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Cheap flights from Santa Fe to Knoxville from $459

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 7/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Fe to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:11 am - 7:30 pm
SAF
-
TYS
7h 19m
1 stop
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$459American Airlines
Sat, Jul 11 - Wed, Jul 15
American Airlines Logo
7:35 am - 4:41 pm
SAF
-
TYS
7h 06m
1 stop
American Airlines Logo
5:37 am - 9:41 am
TYS
-
SAF
6h 04m
1 stop
$500American Airlines
Fri, Jul 10 - Mon, Jul 13
American Airlines Logo
10:11 am - 10:23 pm
SAF
-
TYS
10h 12m
2 stops
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$502American Airlines
Sat, Jul 11 - Wed, Jul 15
American Airlines Logo
7:35 am - 4:41 pm
SAF
-
TYS
7h 06m
1 stop
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$549American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
11:21 am - 7:30 pm
SAF
-
TYS
6h 09m
1 stop
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$560American Airlines
Thu, Jul 30 - Mon, Aug 3
American Airlines Logo
12:58 pm - 11:51 pm
SAF
-
TYS
8h 53m
2 stops
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$567American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
12:58 pm - 11:51 pm
SAF
-
TYS
8h 53m
2 stops
American Airlines Logo
5:31 pm - 10:04 pm
TYS
-
SAF
6h 33m
1 stop
$619American Airlines
Fri, Jul 10 - Mon, Jul 13
United Airlines Logo
7:00 am - 2:36 pm
SAF
-
TYS
5h 36m
1 stop
United Airlines Logo
4:25 pm - 2:49 pm
TYS
-
SAF
24h 24m
1 stop
$650United Airlines
Sat, Dec 5 - Tue, Dec 8
American Airlines Logo
12:58 pm - 11:51 pm
SAF
-
TYS
8h 53m
2 stops
American Airlines Logo
8:56 am - 4:53 pm
TYS
-
SAF
9h 57m
2 stops
$658American Airlines
Tue, Jul 7 - Sat, Jul 11
United Airlines Logo
1:20 pm - 10:20 pm
SAF
-
TYS
7h 00m
1 stop
United Airlines Logo
2:00 pm - 2:49 pm
TYS
-
SAF
26h 49m
2 stops
$660United Airlines
Sat, Dec 5 - Tue, Dec 8

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United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets
United Airlines
Dec 5
SAF7:00 amSanta Fe
5h 36m
1 stop
TYS2:36 pmKnoxville McGhee Tyson
Dec 8
TYS4:25 pmKnoxville McGhee Tyson
24h 24m
1 stop
SAF2:49 pmSanta Fe
$650
United Airlines
Dec 5
SAF1:20 pmSanta Fe
7h 00m
1 stop
TYS10:20 pmKnoxville McGhee Tyson
Dec 8
TYS2:00 pmKnoxville McGhee Tyson
26h 49m
2 stops
SAF2:49 pmSanta Fe
$660
United Airlines
Dec 5
SAF1:20 pmSanta Fe
7h 00m
1 stop
TYS10:20 pmKnoxville McGhee Tyson
Dec 8
TYS4:25 pmKnoxville McGhee Tyson
24h 24m
1 stop
SAF2:49 pmSanta Fe
$661

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Jul 11
SAF10:11 amSanta Fe
7h 19m
1 stop
TYS7:30 pmKnoxville McGhee Tyson
Jul 15
TYS5:31 pmKnoxville McGhee Tyson
6h 33m
1 stop
SAF10:04 pmSanta Fe
$459
American Airlines
Jul 10
SAF7:35 amSanta Fe
7h 06m
1 stop
TYS4:41 pmKnoxville McGhee Tyson
Jul 13
TYS5:37 amKnoxville McGhee Tyson
6h 04m
1 stop
SAF9:41 amSanta Fe
$500
American Airlines
Jul 11
SAF10:11 amSanta Fe
10h 12m
2 stops
TYS10:23 pmKnoxville McGhee Tyson
Jul 15
TYS5:31 pmKnoxville McGhee Tyson
6h 33m
1 stop
SAF10:04 pmSanta Fe
$502

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 7/11

10:11 am-7:30 pm

1 stop7h 19m

Knoxville McGhee Tyson

Wed 7/15

5:31 pm-10:04 pm

1 stop6h 33m

$459

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 7/10

7:35 am-4:41 pm

1 stop7h 06m

Knoxville McGhee Tyson

Mon 7/13

5:37 am-9:41 am

1 stop6h 04m

$500

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 7/11

10:11 am-10:23 pm

2 stops10h 12m

Knoxville McGhee Tyson

Wed 7/15

5:31 pm-10:04 pm

1 stop6h 33m

$502

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 7/7

7:35 am-4:41 pm

1 stop7h 06m

Knoxville McGhee Tyson

Sat 7/11

5:31 pm-10:04 pm

1 stop6h 33m

$549
Quickest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 7/30

11:21 am-7:30 pm

1 stop6h 09m

Knoxville McGhee Tyson

Mon 8/3

5:31 pm-10:04 pm

1 stop6h 33m

$560

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 7/7

12:58 pm-11:51 pm

2 stops8h 53m

Knoxville McGhee Tyson

Sat 7/11

5:31 pm-10:04 pm

1 stop6h 33m

$567

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 7/10

12:58 pm-11:51 pm

2 stops8h 53m

Knoxville McGhee Tyson

Mon 7/13

5:31 pm-10:04 pm

1 stop6h 33m

$619

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 12/5

7:00 am-2:36 pm

1 stop5h 36m

Knoxville McGhee Tyson

Tue 12/8

4:25 pm-2:49 pm

1 stop24h 24m

$650

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 7/7

12:58 pm-11:51 pm

2 stops8h 53m

Knoxville McGhee Tyson

Sat 7/11

8:56 am-4:53 pm

2 stops9h 57m

$658

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 12/5

1:20 pm-10:20 pm

1 stop7h 00m

Knoxville McGhee Tyson

Tue 12/8

2:00 pm-2:49 pm

2 stops26h 49m

$660

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time

6h 57m

Direct flights

None
The fastest flight from Santa Fe to Knoxville takes 6h 57m
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Fe to Knoxville

  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 6h 57m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.1
11,772 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

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