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Cheap flights from Panama City to Greenville from $311

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

American Airlines Logo
3:15 pm - 11:21 pmPTY-GSP
7h 06m1 stop
American Airlines Logo
6:47 pm - 1:49 pmGSP-PTY
19h 02m2 stops
$527American Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Delta Logo
2:21 pm - 10:18 pmPTY-GSP
6h 57m1 stop
Delta Logo
6:35 am - 1:56 pmGSP-PTY
7h 21m1 stop
$644Delta
Find Deal
Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
4:56 pm - 12:27 amPTY-GSP
7h 31m1 stop
American Airlines Logo
6:26 pm - 1:53 pmGSP-PTY
19h 27m2 stops
$665American Airlines
Find Deal
Thu, Dec 18 - Sat, Dec 20
American Airlines Logo
4:56 pm - 12:27 amPTY-GSP
7h 31m1 stop
American Airlines Logo
8:08 pm - 1:53 pmGSP-PTY
17h 45m1 stop
$703American Airlines
Find Deal
Thu, Dec 18 - Sat, Dec 20
Multiple Airlines Logo
2:55 am - 7:23 pmPTY-GSP
15h 28m2 stops
Multiple Airlines Logo
8:03 pm - 10:33 amGSP-PTY
14h 30m1 stop
$995Multiple Airlines
Find Deal
Thu, Oct 30 - Fri, Nov 7

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
Oct 31
PTY3:15 pmPanama City Tocumen Intl
7h 06m
1 stop
GSP11:21 pmGreenville
Nov 7
GSP6:47 pmGreenville
19h 02m
2 stops
PTY1:49 pmPanama City Tocumen Intl
$527
Find similar
American Airlines
Dec 18
PTY4:56 pmPanama City Tocumen Intl
7h 31m
1 stop
GSP12:27 amGreenville
Dec 20
GSP6:26 pmGreenville
19h 27m
2 stops
PTY1:53 pmPanama City Tocumen Intl
$665
Find similar
American Airlines
Dec 18
PTY4:56 pmPanama City Tocumen Intl
7h 31m
1 stop
GSP12:27 amGreenville
Dec 20
GSP8:08 pmGreenville
17h 45m
1 stop
PTY1:53 pmPanama City Tocumen Intl
$703
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 10/31

3:15 pm-11:21 pm

1 stop7h 06m

Greenville

Fri 11/7

6:47 pm-1:49 pm

2 stops19h 02m

$527

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 10/31

2:21 pm-10:18 pm

1 stop6h 57m

Greenville

Fri 11/7

6:35 am-1:56 pm

1 stop7h 21m

$644

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 12/18

4:56 pm-12:27 am

1 stop7h 31m

Greenville

Sat 12/20

6:26 pm-1:53 pm

2 stops19h 27m

$665

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 12/18

4:56 pm-12:27 am

1 stop7h 31m

Greenville

Sat 12/20

8:08 pm-1:53 pm

1 stop17h 45m

$703

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 10/30

2:55 am-7:23 pm

2 stops15h 28m

Greenville

Fri 11/7

8:03 pm-10:33 am

1 stop14h 30m

$995

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

2:21 pm-11:55 pm

1 stop8h 34m

$311

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

3:15 pm-1:03 pm

2 stops20h 48m

$320

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:30 pm-3:42 pm

1 stop23h 12m

$368

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

6:34 pm-8:44 pm

3 stops49h 10m

$376

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:30 pm-5:07 pm

2 stops24h 37m

$2,064

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Greenville?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Panama City Tocumen Intl to Greenville

What airlines fly to Greenville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Greenville from Panama City according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Direct flights

None
There are no direct flights from Panama City to Greenville. There are no popular flight routes from Panama City to Greenville.
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  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 6h 57m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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