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Cheap flights from Santa Fe to Knoxville from $394

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Knoxville departing on 4/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:19 pm - 10:29 pm
SAF
-
TYS
7h 10m
1 stop
United Airlines Logo
4:30 pm - 8:38 pm
TYS
-
SAF
6h 08m
1 stop
$394United Airlines
Tue, Apr 7 - Sat, Apr 11
United Airlines Logo
1:19 pm - 10:29 pm
SAF
-
TYS
7h 10m
1 stop
United Airlines Logo
7:05 am - 5:08 pm
TYS
-
SAF
12h 03m
2 stops
$404United Airlines
Tue, Apr 7 - Sat, Apr 11
United Airlines Logo
1:22 pm - 10:38 pm
SAF
-
TYS
7h 16m
1 stop
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$410United Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
10:30 am - 11:57 pm
SAF
-
TYS
11h 27m
2 stops
United Airlines Logo
7:15 am - 2:46 pm
TYS
-
SAF
9h 31m
2 stops
$415United Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
7:00 am - 3:54 pm
SAF
-
TYS
6h 54m
1 stop
United Airlines Logo
4:56 pm - 8:43 pm
TYS
-
SAF
5h 47m
1 stop
$459United Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
10:42 am - 11:59 pm
SAF
-
TYS
11h 17m
2 stops
American Airlines Logo
11:40 am - 9:07 pm
TYS
-
SAF
11h 27m
2 stops
$479American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
11:56 am - 11:56 pm
SAF
-
TYS
10h 00m
2 stops
American Airlines Logo
7:00 am - 2:55 pm
TYS
-
SAF
9h 55m
2 stops
$508American Airlines
Fri, Apr 10 - Tue, Apr 14
United Airlines Logo
1:22 pm - 11:57 pm
SAF
-
TYS
8h 35m
2 stops
United Airlines Logo
6:30 am - 8:43 pm
TYS
-
SAF
16h 13m
3 stops
$552United Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
6:00 pm - 10:42 am
SAF
-
TYS
14h 42m
2 stops
United Airlines Logo
8:48 am - 2:44 pm
TYS
-
SAF
7h 56m
1 stop
$711United Airlines
Tue, May 26 - Tue, Jun 23
United Airlines Logo
1:22 pm - 10:19 pm
SAF
-
TYS
6h 57m
1 stop
United Airlines Logo
8:48 am - 5:12 pm
TYS
-
SAF
10h 24m
1 stop
$721United Airlines
Tue, May 26 - Tue, Jun 23

United Airlines flights from Santa Fe to Knoxville

Our best United Airlines deals on Santa Fe to Knoxville flight tickets
United Airlines
Apr 7
SAF1:19 pmSanta Fe
7h 10m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Apr 11
TYS4:30 pmKnoxville McGhee Tyson
6h 08m
1 stop
SAF8:38 pmSanta Fe
$394
United Airlines
Apr 7
SAF1:19 pmSanta Fe
7h 10m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Apr 11
TYS7:05 amKnoxville McGhee Tyson
12h 03m
2 stops
SAF5:08 pmSanta Fe
$404
United Airlines
Aug 25
SAF1:22 pmSanta Fe
7h 16m
1 stop
TYS10:38 pmKnoxville McGhee Tyson
Aug 29
TYS7:15 amKnoxville McGhee Tyson
9h 31m
2 stops
SAF2:46 pmSanta Fe
$410

American Airlines flights from Santa Fe to Knoxville

Our best American Airlines deals on Santa Fe to Knoxville flight tickets
American Airlines
Apr 7
SAF10:42 amSanta Fe
11h 17m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Apr 11
TYS11:40 amKnoxville McGhee Tyson
11h 27m
2 stops
SAF9:07 pmSanta Fe
$479
American Airlines
Apr 10
SAF11:56 amSanta Fe
10h 00m
2 stops
TYS11:56 pmKnoxville McGhee Tyson
Apr 14
TYS7:00 amKnoxville McGhee Tyson
9h 55m
2 stops
SAF2:55 pmSanta Fe
$508

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/7

1:19 pm-10:29 pm

1 stop7h 10m

Knoxville McGhee Tyson

Sat 4/11

4:30 pm-8:38 pm

1 stop6h 08m

$394

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/7

1:19 pm-10:29 pm

1 stop7h 10m

Knoxville McGhee Tyson

Sat 4/11

7:05 am-5:08 pm

2 stops12h 03m

$404

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/25

1:22 pm-10:38 pm

1 stop7h 16m

Knoxville McGhee Tyson

Sat 8/29

7:15 am-2:46 pm

2 stops9h 31m

$410

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/25

10:30 am-11:57 pm

2 stops11h 27m

Knoxville McGhee Tyson

Sat 8/29

7:15 am-2:46 pm

2 stops9h 31m

$415
Quickest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/25

7:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sat 8/29

4:56 pm-8:43 pm

1 stop5h 47m

$459

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/7

10:42 am-11:59 pm

2 stops11h 17m

Knoxville McGhee Tyson

Sat 4/11

11:40 am-9:07 pm

2 stops11h 27m

$479

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 4/10

11:56 am-11:56 pm

2 stops10h 00m

Knoxville McGhee Tyson

Tue 4/14

7:00 am-2:55 pm

2 stops9h 55m

$508

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/25

1:22 pm-11:57 pm

2 stops8h 35m

Knoxville McGhee Tyson

Sat 8/29

6:30 am-8:43 pm

3 stops16h 13m

$552

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 5/26

6:00 pm-10:42 am

2 stops14h 42m

Knoxville McGhee Tyson

Tue 6/23

8:48 am-2:44 pm

1 stop7h 56m

$711

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 5/26

1:22 pm-10:19 pm

1 stop6h 57m

Knoxville McGhee Tyson

Tue 6/23

8:48 am-5:12 pm

1 stop10h 24m

$721

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Fe to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Santa Fe according to our data. American Airlines is the first choice among our users, with 57% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Santa Fe to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Knoxville (SAF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Knoxville

Fastest flight time

6h 57m

Direct flights

None
The fastest flight from Santa Fe to Knoxville takes 6h 57m
There are no direct flights from Santa Fe to Knoxville. There are no popular flight routes from Santa Fe to Knoxville.
Search flight deals

  • How far is Santa Fe to Knoxville McGhee Tyson by plane?

    Santa Fe and Knoxville McGhee Tyson are 1230.1 mi apart from one another. 6h 57m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Santa Fe Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Fe Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Fe Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Fe to Knoxville?

Best airlines flying from Santa Fe to Knoxville

Compare and see reviews for airlines that fly from Santa Fe to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.1
11,496 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Santa Fe.

Can I find flights from Santa Fe to Knoxville with flexible booking policies on momondo?

Flights from Santa Fe to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Fe to Knoxville?

momondo helps you find the best flight between Santa Fe and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Fe to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Santa Fe and alert you when they change.

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