40 pm

1 stop4h 25m

$213

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Tue 4/21

7:35 am-11:35 am

1 stop5h 00m

Kansas City

Tue 4/28

4:15 pm-9:40 pm

1 stop4h 25m

$218

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Wed 5/13

5:30 am-8:10 am

1 stop3h 40m

Lambert-St Louis

Wed 5/20

10:19 am-5:53 pm

1 stop6h 34m

$231

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 5/7

11:00 am-3:40 pm

1 stop5h 40m

Lambert-St Louis

Tue 5/12

6:57 pm-11:58 pm

1 stop4h 01m

$272

CharlestonKansas City

CHS - MCI

CHSMCI

Charleston

Tue 4/14

2:58 pm-7:48 pm

1 stop5h 50m

Kansas City

Tue 4/21

3:00 pm-9:59 pm

1 stop5h 59m

$281

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Thu 5/7

3:14 pm-10:04 pm

1 stop7h 50m

Kansas City

Tue 5/12

6:17 am-2:18 pm

1 stop7h 01m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from South Carolina to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, February is the cheapest month to fly from South Carolina to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $276. If you aren’t able to travel to Missouri during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $299.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from South Carolina to Missouri is on a Thursday when prices can be found for as low as $336. Flights from South Carolina to Missouri on a Sunday will generally be more expensive and average around $606. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the morning. momondo users have found flights departing from South Carolina to Missouri in the morning for as low as $378. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly at noon, with an average ticket price of $527. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest South Carolina to Missouri flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Missouri flight prices

What cabin class options are available on South Carolina to Missouri flights?

There is only 1 cabin class available to choose from on South Carolina to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Missouri flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Missouri.

Cheap South Carolina to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Missouri

Best Price Found

$412

Fastest flight time

2h 00m

Direct flights

Every day

Airports in Missouri

55 airports
The best flight deal from South Carolina to Missouri found on momondo in the last 72 hours is $412
The fastest flight from South Carolina to Missouri takes 2h 00m
Direct flights go from South Carolina to Missouri every day.
There are 55 airports in Missouri. From South Carolina there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Missouri?

    Prices for flights from South Carolina to Missouri are updated daily.

  • How many operators does momondo search for flights from South Carolina to Missouri?

  • How old do you have to be to fly from South Carolina to Missouri?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from South Carolina to Missouri?

Best airlines flying from South Carolina to Missouri

Compare and see reviews for airlines that fly from South Carolina to Missouri with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $128Free CancellationRating
7.9
8,341 reviews
Search Delta flights
American AirlinesPriceFrom $177Free CancellationRating
7.1
11,503 reviews
Search American Airlines flights
SouthwestPriceFrom $226Free CancellationRating
8.0
4,331 reviews
Search Southwest flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,491 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Missouri?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Missouri from South Carolina.

Can I find flights from South Carolina to Missouri with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Missouri from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Missouri?

Once you have performed a search for South Carolina to Missouri flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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