Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santa Fe to Knoxville from $153

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 7/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santa Fe to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:00 am - 3:54 pm
SAF
-
TYS
6h 54m
1 stop
United Airlines Logo
4:56 pm - 8:43 pm
TYS
-
SAF
5h 47m
1 stop
$400United Airlines
Sat, Aug 29 - Tue, Sep 1
American Airlines Logo
10:08 am - 11:59 pm
SAF
-
TYS
11h 51m
2 stops
American Airlines Logo
5:33 pm - 9:52 pm
TYS
-
SAF
6h 19m
1 stop
$451American Airlines
Tue, Jun 2 - Tue, Jun 9
United Airlines Logo
3:21 pm - 10:38 pm
SAF
-
TYS
5h 17m
1 stop
United Airlines Logo
5:45 am - 2:46 pm
TYS
-
SAF
11h 01m
2 stops
$478United Airlines
Sat, Aug 29 - Tue, Sep 1
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
5:33 pm - 9:52 pm
TYS
-
SAF
6h 19m
1 stop
$499American Airlines
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
5:37 am - 9:38 am
TYS
-
SAF
6h 01m
1 stop
$506American Airlines
Wed, Jun 24 - Mon, Jun 29
American Airlines Logo
7:30 am - 11:59 pm
SAF
-
TYS
14h 29m
2 stops
American Airlines Logo
5:37 am - 9:38 am
TYS
-
SAF
6h 01m
1 stop
$512American Airlines
Mon, Jun 22 - Tue, Jun 30
American Airlines Logo
7:30 am - 11:59 pm
SAF
-
TYS
14h 29m
2 stops
American Airlines Logo
5:37 am - 9:38 am
TYS
-
SAF
6h 01m
1 stop
$519American Airlines
Mon, Jun 22 - Mon, Jun 29
American Airlines Logo
6:55 am - 11:53 pm
SAF
-
TYS
14h 58m
1 stop
American Airlines Logo
5:33 pm - 9:52 pm
TYS
-
SAF
6h 19m
1 stop
$523American Airlines
Tue, Jun 23 - Tue, Jun 30
United Airlines Logo
7:00 am - 3:54 pm
SAF
-
TYS
6h 54m
1 stop
United Airlines Logo
4:56 pm - 8:43 pm
TYS
-
SAF
5h 47m
1 stop
$539United Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
7:30 am - 4:43 pm
SAF
-
TYS
7h 13m
1 stop
American Airlines Logo
5:37 am - 9:38 am
TYS
-
SAF
6h 01m
1 stop
$543American Airlines
Tue, Jun 23 - Mon, Jun 29

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets
United Airlines
Aug 29
SAF7:00 amSanta Fe
6h 54m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Sep 1
TYS4:56 pmKnoxville McGhee Tyson
5h 47m
1 stop
SAF8:43 pmSanta Fe
$400
United Airlines
Aug 29
SAF3:21 pmSanta Fe
5h 17m
1 stop
TYS10:38 pmKnoxville McGhee Tyson
Sep 1
TYS5:45 amKnoxville McGhee Tyson
11h 01m
2 stops
SAF2:46 pmSanta Fe
$478
United Airlines
Aug 29
SAF7:00 amSanta Fe
6h 54m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Sep 2
TYS4:56 pmKnoxville McGhee Tyson
5h 47m
1 stop
SAF8:43 pmSanta Fe
$539

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Jun 2
SAF10:08 amSanta Fe
11h 51m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Jun 9
TYS5:33 pmKnoxville McGhee Tyson
6h 19m
1 stop
SAF9:52 pmSanta Fe
$451
American Airlines
Jun 24
SAF7:30 amSanta Fe
7h 13m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Jun 30
TYS5:33 pmKnoxville McGhee Tyson
6h 19m
1 stop
SAF9:52 pmSanta Fe
$499
American Airlines
Jun 24
SAF7:30 amSanta Fe
7h 13m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Jun 29
TYS5:37 amKnoxville McGhee Tyson
6h 01m
1 stop
SAF9:38 amSanta Fe
$506

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 8/29

7:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 9/1

4:56 pm-8:43 pm

1 stop5h 47m

$400

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 6/2

10:08 am-11:59 pm

2 stops11h 51m

Knoxville McGhee Tyson

Tue 6/9

5:33 pm-9:52 pm

1 stop6h 19m

$451

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 8/29

3:21 pm-10:38 pm

1 stop5h 17m

Knoxville McGhee Tyson

Tue 9/1

5:45 am-2:46 pm

2 stops11h 01m

$478

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 6/24

7:30 am-4:43 pm

1 stop7h 13m

Knoxville McGhee Tyson

Tue 6/30

5:33 pm-9:52 pm

1 stop6h 19m

$499

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 6/24

7:30 am-4:43 pm

1 stop7h 13m

Knoxville McGhee Tyson

Mon 6/29

5:37 am-9:38 am

1 stop6h 01m

$506

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Mon 6/22

7:30 am-11:59 pm

2 stops14h 29m

Knoxville McGhee Tyson

Tue 6/30

5:37 am-9:38 am

1 stop6h 01m

$512

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Mon 6/22

7:30 am-11:59 pm

2 stops14h 29m

Knoxville McGhee Tyson

Mon 6/29

5:37 am-9:38 am

1 stop6h 01m

$519

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 6/23

6:55 am-11:53 pm

1 stop14h 58m

Knoxville McGhee Tyson

Tue 6/30

5:33 pm-9:52 pm

1 stop6h 19m

$523

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 8/29

7:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Wed 9/2

4:56 pm-8:43 pm

1 stop5h 47m

$539

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 6/23

7:30 am-4:43 pm

1 stop7h 13m

Knoxville McGhee Tyson

Mon 6/29

5:37 am-9:38 am

1 stop6h 01m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Fe and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Santa Fe, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from Santa Fe during December instead. Flights to Knoxville in December, while not as cheap as those in April, still average around $299.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Santa Fe to Knoxville takes 5h 17m
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Fe to Knoxville

  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 5h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.1
11,669 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 6/6
Sat 6/13
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States