Cheap flights from Raleigh to St. Louis from $65

In general, October is the cheapest month to fly from Raleigh to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $350. The month of January is another great option to travel to St. Louis, with average flight prices from Raleigh averaging around $351.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $370. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $431. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Raleigh in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $372 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $526 per ticket.

Fly from Raleigh-Durham to Lambert-St Louis for the best Raleigh-Durham - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Raleigh when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Raleigh for as low as $196 on momondo.

There is only 1 cabin class available to choose from on Raleigh-Durham to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Raleigh to St. Louis.

As of March 2026, prices for Raleigh to St. Louis flights are approximately 17% cheaper when compared to flights at the same time last year.

Southwest, United Airlines, and Delta are the most popular carriers operating from Raleigh-Durham to Lambert-St Louis

Southwest, American Airlines and Delta are the top three most popular airlines that fly to St. Louis from Raleigh according to our data. Southwest is the first choice among our users, with 37% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Nashville (BNA) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Charlotte (CLT) offer the lowest average round-trip price of $212.

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 4h 04m.

Charlotte (CLT) has the shortest average layover time for this route: 0h 57m.

The number of flights available between Raleigh and St. Louis is 1 per day as of March 2026. The most frequent departure time is 6:00AM, with 50% of daily flights leaving at noon.

As of March 2026, there are 10 flights per week flying from Raleigh to St. Louis. The most common day of the week flights depart is Mon, with 20% of flights taking off on this day.