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Cheap flights from Panama City to Greenville from $312

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
GSP
9h 10m
1 stop
American Airlines Logo
11:54 am - 12:46 pm
GSP
-
PTY
25h 52m
2 stops
$517American Airlines
Tue, May 5 - Tue, May 12
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
GSP
9h 10m
1 stop
American Airlines Logo
6:45 pm - 12:46 pm
GSP
-
PTY
19h 01m
1 stop
$522American Airlines
Tue, May 5 - Tue, May 12
American Airlines Logo
1:49 pm - 10:19 am
PTY
-
GSP
19h 30m
2 stops
American Airlines Logo
6:05 pm - 12:46 pm
GSP
-
PTY
19h 41m
2 stops
$567American Airlines
Thu, Apr 16 - Sat, May 2
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
GSP
9h 10m
1 stop
American Airlines Logo
6:45 pm - 12:46 pm
GSP
-
PTY
19h 01m
1 stop
$573American Airlines
Thu, Apr 16 - Sat, May 2
United Airlines Logo
10:55 pm - 10:37 am
PTY
-
GSP
10h 42m
1 stop
United Airlines Logo
7:49 pm - 4:04 am
GSP
-
PTY
9h 15m
1 stop
$598United Airlines
Thu, Jul 23 - Mon, Jul 27
United Airlines Logo
10:55 pm - 10:37 am
PTY
-
GSP
10h 42m
1 stop
United Airlines Logo
5:41 pm - 4:12 pm
GSP
-
PTY
23h 31m
2 stops
$603United Airlines
Thu, Jul 23 - Mon, Jul 27
United Airlines Logo
10:55 pm - 5:00 pm
PTY
-
GSP
17h 05m
2 stops
United Airlines Logo
7:40 pm - 2:14 pm
GSP
-
PTY
19h 34m
2 stops
$646United Airlines
Thu, Jul 23 - Mon, Jul 27
United Airlines Logo
3:30 pm - 9:47 am
PTY
-
GSP
17h 17m
2 stops
United Airlines Logo
5:45 pm - 4:12 pm
GSP
-
PTY
23h 27m
2 stops
$667United Airlines
Thu, Apr 30 - Mon, May 4
United Airlines Logo
3:30 pm - 9:47 am
PTY
-
GSP
17h 17m
2 stops
United Airlines Logo
7:00 am - 2:14 pm
GSP
-
PTY
8h 14m
1 stop
$769United Airlines
Thu, Apr 30 - Mon, May 4
United Airlines Logo
10:00 am - 10:14 pm
PTY
-
GSP
11h 14m
1 stop
United Airlines Logo
12:07 pm - 7:31 pm
GSP
-
PTY
8h 24m
1 stop
$1,188United Airlines
Thu, Apr 30 - Mon, May 4

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
May 5
PTY1:49 pmPanama City Tocumen Intl
9h 10m
1 stop
GSP11:59 pmGreenville
May 12
GSP11:54 amGreenville
25h 52m
2 stops
PTY12:46 pmPanama City Tocumen Intl
$517
American Airlines
May 5
PTY1:49 pmPanama City Tocumen Intl
9h 10m
1 stop
GSP11:59 pmGreenville
May 12
GSP6:45 pmGreenville
19h 01m
1 stop
PTY12:46 pmPanama City Tocumen Intl
$522
American Airlines
Apr 16
PTY1:49 pmPanama City Tocumen Intl
19h 30m
2 stops
GSP10:19 amGreenville
May 2
GSP6:05 pmGreenville
19h 41m
2 stops
PTY12:46 pmPanama City Tocumen Intl
$567

United Airlines flights from Panama City to Greenville

Our best United Airlines deals on Panama City to Greenville flight tickets
United Airlines
Jul 23
PTY10:55 pmPanama City Tocumen Intl
10h 42m
1 stop
GSP10:37 amGreenville
Jul 27
GSP7:49 pmGreenville
9h 15m
1 stop
PTY4:04 amPanama City Tocumen Intl
$598
United Airlines
Jul 23
PTY10:55 pmPanama City Tocumen Intl
10h 42m
1 stop
GSP10:37 amGreenville
Jul 27
GSP5:41 pmGreenville
23h 31m
2 stops
PTY4:12 pmPanama City Tocumen Intl
$603
United Airlines
Jul 23
PTY10:55 pmPanama City Tocumen Intl
17h 05m
2 stops
GSP5:00 pmGreenville
Jul 27
GSP7:40 pmGreenville
19h 34m
2 stops
PTY2:14 pmPanama City Tocumen Intl
$646

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 5/5

1:49 pm-11:59 pm

1 stop9h 10m

Greenville

Tue 5/12

11:54 am-12:46 pm

2 stops25h 52m

$517

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 5/5

1:49 pm-11:59 pm

1 stop9h 10m

Greenville

Tue 5/12

6:45 pm-12:46 pm

1 stop19h 01m

$522

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/16

1:49 pm-10:19 am

2 stops19h 30m

Greenville

Sat 5/2

6:05 pm-12:46 pm

2 stops19h 41m

$567

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/16

1:49 pm-11:59 pm

1 stop9h 10m

Greenville

Sat 5/2

6:45 pm-12:46 pm

1 stop19h 01m

$573

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 7/23

10:55 pm-10:37 am

1 stop10h 42m

Greenville

Mon 7/27

7:49 pm-4:04 am

1 stop9h 15m

$598

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 7/23

10:55 pm-10:37 am

1 stop10h 42m

Greenville

Mon 7/27

5:41 pm-4:12 pm

2 stops23h 31m

$603

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 7/23

10:55 pm-5:00 pm

2 stops17h 05m

Greenville

Mon 7/27

7:40 pm-2:14 pm

2 stops19h 34m

$646

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/30

3:30 pm-9:47 am

2 stops17h 17m

Greenville

Mon 5/4

5:45 pm-4:12 pm

2 stops23h 27m

$667

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/30

3:30 pm-9:47 am

2 stops17h 17m

Greenville

Mon 5/4

7:00 am-2:14 pm

1 stop8h 14m

$769
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/30

10:00 am-10:14 pm

1 stop11h 14m

Greenville

Mon 5/4

12:07 pm-7:31 pm

1 stop8h 24m

$1,188

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Greenville?

American Airlines is the most popular carrier operating from Panama City Tocumen Intl to Greenville

What airlines fly to Greenville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Greenville from Panama City according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Fastest flight time

8h 26m

Direct flights

None
The fastest flight from Panama City to Greenville takes 8h 26m
There are no direct flights from Panama City to Greenville. There are no popular flight routes from Panama City to Greenville.
Search flight deals

  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 8h 26m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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