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Cheap flights from Panama City, Florida to St. Louis from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to St. Louis departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:19 am - 12:43 pm
ECP
-
STL
5h 24m
1 stop
American Airlines Logo
8:00 am - 12:44 pm
STL
-
ECP
4h 44m
1 stop
$205American Airlines
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
2:10 pm - 9:07 pm
ECP
-
STL
6h 57m
1 stop
United Airlines Logo
10:00 am - 9:57 pm
STL
-
ECP
11h 57m
2 stops
$210United Airlines
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
5:00 pm - 10:14 pm
ECP
-
STL
5h 14m
1 stop
United Airlines Logo
7:40 am - 1:14 pm
STL
-
ECP
5h 34m
1 stop
$241United Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
5:00 pm - 10:14 pm
ECP
-
STL
5h 14m
1 stop
United Airlines Logo
10:00 am - 9:57 pm
STL
-
ECP
11h 57m
2 stops
$246United Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
4:57 pm - 10:28 pm
ECP
-
STL
5h 31m
1 stop
United Airlines Logo
7:45 am - 1:18 pm
STL
-
ECP
5h 33m
1 stop
$247United Airlines
Thu, Apr 23 - Wed, May 6
American Airlines Logo
2:00 pm - 11:04 pm
ECP
-
STL
9h 04m
2 stops
American Airlines Logo
11:41 am - 10:17 pm
STL
-
ECP
10h 36m
2 stops
$252American Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
4:55 pm - 10:30 pm
ECP
-
STL
5h 35m
1 stop
United Airlines Logo
6:00 am - 1:21 pm
STL
-
ECP
7h 21m
1 stop
$255United Airlines
Wed, May 20 - Sun, May 24
United Airlines Logo
4:57 pm - 10:28 pm
ECP
-
STL
5h 31m
1 stop
United Airlines Logo
7:45 am - 1:23 pm
STL
-
ECP
5h 38m
1 stop
$256United Airlines
Thu, Apr 2 - Mon, Apr 6
American Airlines Logo
7:19 am - 12:43 pm
ECP
-
STL
5h 24m
1 stop
American Airlines Logo
6:57 pm - 11:49 pm
STL
-
ECP
4h 52m
1 stop
$264American Airlines
Wed, Mar 25 - Wed, Apr 1
American Airlines Logo
7:19 am - 3:35 pm
ECP
-
STL
8h 16m
2 stops
American Airlines Logo
6:57 pm - 11:49 pm
STL
-
ECP
4h 52m
1 stop
$269American Airlines
Wed, Mar 25 - Wed, Apr 1

United Airlines flights from Panama City, Florida to St. Louis

Our best United Airlines deals on Panama City, Florida to St. Louis flight tickets
United Airlines
Mar 5
ECP2:10 pmPanama City NW Florida Beaches
6h 57m
1 stop
STL9:07 pmLambert-St Louis
Mar 9
STL10:00 amLambert-St Louis
11h 57m
2 stops
ECP9:57 pmPanama City NW Florida Beaches
$210
United Airlines
Mar 3
ECP5:00 pmPanama City NW Florida Beaches
5h 14m
1 stop
STL10:14 pmLambert-St Louis
Mar 10
STL7:40 amLambert-St Louis
5h 34m
1 stop
ECP1:14 pmPanama City NW Florida Beaches
$241
United Airlines
Mar 3
ECP5:00 pmPanama City NW Florida Beaches
5h 14m
1 stop
STL10:14 pmLambert-St Louis
Mar 10
STL10:00 amLambert-St Louis
11h 57m
2 stops
ECP9:57 pmPanama City NW Florida Beaches
$246

American Airlines flights from Panama City, Florida to St. Louis

Our best American Airlines deals on Panama City, Florida to St. Louis flight tickets
American Airlines
Mar 5
ECP7:19 amPanama City NW Florida Beaches
5h 24m
1 stop
STL12:43 pmLambert-St Louis
Mar 9
STL8:00 amLambert-St Louis
4h 44m
1 stop
ECP12:44 pmPanama City NW Florida Beaches
$205
American Airlines
Feb 27
ECP12:38 pmPanama City NW Florida Beaches
6h 51m
1 stop
STL7:29 pmLambert-St Louis
Mar 1
STL6:57 pmLambert-St Louis
4h 52m
1 stop
ECP11:49 pmPanama City NW Florida Beaches
$241
American Airlines
Mar 3
ECP2:00 pmPanama City NW Florida Beaches
9h 04m
2 stops
STL11:04 pmLambert-St Louis
Mar 10
STL11:41 amLambert-St Louis
10h 36m
2 stops
ECP10:17 pmPanama City NW Florida Beaches
$252

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 3/5

7:19 am-12:43 pm

1 stop5h 24m

Lambert-St Louis

Mon 3/9

8:00 am-12:44 pm

1 stop4h 44m

$205

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 3/5

2:10 pm-9:07 pm

1 stop6h 57m

Lambert-St Louis

Mon 3/9

10:00 am-9:57 pm

2 stops11h 57m

$210

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 3/3

5:00 pm-10:14 pm

1 stop5h 14m

Lambert-St Louis

Tue 3/10

7:40 am-1:14 pm

1 stop5h 34m

$241

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 3/3

5:00 pm-10:14 pm

1 stop5h 14m

Lambert-St Louis

Tue 3/10

10:00 am-9:57 pm

2 stops11h 57m

$246

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 4/23

4:57 pm-10:28 pm

1 stop5h 31m

Lambert-St Louis

Wed 5/6

7:45 am-1:18 pm

1 stop5h 33m

$247

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 3/3

2:00 pm-11:04 pm

2 stops9h 04m

Lambert-St Louis

Tue 3/10

11:41 am-10:17 pm

2 stops10h 36m

$252

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 5/20

4:55 pm-10:30 pm

1 stop5h 35m

Lambert-St Louis

Sun 5/24

6:00 am-1:21 pm

1 stop7h 21m

$255

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 4/2

4:57 pm-10:28 pm

1 stop5h 31m

Lambert-St Louis

Mon 4/6

7:45 am-1:23 pm

1 stop5h 38m

$256

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 3/25

7:19 am-12:43 pm

1 stop5h 24m

Lambert-St Louis

Wed 4/1

6:57 pm-11:49 pm

1 stop4h 52m

$264

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 3/25

7:19 am-3:35 pm

2 stops8h 16m

Lambert-St Louis

Wed 4/1

6:57 pm-11:49 pm

1 stop4h 52m

$269

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $198. The month of August is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $246.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $345. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $558. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City NW Florida Beaches to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Panama City NW Florida Beaches to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

You could potentially save up to 55% on your flight if you consider stops on a Panama City, Florida to St. Louis flight.

How have Panama City, Florida to St. Louis flight prices changed over time?

As of February 2026, prices for Panama City, Florida to St. Louis flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$205

Fastest flight time

1h 50m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Panama City, Florida in the past 72 hours is $205. The best round-trip flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $363.
The fastest flight from Panama City, Florida to St. Louis takes 1h 50m
Direct flights go from Panama City, Florida to St. Louis every day.
There is 1 airport in St. Louis. From Panama City, Florida there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 50m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $157Free CancellationRating
8.0
4,295 reviews
Search Southwest flights
DeltaPriceFrom $206Free CancellationRating
7.9
8,213 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
St. Peters
Collinsville
Wentzville
Fenton
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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