What airlines fly to Missouri?

Delta, American Airlines and Southwest are the top three most popular airlines that fly to Missouri from South Carolina according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 4 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

How many flights depart from South Carolina to Missouri on average per week?

As of September 2026, 7 flights take off from South Carolina and land in Missouri each week. The most common flight departure day for this route is Sun, with 43% of weekly flights taking off on this day.

How long is the flight from South Carolina to Missouri?

The flight from South Carolina to Missouri depends on which airports you’re departing and arriving from and whether or not you have a layover. If you fly from Charleston (a popular airport in South Carolina) to St. Louis (the most popular airport in Missouri), then the flight time is 2h 05m on average. If you fly from Myrtle Beach (another popular airport in South Carolina) to St. Louis, then the average flight time is 4h.

How many flights depart from South Carolina to Missouri on average per day?

As of September 2026, there are 1 flights per day flying from South Carolina to Missouri. The most common time of day flights depart is 1:00PM, with 66% of flights taking off in the afternoon.

What is the cheapest airline that flies from South Carolina to Missouri?

Delta, United Airlines, and Southwest are the most popular carriers operating from South Carolina to Missouri

When did momondo last update prices for flights from South Carolina to Missouri?

Prices for flights from South Carolina to Missouri are updated daily.

How many operators does momondo search for flights from South Carolina to Missouri?

As of September 2026, there are 4 operators available to choose from for flights from South Carolina to Missouri.

How old do you have to be to fly from South Carolina to Missouri?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$84 Cheap Flights from South Carolina to Missouri in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Missouri

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:25 pm - 2:30 pmCHS Charleston-STL Lambert-St Louis

2h 05mnonstop

4:30 pm - 7:25 pmSTL Lambert-St Louis-CHS Charleston

1h 55mnonstop

$217Southwest

Thu, Oct 22 - Mon, Oct 26

1:25 pm - 2:30 pmCHS Charleston-STL Lambert-St Louis

2h 05mnonstop

11:55 am - 6:45 pmSTL Lambert-St Louis-CHS Charleston

5h 50m1 stop Nashville Intl

$222Southwest

Thu, Oct 22 - Sat, Oct 24

4:58 pm - 9:21 pmCHS Charleston-STL Lambert-St Louis

5h 23m1 stop Chicago O'Hare Intl

1:00 pm - 7:11 pmSTL Lambert-St Louis-CHS Charleston

5h 11m1 stop Washington, D.C. Dulles Intl

$222United Airlines

Wed, Oct 21 - Wed, Oct 28

12:40 pm - 6:15 pmCHS Charleston-STL Lambert-St Louis

6h 35m1 stop Atlanta Hartsfield-Jackson

7:00 am - 1:13 pmSTL Lambert-St Louis-CHS Charleston

5h 13m1 stop Atlanta Hartsfield-Jackson

$227Delta

Wed, Oct 28 - Tue, Nov 3

5:30 am - 9:09 amCHS Charleston-STL Lambert-St Louis

4h 39m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:04 amSTL Lambert-St Louis-CHS Charleston

4h 04m1 stop Atlanta Hartsfield-Jackson

$227Delta

Wed, Oct 28 - Sat, Oct 31

12:17 pm - 6:53 pmCHS Charleston-STL Lambert-St Louis

7h 36m1 stop Chicago O'Hare Intl

6:02 am - 11:30 amSTL Lambert-St Louis-CHS Charleston

4h 28m1 stop Chicago O'Hare Intl

$227American Airlines

Thu, Dec 3 - Tue, Dec 8

7:04 pm - 11:59 pmCHS Charleston-STL Lambert-St Louis

5h 55m1 stop Charlotte Douglas

7:16 am - 2:25 pmSTL Lambert-St Louis-CHS Charleston

6h 09m1 stop Charlotte Douglas

$227American Airlines

Thu, Oct 22 - Sat, Oct 24

7:00 pm - 11:24 pmCHS Charleston-STL Lambert-St Louis

5h 24m1 stop Chicago O'Hare Intl

6:00 am - 2:28 pmSTL Lambert-St Louis-CHS Charleston

7h 28m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$232United Airlines

Thu, Nov 5 - Mon, Nov 9

3:00 pm - 5:40 pmCHS Charleston-STL Lambert-St Louis

27h 40m2 stops Orlando Atlanta Hartsfield-Jackson

4:26 pm - 8:38 amSTL Lambert-St Louis-CHS Charleston

15h 12m1 stop Orlando

$248Multiple Airlines

Tue, Oct 27 - Mon, Nov 2

6:25 pm - 5:40 pmMYR Myrtle Beach Intl-STL Lambert-St Louis

24h 15m2 stops Tampa Atlanta Hartsfield-Jackson

4:30 pm - 10:05 amSTL Lambert-St Louis-MYR Myrtle Beach Intl

16h 35m1 stop Orlando

$344Multiple Airlines

Thu, Oct 15 - Mon, Oct 19

Cheap last minute flights

Enter your travel dates to find the best prices.

12:22 pm - 5:30 pmCHS Charleston-STL Lambert-St Louis

6h 08m1 stop Charlotte Douglas

3:51 pm - 10:37 pmSTL Lambert-St Louis-CHS Charleston

5h 46m1 stop Washington, D.C. Reagan-National

$368American Airlines

Wed, Sep 30 - Wed, Nov 4

6:44 am - 10:59 amCHS Charleston-SGF Springfield-Branson

5h 15m1 stop Dallas/Fort Worth

6:00 am - 12:31 pmSGF Springfield-Branson-CHS Charleston

5h 31m1 stop Dallas/Fort Worth

$385American Airlines

Wed, Sep 30 - Sat, Oct 3

4:58 pm - 11:18 pmCHS Charleston-SGF Springfield-Branson

7h 20m1 stop Chicago O'Hare Intl

3:05 pm - 12:15 amSGF Springfield-Branson-CHS Charleston

8h 10m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$390United Airlines

Wed, Sep 30 - Sat, Oct 3

6:15 am - 12:13 pmCAE Columbia Metropolitan-STL Lambert-St Louis

6h 58m1 stop Chicago O'Hare Intl

8:30 am - 2:26 pmSTL Lambert-St Louis-CAE Columbia Metropolitan

4h 56m1 stop Washington, D.C. Dulles Intl

$408United Airlines

Wed, Sep 30 - Mon, Oct 5

10:12 am - 8:46 amGSP Greenville-MCI Kansas City

23h 34m2 stops Tampa Fort Lauderdale

9:16 am - 6:40 pmMCI Kansas City-GSP Greenville

8h 24m1 stop Fort Lauderdale

$417Multiple Airlines

Thu, Oct 1 - Mon, Oct 5

3:55 pm - 8:40 pmMYR Myrtle Beach Intl-MCI Kansas City

5h 45m1 stop Nashville Intl

3:35 pm - 9:45 pmMCI Kansas City-MYR Myrtle Beach Intl

5h 10m1 stop Nashville Intl

$429Southwest

Fri, Oct 2 - Mon, Oct 5

3:55 pm - 8:40 pmMYR Myrtle Beach Intl-MCI Kansas City

5h 45m1 stop Nashville Intl

5:20 am - 3:20 pmMCI Kansas City-MYR Myrtle Beach Intl

9h 00m2 stops Dallas Love Field Baltimore/Washington

$434Southwest

Fri, Oct 2 - Mon, Oct 5

5:59 pm - 11:51 pmCAE Columbia Metropolitan-MCI Kansas City

6h 52m1 stop Atlanta Hartsfield-Jackson

5:44 am - 1:14 pmMCI Kansas City-CAE Columbia Metropolitan

6h 30m1 stop Atlanta Hartsfield-Jackson

$444Delta

Tue, Sep 29 - Mon, Oct 5

2:38 pm - 8:46 amGSP Greenville-MCI Kansas City

19h 08m1 stop Fort Lauderdale

9:16 am - 6:40 pmMCI Kansas City-GSP Greenville

8h 24m1 stop Fort Lauderdale

$466Multiple Airlines

Thu, Oct 1 - Mon, Oct 5

1:35 pm - 5:37 pmGSP Greenville-MCI Kansas City

5h 02m1 stop Atlanta Hartsfield-Jackson

2:26 pm - 8:37 pmMCI Kansas City-GSP Greenville

5h 11m1 stop Atlanta Hartsfield-Jackson

$807Delta

Thu, Oct 1 - Sat, Oct 3

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

American Airlines flights from South Carolina to Missouri

Our best American Airlines deals on South Carolina to Missouri flight tickets

American Airlines

Dec 3

GSP6:47 pmGreenville

6h 15m

1 stop

STL12:02 amLambert-St Louis

Dec 5

STL2:00 pmLambert-St Louis

5h 34m

1 stop

GSP8:34 pmGreenville

$259

American Airlines

Nov 5

MYR8:35 pmMyrtle Beach Intl

4h 51m

1 stop

MCI12:26 amKansas City

Nov 10

MCI10:58 amKansas City

4h 25m

1 stop

MYR4:23 pmMyrtle Beach Intl

$269

American Airlines

Nov 5

MYR8:35 pmMyrtle Beach Intl

4h 51m

1 stop

MCI12:26 amKansas City

Nov 10

MCI10:58 amKansas City

4h 25m

1 stop

MYR4:23 pmMyrtle Beach Intl

$279

Southwest flights from South Carolina to Missouri

Our best Southwest deals on South Carolina to Missouri flight tickets

Southwest

Oct 22

CHS1:25 pmCharleston

2h 05m

STL2:30 pmLambert-St Louis

Oct 26

STL4:30 pmLambert-St Louis

1h 55m

CHS7:25 pmCharleston

$217

Southwest

Oct 22

CHS1:25 pmCharleston

2h 05m

STL2:30 pmLambert-St Louis

Oct 26

STL2:30 pmLambert-St Louis

6h 05m

1 stop

CHS9:35 pmCharleston

$227

Southwest

Oct 21

CHS1:55 pmCharleston

7h 05m

2 stops

STL8:00 pmLambert-St Louis

Oct 28

STL2:10 pmLambert-St Louis

4h 25m

1 stop

CHS7:35 pmCharleston

$232

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Thu 10/22

1:25 pm-2:30 pm

Nonstop2h 05m

Lambert-St Louis

Mon 10/26

4:30 pm-7:25 pm

Nonstop1h 55m

$217

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Thu 10/22

1:25 pm-2:30 pm

Nonstop2h 05m

Lambert-St Louis

Sat 10/24

11:55 am-6:45 pm

1 stop5h 50m

$222

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Wed 10/21

4:58 pm-9:21 pm

1 stop5h 23m

Lambert-St Louis

Wed 10/28

1:00 pm-7:11 pm

1 stop5h 11m

$222

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Wed 10/28

12:40 pm-6:15 pm

1 stop6h 35m

Lambert-St Louis

Tue 11/3

7:00 am-1:13 pm

1 stop5h 13m

$227

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Wed 10/28

5:30 am-9:09 am

1 stop4h 39m

Lambert-St Louis

Sat 10/31

6:00 am-11:04 am

1 stop4h 04m

$227

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Thu 12/3

12:17 pm-6:53 pm

1 stop7h 36m

Lambert-St Louis

Tue 12/8

6:02 am-11:30 am

1 stop4h 28m

$227

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Thu 10/22

7:04 pm-11:59 pm

1 stop5h 55m

Lambert-St Louis

Sat 10/24

7:16 am-2:25 pm

1 stop6h 09m

$227

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Thu 11/5

7:00 pm-11:24 pm

1 stop5h 24m

Lambert-St Louis

Mon 11/9

6:00 am-2:28 pm

2 stops7h 28m

$232

CharlestonSt. Louis

CHS Charleston - STL Lambert-St Louis

CHSSTL

Charleston

Tue 10/27

3:00 pm-5:40 pm

2 stops27h 40m

Lambert-St Louis

Mon 11/2

4:26 pm-8:38 am

1 stop15h 12m

$248

Myrtle BeachSt. Louis

MYR Myrtle Beach Intl - STL Lambert-St Louis

MYRSTL

Myrtle Beach Intl

Thu 10/15

6:25 pm-5:40 pm

2 stops24h 15m

Lambert-St Louis

Mon 10/19

4:30 pm-10:05 am

1 stop16h 35m

$344

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Missouri?

In general, September is the cheapest month to fly from South Carolina to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $353. If you aren’t able to travel to Missouri during the month of September, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $353.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from South Carolina to Missouri is on a Wednesday when prices can be found for as low as $330. Flights from South Carolina to Missouri on a Sunday will generally be more expensive and average around $606. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from South Carolina to Missouri in the afternoon for as low as $381. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly at noon, with an average ticket price of $496. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest South Carolina to Missouri flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Missouri flight prices

What cabin class options are available on South Carolina to Missouri flights?

There is only 1 cabin class available to choose from on South Carolina to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Missouri flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Missouri.

Cheap South Carolina to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Missouri

Best Price Found	$84
Fastest flight time	1h 53m
Direct flights	Mon, Tue, Fri and Sat
Airports in Missouri	55 airports

The best one-way flight to Missouri from South Carolina in the past 72 hours is $84. The best round-trip flight deal from South Carolina to Missouri found on momondo in the last 72 hours is $217.

The fastest flight from South Carolina to Missouri takes 1h 53m

Direct flights go from South Carolina to Missouri on Monday, Tuesday, Friday and Saturday. There are no airlines offering direct flights.

There are 55 airports in Missouri. From South Carolina there are direct flights to Lambert-St Louis (STL).

Search flight deals

Frequently asked questions about flying from South Carolina to Missouri

When did momondo last update prices for flights from South Carolina to Missouri?
Prices for flights from South Carolina to Missouri are updated daily.
How many operators does momondo search for flights from South Carolina to Missouri?
As of September 2026, there are 4 operators available to choose from for flights from South Carolina to Missouri.
How old do you have to be to fly from South Carolina to Missouri?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from South Carolina to Missouri?
Based on momondo bookings for flights between South Carolina and Missouri, the leading plane model is Boeing 737-800 Passenger/BBJ2 (winglets), making up 18.64% of the total bookings. Other popular models include Boeing 737 MAX 8 with 13.56%, Airbus A320-100/200 with 10.17%, and Boeing 717-200 with 6.78%.

Best airlines flying from South Carolina to Missouri

Compare and see reviews for airlines that fly from South Carolina to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $158	Free Cancellation	Rating 7.8 8,605 reviews	Search Delta flights
Southwest	PriceFrom $228	Free Cancellation	Rating 8.0 4,202 reviews	Search Southwest flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.0 12,097 reviews	Search American Airlines flights
United Airlines	PriceFrom $253	Free Cancellation	Rating 7.4 10,245 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Missouri?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Missouri from South Carolina.

Can I find flights from South Carolina to Missouri with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Missouri from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Missouri?

Once you have performed a search for South Carolina to Missouri flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Wed 10/28

Wed 11/4

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Missouri

Popular cities

Other flights from South Carolina

Other flights to Missouri

Airlines

Complete your trip

Feeling lucky

Popular cities in Missouri

Flights to New Yorkfrom $56

Flights to Los Angelesfrom $53

Flights to Orlandofrom $49

Flights to Miamifrom $77

Flights to San Franciscofrom $43

Flights to Chicagofrom $63

Flights to Las Vegasfrom $44

Flights to Washington, D.C.from $45

Flights to Fort Lauderdalefrom $60

Flights to Bostonfrom $103

Flights to Atlantafrom $38

Flights to Dallasfrom $76

Cheap flights from South Carolina to Missouri from $84

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Missouri departing on 10/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Find the cheapest flights from South Carolina to Missouri

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Cheap direct flights

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

American Airlines flights from South Carolina to Missouri

Our best American Airlines deals on South Carolina to Missouri flight tickets

Southwest flights from South Carolina to Missouri

Our best Southwest deals on South Carolina to Missouri flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

See travel insights to Missouri from

How to get the cheapest flight ticket from South Carolina to Missouri

What is the cheapest month to fly to Missouri?

What is the cheapest day to depart on your flight to Missouri?

What is the cheapest time of day to depart on your flight to Missouri?

What is the cheapest South Carolina to Missouri flight route?

What cabin class options are available on South Carolina to Missouri flights?

Can stopping save me money on South Carolina to Missouri flights?

What is the cheapest airline that flies from South Carolina to Missouri?

What airlines fly to Missouri?

How many flights depart from South Carolina to Missouri on average per day?

How many flights depart from South Carolina to Missouri on average per week?

How long is the flight from South Carolina to Missouri?

Cheap South Carolina to Missouri flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Airports in Missouri

Frequently asked questions about flying from South Carolina to Missouri

Best airlines flying from South Carolina to Missouri

Compare and see reviews for airlines that fly from South Carolina to Missouri with momondo

Why use momondo?

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Missouri

Popular cities in Missouri

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Missouri flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Missouri

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Complete your trip to Missouri

Explore popular destinations other users love

According to popular flight searches on momondo this year