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Cheap flights from Santa Ana to Des Moines from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Des Moines departing on 5/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
$134Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
$137Allegiant Air
Thu, Sep 3 - Sun, Sep 6
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
$140Allegiant Air
Thu, Sep 3 - Sun, Sep 6
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
$141Allegiant Air
Thu, Sep 3 - Sun, Sep 6
Allegiant Air Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
$147Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
$151Allegiant Air
Thu, Sep 3 - Thu, Sep 10
Allegiant Air Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
Allegiant Air Logo
8:00 am - 9:42 am
DSM
-
SNA
3h 42mnonstop
$156Allegiant Air
Thu, May 21 - Sun, May 24
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
$161Allegiant Air
Thu, Sep 3 - Thu, Sep 10
Allegiant Air Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
Allegiant Air Logo
8:00 am - 9:42 am
DSM
-
SNA
3h 42mnonstop
$162Allegiant Air
Thu, May 21 - Sun, May 24
Allegiant Air Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
Allegiant Air Logo
8:00 am - 9:42 am
DSM
-
SNA
3h 42mnonstop
$171Allegiant Air
Thu, May 21 - Sun, May 24

Allegiant Air flights from Santa Ana to Des Moines

Our best Allegiant Air deals on Santa Ana to Des Moines flight tickets
Allegiant Air
May 8
SNA12:41 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:58 pmDes Moines
May 11
DSM10:00 amDes Moines
3h 51m
SNA11:51 amSanta Ana J. Wayne/Orange Cnty
$134
Allegiant Air
Sep 3
SNA12:27 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:44 pmDes Moines
Sep 6
DSM10:00 amDes Moines
3h 37m
SNA11:37 amSanta Ana J. Wayne/Orange Cnty
$137
Allegiant Air
Sep 3
SNA12:27 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:44 pmDes Moines
Sep 6
DSM10:00 amDes Moines
3h 37m
SNA11:37 amSanta Ana J. Wayne/Orange Cnty
$140

United Airlines flights from Santa Ana to Des Moines

Our best United Airlines deals on Santa Ana to Des Moines flight tickets
United Airlines
Aug 19
SNA4:00 pmSanta Ana J. Wayne/Orange Cnty
5h 55m
1 stop
DSM11:55 pmDes Moines
Aug 26
DSM5:50 amDes Moines
8h 16m
2 stops
SNA12:06 pmSanta Ana J. Wayne/Orange Cnty
$244
United Airlines
Apr 23
SNA12:15 pmSanta Ana J. Wayne/Orange Cnty
8h 28m
1 stop
DSM10:43 pmDes Moines
Apr 26
DSM5:30 amDes Moines
8h 48m
2 stops
SNA12:18 pmSanta Ana J. Wayne/Orange Cnty
$662
United Airlines
Apr 23
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
10h 07m
2 stops
DSM11:17 pmDes Moines
Apr 26
DSM5:30 amDes Moines
8h 48m
2 stops
SNA12:18 pmSanta Ana J. Wayne/Orange Cnty
$667

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Santa Ana to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

12:41 pm-5:58 pm

Nonstop3h 17m

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

$134
Quickest round-trip

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

12:27 pm-5:44 pm

Nonstop3h 17m

Des Moines

Sun 9/6

10:00 am-11:37 am

Nonstop3h 37m

$137

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

12:27 pm-5:44 pm

Nonstop3h 17m

Des Moines

Sun 9/6

10:00 am-11:37 am

Nonstop3h 37m

$140

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

12:27 pm-5:44 pm

Nonstop3h 17m

Des Moines

Sun 9/6

10:00 am-11:37 am

Nonstop3h 37m

$141

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

12:41 pm-5:58 pm

Nonstop3h 17m

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

$147

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

12:27 pm-5:44 pm

Nonstop3h 17m

Des Moines

Thu 9/10

10:00 am-11:37 am

Nonstop3h 37m

$151

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

Des Moines

Sun 5/24

8:00 am-9:42 am

Nonstop3h 42m

$156

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

12:27 pm-5:44 pm

Nonstop3h 17m

Des Moines

Thu 9/10

10:00 am-11:37 am

Nonstop3h 37m

$161

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

Des Moines

Sun 5/24

8:00 am-9:42 am

Nonstop3h 42m

$162

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

Des Moines

Sun 5/24

8:00 am-9:42 am

Nonstop3h 42m

$171

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then April is your next best option. Flight prices from Santa Ana to Des Moines during April average around $188.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $349. Flights from Santa Ana to Des Moines on a Sunday will generally be more expensive and average around $478. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana J. Wayne/Orange Cnty to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana J. Wayne/Orange Cnty to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santa Ana to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Santa Ana to Des Moines.

How have Santa Ana to Des Moines flight prices changed over time?

As of April 2026, prices for Santa Ana to Des Moines flights are approximately 208% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Des Moines

Best Price Found

$154

Fastest flight time

3h 14m

Direct flights

Mon, Tue, Fri and Sat

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Santa Ana in the past 72 hours is $154. The best round-trip flight deal from Santa Ana to Des Moines found on momondo in the last 72 hours is $196.
The fastest flight from Santa Ana to Des Moines takes 3h 14m
Direct flights go from Santa Ana to Des Moines on Monday, Tuesday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Santa Ana there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Santa Ana to Des Moines

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 14m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana to Des Moines?

  • What is the most popular airline from Santa Ana to Des Moines?

Best airlines flying from Santa Ana to Des Moines

Compare and see reviews for airlines that fly from Santa Ana to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $124Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $300Free CancellationRating
7.1
11,569 reviews
Search American Airlines flights
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,579 reviews
Search United Airlines flights

  • Allegiant Air Flights From Santa Ana to Des Moines

    Allegiant Air is one of the most popular airlines flying from Santa Ana to Des Moines, operating 2 flights/week on average for this route. A good Allegiant Air flight deal for Santa Ana to Des Moines starts from $124 round-trip, up to an average price of $197. Our users have rated Allegiant Air at 7.3/10.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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