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Guatemala reopened Guatemala International Airport on September 18. Travelers who have been in the UK or South Africa in the past 14 days prior to their travel will not be permitted to enter Guatemala. This measure is not applicable to Guatemalan nationals, permanent residents, and diplomats with accreditation, but they will be subject to self-isolation upon arrival.

Travelers must have a medical certificate with a negative COVID-19 PCR or antigen test result taken within 72 hours prior to arrival. Children under the of age 10, travelers with a medical discharge of a COVID-19 infection which occurred at most 3 months before arrival and have a medical certificate issued at least 10 days after being diagnosed, and travelers with a certificate of vaccination against COVID-19 if the last dose was administrated at least 2 weeks are exempt from presenting a COVID-19 PCR-RT test result. Travelers must complete a Health Pass form 24 hours prior to arrival. This will generate a QR code, which must be presented upon arrival, together with the negative COVID-19 PCR test result. From 6 January 2021, travelers who do not have a negative COVID-19 PCR or antigen test, will be required to take a test upon arrival at La Aurora International Airport at a cost of US $25 or Q200 (Quetzales, local currency).

There are no quarantine requirements. Upon arrival, travelers must present a medical certificate with a negative COVID-19 PCR or antigen test result taken within 96 hours prior to arrival. However, Guatemalan nationals, permanent residents, and diplomats with accreditation who have been in the UK or South Africa in the past 14 days prior to their arrival are subject to a 10-day self-isolation at their place of residence. Upon arrival in Guatemala, travelers may be subject to a clinical evaluation. They will be asked to complete an immigration form with the address where they will be staying. Local authorities will provide further instructions about the place where they should complete the quarantine and any other details they should provide upon arrival.