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Cheap flights from San Diego to Florida Keys from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Florida Keys departing on 4/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to Florida Keys

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:55 am - 12:47 am
SAN
-
MIA
14h 52m
2 stops
Frontier Logo
5:50 am - 12:08 am
MIA
-
SAN
21h 18m
1 stop
$258Frontier
Thu, Mar 12 - Tue, Mar 17
Frontier Logo
8:25 am - 5:38 am
SAN
-
MIA
18h 13m
1 stop
Frontier Logo
5:05 am - 11:40 pm
MIA
-
SAN
21h 35m
2 stops
$259Frontier
Tue, Mar 10 - Sat, Mar 14
Frontier Logo
11:59 am - 5:14 am
SAN
-
MIA
14h 15m
1 stop
Frontier Logo
4:25 pm - 12:16 am
MIA
-
SAN
10h 51m
1 stop
$260Frontier
Thu, Feb 26 - Sat, Mar 7
Frontier Logo
9:45 am - 9:09 pm
SAN
-
MIA
8h 24m
1 stop
Frontier Logo
7:17 pm - 9:41 pm
MIA
-
SAN
29h 24m
2 stops
$261Frontier
Fri, Feb 27 - Mon, Mar 2
Multiple Airlines Logo
6:25 am - 12:16 pm
SAN
-
MIA
26h 51m
2 stops
Multiple Airlines Logo
6:40 am - 10:26 am
MIA
-
SAN
30h 46m
1 stop
$264Multiple Airlines
Mon, Feb 16 - Fri, Feb 20
Multiple Airlines Logo
9:45 am - 2:56 pm
SAN
-
MIA
26h 11m
1 stop
Multiple Airlines Logo
6:25 am - 12:08 am
MIA
-
SAN
20h 43m
1 stop
$266Multiple Airlines
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
8:15 am - 10:57 pm
SAN
-
EYW
11h 42m
2 stops
American Airlines Logo
6:45 am - 11:16 am
EYW
-
SAN
7h 31m
1 stop
$290American Airlines
Wed, May 6 - Tue, May 12
American Airlines Logo
12:53 pm - 10:57 pm
SAN
-
EYW
7h 04m
1 stop
American Airlines Logo
6:45 am - 11:16 am
EYW
-
SAN
7h 31m
1 stop
$312American Airlines
Wed, May 6 - Tue, May 12
United Airlines Logo
10:59 am - 10:09 pm
SAN
-
EYW
8h 10m
1 stop
United Airlines Logo
4:34 pm - 10:00 pm
EYW
-
SAN
8h 26m
1 stop
$397United Airlines
Thu, Feb 19 - Sat, Feb 21
United Airlines Logo
10:59 am - 10:09 pm
SAN
-
EYW
8h 10m
1 stop
United Airlines Logo
4:34 pm - 11:40 pm
EYW
-
SAN
10h 06m
2 stops
$403United Airlines
Thu, Feb 19 - Sat, Feb 21

Frontier flights from San Diego to Florida Keys

Our best Frontier deals on San Diego to Florida Keys flight tickets
Frontier
Feb 4
SAN7:00 amSan Diego
10h 59m
1 stop
MIA8:59 pmMiami
Mar 9
MIA12:12 pmMiami
12h 55m
1 stop
SAN10:07 pmSan Diego
$260
Frontier
Feb 27
SAN9:45 amSan Diego
8h 24m
1 stop
MIA9:09 pmMiami
Mar 2
MIA7:17 pmMiami
29h 24m
2 stops
SAN9:41 pmSan Diego
$261
Frontier
Feb 12
SAN6:25 amSan Diego
19h 49m
1 stop
MIA5:14 amMiami
Feb 18
MIA6:25 amMiami
18h 16m
1 stop
SAN9:41 pmSan Diego
$262

American Airlines flights from San Diego to Florida Keys

Our best American Airlines deals on San Diego to Florida Keys flight tickets
American Airlines
May 6
SAN8:15 amSan Diego
11h 42m
2 stops
EYW10:57 pmKey West
May 12
EYW6:45 amKey West
7h 31m
1 stop
SAN11:16 amSan Diego
$290
American Airlines
Mar 3
SAN10:30 pmSan Diego
4h 51m
MIA6:21 amMiami
Mar 10
MIA1:55 pmMiami
10h 44m
1 stop
SAN9:39 pmSan Diego
$311
American Airlines
May 6
SAN12:53 pmSan Diego
7h 04m
1 stop
EYW10:57 pmKey West
May 12
EYW6:45 amKey West
7h 31m
1 stop
SAN11:16 amSan Diego
$312

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from San Diego to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Thu 3/12

6:55 am-12:47 am

2 stops14h 52m

Miami

Tue 3/17

5:50 am-12:08 am

1 stop21h 18m

$258

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 3/10

8:25 am-5:38 am

1 stop18h 13m

Miami

Sat 3/14

5:05 am-11:40 pm

2 stops21h 35m

$259

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Thu 2/26

11:59 am-5:14 am

1 stop14h 15m

Miami

Sat 3/7

4:25 pm-12:16 am

1 stop10h 51m

$260

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 2/27

9:45 am-9:09 pm

1 stop8h 24m

Miami

Mon 3/2

7:17 pm-9:41 pm

2 stops29h 24m

$261

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Mon 2/16

6:25 am-12:16 pm

2 stops26h 51m

Miami

Fri 2/20

6:40 am-10:26 am

1 stop30h 46m

$264

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 2/18

9:45 am-2:56 pm

1 stop26h 11m

Miami

Sat 2/21

6:25 am-12:08 am

1 stop20h 43m

$266

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Wed 5/6

8:15 am-10:57 pm

2 stops11h 42m

Key West

Tue 5/12

6:45 am-11:16 am

1 stop7h 31m

$290

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Wed 5/6

12:53 pm-10:57 pm

1 stop7h 04m

Key West

Tue 5/12

6:45 am-11:16 am

1 stop7h 31m

$312

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Thu 2/19

10:59 am-10:09 pm

1 stop8h 10m

Key West

Sat 2/21

4:34 pm-10:00 pm

1 stop8h 26m

$397

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Thu 2/19

10:59 am-10:09 pm

1 stop8h 10m

Key West

Sat 2/21

4:34 pm-11:40 pm

2 stops10h 06m

$403

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from San Diego to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of October is another great option to travel to Florida Keys, with average flight prices from San Diego averaging around $409.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from San Diego to Florida Keys is on a Saturday when prices can be found for as low as $517. The most expensive day to fly to Florida Keys is Thursday, with ticket prices averaging around $550.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is at noon. momondo users have found flights departing from San Diego to Florida Keys at noon for as low as $475. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the evening are often more expensive with an average ticket price of $546.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $451 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from San Diego for as low as $403 on momondo.

Can stopping save me money on San Diego to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between San Diego to Florida Keys.

Cheap San Diego to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Florida Keys

Fastest flight time

4h 42m

Direct flights

Every day

Airports in Florida Keys

3 airports
The fastest flight from San Diego to Florida Keys takes 4h 42m
Direct flights go from San Diego to Florida Keys every day.
There are 3 airports in Florida Keys. From San Diego there are direct flights to Miami (MIA).
Search flight deals

  • When did momondo last update prices for flights from San Diego Airport to Florida Keys?

    Prices for flights from San Diego Airport to Florida Keys are updated daily.

  • How many operators does momondo search for flights from San Diego Airport to Florida Keys?

  • How old do you have to be to fly from San Diego Airport to Florida Keys?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from San Diego to Florida Keys?

Best airlines flying from San Diego to Florida Keys

Compare and see reviews for airlines that fly from San Diego to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $269Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $297Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Florida Keys with flexible booking policies on momondo?

Flights from San Diego to Florida Keys with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Diego to Florida Keys?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florida Keys from San Diego.

I’m not ready to book a flight from San Diego to Florida Keys right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Diego to Florida Keys flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Florida Keys trip

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Find better results for your trip to Florida Keys

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Popular flights according to clicks in the last 7 days on momondo
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