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Cheap flights from Santa Ana, California to Des Moines from $125

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
4:50 pm - 10:07 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
Allegiant Air Logo
1:42 pm - 3:20 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$156Allegiant Air
Thu, Nov 12 - Sun, Nov 15
Multiple Airlines Logo
11:38 am - 7:35 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 57m1 stop Denver Intl
Multiple Airlines Logo
1:42 pm - 3:20 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$209Multiple Airlines
Fri, Nov 13 - Sun, Nov 15
Allegiant Air Logo
4:50 pm - 10:07 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
Allegiant Air Logo
1:42 pm - 3:20 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$215Allegiant Air
Thu, Nov 5 - Sun, Nov 8
Allegiant Air Logo
4:50 pm - 10:07 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
Allegiant Air Logo
2:22 pm - 4:00 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$225Allegiant Air
Thu, Nov 5 - Thu, Nov 12
Multiple Airlines Logo
11:38 am - 7:35 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 57m1 stop Denver Intl
Multiple Airlines Logo
8:04 pm - 3:03 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
20h 59m1 stop Las Vegas Harry Reid Intl
$234Multiple Airlines
Fri, Nov 13 - Mon, Nov 16
Multiple Airlines Logo
7:30 am - 8:04 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
10h 34m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
1:42 pm - 3:20 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
$243Multiple Airlines
Thu, Nov 12 - Sun, Nov 15
American Airlines Logo
1:25 pm - 8:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 34m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
2:05 pm - 9:32 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
9h 27m1 stop Chicago O'Hare Intl
$355American Airlines
Sat, Dec 5 - Sat, Dec 12
United Airlines Logo
2:22 pm - 10:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 37m1 stop Chicago O'Hare Intl
United Airlines Logo
5:09 pm - 9:19 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
6h 10m1 stop Denver Intl
$355United Airlines
Thu, Nov 5 - Thu, Nov 12
United Airlines Logo
1:00 pm - 8:33 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 33m1 stop Denver Intl
United Airlines Logo
1:15 pm - 9:09 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
9h 54m2 stops Chicago O'Hare Intl Denver Intl
$360United Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
4:32 pm - 11:36 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 04m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
5:23 am - 11:10 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
7h 47m1 stop Dallas/Fort Worth
$372American Airlines
Sat, Nov 21 - Sun, Nov 22

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Allegiant Air flights from Santa Ana, California to Des Moines

Our best Allegiant Air deals on Santa Ana, California to Des Moines flight tickets
Allegiant Air
Nov 12
SNA4:50 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM10:07 pmDes Moines
Nov 15
DSM1:42 pmDes Moines
3h 38m
SNA3:20 pmSanta Ana J. Wayne/Orange Cnty
$156
Allegiant Air
Nov 5
SNA4:50 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM10:07 pmDes Moines
Nov 8
DSM1:42 pmDes Moines
3h 38m
SNA3:20 pmSanta Ana J. Wayne/Orange Cnty
$215
Allegiant Air
Nov 5
SNA4:50 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM10:07 pmDes Moines
Nov 12
DSM2:22 pmDes Moines
3h 38m
SNA4:00 pmSanta Ana J. Wayne/Orange Cnty
$225

Delta flights from Santa Ana, California to Des Moines

Our best Delta deals on Santa Ana, California to Des Moines flight tickets
Delta
Nov 13
SNA12:47 pmSanta Ana J. Wayne/Orange Cnty
6h 26m
1 stop
DSM9:13 pmDes Moines
Nov 18
DSM2:48 pmDes Moines
8h 07m
1 stop
SNA8:55 pmSanta Ana J. Wayne/Orange Cnty
$355
Delta
Nov 9
SNA9:53 amSanta Ana J. Wayne/Orange Cnty
9h 20m
2 stops
DSM9:13 pmDes Moines
Nov 18
DSM2:48 pmDes Moines
8h 07m
1 stop
SNA8:55 pmSanta Ana J. Wayne/Orange Cnty
$360
Delta
Nov 9
SNA9:53 amSanta Ana J. Wayne/Orange Cnty
9h 20m
2 stops
DSM9:13 pmDes Moines
Nov 13
DSM11:00 amDes Moines
13h 30m
2 stops
SNA10:30 pmSanta Ana J. Wayne/Orange Cnty
$366

momondo Fare Finder

 
Use the filters below to find and compare flights from Santa Ana, California to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/12

4:50 pm-10:07 pm

Nonstop3h 17m

Des Moines

Sun 11/15

1:42 pm-3:20 pm

Nonstop3h 38m

$156

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 11/13

11:38 am-7:35 pm

1 stop5h 57m

Des Moines

Sun 11/15

1:42 pm-3:20 pm

Nonstop3h 38m

$209

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/5

4:50 pm-10:07 pm

Nonstop3h 17m

Des Moines

Sun 11/8

1:42 pm-3:20 pm

Nonstop3h 38m

$215

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/5

4:50 pm-10:07 pm

Nonstop3h 17m

Des Moines

Thu 11/12

2:22 pm-4:00 pm

Nonstop3h 38m

$225

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 11/13

11:38 am-7:35 pm

1 stop5h 57m

Des Moines

Mon 11/16

8:04 pm-3:03 pm

1 stop20h 59m

$234

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/12

7:30 am-8:04 pm

1 stop10h 34m

Des Moines

Sun 11/15

1:42 pm-3:20 pm

Nonstop3h 38m

$243

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sat 12/5

1:25 pm-8:59 pm

1 stop5h 34m

Des Moines

Sat 12/12

2:05 pm-9:32 pm

1 stop9h 27m

$355

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/5

2:22 pm-10:59 pm

1 stop6h 37m

Des Moines

Thu 11/12

5:09 pm-9:19 pm

1 stop6h 10m

$355

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sat 12/5

1:00 pm-8:33 pm

1 stop5h 33m

Des Moines

Sat 12/12

1:15 pm-9:09 pm

2 stops9h 54m

$360

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sat 11/21

4:32 pm-11:36 pm

1 stop5h 04m

Des Moines

Sun 11/22

5:23 am-11:10 am

1 stop7h 47m

$372

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana, California to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $197 to $354.
The lowest price recently found on this route was $156.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then October is your next best option. Flight prices from Santa Ana, California to Des Moines during October average around $220.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana, California to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $372. Flights from Santa Ana, California to Des Moines on a Monday will generally be more expensive and average around $602. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Santa Ana, California to Des Moines in the morning for as low as $388. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $412. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana, California to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana, California to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santa Ana, California to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Santa Ana, California to Des Moines.

How have Santa Ana, California to Des Moines flight prices changed over time?

As of October 2026, prices for Santa Ana, California to Des Moines flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Des Moines

Best Price Found

$125

Fastest flight time

3h 15m

Direct flights

Mon, Thu, Fri, Sat and Sun

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Santa Ana, California in the past 72 hours is $125. The best round-trip flight deal from Santa Ana, California to Des Moines found on momondo in the last 72 hours is $156.
The fastest flight from Santa Ana, California to Des Moines takes 3h 15m
Direct flights go from Santa Ana, California to Des Moines on Monday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Des Moines. From Santa Ana, California there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Des Moines

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 15m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana, California to Des Moines?

  • What is the most popular airline from Santa Ana, California to Des Moines?

Best airlines flying from Santa Ana, California to Des Moines

Compare and see reviews for airlines that fly from Santa Ana, California to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $141Free CancellationRating
7.3
678 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $260Free CancellationRating
7.0
12,168 reviews
Search American Airlines flights
United AirlinesPriceFrom $346Free CancellationRating
7.4
10,362 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Boone
Johnston
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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