What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 68% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

There is 1 operator available for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport as of August 2025.

How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$264 Cheap Flights from Santa Fe to Knoxville (SAF-TYS) in 2025

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Find the cheapest flights from Santa Fe to Knoxville (SAF-TYS)

Round-trip

One-way

Cheap round-trip flights

5:18 pm - 12:21 amSAF-TYS

5h 03m1 stop

4:37 pm - 9:06 pmTYS-SAF

6h 29m1 stop

$264American Airlines

Find Deal

Tue, Sep 16 - Tue, Sep 23

6:15 am - 3:41 pmSAF-TYS

7h 26m1 stop

6:00 am - 2:51 pmTYS-SAF

10h 51m2 stops

$274American Airlines

Find Deal

Tue, Sep 16 - Tue, Sep 23

10:03 am - 11:03 pmSAF-TYS

11h 00m2 stops

6:00 am - 2:51 pmTYS-SAF

10h 51m2 stops

$279American Airlines

Find Deal

Tue, Sep 16 - Tue, Sep 23

5:18 pm - 12:21 amSAF-TYS

5h 03m1 stop

4:37 pm - 9:06 pmTYS-SAF

6h 29m1 stop

$314American Airlines

Find Deal

Fri, Sep 5 - Mon, Sep 8

11:47 am - 11:03 pmSAF-TYS

9h 16m2 stops

4:37 pm - 9:56 pmTYS-SAF

7h 19m1 stop

$324American Airlines

Find Deal

Fri, Sep 5 - Mon, Sep 8

7:00 am - 3:10 pmSAF-TYS

6h 10m1 stop

4:40 pm - 10:00 pmTYS-SAF

7h 20m1 stop

$369United Airlines

Find Deal

Tue, Sep 16 - Tue, Sep 23

10:03 am - 11:03 pmSAF-TYS

11h 00m2 stops

12:15 pm - 9:06 pmTYS-SAF

10h 51m2 stops

$441American Airlines

Find Deal

Fri, Sep 5 - Mon, Sep 8

4:56 pm - 11:51 pmSAF-TYS

4h 55m1 stop

6:00 am - 9:51 amTYS-SAF

5h 51m1 stop

$538American Airlines

Find Deal

Thu, Oct 16 - Sun, Oct 19

12:26 pm - 11:53 pmSAF-TYS

9h 27m2 stops

6:00 am - 9:51 amTYS-SAF

5h 51m1 stop

$548American Airlines

Find Deal

Thu, Oct 16 - Sun, Oct 19

1:31 pm - 10:30 pmSAF-TYS

6h 59m1 stop

4:40 pm - 9:23 amTYS-SAF

18h 43m1 stop

$633United Airlines

Find Deal

Wed, Sep 3 - Sun, Sep 7

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets

American Airlines

Sep 16

SAF5:18 pmSanta Fe

5h 03m

1 stop

TYS12:21 amKnoxville McGhee Tyson

Sep 23

TYS4:37 pmKnoxville McGhee Tyson

6h 29m

1 stop

SAF9:06 pmSanta Fe

$264

Find similar

American Airlines

Sep 16

SAF6:15 amSanta Fe

7h 26m

1 stop

TYS3:41 pmKnoxville McGhee Tyson

Sep 23

TYS6:00 amKnoxville McGhee Tyson

10h 51m

2 stops

SAF2:51 pmSanta Fe

$274

Find similar

American Airlines

Sep 16

SAF10:03 amSanta Fe

11h 00m

2 stops

TYS11:03 pmKnoxville McGhee Tyson

Sep 23

TYS6:00 amKnoxville McGhee Tyson

10h 51m

2 stops

SAF2:51 pmSanta Fe

$279

Find similar

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets

United Airlines

Sep 16

SAF7:00 amSanta Fe

6h 10m

1 stop

TYS3:10 pmKnoxville McGhee Tyson

Sep 23

TYS4:40 pmKnoxville McGhee Tyson

7h 20m

1 stop

SAF10:00 pmSanta Fe

$369

Find similar

United Airlines

Sep 3

SAF1:31 pmSanta Fe

6h 59m

1 stop

TYS10:30 pmKnoxville McGhee Tyson

Sep 7

TYS4:40 pmKnoxville McGhee Tyson

18h 43m

1 stop

SAF9:23 amSanta Fe

$633

Find similar

United Airlines

Oct 7

SAF1:23 pmSanta Fe

19h 06m

2 stops

TYS10:29 amKnoxville McGhee Tyson

Oct 10

TYS4:40 pmKnoxville McGhee Tyson

18h 44m

1 stop

SAF9:24 amSanta Fe

$646

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 9/16

5:18 pm-12:21 am

1 stop5h 03m

Knoxville McGhee Tyson

Tue 9/23

4:37 pm-9:06 pm

1 stop6h 29m

$264

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 9/16

6:15 am-3:41 pm

1 stop7h 26m

Knoxville McGhee Tyson

Tue 9/23

6:00 am-2:51 pm

2 stops10h 51m

$274

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 9/16

10:03 am-11:03 pm

2 stops11h 00m

Knoxville McGhee Tyson

Tue 9/23

6:00 am-2:51 pm

2 stops10h 51m

$279

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 9/5

5:18 pm-12:21 am

1 stop5h 03m

Knoxville McGhee Tyson

Mon 9/8

4:37 pm-9:06 pm

1 stop6h 29m

$314

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 9/5

11:47 am-11:03 pm

2 stops9h 16m

Knoxville McGhee Tyson

Mon 9/8

4:37 pm-9:56 pm

1 stop7h 19m

$324

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 9/16

7:00 am-3:10 pm

1 stop6h 10m

Knoxville McGhee Tyson

Tue 9/23

4:40 pm-10:00 pm

1 stop7h 20m

$369

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 9/5

10:03 am-11:03 pm

2 stops11h 00m

Knoxville McGhee Tyson

Mon 9/8

12:15 pm-9:06 pm

2 stops10h 51m

$441

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 10/16

4:56 pm-11:51 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sun 10/19

6:00 am-9:51 am

1 stop5h 51m

$538

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 10/16

12:26 pm-11:53 pm

2 stops9h 27m

Knoxville McGhee Tyson

Sun 10/19

6:00 am-9:51 am

1 stop5h 51m

$548

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 9/3

1:31 pm-10:30 pm

1 stop6h 59m

Knoxville McGhee Tyson

Sun 9/7

4:40 pm-9:23 am

1 stop18h 43m

$633

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Fe to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $368. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Santa Fe to Knoxville for around $644.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Fe to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $463.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Direct flights	None

There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.

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How far is Santa Fe to Knoxville McGhee Tyson by plane?
Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 4h 55m is a normal flight duration for this route.
When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?
There is 1 operator available for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport as of August 2025.
How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Santa Fe to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Santa Fe to Knoxville is American Airlines (100% of total bookings).

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $298	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Newport

Lenoir City

Alcoa

Oak Ridge

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.