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Cheap flights from Panama City to Greenville from $294

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 9/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to Greenville

Cheap round-trip flights

United Airlines Logo
7:55 am - 10:00 pmPTY-GSP
13h 05m1 stop
United Airlines Logo
7:00 am - 6:37 pmGSP-PTY
12h 37m1 stop
$576United Airlines
Find Deal
Tue, Aug 12 - Sat, Sep 6
American Airlines Logo
3:30 pm - 11:35 pmPTY-GSP
7h 05m1 stop
American Airlines Logo
6:00 am - 2:31 pmGSP-PTY
9h 31m1 stop
$585American Airlines
Find Deal
Wed, Aug 13 - Sat, Sep 6
American Airlines Logo
3:30 pm - 11:41 amPTY-GSP
19h 11m2 stops
American Airlines Logo
6:00 am - 2:31 pmGSP-PTY
9h 31m1 stop
$590American Airlines
Find Deal
Tue, Aug 12 - Sat, Sep 6

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
Aug 13
PTY3:30 pmPanama City Tocumen Intl
7h 05m
1 stop
GSP11:35 pmGreenville
Sep 6
GSP6:00 amGreenville
9h 31m
1 stop
PTY2:31 pmPanama City Tocumen Intl
$585
Find similar
American Airlines
Aug 12
PTY3:30 pmPanama City Tocumen Intl
19h 11m
2 stops
GSP11:41 amGreenville
Sep 6
GSP6:00 amGreenville
9h 31m
1 stop
PTY2:31 pmPanama City Tocumen Intl
$590
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/12

7:55 am-10:00 pm

1 stop13h 05m

Greenville

Sat 9/6

7:00 am-6:37 pm

1 stop12h 37m

$576

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 8/13

3:30 pm-11:35 pm

1 stop7h 05m

Greenville

Sat 9/6

6:00 am-2:31 pm

1 stop9h 31m

$585

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/12

3:30 pm-11:41 am

2 stops19h 11m

Greenville

Sat 9/6

6:00 am-2:31 pm

1 stop9h 31m

$590

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:31 pm-11:56 pm

1 stop7h 25m

$294

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:31 pm-12:28 pm

2 stops19h 57m

$299

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 9/25

3:20 am-6:46 pm

2 stops14h 26m

$344

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Greenville?

American Airlines is the most popular carrier operating from Panama City Tocumen Intl to Greenville

What airlines fly to Greenville?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Greenville from Panama City according to our data. United Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Best Price Found

$294

Fastest flight time

7h 05m

Direct flights

None

Airports in Greenville

1 airport
The best one-way flight to Greenville from Panama City in the past 72 hours is $294. The best round-trip flight deal from Panama City to Greenville found on momondo in the last 72 hours is $576.
The fastest flight from Panama City to Greenville takes 7h 05m
There are no direct flights from Panama City to Greenville. Popular non-direct route for this connection is Panama City Tocumen Intl Airport - Greenville Airport.
There is 1 airport near Greenville: Greenville (GSP)
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  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 7h 05m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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