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Cheap flights from Santa Fe to Knoxville from $424

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Fe to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:05 am - 1:53 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 48m1 stop Dallas/Fort Worth
American Airlines Logo
5:35 pm - 9:37 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 02m1 stop Dallas/Fort Worth
$424American Airlines
Tue, Sep 15 - Sat, Sep 19
American Airlines Logo
2:08 pm - 11:18 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
7h 10m1 stop Dallas/Fort Worth
American Airlines Logo
5:35 pm - 9:37 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
6h 02m1 stop Dallas/Fort Worth
$426American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
2:08 pm - 11:18 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
7h 10m1 stop Dallas/Fort Worth
American Airlines Logo
6:00 am - 9:43 amTYS  Knoxville McGhee Tyson-SAF Santa Fe
5h 43m1 stop Dallas/Fort Worth
$426American Airlines
Tue, Sep 8 - Wed, Sep 16
United Airlines Logo
7:00 am - 2:36 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 36m1 stop Denver Intl
United Airlines Logo
4:25 pm - 10:01 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
7h 36m1 stop Denver Intl
$459United Airlines
Sat, Dec 5 - Tue, Dec 8
American Airlines Logo
6:05 am - 1:53 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 48m1 stop Dallas/Fort Worth
American Airlines Logo
3:21 pm - 6:54 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
5h 33m1 stop Dallas/Fort Worth
$459American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
6:05 am - 1:53 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 48m1 stop Dallas/Fort Worth
American Airlines Logo
10:12 am - 9:37 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
13h 25m2 stops Charlotte Douglas Dallas/Fort Worth
$492American Airlines
Tue, Sep 15 - Sat, Sep 19
United Airlines Logo
3:21 pm - 10:29 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 08m1 stop Denver Intl
United Airlines Logo
4:50 pm - 8:36 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
5h 46m1 stop Denver Intl
$494United Airlines
Fri, Aug 28 - Tue, Sep 1
United Airlines Logo
7:00 am - 8:54 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
11h 54m2 stops Denver Intl Newark
United Airlines Logo
4:25 pm - 10:01 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
7h 36m1 stop Denver Intl
$504United Airlines
Sat, Dec 5 - Tue, Dec 8
United Airlines Logo
3:21 pm - 10:29 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 08m1 stop Denver Intl
United Airlines Logo
7:15 am - 5:11 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
11h 56m2 stops Houston George Bush Intcntl Denver Intl
$504United Airlines
Fri, Aug 28 - Tue, Sep 1
American Airlines Logo
6:05 am - 1:53 pmSAF  Santa Fe-TYS Knoxville McGhee Tyson
5h 48m1 stop Dallas/Fort Worth
American Airlines Logo
3:21 pm - 9:37 pmTYS  Knoxville McGhee Tyson-SAF Santa Fe
8h 16m1 stop Dallas/Fort Worth
$519American Airlines
Mon, Sep 14 - Sat, Sep 19

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American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Sep 15
SAF6:05 amSanta Fe
5h 48m
1 stop
TYS1:53 pmKnoxville McGhee Tyson
Sep 19
TYS5:35 pmKnoxville McGhee Tyson
6h 02m
1 stop
SAF9:37 pmSanta Fe
$424
American Airlines
Sep 8
SAF2:08 pmSanta Fe
7h 10m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Sep 15
TYS5:35 pmKnoxville McGhee Tyson
6h 02m
1 stop
SAF9:37 pmSanta Fe
$426
American Airlines
Sep 16
SAF6:05 amSanta Fe
5h 48m
1 stop
TYS1:53 pmKnoxville McGhee Tyson
Sep 19
TYS3:21 pmKnoxville McGhee Tyson
5h 33m
1 stop
SAF6:54 pmSanta Fe
$459

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets
United Airlines
Aug 28
SAF3:21 pmSanta Fe
5h 08m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Sep 1
TYS4:50 pmKnoxville McGhee Tyson
5h 46m
1 stop
SAF8:36 pmSanta Fe
$494
United Airlines
Aug 28
SAF3:21 pmSanta Fe
5h 08m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Sep 1
TYS7:15 amKnoxville McGhee Tyson
11h 56m
2 stops
SAF5:11 pmSanta Fe
$504
United Airlines
Sep 15
SAF1:22 pmSanta Fe
9h 01m
2 stops
TYS12:23 amKnoxville McGhee Tyson
Sep 19
TYS4:50 pmKnoxville McGhee Tyson
5h 38m
1 stop
SAF8:28 pmSanta Fe
$526

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Tue 9/15

6:05 am-1:53 pm

1 stop5h 48m

Knoxville McGhee Tyson

Sat 9/19

5:35 pm-9:37 pm

1 stop6h 02m

$424

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Tue 9/8

2:08 pm-11:18 pm

1 stop7h 10m

Knoxville McGhee Tyson

Tue 9/15

5:35 pm-9:37 pm

1 stop6h 02m

$426

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Tue 9/8

2:08 pm-11:18 pm

1 stop7h 10m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-9:43 am

1 stop5h 43m

$426

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Sat 12/5

7:00 am-2:36 pm

1 stop5h 36m

Knoxville McGhee Tyson

Tue 12/8

4:25 pm-10:01 pm

1 stop7h 36m

$459

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Wed 9/16

6:05 am-1:53 pm

1 stop5h 48m

Knoxville McGhee Tyson

Sat 9/19

3:21 pm-6:54 pm

1 stop5h 33m

$459

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Tue 9/15

6:05 am-1:53 pm

1 stop5h 48m

Knoxville McGhee Tyson

Sat 9/19

10:12 am-9:37 pm

2 stops13h 25m

$492
Quickest round-trip

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Fri 8/28

3:21 pm-10:29 pm

1 stop5h 08m

Knoxville McGhee Tyson

Tue 9/1

4:50 pm-8:36 pm

1 stop5h 46m

$494

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Sat 12/5

7:00 am-8:54 pm

2 stops11h 54m

Knoxville McGhee Tyson

Tue 12/8

4:25 pm-10:01 pm

1 stop7h 36m

$504

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Fri 8/28

3:21 pm-10:29 pm

1 stop5h 08m

Knoxville McGhee Tyson

Tue 9/1

7:15 am-5:11 pm

2 stops11h 56m

$504

Santa FeKnoxville

SAF Santa Fe - TYS Knoxville McGhee Tyson

SAFTYS

Santa Fe

Mon 9/14

6:05 am-1:53 pm

1 stop5h 48m

Knoxville McGhee Tyson

Sat 9/19

3:21 pm-9:37 pm

1 stop8h 16m

$519

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 59% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 4 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time

5h 08m

Direct flights

None
The fastest flight from Santa Fe to Knoxville takes 5h 08m
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Fe to Knoxville

  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 5h 08m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $270Free CancellationRating
7.1
11,941 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

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