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Cheap flights from Panama City to Greenville from $423

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 5/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:40 pm - 11:16 pm
PTY
-
GSP
6h 36m
1 stop
American Airlines Logo
8:40 pm - 2:00 pm
GSP
-
PTY
18h 20m
2 stops
$532American Airlines
Wed, Sep 30 - Sun, Oct 4
Delta Logo
2:15 pm - 11:43 pm
PTY
-
GSP
8h 28m
1 stop
Delta Logo
6:45 am - 12:50 pm
GSP
-
PTY
7h 05m
1 stop
$617Delta
Thu, May 21 - Fri, Jun 5
United Airlines Logo
9:45 am - 11:05 pm
PTY
-
GSP
12h 20m
1 stop
United Airlines Logo
6:30 am - 7:31 pm
GSP
-
PTY
14h 01m
1 stop
$620United Airlines
Tue, Sep 22 - Thu, Sep 24
United Airlines Logo
9:45 am - 11:29 pm
PTY
-
GSP
12h 44m
1 stop
United Airlines Logo
6:30 am - 7:31 pm
GSP
-
PTY
14h 01m
1 stop
$632United Airlines
Wed, Sep 30 - Sun, Oct 4
American Airlines Logo
1:14 pm - 10:08 am
PTY
-
GSP
19h 54m
2 stops
American Airlines Logo
7:32 pm - 12:13 pm
GSP
-
PTY
17h 41m
2 stops
$649American Airlines
Thu, May 21 - Fri, Jun 5
United Airlines Logo
9:45 am - 9:43 am
PTY
-
GSP
22h 58m
2 stops
United Airlines Logo
11:18 am - 7:31 pm
GSP
-
PTY
9h 13m
1 stop
$667United Airlines
Tue, Sep 22 - Thu, Sep 24
United Airlines Logo
3:30 pm - 5:02 pm
PTY
-
GSP
24h 32m
2 stops
United Airlines Logo
5:41 pm - 2:14 pm
GSP
-
PTY
21h 33m
2 stops
$685United Airlines
Tue, Sep 22 - Thu, Sep 24
Multiple Airlines Logo
5:55 pm - 7:04 pm
PTY
-
GSP
24h 09m
3 stops
Multiple Airlines Logo
6:35 pm - 2:15 pm
GSP
-
PTY
20h 40m
3 stops
$1,941Multiple Airlines
Thu, May 21 - Fri, Jun 5

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
Sep 30
PTY3:40 pmPanama City Tocumen Intl
6h 36m
1 stop
GSP11:16 pmGreenville
Oct 4
GSP8:40 pmGreenville
18h 20m
2 stops
PTY2:00 pmPanama City Tocumen Intl
$532
American Airlines
May 21
PTY1:14 pmPanama City Tocumen Intl
19h 54m
2 stops
GSP10:08 amGreenville
Jun 5
GSP7:32 pmGreenville
17h 41m
2 stops
PTY12:13 pmPanama City Tocumen Intl
$649

United Airlines flights from Panama City to Greenville

Our best United Airlines deals on Panama City to Greenville flight tickets
United Airlines
Sep 22
PTY9:45 amPanama City Tocumen Intl
12h 20m
1 stop
GSP11:05 pmGreenville
Sep 24
GSP6:30 amGreenville
14h 01m
1 stop
PTY7:31 pmPanama City Tocumen Intl
$620
United Airlines
Sep 30
PTY9:45 amPanama City Tocumen Intl
12h 44m
1 stop
GSP11:29 pmGreenville
Oct 4
GSP6:30 amGreenville
14h 01m
1 stop
PTY7:31 pmPanama City Tocumen Intl
$632
United Airlines
Sep 22
PTY9:45 amPanama City Tocumen Intl
22h 58m
2 stops
GSP9:43 amGreenville
Sep 24
GSP11:18 amGreenville
9h 13m
1 stop
PTY7:31 pmPanama City Tocumen Intl
$667

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 9/30

3:40 pm-11:16 pm

1 stop6h 36m

Greenville

Sun 10/4

8:40 pm-2:00 pm

2 stops18h 20m

$532
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/21

2:15 pm-11:43 pm

1 stop8h 28m

Greenville

Fri 6/5

6:45 am-12:50 pm

1 stop7h 05m

$617

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/22

9:45 am-11:05 pm

1 stop12h 20m

Greenville

Thu 9/24

6:30 am-7:31 pm

1 stop14h 01m

$620

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 9/30

9:45 am-11:29 pm

1 stop12h 44m

Greenville

Sun 10/4

6:30 am-7:31 pm

1 stop14h 01m

$632

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/21

1:14 pm-10:08 am

2 stops19h 54m

Greenville

Fri 6/5

7:32 pm-12:13 pm

2 stops17h 41m

$649

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/22

9:45 am-9:43 am

2 stops22h 58m

Greenville

Thu 9/24

11:18 am-7:31 pm

1 stop9h 13m

$667

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 9/22

3:30 pm-5:02 pm

2 stops24h 32m

Greenville

Thu 9/24

5:41 pm-2:14 pm

2 stops21h 33m

$685

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/21

5:55 pm-7:04 pm

3 stops24h 09m

Greenville

Fri 6/5

6:35 pm-2:15 pm

3 stops20h 40m

$1,941
Cheapest one-way
Quickest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

2:15 pm-11:43 pm

1 stop8h 28m

$423

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

7:55 am-10:58 pm

2 stops14h 03m

$432

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Greenville?

Delta and United Airlines are the most popular carriers operating from Panama City Tocumen Intl to Greenville

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Fastest flight time

8h 28m

Direct flights

None
The fastest flight from Panama City to Greenville takes 8h 28m
There are no direct flights from Panama City to Greenville. There are no popular flight routes from Panama City to Greenville.
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Frequently asked questions about flying from Panama City to Greenville

  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 8h 28m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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