Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Santa Ana, California to Florence from $480

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Florence departing on 11/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santa Ana, California to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:43 am - 10:53 pmSNA-FLO
9h 10m2 stops
American Airlines Logo
11:16 am - 8:10 pmFLO-SNA
11h 54m2 stops
$575American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
8:55 am - 10:53 pmSNA-FLO
10h 58m1 stop
American Airlines Logo
5:15 am - 12:38 pmFLO-SNA
10h 23m2 stops
$850American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
8:55 am - 10:53 pmSNA-FLO
10h 58m1 stop
American Airlines Logo
5:15 am - 12:38 pmFLO-SNA
10h 23m2 stops
$855American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
8:55 am - 10:53 pmSNA-FLO
10h 58m1 stop
American Airlines Logo
11:16 am - 8:48 pmFLO-SNA
12h 32m1 stop
$875American Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
American Airlines Logo
9:59 am - 11:41 pmSNA-FLO
10h 42m2 stops
American Airlines Logo
5:15 am - 11:37 amFLO-SNA
9h 22m2 stops
$1,023American Airlines
Find Deal
Wed, Nov 26 - Sun, Nov 30
American Airlines Logo
1:27 pm - 10:45 amSNA-FLO
18h 18m2 stops
American Airlines Logo
5:15 am - 3:22 pmFLO-SNA
13h 07m2 stops
$1,056American Airlines
Find Deal
Thu, Nov 27 - Sun, Nov 30
American Airlines Logo
7:45 am - 6:07 pmSNA-FLO
7h 22m1 stop
American Airlines Logo
5:15 am - 3:22 pmFLO-SNA
13h 07m2 stops
$1,126American Airlines
Find Deal
Wed, Nov 26 - Sun, Nov 30
American Airlines Logo
7:45 am - 6:07 pmSNA-FLO
7h 22m1 stop
American Airlines Logo
6:33 pm - 8:43 pmFLO-SNA
29h 10m1 stop
$1,198American Airlines
Find Deal
Wed, Nov 26 - Sun, Nov 30

American Airlines flights from Santa Ana, California to Florence, South Carolina

Our best American Airlines deals on Santa Ana, California to Florence, South Carolina flight tickets
American Airlines
Dec 10
SNA10:43 amSanta Ana J. Wayne/Orange Cnty
9h 10m
2 stops
FLO10:53 pmFlorence
Dec 13
FLO11:16 amFlorence
11h 54m
2 stops
SNA8:10 pmSanta Ana J. Wayne/Orange Cnty
$575
Find similar
American Airlines
Dec 10
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
10h 58m
1 stop
FLO10:53 pmFlorence
Dec 13
FLO5:15 amFlorence
10h 23m
2 stops
SNA12:38 pmSanta Ana J. Wayne/Orange Cnty
$850
Find similar
American Airlines
Dec 10
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
10h 58m
1 stop
FLO10:53 pmFlorence
Dec 13
FLO5:15 amFlorence
10h 23m
2 stops
SNA12:38 pmSanta Ana J. Wayne/Orange Cnty
$855
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Santa Ana, California to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

10:43 am-10:53 pm

2 stops9h 10m

Florence

Sat 12/13

11:16 am-8:10 pm

2 stops11h 54m

$575

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

8:55 am-10:53 pm

1 stop10h 58m

Florence

Sat 12/13

5:15 am-12:38 pm

2 stops10h 23m

$850

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

8:55 am-10:53 pm

1 stop10h 58m

Florence

Sat 12/13

5:15 am-12:38 pm

2 stops10h 23m

$855

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

8:55 am-10:53 pm

1 stop10h 58m

Florence

Sat 12/13

11:16 am-8:48 pm

1 stop12h 32m

$875

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 11/26

9:59 am-11:41 pm

2 stops10h 42m

Florence

Sun 11/30

5:15 am-11:37 am

2 stops9h 22m

$1,023

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 11/27

1:27 pm-10:45 am

2 stops18h 18m

Florence

Sun 11/30

5:15 am-3:22 pm

2 stops13h 07m

$1,056

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 11/26

7:45 am-6:07 pm

1 stop7h 22m

Florence

Sun 11/30

5:15 am-3:22 pm

2 stops13h 07m

$1,126

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 11/26

7:45 am-6:07 pm

1 stop7h 22m

Florence

Sun 11/30

6:33 pm-8:43 pm

1 stop29h 10m

$1,198

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Wed 11/26

9:59 am-11:41 pm

2 stops10h 42m

$480

Santa AnaFlorence

SNA - FLO

SNAFLO

Santa Ana J. Wayne/Orange Cnty

Thu 11/27

1:27 pm-6:07 pm

2 stops25h 40m

$505

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Florence from

How to get the cheapest flight ticket from Santa Ana, California to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Santa Ana, California is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $472. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Santa Ana, California because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $759.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is at noon. momondo users have found flights departing from Santa Ana, California to Florence, South Carolina at noon for as low as $695. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $714 per ticket.

When to book flights from Santa Ana, California to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Florence, South Carolina (SNA to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Florence, South Carolina

Direct flights

None
There are no direct flights from Santa Ana, California to Florence, South Carolina. There are no popular flight routes from Santa Ana, California to Florence, South Carolina.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Florence by plane?

    Santa Ana J. Wayne/Orange Cnty and Florence are 2169.2 mi apart from one another. 7h 22m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Florence Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Florence Airport are updated daily.

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Santa Ana which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Santa Ana to Florence?

momondo helps you find the best flight between Santa Ana and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santa Ana to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 11/22
Sat 11/29
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States