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Cheap flights from Santa Ana, California to Des Moines from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Des Moines departing on 3/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana, California to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:45 am - 3:01 pm
SNA
-
DSM
3h 16mnonstop
Allegiant Air Logo
7:00 am - 8:55 am
DSM
-
SNA
3h 55mnonstop
$144Allegiant Air
vie., mar. 6 - lun., mar. 9
Allegiant Air Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
Allegiant Air Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
$152Allegiant Air
jue., ene. 22 - dom., ene. 25
Multiple Airlines Logo
9:45 am - 3:01 pm
SNA
-
DSM
3h 16mnonstop
Multiple Airlines Logo
8:21 pm - 8:55 am
DSM
-
SNA
38h 34m2 stops
$183Multiple Airlines
vie., mar. 6 - lun., mar. 9
Multiple Airlines Logo
4:37 pm - 10:51 pm
SNA
-
DSM
28h 14m1 stop
Multiple Airlines Logo
7:45 pm - 10:46 am
DSM
-
SNA
17h 01m1 stop
$185Multiple Airlines
jue., feb. 19 - dom., feb. 22
Frontier Logo
7:25 pm - 6:19 pm
SNA
-
DSM
20h 54m2 stops
Frontier Logo
7:45 pm - 10:46 am
DSM
-
SNA
17h 01m1 stop
$186Frontier
jue., feb. 19 - dom., feb. 22
Multiple Airlines Logo
4:37 pm - 6:47 pm
SNA
-
DSM
24h 10m2 stops
Multiple Airlines Logo
7:27 pm - 10:46 am
DSM
-
SNA
17h 19m1 stop
$196Multiple Airlines
mié., feb. 11 - dom., feb. 15
Multiple Airlines Logo
9:45 am - 3:01 pm
SNA
-
DSM
3h 16mnonstop
Multiple Airlines Logo
3:32 pm - 12:25 pm
DSM
-
SNA
22h 53m1 stop
$214Multiple Airlines
vie., mar. 6 - lun., mar. 9
Multiple Airlines Logo
2:39 pm - 3:40 pm
SNA
-
DSM
23h 01m1 stop
Multiple Airlines Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
$219Multiple Airlines
jue., ene. 22 - dom., ene. 25
Multiple Airlines Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
Multiple Airlines Logo
8:30 am - 2:11 pm
DSM
-
SNA
31h 41m2 stops
$220Multiple Airlines
jue., ene. 22 - dom., ene. 25
Multiple Airlines Logo
1:20 pm - 2:42 pm
SNA
-
DSM
23h 22m1 stop
Multiple Airlines Logo
7:27 pm - 10:46 am
DSM
-
SNA
17h 19m1 stop
$236Multiple Airlines
mié., feb. 11 - dom., feb. 15

American Airlines flights from Santa Ana, California to Des Moines

Our best American Airlines deals on Santa Ana, California to Des Moines flight tickets
American Airlines
Apr 3
SNA3:24 pmSanta Ana J. Wayne/Orange Cnty
6h 24m
1 stop
DSM11:48 pmDes Moines
Apr 7
DSM1:38 pmDes Moines
9h 36m
1 stop
SNA9:14 pmSanta Ana J. Wayne/Orange Cnty
$322
American Airlines
Jan 11
SNA8:05 amSanta Ana J. Wayne/Orange Cnty
6h 19m
1 stop
DSM4:24 pmDes Moines
Jan 14
DSM5:51 pmDes Moines
7h 05m
1 stop
SNA10:56 pmSanta Ana J. Wayne/Orange Cnty
$796

United Airlines flights from Santa Ana, California to Des Moines

Our best United Airlines deals on Santa Ana, California to Des Moines flight tickets
United Airlines
Feb 11
SNA10:00 amSanta Ana J. Wayne/Orange Cnty
11h 44m
2 stops
DSM11:44 pmDes Moines
Feb 15
DSM5:30 amDes Moines
8h 48m
2 stops
SNA12:18 pmSanta Ana J. Wayne/Orange Cnty
$333
United Airlines
Feb 10
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 02m
1 stop
DSM5:47 pmDes Moines
Feb 13
DSM7:52 amDes Moines
8h 19m
1 stop
SNA2:11 pmSanta Ana J. Wayne/Orange Cnty
$402
United Airlines
Apr 3
SNA7:00 amSanta Ana J. Wayne/Orange Cnty
7h 15m
1 stop
DSM4:15 pmDes Moines
Apr 7
DSM8:04 amDes Moines
11h 29m
2 stops
SNA5:33 pmSanta Ana J. Wayne/Orange Cnty
$407

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 8, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

vie. 3/6

9:45 am-3:01 pm

Nonstop3h 16m

Des Moines

lun. 3/9

7:00 am-8:55 am

Nonstop3h 55m

$144

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

jue. 1/22

9:37 am-3:03 pm

Nonstop3h 26m

Des Moines

dom. 1/25

7:00 am-8:47 am

Nonstop3h 47m

$152

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

vie. 3/6

9:45 am-3:01 pm

Nonstop3h 16m

Des Moines

lun. 3/9

8:21 pm-8:55 am

2 stops38h 34m

$183

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

jue. 2/19

4:37 pm-10:51 pm

1 stop28h 14m

Des Moines

dom. 2/22

7:45 pm-10:46 am

1 stop17h 01m

$185

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

jue. 2/19

7:25 pm-6:19 pm

2 stops20h 54m

Des Moines

dom. 2/22

7:45 pm-10:46 am

1 stop17h 01m

$186

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

mié. 2/11

4:37 pm-6:47 pm

2 stops24h 10m

Des Moines

dom. 2/15

7:27 pm-10:46 am

1 stop17h 19m

$196

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

vie. 3/6

9:45 am-3:01 pm

Nonstop3h 16m

Des Moines

lun. 3/9

3:32 pm-12:25 pm

1 stop22h 53m

$214

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

jue. 1/22

2:39 pm-3:40 pm

1 stop23h 01m

Des Moines

dom. 1/25

7:00 am-8:47 am

Nonstop3h 47m

$219

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

jue. 1/22

9:37 am-3:03 pm

Nonstop3h 26m

Des Moines

dom. 1/25

8:30 am-2:11 pm

2 stops31h 41m

$220

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

mié. 2/11

1:20 pm-2:42 pm

1 stop23h 22m

Des Moines

dom. 2/15

7:27 pm-10:46 am

1 stop17h 19m

$236

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana, California to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then September is your next best option. Flight prices from Santa Ana, California to Des Moines during September average around $198.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana, California to Des Moines is on a Friday. Travelers who choose to depart for Des Moines on a Friday will often find tickets for as low as $349. Flights from Santa Ana, California to Des Moines on a Sunday will generally be more expensive and average around $534. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana J. Wayne/Orange Cnty to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana J. Wayne/Orange Cnty to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Santa Ana, California to Des Moines flight prices changed over time?

As of January 2026, prices for Santa Ana, California to Des Moines flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Des Moines

Best Price Found

$92

Fastest flight time

3h 16m

Direct flights

Mon, Tue, Fri and Sat

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Santa Ana, California in the past 72 hours is $92. The best round-trip flight deal from Santa Ana, California to Des Moines found on momondo in the last 72 hours is $153.
The fastest flight from Santa Ana, California to Des Moines takes 3h 16m
Direct flights go from Santa Ana, California to Des Moines on Monday, Tuesday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Santa Ana, California there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 16m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana, California to Des Moines?

  • What is the most popular airline from Santa Ana, California to Des Moines?

Best airlines flying from Santa Ana, California to Des Moines

Compare and see reviews for airlines that fly from Santa Ana, California to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $114Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $276Free CancellationRating
7.2
11,094 reviews
Search American Airlines flights
SouthwestPriceFrom $352Free CancellationRating
8.0
4,250 reviews
Search Southwest flights
United AirlinesPriceFrom $446Free CancellationRating
7.4
9,139 reviews
Search United Airlines flights

  • Allegiant Air Flights From Santa Ana, California to Des Moines

    Allegiant Air is one of the most popular airlines flying from Santa Ana, California to Des Moines, operating 1 flight/week on average for this route. A good Allegiant Air flight deal for Santa Ana, California to Des Moines starts from $114 round-trip, up to an average price of $188. Our users have rated Allegiant Air at 7.2/10.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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