Cheap flights from Panama City to Guatemala City from $159

The cheapest month to fly to Guatemala City from Panama City is in June. Flight prices, which tend to average around $234, are often lower during this time because this is during the off-season. If you’re not able to fly to Guatemala City in June, then May is your next best option. Flight prices from Panama City to Guatemala City during May average around $256.

The cheapest day to depart from Panama City to Guatemala City is on a Saturday when prices can be found for as low as $271. On the other hand, Wednesday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $312.

Our data shows that the cheapest Panama City to Guatemala City flights are usually those with departure times in the evening. Our users have found flights to Guatemala City in the evening for as low as $290. Flights to Guatemala City are more costly in the afternoon, with an average ticket price of $328. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Panama City Tocumen Intl to Guatemala City La Aurora for the best Panama City Tocumen Intl - Guatemala City La Aurora flight prices

You are more likely to see cheaper flights to Guatemala City from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Guatemala City for around $283 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guatemala City from Panama City for as low as $255 on momondo.

You could potentially save up to 22% on your flight if you consider stops on a Panama City to Guatemala City flight.

As of May 2026, prices for Panama City to Guatemala City flights are approximately 17% cheaper when compared to flights at the same time last year.

Historically, on average around 4% of flights between Panama City and Guatemala City have experienced a delay on any given week. The average delay length over the past 12 months has been 113 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 4% of their flights experiencing any sort of delay.

San José (SJO) was the most common stop: 57% of momondo users choosing 1-stop flights on this route connected there.

Flights via San José (SJO) offer the lowest average round-trip price of $241.

Flights connecting via San Salvador (SAL) have the shortest average one-way travel time: 3h 58m.

San Salvador (SAL) has the shortest average layover time for this route: 1h 12m.

17 flights are operational daily from Panama City to Guatemala City as of May 2026. The most popular departure time for this route is 9:00PM, with 69% of flights per day taking off in the evening.

As of May 2026, there are 120 flights per week flying from Panama City to Guatemala City. The most common day of the week flights depart is Thu, with 16% of flights taking off on this day.