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Cheap flights from Panama City, Florida to St. Louis from $109

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:12 am - 10:51 amECP  Panama City NW Florida Beaches-STL Lambert-St Louis
3h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:25 pm - 9:06 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
6h 41m1 stop Atlanta Hartsfield-Jackson
$237Delta
Sat, Oct 24 - Mon, Oct 26
Delta Logo
7:12 am - 1:20 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
6h 08m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:35 amSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
4h 35m1 stop Atlanta Hartsfield-Jackson
$237Delta
Sat, Oct 24 - Mon, Oct 26
Delta Logo
6:00 am - 10:51 amECP  Panama City NW Florida Beaches-STL Lambert-St Louis
4h 51m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:14 am - 4:37 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
6h 23m1 stop Atlanta Hartsfield-Jackson
$237Delta
Tue, Oct 13 - Tue, Oct 20
Delta Logo
7:12 am - 10:51 amECP  Panama City NW Florida Beaches-STL Lambert-St Louis
3h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:35 pm - 9:06 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
3h 31m1 stop Atlanta Hartsfield-Jackson
$237Delta
Tue, Oct 6 - Tue, Oct 13
United Airlines Logo
11:41 am - 9:21 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
9h 40m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
3:12 pm - 10:18 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
7h 06m1 stop Houston George Bush Intcntl
$255United Airlines
Tue, Oct 6 - Tue, Oct 13
Southwest Logo
3:20 pm - 5:10 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 50mnonstop
Southwest Logo
12:55 pm - 2:40 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
1h 45mnonstop
$295Southwest
Tue, Oct 13 - Tue, Oct 20
Southwest Logo
3:20 pm - 5:10 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 50mnonstop
Southwest Logo
1:40 pm - 8:45 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
7h 05m1 stop Dallas Love Field
$305Southwest
Tue, Oct 6 - Tue, Oct 13
Southwest Logo
3:20 pm - 5:10 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 50mnonstop
Southwest Logo
6:00 am - 10:55 amSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
4h 55m1 stop Dallas Love Field
$305Southwest
Tue, Oct 13 - Tue, Oct 20
United Airlines Logo
8:50 am - 2:05 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 15m1 stop Houston George Bush Intcntl
United Airlines Logo
7:30 am - 1:17 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
5h 47m1 stop Chicago O'Hare Intl
$317United Airlines
Tue, Feb 2 - Wed, Feb 3
United Airlines Logo
6:20 am - 3:43 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
9h 23m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:15 am - 2:23 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
8h 08m1 stop Houston George Bush Intcntl
$322United Airlines
Sat, Oct 24 - Mon, Oct 26

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United Airlines flights from Panama City, Florida to St. Louis

Our best United Airlines deals on Panama City, Florida to St. Louis flight tickets
United Airlines
Oct 6
ECP11:41 amPanama City NW Florida Beaches
9h 40m
2 stops
STL9:21 pmLambert-St Louis
Oct 13
STL3:12 pmLambert-St Louis
7h 06m
1 stop
ECP10:18 pmPanama City NW Florida Beaches
$255
United Airlines
Feb 2
ECP8:50 amPanama City NW Florida Beaches
5h 15m
1 stop
STL2:05 pmLambert-St Louis
Feb 3
STL7:30 amLambert-St Louis
5h 47m
1 stop
ECP1:17 pmPanama City NW Florida Beaches
$317
United Airlines
Oct 24
ECP6:20 amPanama City NW Florida Beaches
9h 23m
2 stops
STL3:43 pmLambert-St Louis
Oct 26
STL8:30 amLambert-St Louis
7h 48m
1 stop
ECP4:18 pmPanama City NW Florida Beaches
$322

Delta flights from Panama City, Florida to St. Louis

Our best Delta deals on Panama City, Florida to St. Louis flight tickets
Delta
Oct 24
ECP7:12 amPanama City NW Florida Beaches
3h 39m
1 stop
STL10:51 amLambert-St Louis
Oct 26
STL2:25 pmLambert-St Louis
6h 41m
1 stop
ECP9:06 pmPanama City NW Florida Beaches
$237
Delta
Oct 9
ECP6:00 amPanama City NW Florida Beaches
4h 55m
1 stop
STL10:55 amLambert-St Louis
Oct 12
STL5:35 pmLambert-St Louis
3h 31m
1 stop
ECP9:06 pmPanama City NW Florida Beaches
$283
Delta
Oct 24
ECP7:12 amPanama City NW Florida Beaches
6h 08m
1 stop
STL1:20 pmLambert-St Louis
Oct 26
STL6:00 amLambert-St Louis
4h 35m
1 stop
ECP10:35 amPanama City NW Florida Beaches
$393

momondo Fare Finder

 
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

7:12 am-10:51 am

1 stop3h 39m

Lambert-St Louis

Mon 10/26

2:25 pm-9:06 pm

1 stop6h 41m

$237

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

7:12 am-1:20 pm

1 stop6h 08m

Lambert-St Louis

Mon 10/26

6:00 am-10:35 am

1 stop4h 35m

$237

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/13

6:00 am-10:51 am

1 stop4h 51m

Lambert-St Louis

Tue 10/20

10:14 am-4:37 pm

1 stop6h 23m

$237

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/6

7:12 am-10:51 am

1 stop3h 39m

Lambert-St Louis

Tue 10/13

5:35 pm-9:06 pm

1 stop3h 31m

$237

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/6

11:41 am-9:21 pm

2 stops9h 40m

Lambert-St Louis

Tue 10/13

3:12 pm-10:18 pm

1 stop7h 06m

$255
Quickest round-trip

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/13

3:20 pm-5:10 pm

Nonstop1h 50m

Lambert-St Louis

Tue 10/20

12:55 pm-2:40 pm

Nonstop1h 45m

$295

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/6

3:20 pm-5:10 pm

Nonstop1h 50m

Lambert-St Louis

Tue 10/13

1:40 pm-8:45 pm

1 stop7h 05m

$305

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 10/13

3:20 pm-5:10 pm

Nonstop1h 50m

Lambert-St Louis

Tue 10/20

6:00 am-10:55 am

1 stop4h 55m

$305

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Tue 2/2

8:50 am-2:05 pm

1 stop5h 15m

Lambert-St Louis

Wed 2/3

7:30 am-1:17 pm

1 stop5h 47m

$317

Panama CitySt. Louis

ECP Panama City NW Florida Beaches - STL Lambert-St Louis

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

6:20 am-3:43 pm

2 stops9h 23m

Lambert-St Louis

Mon 10/26

6:15 am-2:23 pm

1 stop8h 08m

$322

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $253 to $375.
The lowest price recently found on this route was $237.

What is the cheapest month to fly to St. Louis?

In general, December is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $262. The month of October is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $307.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $375. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $557. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City, Florida to St. Louis flights?

There is only 1 cabin class available to choose from on Panama City, Florida to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Panama City, Florida to St. Louis.

How have Panama City, Florida to St. Louis flight prices changed over time?

As of September 2026, prices for Panama City, Florida to St. Louis flights are approximately 82% more expensive when compared to flights at the same time last year.

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$109

Fastest flight time

1h 45m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Panama City, Florida in the past 72 hours is $109. The best round-trip flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $237.
The fastest flight from Panama City, Florida to St. Louis takes 1h 45m
Direct flights go from Panama City, Florida to St. Louis every day.
There is 1 airport in St. Louis. From Panama City, Florida there are direct flights to Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from Panama City, Florida to St. Louis

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 45m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.8
8,553 reviews
Search Delta flights
SouthwestPriceFrom $227Free CancellationRating
8.0
4,195 reviews
Search Southwest flights

  • Southwest Flights From Panama City, Florida to St. Louis

    Southwest operates around 2 flights from Panama City, Florida to St. Louis every week. The average price of these flights found in the last 72 hours has been $358, but momondo users have found Southwest deals from Panama City, Florida to St. Louis from as low as $227 round-trip. Southwest has been scored 8.0/10 in 4,195 reviews.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Maryland Heights
St. Peters
Alton
Collinsville
Florissant
Hermann
O'Fallon
Clayton
Farmington
Fenton
Festus
Wentzville
Edwardsville
Eureka
Litchfield
Grafton
Waterloo

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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