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Cheap flights from Panama City to Greenville from $322

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Greenville departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:40 pm - 12:15 pm
PTY
-
GSP
21h 35m
2 stops
American Airlines Logo
6:22 pm - 3:01 pm
GSP
-
PTY
21h 39m
2 stops
$549American Airlines
Thu, Mar 19 - Sun, Mar 29
United Airlines Logo
4:41 pm - 3:36 pm
PTY
-
GSP
22h 55m
1 stop
United Airlines Logo
4:55 pm - 6:38 pm
GSP
-
PTY
26h 43m
1 stop
$557United Airlines
Tue, Feb 24 - Tue, Mar 10
American Airlines Logo
1:40 pm - 10:44 am
PTY
-
GSP
20h 04m
2 stops
American Airlines Logo
7:26 pm - 12:41 pm
GSP
-
PTY
18h 15m
1 stop
$560American Airlines
Thu, Mar 19 - Sun, Mar 29
United Airlines Logo
7:55 am - 10:11 pm
PTY
-
GSP
13h 16m
1 stop
United Airlines Logo
4:55 pm - 4:12 pm
GSP
-
PTY
24h 17m
1 stop
$565United Airlines
Thu, May 28 - Mon, Jun 1
American Airlines Logo
2:40 pm - 10:19 am
PTY
-
GSP
19h 39m
2 stops
American Airlines Logo
7:37 pm - 2:20 pm
GSP
-
PTY
19h 43m
2 stops
$571American Airlines
Tue, Feb 24 - Tue, Mar 10
Multiple Airlines Logo
12:03 pm - 8:56 pm
PTY
-
GSP
7h 53m
1 stop
Multiple Airlines Logo
9:46 pm - 8:19 pm
GSP
-
PTY
23h 33m
1 stop
$586Multiple Airlines
Thu, Mar 19 - Sun, Mar 29
United Airlines Logo
10:00 am - 10:11 pm
PTY
-
GSP
11h 11m
1 stop
United Airlines Logo
7:00 am - 4:12 pm
GSP
-
PTY
10h 12m
1 stop
$625United Airlines
Thu, May 28 - Mon, Jun 1
American Airlines Logo
2:40 pm - 10:19 am
PTY
-
GSP
19h 39m
2 stops
American Airlines Logo
6:40 am - 2:20 pm
GSP
-
PTY
8h 40m
1 stop
$637American Airlines
Tue, Feb 24 - Tue, Mar 10

United Airlines flights from Panama City to Greenville

Our best United Airlines deals on Panama City to Greenville flight tickets
United Airlines
Feb 24
PTY4:41 pmPanama City Tocumen Intl
22h 55m
1 stop
GSP3:36 pmGreenville
Mar 10
GSP4:55 pmGreenville
26h 43m
1 stop
PTY6:38 pmPanama City Tocumen Intl
$557
United Airlines
May 28
PTY7:55 amPanama City Tocumen Intl
13h 16m
1 stop
GSP10:11 pmGreenville
Jun 1
GSP4:55 pmGreenville
24h 17m
1 stop
PTY4:12 pmPanama City Tocumen Intl
$565
United Airlines
May 28
PTY10:00 amPanama City Tocumen Intl
11h 11m
1 stop
GSP10:11 pmGreenville
Jun 1
GSP7:00 amGreenville
10h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
$625

American Airlines flights from Panama City to Greenville

Our best American Airlines deals on Panama City to Greenville flight tickets
American Airlines
Mar 19
PTY1:40 pmPanama City Tocumen Intl
21h 35m
2 stops
GSP12:15 pmGreenville
Mar 29
GSP6:22 pmGreenville
21h 39m
2 stops
PTY3:01 pmPanama City Tocumen Intl
$549
American Airlines
Mar 19
PTY1:40 pmPanama City Tocumen Intl
20h 04m
2 stops
GSP10:44 amGreenville
Mar 29
GSP7:26 pmGreenville
18h 15m
1 stop
PTY12:41 pmPanama City Tocumen Intl
$560
American Airlines
Feb 24
PTY2:40 pmPanama City Tocumen Intl
19h 39m
2 stops
GSP10:19 amGreenville
Mar 10
GSP7:37 pmGreenville
19h 43m
2 stops
PTY2:20 pmPanama City Tocumen Intl
$571

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/19

1:40 pm-12:15 pm

2 stops21h 35m

Greenville

Sun 3/29

6:22 pm-3:01 pm

2 stops21h 39m

$549

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 2/24

4:41 pm-3:36 pm

1 stop22h 55m

Greenville

Tue 3/10

4:55 pm-6:38 pm

1 stop26h 43m

$557

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/19

1:40 pm-10:44 am

2 stops20h 04m

Greenville

Sun 3/29

7:26 pm-12:41 pm

1 stop18h 15m

$560

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/28

7:55 am-10:11 pm

1 stop13h 16m

Greenville

Mon 6/1

4:55 pm-4:12 pm

1 stop24h 17m

$565

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 2/24

2:40 pm-10:19 am

2 stops19h 39m

Greenville

Tue 3/10

7:37 pm-2:20 pm

2 stops19h 43m

$571

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/19

12:03 pm-8:56 pm

1 stop7h 53m

Greenville

Sun 3/29

9:46 pm-8:19 pm

1 stop23h 33m

$586

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/28

10:00 am-10:11 pm

1 stop11h 11m

Greenville

Mon 6/1

7:00 am-4:12 pm

1 stop10h 12m

$625

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 2/24

2:40 pm-10:19 am

2 stops19h 39m

Greenville

Tue 3/10

6:40 am-2:20 pm

1 stop8h 40m

$637

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 5/10

2:20 pm-11:53 pm

1 stop8h 33m

$322

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 5/10

7:55 am-10:14 pm

1 stop13h 19m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Greenville?

Delta, United Airlines, and American Airlines are the most popular carriers operating from Panama City Tocumen Intl to Greenville

What airlines fly to Greenville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Greenville from Panama City according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When to book flights from Panama City to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Greenville (PTY to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Greenville

Fastest flight time

7h 53m

Direct flights

None
The fastest flight from Panama City to Greenville takes 7h 53m
There are no direct flights from Panama City to Greenville. There are no popular flight routes from Panama City to Greenville.
Search flight deals

  • How far is Panama City Tocumen Intl to Greenville by plane?

    The distance between Panama City Tocumen Intl and Greenville is about 1795.3 mi. By plane, this route typically takes 7h 53m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Greenville Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Greenville Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Greenville.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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