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Cheap flights from Santa Ana to Des Moines from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Des Moines departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
11:37 am - 4:59 pmSNA-DSM
3h 22mnonstop
Allegiant Air Logo
9:00 am - 10:47 amDSM-SNA
3h 47mnonstop
$114Allegiant Air
Find Deal
Thu, Nov 13 - Sun, Nov 16
Allegiant Air Logo
11:25 am - 4:44 pmSNA-DSM
3h 19mnonstop
Allegiant Air Logo
9:00 am - 10:47 amDSM-SNA
3h 47mnonstop
$156Allegiant Air
Find Deal
Sun, Nov 2 - Sun, Nov 9
Multiple Airlines Logo
11:37 am - 4:59 pmSNA-DSM
3h 22mnonstop
Multiple Airlines Logo
2:32 pm - 11:16 amDSM-SNA
22h 44m1 stop
$163Multiple Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
Multiple Airlines Logo
1:49 pm - 1:49 pmSNA-DSM
22h 00m2 stops
Multiple Airlines Logo
9:00 am - 10:47 amDSM-SNA
3h 47mnonstop
$184Multiple Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
Multiple Airlines Logo
11:25 am - 4:44 pmSNA-DSM
3h 19mnonstop
Multiple Airlines Logo
2:32 pm - 1:30 pmDSM-SNA
24h 58m1 stop
$186Multiple Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
Frontier Logo
1:49 pm - 1:49 pmSNA-DSM
22h 00m2 stops
Frontier Logo
2:32 pm - 11:16 amDSM-SNA
22h 44m1 stop
$198Frontier
Find Deal
Thu, Nov 13 - Sun, Nov 16
Frontier Logo
7:11 pm - 1:47 pmSNA-DSM
16h 36m2 stops
Frontier Logo
2:32 pm - 11:16 amDSM-SNA
22h 44m1 stop
$251Frontier
Find Deal
Sun, Nov 2 - Sun, Nov 9
American Airlines Logo
8:15 am - 6:46 pmSNA-DSM
8h 31m1 stop
American Airlines Logo
5:00 am - 9:53 amDSM-SNA
6h 53m1 stop
$261American Airlines
Find Deal
Fri, Oct 31 - Tue, Nov 4
American Airlines Logo
6:45 am - 4:51 pmSNA-DSM
8h 06m2 stops
American Airlines Logo
4:02 pm - 9:39 pmDSM-SNA
7h 37m1 stop
$266American Airlines
Find Deal
Tue, Nov 4 - Tue, Nov 11
Delta Logo
12:26 pm - 10:30 pmSNA-DSM
8h 04m1 stop
Delta Logo
7:03 am - 12:54 pmDSM-SNA
7h 51m1 stop
$309Delta
Find Deal
Sat, Nov 1 - Wed, Nov 5

Alaska Airlines flights from Santa Ana to Des Moines

Our best Alaska Airlines deals on Santa Ana to Des Moines flight tickets
Alaska Airlines
Oct 11
SNA10:17 amSanta Ana J. Wayne/Orange Cnty
11h 06m
2 stops
DSM11:23 pmDes Moines
Oct 18
DSM7:30 amDes Moines
11h 27m
2 stops
SNA4:57 pmSanta Ana J. Wayne/Orange Cnty
$735
Find similar
Alaska Airlines
Oct 14
SNA10:17 amSanta Ana J. Wayne/Orange Cnty
11h 45m
2 stops
DSM12:02 amDes Moines
Oct 15
DSM5:00 amDes Moines
11h 17m
2 stops
SNA2:17 pmSanta Ana J. Wayne/Orange Cnty
$743
Find similar
Alaska Airlines
Oct 17
SNA10:17 amSanta Ana J. Wayne/Orange Cnty
11h 06m
2 stops
DSM11:23 pmDes Moines
Oct 19
DSM5:00 amDes Moines
11h 17m
2 stops
SNA2:17 pmSanta Ana J. Wayne/Orange Cnty
$835
Find similar

Allegiant Air flights from Santa Ana to Des Moines

Our best Allegiant Air deals on Santa Ana to Des Moines flight tickets
Allegiant Air
Nov 13
SNA11:37 amSanta Ana J. Wayne/Orange Cnty
3h 22m
DSM4:59 pmDes Moines
Nov 16
DSM9:00 amDes Moines
3h 47m
SNA10:47 amSanta Ana J. Wayne/Orange Cnty
$114
Find similar
Allegiant Air
Nov 2
SNA11:25 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM4:44 pmDes Moines
Nov 9
DSM9:00 amDes Moines
3h 47m
SNA10:47 amSanta Ana J. Wayne/Orange Cnty
$156
Find similar
Allegiant Air
Oct 23
SNA10:25 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:44 pmDes Moines
Oct 26
DSM8:00 amDes Moines
3h 35m
SNA9:35 amSanta Ana J. Wayne/Orange Cnty
$275
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 6, 2025.
Use the filters below to find and compare flights from Santa Ana to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

11:37 am-4:59 pm

Nonstop3h 22m

Des Moines

Sun 11/16

9:00 am-10:47 am

Nonstop3h 47m

$114

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

11:25 am-4:44 pm

Nonstop3h 19m

Des Moines

Sun 11/9

9:00 am-10:47 am

Nonstop3h 47m

$156

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

11:37 am-4:59 pm

Nonstop3h 22m

Des Moines

Sun 11/16

2:32 pm-11:16 am

1 stop22h 44m

$163

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

1:49 pm-1:49 pm

2 stops22h 00m

Des Moines

Sun 11/16

9:00 am-10:47 am

Nonstop3h 47m

$184

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 10/30

11:25 am-4:44 pm

Nonstop3h 19m

Des Moines

Mon 11/3

2:32 pm-1:30 pm

1 stop24h 58m

$186

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

1:49 pm-1:49 pm

2 stops22h 00m

Des Moines

Sun 11/16

2:32 pm-11:16 am

1 stop22h 44m

$198

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

7:11 pm-1:47 pm

2 stops16h 36m

Des Moines

Sun 11/9

2:32 pm-11:16 am

1 stop22h 44m

$251

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 10/31

8:15 am-6:46 pm

1 stop8h 31m

Des Moines

Tue 11/4

5:00 am-9:53 am

1 stop6h 53m

$261

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

6:45 am-4:51 pm

2 stops8h 06m

Des Moines

Tue 11/11

4:02 pm-9:39 pm

1 stop7h 37m

$266

Santa AnaDes Moines

SNA - DSM

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sat 11/1

12:26 pm-10:30 pm

1 stop8h 04m

Des Moines

Wed 11/5

7:03 am-12:54 pm

1 stop7h 51m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Ana to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from Santa Ana to Des Moines during September average around $198.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Santa Ana to Des Moines is on a Friday. Travelers who choose to depart for Des Moines on a Friday will often find tickets for as low as $228. Flights from Santa Ana to Des Moines on a Monday will generally be more expensive and average around $434. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Santa Ana to Des Moines in the morning for as low as $305. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $484. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Santa Ana J. Wayne/Orange Cnty to Des Moines flight route?

Fly from Santa Ana J. Wayne/Orange Cnty to Des Moines for the best Santa Ana J. Wayne/Orange Cnty - Des Moines flight prices

What cabin class options are available on Santa Ana J. Wayne/Orange Cnty to Des Moines flights?

There is only 1 cabin class available to choose from on Santa Ana J. Wayne/Orange Cnty to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Santa Ana to Des Moines flight prices changed over time?

As of October 2025, prices for Santa Ana to Des Moines flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Des Moines (SNA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Des Moines

Best Price Found

$84

Fastest flight time

3h 17m

Direct flights

Mon, Wed, Fri and Sun

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Santa Ana in the past 72 hours is $84. The best round-trip flight deal from Santa Ana to Des Moines found on momondo in the last 72 hours is $181.
The fastest flight from Santa Ana to Des Moines takes 3h 17m
Direct flights go from Santa Ana to Des Moines on Monday, Wednesday, Friday and Sunday. The only airline offering direct flights is Allegiant Air.
There is 1 airport near Des Moines: Des Moines (DSM)
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Des Moines by plane?

    A flight from Santa Ana J. Wayne/Orange Cnty to Des Moines will travel around 1425.0 mi. By plane, this route typically takes 3h 18m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Santa Ana to Des Moines?

  • What is the most popular airline from Santa Ana to Des Moines?

Best airlines flying from Santa Ana to Des Moines

Compare and see reviews for airlines that fly from Santa Ana to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $114Free CancellationRating
7.2
697 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,044 reviews
Search American Airlines flights
SouthwestPriceFrom $358Free CancellationRating
8.0
4,232 reviews
Search Southwest flights
United AirlinesPriceFrom $446Free CancellationRating
7.4
8,955 reviews
Search United Airlines flights

  • Southwest Flights From Santa Ana to Des Moines

    Southwest is one of the most popular airlines flying from Santa Ana to Des Moines, operating 1 flight/week on average for this route. A good Southwest flight deal for Santa Ana to Des Moines starts from $358 round-trip, up to an average price of $449. Our users have rated Southwest at 8.0/10.

  • Allegiant Air Flights From Santa Ana to Des Moines

    Allegiant Air is also a popular choice for this route. Allegiant Air flight deals for Santa Ana to Des Moines start from as low as $114 round-trip, depending on your selected dates, with average Allegiant Air deals seen on momondo around $197. Allegiant Air operates 2 flights to Des Moines from Santa Ana in an average week. Users have rated it 7.2/10 across 697 reviews.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Santa Ana with this policy.

How can momondo help me find flights from Santa Ana to Des Moines?

Once all potential Santa Ana to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Ana to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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