What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 64% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

There is 1 operator available for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport as of December 2025.

How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$294 Cheap Flights from Santa Fe to Knoxville in 2025/26

1 adult

0 bags

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Find the cheapest flights from Santa Fe to Knoxville

Round-trip

One-way

Cheap round-trip flights

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1:16 pm - 10:31 pm

SAF

TYS

7h 15m1 stop

9:30 am - 8:47 pm

TYS

SAF

13h 17m2 stops

$367United Airlines

Sat, Jan 10 - Wed, Jan 14

1:16 pm - 11:44 pm

SAF

TYS

8h 28m2 stops

11:10 am - 8:47 pm

TYS

SAF

11h 37m2 stops

$372United Airlines

Sat, Jan 10 - Wed, Jan 14

1:16 pm - 10:31 pm

SAF

TYS

7h 15m1 stop

11:10 am - 8:47 pm

TYS

SAF

11h 37m2 stops

$374United Airlines

Sat, Jan 10 - Wed, Jan 14

1:16 pm - 10:31 pm

SAF

TYS

7h 15m1 stop

8:45 am - 2:54 pm

TYS

SAF

8h 09m1 stop

$424United Airlines

Sat, Jan 10 - Wed, Jan 14

1:16 pm - 11:44 pm

SAF

TYS

8h 28m2 stops

11:10 am - 8:47 pm

TYS

SAF

11h 37m2 stops

$439United Airlines

Sat, Jan 10 - Wed, Jan 14

1:16 pm - 10:31 pm

SAF

TYS

7h 15m1 stop

4:25 pm - 9:30 am

TYS

SAF

19h 05m1 stop

$454United Airlines

Sat, Jan 10 - Wed, Jan 14

6:02 pm - 10:29 pm

SAF

TYS

26h 27m1 stop

6:59 am - 2:54 pm

TYS

SAF

9h 55m2 stops

$618United Airlines

Sat, Jan 3 - Wed, Jan 7

6:02 pm - 2:48 pm

SAF

TYS

18h 46m2 stops

6:59 am - 2:54 pm

TYS

SAF

9h 55m2 stops

$652United Airlines

Sat, Jan 3 - Wed, Jan 7

6:15 am - 3:39 pm

SAF

TYS

7h 24m1 stop

4:41 pm - 9:09 pm

TYS

SAF

6h 28m1 stop

$708American Airlines

Sat, Jan 3 - Wed, Jan 7

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets

United Airlines

Jan 10

SAF1:16 pmSanta Fe

7h 15m

1 stop

TYS10:31 pmKnoxville McGhee Tyson

Jan 14

TYS8:45 amKnoxville McGhee Tyson

5h 54m

1 stop

SAF12:39 pmSanta Fe

$364

Find similar

United Airlines

Jan 10

SAF1:16 pmSanta Fe

7h 15m

1 stop

TYS10:31 pmKnoxville McGhee Tyson

Jan 14

TYS9:30 amKnoxville McGhee Tyson

13h 17m

2 stops

SAF8:47 pmSanta Fe

$367

Find similar

United Airlines

Jan 10

SAF1:16 pmSanta Fe

8h 28m

2 stops

TYS11:44 pmKnoxville McGhee Tyson

Jan 14

TYS11:10 amKnoxville McGhee Tyson

11h 37m

2 stops

SAF8:47 pmSanta Fe

$372

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-10:31 pm

1 stop7h 15m

Knoxville McGhee Tyson

Wed 1/14

9:30 am-8:47 pm

2 stops13h 17m

$367

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-11:44 pm

2 stops8h 28m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-8:47 pm

2 stops11h 37m

$372

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-10:31 pm

1 stop7h 15m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-8:47 pm

2 stops11h 37m

$374

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-10:31 pm

1 stop7h 15m

Knoxville McGhee Tyson

Wed 1/14

8:45 am-2:54 pm

1 stop8h 09m

$424

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-11:44 pm

2 stops8h 28m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-8:47 pm

2 stops11h 37m

$439

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/10

1:16 pm-10:31 pm

1 stop7h 15m

Knoxville McGhee Tyson

Wed 1/14

4:25 pm-9:30 am

1 stop19h 05m

$454

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/3

6:02 pm-10:29 pm

1 stop26h 27m

Knoxville McGhee Tyson

Wed 1/7

6:59 am-2:54 pm

2 stops9h 55m

$618

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/3

6:02 pm-2:48 pm

2 stops18h 46m

Knoxville McGhee Tyson

Wed 1/7

6:59 am-2:54 pm

2 stops9h 55m

$652

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/3

6:15 am-3:39 pm

1 stop7h 24m

Knoxville McGhee Tyson

Wed 1/7

4:41 pm-9:09 pm

1 stop6h 28m

$708

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Fe to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $368. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Santa Fe to Knoxville for around $644.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Fe to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $463.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time	7h 15m
Direct flights	None

The fastest flight from Santa Fe to Knoxville takes 7h 15m

There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.

Search flight deals

How far is Santa Fe to Knoxville McGhee Tyson by plane?
Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 7h 15m is a normal flight duration for this route.
When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?
There is 1 operator available for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport as of December 2025.
How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Santa Fe to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Santa Fe to Knoxville is American Airlines (100% of total bookings).

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $264	Free Cancellation	Rating 7.2 11,054 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Maryville

Crossville

Murphy

Alcoa

Oak Ridge

Newport

Lenoir City

Kodak

Dandridge

Jefferson City

Clinton

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.