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Cheap flights from South Carolina to Gainesville from $273

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Gainesville departing on 9/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from South Carolina to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
12:00 pm - 4:04 pmGSP  Greenville-GNV Gainesville Regional
4h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:20 am - 2:49 pmGNV  Gainesville Regional-GSP Greenville
4h 29m1 stop Atlanta Hartsfield-Jackson
$357Delta
Wed, Jan 13 - Tue, Jan 19
Delta Logo
5:45 am - 9:31 amGSP  Greenville-GNV Gainesville Regional
3h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:05 am - 11:08 amGNV  Gainesville Regional-GSP Greenville
5h 03m1 stop Atlanta Hartsfield-Jackson
$367Delta
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
8:05 pm - 9:53 pmCLT  Charlotte Douglas-GNV Gainesville Regional
1h 48mnonstop
American Airlines Logo
6:38 pm - 8:29 pmGNV  Gainesville Regional-CLT Charlotte Douglas
1h 51mnonstop
$403American Airlines
Wed, Nov 11 - Tue, Nov 17
American Airlines Logo
2:21 pm - 3:58 pmCLT  Charlotte Douglas-GNV Gainesville Regional
1h 37mnonstop
American Airlines Logo
4:39 pm - 6:28 pmGNV  Gainesville Regional-CLT Charlotte Douglas
1h 49mnonstop
$403American Airlines
Sat, Sep 12 - Sat, Sep 19
American Airlines Logo
6:07 pm - 11:02 pmCLT  Charlotte Douglas-GNV Gainesville Regional
4h 55m1 stop Miami
American Airlines Logo
4:30 pm - 6:17 pmGNV  Gainesville Regional-CLT Charlotte Douglas
1h 47mnonstop
$413American Airlines
Wed, Nov 11 - Tue, Nov 17
American Airlines Logo
2:21 pm - 3:58 pmCLT  Charlotte Douglas-GNV Gainesville Regional
1h 37mnonstop
American Airlines Logo
6:00 am - 12:10 pmGNV  Gainesville Regional-CLT Charlotte Douglas
6h 10m1 stop Miami
$413American Airlines
Sat, Sep 12 - Sat, Sep 19
Delta Logo
6:00 am - 9:31 amCLT  Charlotte Douglas-GNV Gainesville Regional
3h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:18 am - 1:30 pmGNV  Gainesville Regional-CLT Charlotte Douglas
3h 12m1 stop Atlanta Hartsfield-Jackson
$423Delta
Fri, Sep 11 - Sat, Sep 12
Delta Logo
7:40 am - 12:39 pmCLT  Charlotte Douglas-GNV Gainesville Regional
4h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:00 pm - 8:21 pmGNV  Gainesville Regional-CLT Charlotte Douglas
3h 21m1 stop Atlanta Hartsfield-Jackson
$423Delta
Thu, Sep 10 - Sat, Sep 12
Delta Logo
6:00 am - 9:31 amCLT  Charlotte Douglas-GNV Gainesville Regional
3h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:00 pm - 8:21 pmGNV  Gainesville Regional-CLT Charlotte Douglas
3h 21m1 stop Atlanta Hartsfield-Jackson
$423Delta
Wed, Sep 9 - Sat, Sep 12
Delta Logo
9:42 am - 2:59 pmCLT  Charlotte Douglas-GNV Gainesville Regional
5h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:53 pm - 7:12 pmGNV  Gainesville Regional-CLT Charlotte Douglas
3h 19m1 stop Atlanta Hartsfield-Jackson
$423Delta
Wed, Nov 11 - Tue, Nov 17

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American Airlines flights from South Carolina to Gainesville

Our best American Airlines deals on South Carolina to Gainesville flight tickets
American Airlines
Sep 9
CLT8:40 amCharlotte Douglas
1h 39m
GNV10:19 amGainesville Regional
Sep 16
GNV4:39 pmGainesville Regional
1h 49m
CLT6:28 pmCharlotte Douglas
$403
American Airlines
Sep 9
CLT8:40 amCharlotte Douglas
1h 39m
GNV10:19 amGainesville Regional
Sep 16
GNV6:00 amGainesville Regional
4h 20m
1 stop
CLT10:20 amCharlotte Douglas
$413
American Airlines
Oct 21
CLT7:30 amCharlotte Douglas
1h 39m
GNV9:09 amGainesville Regional
Oct 26
GNV7:34 pmGainesville Regional
1h 53m
CLT9:27 pmCharlotte Douglas
$444

Delta flights from South Carolina to Gainesville

Our best Delta deals on South Carolina to Gainesville flight tickets
Delta
Jan 13
GSP12:00 pmGreenville
4h 04m
1 stop
GNV4:04 pmGainesville Regional
Jan 19
GNV10:20 amGainesville Regional
4h 29m
1 stop
GSP2:49 pmGreenville
$357
Delta
Sep 10
GSP5:45 amGreenville
3h 46m
1 stop
GNV9:31 amGainesville Regional
Sep 16
GNV6:05 amGainesville Regional
5h 03m
1 stop
GSP11:08 amGreenville
$367
Delta
Sep 12
CLT6:00 amCharlotte Douglas
3h 31m
1 stop
GNV9:31 amGainesville Regional
Sep 19
GNV10:18 amGainesville Regional
5h 53m
1 stop
CLT4:11 pmCharlotte Douglas
$423

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleGainesville

GSP Greenville - GNV Gainesville Regional

GSPGNV

Greenville

Wed 1/13

12:00 pm-4:04 pm

1 stop4h 04m

Gainesville Regional

Tue 1/19

10:20 am-2:49 pm

1 stop4h 29m

$357

GreenvilleGainesville

GSP Greenville - GNV Gainesville Regional

GSPGNV

Greenville

Thu 9/10

5:45 am-9:31 am

1 stop3h 46m

Gainesville Regional

Wed 9/16

6:05 am-11:08 am

1 stop5h 03m

$367

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Wed 11/11

8:05 pm-9:53 pm

Nonstop1h 48m

Gainesville Regional

Tue 11/17

6:38 pm-8:29 pm

Nonstop1h 51m

$403
Quickest round-trip

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Sat 9/12

2:21 pm-3:58 pm

Nonstop1h 37m

Gainesville Regional

Sat 9/19

4:39 pm-6:28 pm

Nonstop1h 49m

$403

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Wed 11/11

6:07 pm-11:02 pm

1 stop4h 55m

Gainesville Regional

Tue 11/17

4:30 pm-6:17 pm

Nonstop1h 47m

$413

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Sat 9/12

2:21 pm-3:58 pm

Nonstop1h 37m

Gainesville Regional

Sat 9/19

6:00 am-12:10 pm

1 stop6h 10m

$413

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Fri 9/11

6:00 am-9:31 am

1 stop3h 31m

Gainesville Regional

Sat 9/12

10:18 am-1:30 pm

1 stop3h 12m

$423

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Thu 9/10

7:40 am-12:39 pm

1 stop4h 59m

Gainesville Regional

Sat 9/12

5:00 pm-8:21 pm

1 stop3h 21m

$423

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Wed 9/9

6:00 am-9:31 am

1 stop3h 31m

Gainesville Regional

Sat 9/12

5:00 pm-8:21 pm

1 stop3h 21m

$423

CharlotteGainesville

CLT Charlotte Douglas - GNV Gainesville Regional

CLTGNV

Charlotte Douglas

Wed 11/11

9:42 am-2:59 pm

1 stop5h 17m

Gainesville Regional

Tue 11/17

3:53 pm-7:12 pm

1 stop3h 19m

$423

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from South Carolina to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from South Carolina to Gainesville Regional?

Delta and American Airlines are the most popular carriers operating from South Carolina to Gainesville Regional

What airlines fly to Gainesville?

Breeze Airways, Allegiant Air and American Airlines are the top three most popular airlines that fly to Gainesville from South Carolina according to our data. Breeze Airways is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

Cheap South Carolina to Gainesville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Gainesville

Fastest flight time

1h 36m

Direct flights

Mon, Thu, Fri, Sat and Sun

Airports in Gainesville

1 airport
The fastest flight from South Carolina to Gainesville takes 1h 36m
Direct flights go from South Carolina to Gainesville on Monday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Gainesville. From South Carolina there are direct flights to Gainesville Regional (GNV).
Search flight deals

Frequently asked questions about flying from South Carolina to Gainesville

  • When did momondo last update prices for flights from South Carolina to Gainesville Regional Airport?

    Prices for flights from South Carolina to Gainesville Regional Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Gainesville Regional Airport?

  • How old do you have to be to fly from South Carolina to Gainesville Regional Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The travel and health documents you'll need for your trip to Gainesville Regional Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Gainesville Regional Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Gainesville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Carolina to Gainesville for you.

Can I find flights from South Carolina to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Gainesville?

Once you have performed a search for South Carolina to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Gainesville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Gainesville, momondo offers a useful price alert feature which will track prices for flights to Gainesville from South Carolina and alert you when they change.

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