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Cheap flights from Santa Ana to Des Moines from $88

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Des Moines departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:50 am - 3:06 pm
SNA
-
DSM
3h 16mnonstop
Allegiant Air Logo
7:00 am - 8:55 am
DSM
-
SNA
3h 55mnonstop
$140Allegiant Air
Mon, Mar 16 - Mon, Mar 23
Allegiant Air Logo
9:50 am - 3:06 pm
SNA
-
DSM
3h 16mnonstop
Allegiant Air Logo
7:00 am - 8:55 am
DSM
-
SNA
3h 55mnonstop
$148Allegiant Air
Mon, Mar 16 - Mon, Mar 23
Allegiant Air Logo
12:26 pm - 5:43 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
$193Allegiant Air
Fri, Apr 24 - Mon, Apr 27
Multiple Airlines Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
Multiple Airlines Logo
3:32 pm - 9:13 pm
DSM
-
SNA
7h 41m
1 stop
$216Multiple Airlines
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
6:45 am - 7:16 pm
SNA
-
DSM
34h 31m
2 stops
Multiple Airlines Logo
9:45 pm - 9:53 am
DSM
-
SNA
14h 08m
1 stop
$227Multiple Airlines
Fri, Mar 27 - Mon, Apr 6
Multiple Airlines Logo
6:45 am - 7:16 pm
SNA
-
DSM
34h 31m
2 stops
Multiple Airlines Logo
8:00 am - 9:51 am
DSM
-
SNA
3h 51mnonstop
$228Multiple Airlines
Fri, Mar 27 - Mon, Apr 6
Allegiant Air Logo
9:45 am - 3:02 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
8:00 am - 9:51 am
DSM
-
SNA
3h 51mnonstop
$229Allegiant Air
Fri, Mar 27 - Mon, Apr 6
Multiple Airlines Logo
9:50 am - 3:06 pm
SNA
-
DSM
3h 16mnonstop
Multiple Airlines Logo
3:32 pm - 3:33 pm
DSM
-
SNA
26h 01m
1 stop
$231Multiple Airlines
Mon, Mar 16 - Mon, Mar 23
Multiple Airlines Logo
7:25 am - 9:24 pm
SNA
-
DSM
11h 59m
1 stop
Multiple Airlines Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
$236Multiple Airlines
Fri, Apr 24 - Mon, Apr 27
Multiple Airlines Logo
2:53 pm - 7:16 pm
SNA
-
DSM
26h 23m
2 stops
Multiple Airlines Logo
9:45 pm - 9:53 am
DSM
-
SNA
14h 08m
1 stop
$245Multiple Airlines
Thu, Mar 26 - Mon, Apr 6

Allegiant Air flights from Santa Ana to Des Moines

Our best Allegiant Air deals on Santa Ana to Des Moines flight tickets
Allegiant Air
Mar 16
SNA9:50 amSanta Ana J. Wayne/Orange Cnty
3h 16m
DSM3:06 pmDes Moines
Mar 23
DSM7:00 amDes Moines
3h 55m
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
$140
Allegiant Air
Mar 16
SNA9:50 amSanta Ana J. Wayne/Orange Cnty
3h 16m
DSM3:06 pmDes Moines
Mar 23
DSM7:00 amDes Moines
3h 55m
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
$148
Allegiant Air
Apr 24
SNA12:26 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:43 pmDes Moines
Apr 27
DSM9:45 amDes Moines
3h 51m
SNA11:36 amSanta Ana J. Wayne/Orange Cnty
$193

American Airlines flights from Santa Ana to Des Moines

Our best American Airlines deals on Santa Ana to Des Moines flight tickets
American Airlines
Mar 16
SNA3:24 pmSanta Ana J. Wayne/Orange Cnty
6h 16m
1 stop
DSM11:40 pmDes Moines
Mar 23
DSM2:28 pmDes Moines
6h 30m
1 stop
SNA6:58 pmSanta Ana J. Wayne/Orange Cnty
$301
American Airlines
Apr 8
SNA2:47 pmSanta Ana J. Wayne/Orange Cnty
7h 02m
1 stop
DSM11:49 pmDes Moines
Apr 12
DSM6:00 amDes Moines
8h 38m
1 stop
SNA12:38 pmSanta Ana J. Wayne/Orange Cnty
$328
American Airlines
Apr 23
SNA1:36 pmSanta Ana J. Wayne/Orange Cnty
8h 13m
1 stop
DSM11:49 pmDes Moines
Apr 26
DSM6:26 pmDes Moines
5h 39m
1 stop
SNA10:05 pmSanta Ana J. Wayne/Orange Cnty
$329

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Santa Ana to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

9:50 am-3:06 pm

Nonstop3h 16m

Des Moines

Mon 3/23

7:00 am-8:55 am

Nonstop3h 55m

$140

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

9:50 am-3:06 pm

Nonstop3h 16m

Des Moines

Mon 3/23

7:00 am-8:55 am

Nonstop3h 55m

$148

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 4/24

12:26 pm-5:43 pm

Nonstop3h 17m

Des Moines

Mon 4/27

9:45 am-11:36 am

Nonstop3h 51m

$193

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 4/10

12:41 pm-5:58 pm

Nonstop3h 17m

Des Moines

Mon 4/13

3:32 pm-9:13 pm

1 stop7h 41m

$216

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 3/27

6:45 am-7:16 pm

2 stops34h 31m

Des Moines

Mon 4/6

9:45 pm-9:53 am

1 stop14h 08m

$227

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 3/27

6:45 am-7:16 pm

2 stops34h 31m

Des Moines

Mon 4/6

8:00 am-9:51 am

Nonstop3h 51m

$228

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 3/27

9:45 am-3:02 pm

Nonstop3h 17m

Des Moines

Mon 4/6

8:00 am-9:51 am

Nonstop3h 51m

$229

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

9:50 am-3:06 pm

Nonstop3h 16m

Des Moines

Mon 3/23

3:32 pm-3:33 pm

1 stop26h 01m

$231

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 4/24

7:25 am-9:24 pm

1 stop11h 59m

Des Moines

Mon 4/27

9:45 am-11:36 am

Nonstop3h 51m

$236

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 3/26

2:53 pm-7:16 pm

2 stops26h 23m

Des Moines

Mon 4/6

9:45 pm-9:53 am

1 stop14h 08m

$245

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then September is your next best option. Flight prices from Santa Ana to Des Moines during September average around $198.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana to Des Moines is on a Monday. Travelers who choose to depart for Des Moines on a Monday will often find tickets for as low as $341. Flights from Santa Ana to Des Moines on a Sunday will generally be more expensive and average around $534. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana J. Wayne/Orange Cnty to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana J. Wayne/Orange Cnty to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santa Ana to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Santa Ana to Des Moines.

How have Santa Ana to Des Moines flight prices changed over time?

As of February 2026, prices for Santa Ana to Des Moines flights are approximately 3% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Des Moines

Best Price Found

$190

Fastest flight time

3h 16m

Direct flights

Tue and Sat

Airports in Des Moines

1 airport
The best flight deal from Santa Ana to Des Moines found on momondo in the last 72 hours is $190
The fastest flight from Santa Ana to Des Moines takes 3h 16m
Direct flights go from Santa Ana to Des Moines on Tuesday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Des Moines. From Santa Ana there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 16m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana to Des Moines?

  • What is the most popular airline from Santa Ana to Des Moines?

Best airlines flying from Santa Ana to Des Moines

Compare and see reviews for airlines that fly from Santa Ana to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $119Free CancellationRating
7.2
714 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,345 reviews
Search American Airlines flights
United AirlinesPriceFrom $446Free CancellationRating
7.4
9,343 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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