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Cheap flights from Santa Ana, California to Des Moines from $109

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:28 am - 2:43 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$137Allegiant Air
Thu, Oct 1 - Sun, Oct 4
Allegiant Air Logo
9:28 am - 2:43 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$140Allegiant Air
Thu, Oct 1 - Sun, Oct 4
Allegiant Air Logo
9:28 am - 2:43 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$141Allegiant Air
Thu, Oct 1 - Sun, Oct 4
Multiple Airlines Logo
4:35 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
16h 22m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$171Multiple Airlines
Thu, Oct 1 - Sun, Oct 4
Multiple Airlines Logo
4:35 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
16h 22m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$176Multiple Airlines
Thu, Oct 1 - Sun, Oct 4
Multiple Airlines Logo
4:35 pm - 10:57 amSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
16h 22m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
7:00 am - 8:38 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$181Multiple Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
3:30 pm - 12:14 amSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 44m1 stop Chicago O'Hare Intl
American Airlines Logo
6:14 am - 11:00 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
6h 46m1 stop Dallas/Fort Worth
$355American Airlines
Thu, Oct 15 - Tue, Oct 20
American Airlines Logo
8:00 am - 5:46 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
7h 46m1 stop Dallas/Fort Worth
American Airlines Logo
8:10 am - 12:33 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
6h 23m1 stop Phoenix Sky Harbor Intl
$355American Airlines
Sat, Nov 14 - Mon, Nov 16
United Airlines Logo
4:15 pm - 11:48 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 33m1 stop Denver Intl
United Airlines Logo
6:00 am - 11:41 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
7h 41m1 stop Chicago O'Hare Intl
$355United Airlines
Wed, Oct 21 - Sat, Oct 24
United Airlines Logo
4:15 pm - 11:48 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 33m1 stop Denver Intl
United Airlines Logo
1:27 pm - 8:51 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
9h 24m2 stops Denver Intl San Francisco
$360United Airlines
Wed, Oct 21 - Sat, Oct 24

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Allegiant Air flights from Santa Ana, California to Des Moines

Our best Allegiant Air deals on Santa Ana, California to Des Moines flight tickets
Allegiant Air
Oct 1
SNA9:28 amSanta Ana J. Wayne/Orange Cnty
3h 15m
DSM2:43 pmDes Moines
Oct 4
DSM7:00 amDes Moines
3h 38m
SNA8:38 amSanta Ana J. Wayne/Orange Cnty
$137
Allegiant Air
Oct 1
SNA9:28 amSanta Ana J. Wayne/Orange Cnty
3h 15m
DSM2:43 pmDes Moines
Oct 4
DSM7:00 amDes Moines
3h 38m
SNA8:38 amSanta Ana J. Wayne/Orange Cnty
$140
Allegiant Air
Oct 1
SNA9:28 amSanta Ana J. Wayne/Orange Cnty
3h 15m
DSM2:43 pmDes Moines
Oct 4
DSM7:00 amDes Moines
3h 38m
SNA8:38 amSanta Ana J. Wayne/Orange Cnty
$141

American Airlines flights from Santa Ana, California to Des Moines

Our best American Airlines deals on Santa Ana, California to Des Moines flight tickets
American Airlines
Sep 10
SNA3:11 pmSanta Ana J. Wayne/Orange Cnty
6h 53m
1 stop
DSM12:04 amDes Moines
Sep 13
DSM5:30 amDes Moines
5h 41m
1 stop
SNA9:11 amSanta Ana J. Wayne/Orange Cnty
$466
American Airlines
Sep 1
SNA3:21 pmSanta Ana J. Wayne/Orange Cnty
6h 59m
1 stop
DSM12:20 amDes Moines
Sep 3
DSM2:39 pmDes Moines
6h 06m
1 stop
SNA6:45 pmSanta Ana J. Wayne/Orange Cnty
$787

momondo Fare Finder

 
Use the filters below to find and compare flights from Santa Ana, California to Des Moines that are best for you.

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Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

9:28 am-2:43 pm

Nonstop3h 15m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$137

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

9:28 am-2:43 pm

Nonstop3h 15m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$140

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

9:28 am-2:43 pm

Nonstop3h 15m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$141

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

4:35 pm-10:57 am

1 stop16h 22m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$171

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

4:35 pm-10:57 am

1 stop16h 22m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$176

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/1

4:35 pm-10:57 am

1 stop16h 22m

Des Moines

Sun 10/4

7:00 am-8:38 am

Nonstop3h 38m

$181

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/15

3:30 pm-12:14 am

1 stop6h 44m

Des Moines

Tue 10/20

6:14 am-11:00 am

1 stop6h 46m

$355

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sat 11/14

8:00 am-5:46 pm

1 stop7h 46m

Des Moines

Mon 11/16

8:10 am-12:33 pm

1 stop6h 23m

$355

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

4:15 pm-11:48 pm

1 stop5h 33m

Des Moines

Sat 10/24

6:00 am-11:41 am

1 stop7h 41m

$355

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

4:15 pm-11:48 pm

1 stop5h 33m

Des Moines

Sat 10/24

1:27 pm-8:51 pm

2 stops9h 24m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana, California to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $195 to $346.
The lowest price recently found on this route was $137.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then September is your next best option. Flight prices from Santa Ana, California to Des Moines during September average around $198.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana, California to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $355. Flights from Santa Ana, California to Des Moines on a Monday will generally be more expensive and average around $527. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Santa Ana, California to Des Moines in the morning for as low as $384. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $695. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana, California to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana, California to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santa Ana, California to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Santa Ana, California to Des Moines.

How have Santa Ana, California to Des Moines flight prices changed over time?

As of August 2026, prices for Santa Ana, California to Des Moines flights are approximately 120% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Des Moines

Best Price Found

$109

Fastest flight time

3h 15m

Direct flights

Mon, Thu and Fri

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Santa Ana, California in the past 72 hours is $109. The best round-trip flight deal from Santa Ana, California to Des Moines found on momondo in the last 72 hours is $137.
The fastest flight from Santa Ana, California to Des Moines takes 3h 15m
Direct flights go from Santa Ana, California to Des Moines on Monday, Thursday and Friday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Santa Ana, California there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Des Moines

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 15m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana, California to Des Moines?

  • What is the most popular airline from Santa Ana, California to Des Moines?

Best airlines flying from Santa Ana, California to Des Moines

Compare and see reviews for airlines that fly from Santa Ana, California to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $141Free CancellationRating
7.3
676 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $260Free CancellationRating
7.1
12,021 reviews
Search American Airlines flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
10,139 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Boone
Johnston
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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