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Cheap flights from Panama City to Greenville from $451

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Panama City to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:00 am - 9:51 amPTY  Panama City Tocumen Intl-GSP Greenville
23h 51m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
7:43 pm - 7:38 pmGSP  Greenville-PTY Panama City Tocumen Intl
23h 55m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
$604United Airlines
Mon, Nov 23 - Fri, Nov 27
Delta Logo
3:30 pm - 10:17 pmPTY  Panama City Tocumen Intl-GSP Greenville
6h 47m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 2:05 pmGSP  Greenville-PTY Panama City Tocumen Intl
8h 35m1 stop Atlanta Hartsfield-Jackson
$604Delta
Mon, Nov 23 - Fri, Nov 27
United Airlines Logo
3:41 pm - 9:59 pmPTY  Panama City Tocumen Intl-GSP Greenville
29h 18m1 stop Houston George Bush Intcntl
United Airlines Logo
7:43 pm - 1:45 pmGSP  Greenville-PTY Panama City Tocumen Intl
19h 02m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
$626United Airlines
Mon, Oct 26 - Fri, Oct 30
United Airlines Logo
3:41 pm - 10:59 pmPTY  Panama City Tocumen Intl-GSP Greenville
30h 18m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
7:43 pm - 7:02 pmGSP  Greenville-PTY Panama City Tocumen Intl
24h 19m2 stops Washington, D.C. Dulles Intl Newark
$626United Airlines
Mon, Oct 26 - Fri, Oct 30
United Airlines Logo
9:45 am - 9:35 amPTY  Panama City Tocumen Intl-GSP Greenville
22h 50m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
11:30 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
9h 01m1 stop Newark
$627United Airlines
Mon, Sep 14 - Wed, Oct 7
United Airlines Logo
9:45 am - 9:35 amPTY  Panama City Tocumen Intl-GSP Greenville
22h 50m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
6:20 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
14h 11m2 stops Chicago O'Hare Intl Newark
$627United Airlines
Tue, Sep 15 - Mon, Oct 5
United Airlines Logo
9:45 am - 9:35 amPTY  Panama City Tocumen Intl-GSP Greenville
22h 50m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
6:00 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
14h 31m1 stop Newark
$627United Airlines
Tue, Sep 15 - Thu, Oct 1
United Airlines Logo
9:45 am - 11:15 pmPTY  Panama City Tocumen Intl-GSP Greenville
12h 30m1 stop Newark
United Airlines Logo
6:00 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
14h 31m1 stop Newark
$627United Airlines
Mon, Sep 14 - Mon, Oct 5
United Airlines Logo
9:45 am - 9:35 amPTY  Panama City Tocumen Intl-GSP Greenville
22h 50m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
6:00 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
14h 31m1 stop Newark
$627United Airlines
Wed, Sep 16 - Mon, Oct 5
United Airlines Logo
9:45 am - 9:35 amPTY  Panama City Tocumen Intl-GSP Greenville
22h 50m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
6:20 am - 7:31 pmGSP  Greenville-PTY Panama City Tocumen Intl
14h 11m2 stops Chicago O'Hare Intl Newark
$627United Airlines
Wed, Sep 16 - Tue, Oct 6

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Delta flights from Panama City to Greenville

Our best Delta deals on Panama City to Greenville flight tickets
Delta
Nov 23
PTY3:30 pmPanama City Tocumen Intl
6h 47m
1 stop
GSP10:17 pmGreenville
Nov 27
GSP5:30 amGreenville
8h 35m
1 stop
PTY2:05 pmPanama City Tocumen Intl
$604
Delta
Sep 14
PTY2:23 pmPanama City Tocumen Intl
7h 32m
1 stop
GSP10:55 pmGreenville
Oct 2
GSP11:53 amGreenville
26h 05m
1 stop
PTY12:58 pmPanama City Tocumen Intl
$704
Delta
Aug 20
PTY2:20 pmPanama City Tocumen Intl
7h 39m
1 stop
GSP10:59 pmGreenville
Aug 25
GSP6:55 amGreenville
7h 00m
1 stop
PTY12:55 pmPanama City Tocumen Intl
$832

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
Oct 26
PTY2:02 pmPanama City Tocumen Intl
7h 50m
1 stop
GSP10:52 pmGreenville
Oct 30
GSP8:08 pmGreenville
17h 54m
1 stop
PTY1:02 pmPanama City Tocumen Intl
$657
American Airlines
Nov 23
PTY3:15 pmPanama City Tocumen Intl
24h 02m
2 stops
GSP3:17 pmGreenville
Nov 27
GSP7:42 pmGreenville
18h 34m
1 stop
PTY2:16 pmPanama City Tocumen Intl
$660
American Airlines
Sep 17
PTY1:16 pmPanama City Tocumen Intl
20h 07m
2 stops
GSP10:23 amGreenville
Oct 4
GSP7:46 pmGreenville
18h 16m
2 stops
PTY1:02 pmPanama City Tocumen Intl
$685

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 11/23

10:00 am-9:51 am

2 stops23h 51m

Greenville

Fri 11/27

7:43 pm-7:38 pm

2 stops23h 55m

$604
Quickest round-trip

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 11/23

3:30 pm-10:17 pm

1 stop6h 47m

Greenville

Fri 11/27

5:30 am-2:05 pm

1 stop8h 35m

$604

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 10/26

3:41 pm-9:59 pm

1 stop29h 18m

Greenville

Fri 10/30

7:43 pm-1:45 pm

2 stops19h 02m

$626

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 10/26

3:41 pm-10:59 pm

2 stops30h 18m

Greenville

Fri 10/30

7:43 pm-7:02 pm

2 stops24h 19m

$626

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 9/14

9:45 am-9:35 am

2 stops22h 50m

Greenville

Wed 10/7

11:30 am-7:31 pm

1 stop9h 01m

$627

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Tue 9/15

9:45 am-9:35 am

2 stops22h 50m

Greenville

Mon 10/5

6:20 am-7:31 pm

2 stops14h 11m

$627

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Tue 9/15

9:45 am-9:35 am

2 stops22h 50m

Greenville

Thu 10/1

6:00 am-7:31 pm

1 stop14h 31m

$627

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 9/14

9:45 am-11:15 pm

1 stop12h 30m

Greenville

Mon 10/5

6:00 am-7:31 pm

1 stop14h 31m

$627

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 9/16

9:45 am-9:35 am

2 stops22h 50m

Greenville

Mon 10/5

6:00 am-7:31 pm

1 stop14h 31m

$627

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 9/16

9:45 am-9:35 am

2 stops22h 50m

Greenville

Tue 10/6

6:20 am-7:31 pm

2 stops14h 11m

$627

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Panama City to Greenville flights?

You could potentially save up to 24% on your flight if you consider stops on a Panama City to Greenville flight.

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Fastest flight time

10h 42m

Direct flights

None
The fastest flight from Panama City to Greenville takes 10h 42m
There are no direct flights from Panama City to Greenville. There are no popular flight routes from Panama City to Greenville.
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Frequently asked questions about flying from Panama City to Greenville

  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 10h 42m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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