What airlines fly to Gainesville?

American Airlines, Spirit Airlines and Delta are the top three most popular airlines that fly to Gainesville from South Carolina according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Gainesville. Keep in mind that there are 6 different airlines that fly to Gainesville on a routine basis, so you have a few additional options to choose from.

How many flights depart from South Carolina to Gainesville on average per week?

The number of flights available between South Carolina and Gainesville is 33 per week as of November 2025. The most frequent departure day is Thu, with 18% of weekly flights leaving on this day.

How long does it take to fly to Gainesville?

Flight times vary depending on what airport in South Carolina you fly out of and what airport in Gainesville you fly into. For example, flying from Charleston to Orlando Airport takes 1h 26m on average. On the other hand, flying from Myrtle Beach to Orlando Airport takes 1h 29m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What is the cheapest airline that flies from South Carolina to Gainesville Regional?

Delta and American Airlines are the most popular carriers operating from South Carolina to Gainesville Regional

When did momondo last update prices for flights from South Carolina to Gainesville Regional Airport?

Prices for flights from South Carolina to Gainesville Regional Airport are refreshed on a daily basis.

How many operators does momondo search for flights from South Carolina to Gainesville Regional Airport?

The number of operators available for flights from South Carolina to Gainesville Regional Airport is 2 as of November 2025.

How old do you have to be to fly from South Carolina to Gainesville Regional Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Gainesville Regional Airport.

What documentation or ID do you need to fly to Gainesville Regional Airport?

The travel and health documents you'll need for your trip to Gainesville Regional Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Gainesville Regional Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$223 Cheap Flights from South Carolina to Gainesville in 2025/26

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Find the cheapest flights from South Carolina to Gainesville

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Cheap round-trip flights

Enter your travel dates to find the best prices.

6:33 am - 12:58 pmCLT-GNV

6h 25m1 stop

3:41 pm - 9:26 pmGNV-CLT

5h 45m1 stop

$245Delta

Find Deal

Fri, Dec 5 - Fri, Dec 12

8:19 am - 12:58 pmCLT-GNV

4h 39m1 stop

6:27 pm - 9:37 pmGNV-CLT

3h 10m1 stop

$295Delta

Find Deal

Wed, Dec 10 - Mon, Jan 5

5:27 am - 9:25 amCLT-GNV

3h 58m1 stop

10:08 am - 2:25 pmGNV-CLT

4h 17m1 stop

$305Delta

Find Deal

Thu, Dec 11 - Sat, Jan 3

9:40 pm - 11:33 pmCLT-GNV

1h 53mnonstop

6:30 am - 8:19 amGNV-CLT

1h 49mnonstop

$315American Airlines

Find Deal

Wed, Dec 10 - Sat, Jan 3

1:24 pm - 3:04 pmCLT-GNV

1h 40mnonstop

6:36 am - 8:20 amGNV-CLT

1h 44mnonstop

$317American Airlines

Find Deal

Sat, Nov 22 - Sat, Nov 29

6:39 pm - 11:59 pmCLT-GNV

5h 20m1 stop

6:36 am - 8:20 amGNV-CLT

1h 44mnonstop

$327American Airlines

Find Deal

Sat, Nov 22 - Sat, Nov 29

10:08 am - 2:56 pmGSP-GNV

4h 48m1 stop

6:00 am - 11:15 amGNV-GSP

5h 15m1 stop

$327Delta

Find Deal

Fri, Dec 5 - Sun, Dec 7

1:50 pm - 11:58 pmGSP-GNV

10h 08m2 stops

6:00 am - 9:56 amGNV-GSP

3h 56m1 stop

$332American Airlines

Find Deal

Fri, Dec 5 - Sun, Dec 7

9:40 pm - 11:33 pmCLT-GNV

1h 53mnonstop

4:59 pm - 6:46 pmGNV-CLT

1h 47mnonstop

$335American Airlines

Find Deal

Wed, Dec 10 - Mon, Jan 5

6:45 pm - 11:58 pmCLT-GNV

5h 13m1 stop

6:30 am - 8:19 amGNV-CLT

1h 49mnonstop

$355American Airlines

Find Deal

Wed, Dec 10 - Sun, Jan 4

American Airlines flights from South Carolina to Gainesville

Our best American Airlines deals on South Carolina to Gainesville flight tickets

American Airlines

Dec 10

CLT9:40 pmCharlotte Douglas

1h 53m

GNV11:33 pmGainesville Regional

Jan 3

GNV6:30 amGainesville Regional

1h 49m

CLT8:19 amCharlotte Douglas

$315

Find similar

American Airlines

Nov 22

CLT1:24 pmCharlotte Douglas

1h 40m

GNV3:04 pmGainesville Regional

Nov 29

GNV6:36 amGainesville Regional

1h 44m

CLT8:20 amCharlotte Douglas

$317

Find similar

American Airlines

Nov 22

CLT6:39 pmCharlotte Douglas

5h 20m

1 stop

GNV11:59 pmGainesville Regional

Nov 29

GNV6:36 amGainesville Regional

1h 44m

CLT8:20 amCharlotte Douglas

$327

Find similar

Delta flights from South Carolina to Gainesville

Our best Delta deals on South Carolina to Gainesville flight tickets

Delta

Dec 5

CLT6:33 amCharlotte Douglas

6h 25m

1 stop

GNV12:58 pmGainesville Regional

Dec 12

GNV3:41 pmGainesville Regional

5h 45m

1 stop

CLT9:26 pmCharlotte Douglas

$245

Find similar

Delta

Dec 10

CLT6:33 amCharlotte Douglas

6h 25m

1 stop

GNV12:58 pmGainesville Regional

Jan 3

GNV10:08 amGainesville Regional

4h 17m

1 stop

CLT2:25 pmCharlotte Douglas

$295

Find similar

Delta

Dec 11

CLT5:27 amCharlotte Douglas

3h 58m

1 stop

GNV9:25 amGainesville Regional

Jan 3

GNV10:08 amGainesville Regional

4h 17m

1 stop

CLT2:25 pmCharlotte Douglas

$305

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Fri 12/5

6:33 am-12:58 pm

1 stop6h 25m

Gainesville Regional

Fri 12/12

3:41 pm-9:26 pm

1 stop5h 45m

$245

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 12/10

8:19 am-12:58 pm

1 stop4h 39m

Gainesville Regional

Mon 1/5

6:27 pm-9:37 pm

1 stop3h 10m

$295

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Thu 12/11

5:27 am-9:25 am

1 stop3h 58m

Gainesville Regional

Sat 1/3

10:08 am-2:25 pm

1 stop4h 17m

$305

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 12/10

9:40 pm-11:33 pm

Nonstop1h 53m

Gainesville Regional

Sat 1/3

6:30 am-8:19 am

Nonstop1h 49m

$315

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 11/22

1:24 pm-3:04 pm

Nonstop1h 40m

Gainesville Regional

Sat 11/29

6:36 am-8:20 am

Nonstop1h 44m

$317

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Sat 11/22

6:39 pm-11:59 pm

1 stop5h 20m

Gainesville Regional

Sat 11/29

6:36 am-8:20 am

Nonstop1h 44m

$327

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Fri 12/5

10:08 am-2:56 pm

1 stop4h 48m

Gainesville Regional

Sun 12/7

6:00 am-11:15 am

1 stop5h 15m

$327

GreenvilleGainesville

GSP - GNV

GSPGNV

Greenville

Fri 12/5

1:50 pm-11:58 pm

2 stops10h 08m

Gainesville Regional

Sun 12/7

6:00 am-9:56 am

1 stop3h 56m

$332

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 12/10

9:40 pm-11:33 pm

Nonstop1h 53m

Gainesville Regional

Mon 1/5

4:59 pm-6:46 pm

Nonstop1h 47m

$335

CharlotteGainesville

CLT - GNV

CLTGNV

Charlotte Douglas

Wed 12/10

6:45 pm-11:58 pm

1 stop5h 13m

Gainesville Regional

Sun 1/4

6:30 am-8:19 am

Nonstop1h 49m

$355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest time of day to depart on your flight to Gainesville?

In the morning is the cheapest time of day to fly from South Carolina to Gainesville when you can find flight prices for as low as $418. Flying to Gainesville in the morning is an ideal time because this is during off-peak travel hours. Flights to Gainesville are more costly in the evening, with an average ticket price of $492. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

Cheap South Carolina to Gainesville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Gainesville

Fastest flight time	1h 40m
Direct flights	Every day
Airports in Gainesville	1 airport

The fastest flight from South Carolina to Gainesville takes 1h 40m

Direct flights go from South Carolina to Gainesville every day.

There is 1 airport near Gainesville: Gainesville Regional (GNV)

Search flight deals

When did momondo last update prices for flights from South Carolina to Gainesville Regional Airport?
Prices for flights from South Carolina to Gainesville Regional Airport are refreshed on a daily basis.
How many operators does momondo search for flights from South Carolina to Gainesville Regional Airport?
The number of operators available for flights from South Carolina to Gainesville Regional Airport is 2 as of November 2025.
How old do you have to be to fly from South Carolina to Gainesville Regional Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Gainesville Regional Airport.
What documentation or ID do you need to fly to Gainesville Regional Airport?
The travel and health documents you'll need for your trip to Gainesville Regional Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Gainesville Regional Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Gainesville

Compare and see reviews for airlines that fly from South Carolina to Gainesville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $296	Free Cancellation	Rating 7.9 8,001 reviews		Search Delta flights

Lake City

Alachua

Trenton

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Gainesville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Carolina to Gainesville for you.

Can I find flights from South Carolina to Gainesville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Gainesville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Gainesville?

Once you have performed a search for South Carolina to Gainesville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Gainesville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Gainesville, momondo offers a useful price alert feature which will track prices for flights to Gainesville from South Carolina and alert you when they change.

An easier way to manage your Gainesville trip

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Cheap flights from South Carolina to Gainesville from $223

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Gainesville departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from South Carolina to Gainesville

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Our best Delta deals on South Carolina to Gainesville flight tickets

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Use the filters below to find and compare flights from South Carolina to Gainesville that are best for you.

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How to get the cheapest flight ticket from South Carolina to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Gainesville?

What is the cheapest airline that flies from South Carolina to Gainesville Regional?

Delta and American Airlines are the most popular carriers operating from South Carolina to Gainesville Regional

What airlines fly to Gainesville?

How many flights depart from South Carolina to Gainesville on average per week?

The number of flights available between South Carolina and Gainesville is 33 per week as of November 2025. The most frequent departure day is Thu, with 18% of weekly flights leaving on this day.

How long does it take to fly to Gainesville?

Cheap South Carolina to Gainesville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Gainesville

Fastest flight time

Direct flights

Airports in Gainesville

When did momondo last update prices for flights from South Carolina to Gainesville Regional Airport?

How many operators does momondo search for flights from South Carolina to Gainesville Regional Airport?

How old do you have to be to fly from South Carolina to Gainesville Regional Airport?

What documentation or ID do you need to fly to Gainesville Regional Airport?

Best airlines flying from South Carolina to Gainesville

Compare and see reviews for airlines that fly from South Carolina to Gainesville with momondo

Traveling to a place near Gainesville?

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Gainesville?

Can I find flights from South Carolina to Gainesville with flexible booking policies on momondo?

How can momondo help me find flights from South Carolina to Gainesville?

I’m not ready to book a flight from South Carolina to Gainesville right now. Can momondo alert me if prices change?

An easier way to manage your Gainesville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Florida