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Cheap flights from Santa Fe to Knoxville from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 11/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Fe to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:52 am - 5:32 pmSAF-TYS
4h 40m1 stop
American Airlines Logo
5:51 am - 3:47 pmTYS-SAF
11h 56m2 stops
$444American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
7:22 pm - 8:27 amSAF-TYS
11h 05m2 stops
American Airlines Logo
5:51 am - 3:47 pmTYS-SAF
11h 56m2 stops
$449American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:03 am - 2:05 pmSAF-TYS
6h 02m1 stop
American Airlines Logo
5:51 am - 9:26 amTYS-SAF
5h 35m1 stop
$486American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
10:52 am - 5:32 pmSAF-TYS
4h 40m1 stop
American Airlines Logo
5:51 am - 9:26 amTYS-SAF
5h 35m1 stop
$492American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
10:52 am - 5:32 pmSAF-TYS
4h 40m1 stop
American Airlines Logo
6:56 am - 3:06 pmTYS-SAF
10h 10m2 stops
$496American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:03 am - 7:13 pmSAF-TYS
11h 10m2 stops
American Airlines Logo
5:51 am - 3:47 pmTYS-SAF
11h 56m2 stops
$501American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Feb 21
SAF10:52 amSanta Fe
4h 40m
1 stop
TYS5:32 pmKnoxville McGhee Tyson
Feb 25
TYS5:51 amKnoxville McGhee Tyson
11h 56m
2 stops
SAF3:47 pmSanta Fe
$444
Find similar
American Airlines
Feb 21
SAF7:22 pmSanta Fe
11h 05m
2 stops
TYS8:27 amKnoxville McGhee Tyson
Feb 25
TYS5:51 amKnoxville McGhee Tyson
11h 56m
2 stops
SAF3:47 pmSanta Fe
$449
Find similar
American Airlines
Feb 21
SAF6:03 amSanta Fe
6h 02m
1 stop
TYS2:05 pmKnoxville McGhee Tyson
Feb 25
TYS5:51 amKnoxville McGhee Tyson
5h 35m
1 stop
SAF9:26 amSanta Fe
$486
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 25, 2025.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

10:52 am-5:32 pm

1 stop4h 40m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-3:47 pm

2 stops11h 56m

$444

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

7:22 pm-8:27 am

2 stops11h 05m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-3:47 pm

2 stops11h 56m

$449

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

6:03 am-2:05 pm

1 stop6h 02m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-9:26 am

1 stop5h 35m

$486

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

10:52 am-5:32 pm

1 stop4h 40m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-9:26 am

1 stop5h 35m

$492

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

10:52 am-5:32 pm

1 stop4h 40m

Knoxville McGhee Tyson

Wed 2/25

6:56 am-3:06 pm

2 stops10h 10m

$496

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 2/21

6:03 am-7:13 pm

2 stops11h 10m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-3:47 pm

2 stops11h 56m

$501

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 11/19

6:15 am-3:35 pm

1 stop7h 20m

$290

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 11/19

6:15 am-6:54 pm

2 stops10h 39m

$300

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 11/18

6:15 am-3:22 pm

1 stop7h 07m

$330

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 11/18

9:58 am-11:59 pm

2 stops12h 01m

$340

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Fe to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $368. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Santa Fe to Knoxville for around $644.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Fe to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $463.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Direct flights

None
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
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  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 4h 40m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

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