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Cheap flights from Santa Fe to Knoxville from $488

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 4/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Fe to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:49 pm - 3:06 pm
SAF
-
TYS
19h 17m
1 stop
United Airlines Logo
7:05 am - 5:13 pm
TYS
-
SAF
12h 08m
2 stops
$488United Airlines
Sat, Apr 4 - Sat, Apr 25
United Airlines Logo
5:49 pm - 3:06 pm
SAF
-
TYS
19h 17m
1 stop
United Airlines Logo
4:30 pm - 9:09 am
TYS
-
SAF
18h 39m
1 stop
$542United Airlines
Sat, Apr 4 - Sat, Apr 25
American Airlines Logo
4:15 pm - 11:51 pm
SAF
-
TYS
5h 36m
1 stop
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
$660American Airlines
Thu, Mar 26 - Sun, Mar 29
United Airlines Logo
5:49 pm - 10:08 am
SAF
-
TYS
14h 19m
2 stops
United Airlines Logo
7:05 am - 5:13 pm
TYS
-
SAF
12h 08m
2 stops
$664United Airlines
Sat, Apr 4 - Sat, Apr 25
American Airlines Logo
4:15 pm - 11:51 pm
SAF
-
TYS
5h 36m
1 stop
American Airlines Logo
5:40 am - 3:05 pm
TYS
-
SAF
11h 25m
2 stops
$724American Airlines
Thu, Mar 26 - Sun, Mar 29
American Airlines Logo
12:54 pm - 11:59 pm
SAF
-
TYS
9h 05m
2 stops
American Airlines Logo
5:40 am - 3:05 pm
TYS
-
SAF
11h 25m
2 stops
$787American Airlines
Thu, Mar 26 - Sun, Mar 29

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets
United Airlines
Apr 4
SAF5:49 pmSanta Fe
19h 17m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 25
TYS7:05 amKnoxville McGhee Tyson
12h 08m
2 stops
SAF5:13 pmSanta Fe
$488
United Airlines
Apr 4
SAF5:49 pmSanta Fe
19h 17m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 25
TYS4:30 pmKnoxville McGhee Tyson
18h 39m
1 stop
SAF9:09 amSanta Fe
$542
United Airlines
Apr 4
SAF5:49 pmSanta Fe
14h 19m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Apr 25
TYS7:05 amKnoxville McGhee Tyson
12h 08m
2 stops
SAF5:13 pmSanta Fe
$664

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Mar 26
SAF4:15 pmSanta Fe
5h 36m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Mar 29
TYS5:40 amKnoxville McGhee Tyson
5h 59m
1 stop
SAF9:39 amSanta Fe
$660
American Airlines
Mar 26
SAF4:15 pmSanta Fe
5h 36m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Mar 29
TYS5:40 amKnoxville McGhee Tyson
11h 25m
2 stops
SAF3:05 pmSanta Fe
$724
American Airlines
Mar 26
SAF12:54 pmSanta Fe
9h 05m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Mar 29
TYS5:40 amKnoxville McGhee Tyson
11h 25m
2 stops
SAF3:05 pmSanta Fe
$787

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 4/4

5:49 pm-3:06 pm

1 stop19h 17m

Knoxville McGhee Tyson

Sat 4/25

7:05 am-5:13 pm

2 stops12h 08m

$488

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 4/4

5:49 pm-3:06 pm

1 stop19h 17m

Knoxville McGhee Tyson

Sat 4/25

4:30 pm-9:09 am

1 stop18h 39m

$542

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 3/26

4:15 pm-11:51 pm

1 stop5h 36m

Knoxville McGhee Tyson

Sun 3/29

5:40 am-9:39 am

1 stop5h 59m

$660

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 4/4

5:49 pm-10:08 am

2 stops14h 19m

Knoxville McGhee Tyson

Sat 4/25

7:05 am-5:13 pm

2 stops12h 08m

$664

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 3/26

4:15 pm-11:51 pm

1 stop5h 36m

Knoxville McGhee Tyson

Sun 3/29

5:40 am-3:05 pm

2 stops11h 25m

$724

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 3/26

12:54 pm-11:59 pm

2 stops9h 05m

Knoxville McGhee Tyson

Sun 3/29

5:40 am-3:05 pm

2 stops11h 25m

$787

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time

6h 14m

Direct flights

None
The fastest flight from Santa Fe to Knoxville takes 6h 14m
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
Search flight deals

  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 6h 14m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

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