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Cheap flights from Panama City, Florida to St. Louis from $89

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to St. Louis departing on 3/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

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American Airlines Logo
1:25 pm - 9:31 pmECP-STL
8h 06m1 stop
American Airlines Logo
6:59 pm - 11:50 pmSTL-ECP
4h 51m1 stop
$179American Airlines
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Thu, Feb 12 - Sun, Feb 15
Delta Logo
6:59 pm - 11:42 pmECP-STL
4h 43m1 stop
Delta Logo
7:02 pm - 11:06 pmSTL-ECP
4h 04m1 stop
$207Delta
Find Deal
Fri, Dec 5 - Sun, Dec 7
American Airlines Logo
12:08 pm - 8:38 pmECP-STL
8h 30m2 stops
American Airlines Logo
6:53 pm - 11:55 pmSTL-ECP
5h 02m1 stop
$212American Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Southwest Logo
10:00 am - 5:25 pmECP-STL
7h 25m2 stops
Southwest Logo
10:00 am - 5:35 pmSTL-ECP
7h 35m2 stops
$217Southwest
Find Deal
Thu, Dec 4 - Sun, Dec 7
American Airlines Logo
12:08 pm - 10:47 pmECP-STL
10h 39m2 stops
American Airlines Logo
6:53 pm - 11:55 pmSTL-ECP
5h 02m1 stop
$254American Airlines
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Fri, Dec 5 - Sun, Dec 7
American Airlines Logo
10:30 am - 9:31 pmECP-STL
11h 01m2 stops
American Airlines Logo
6:59 pm - 11:50 pmSTL-ECP
4h 51m1 stop
$264American Airlines
Find Deal
Thu, Feb 12 - Sun, Feb 15
United Airlines Logo
5:00 pm - 10:14 pmECP-STL
5h 14m1 stop
United Airlines Logo
6:00 am - 12:04 pmSTL-ECP
6h 04m1 stop
$289United Airlines
Find Deal
Thu, Feb 12 - Sun, Feb 15
Delta Logo
4:04 pm - 9:40 pmECP-STL
5h 36m1 stop
Delta Logo
1:22 pm - 6:17 pmSTL-ECP
4h 55m1 stop
$339Delta
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Fri, Dec 26 - Tue, Dec 30
Southwest Logo
9:55 am - 7:15 pmECP-STL
9h 20m2 stops
Southwest Logo
5:25 am - 3:45 pmSTL-ECP
10h 20m2 stops
$359Southwest
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Thu, Feb 12 - Sun, Feb 15
United Airlines Logo
3:00 pm - 10:22 pmECP-STL
7h 22m1 stop
United Airlines Logo
8:20 am - 1:57 pmSTL-ECP
5h 37m1 stop
$544United Airlines
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Thu, Nov 20 - Mon, Nov 24

Delta flights from Panama City, Florida to St. Louis

Our best Delta deals on Panama City, Florida to St. Louis flight tickets
Delta
Dec 5
ECP6:59 pmPanama City NW Florida Beaches
4h 43m
1 stop
STL11:42 pmLambert-St Louis
Dec 7
STL7:02 pmLambert-St Louis
4h 04m
1 stop
ECP11:06 pmPanama City NW Florida Beaches
$207
Find similar
Delta
Dec 26
ECP4:04 pmPanama City NW Florida Beaches
5h 36m
1 stop
STL9:40 pmLambert-St Louis
Dec 30
STL1:22 pmLambert-St Louis
4h 55m
1 stop
ECP6:17 pmPanama City NW Florida Beaches
$339
Find similar
Delta
Dec 27
ECP7:02 pmPanama City NW Florida Beaches
4h 40m
1 stop
STL11:42 pmLambert-St Louis
Dec 30
STL7:00 amLambert-St Louis
6h 19m
1 stop
ECP1:19 pmPanama City NW Florida Beaches
$357
Find similar

Southwest flights from Panama City, Florida to St. Louis

Our best Southwest deals on Panama City, Florida to St. Louis flight tickets
Southwest
Dec 4
ECP10:00 amPanama City NW Florida Beaches
7h 25m
2 stops
STL5:25 pmLambert-St Louis
Dec 7
STL10:00 amLambert-St Louis
7h 35m
2 stops
ECP5:35 pmPanama City NW Florida Beaches
$217
Find similar
Southwest
Feb 12
ECP9:55 amPanama City NW Florida Beaches
9h 20m
2 stops
STL7:15 pmLambert-St Louis
Feb 15
STL5:25 amLambert-St Louis
10h 20m
2 stops
ECP3:45 pmPanama City NW Florida Beaches
$359
Find similar
Southwest
Dec 27
ECP6:00 pmPanama City NW Florida Beaches
6h 15m
1 stop
STL12:15 amLambert-St Louis
Dec 30
STL5:20 amLambert-St Louis
6h 50m
1 stop
ECP12:10 pmPanama City NW Florida Beaches
$374
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momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 2/12

1:25 pm-9:31 pm

1 stop8h 06m

Lambert-St Louis

Sun 2/15

6:59 pm-11:50 pm

1 stop4h 51m

$179

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

6:59 pm-11:42 pm

1 stop4h 43m

Lambert-St Louis

Sun 12/7

7:02 pm-11:06 pm

1 stop4h 04m

$207

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

12:08 pm-8:38 pm

2 stops8h 30m

Lambert-St Louis

Sun 12/7

6:53 pm-11:55 pm

1 stop5h 02m

$212

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 12/4

10:00 am-5:25 pm

2 stops7h 25m

Lambert-St Louis

Sun 12/7

10:00 am-5:35 pm

2 stops7h 35m

$217

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

12:08 pm-10:47 pm

2 stops10h 39m

Lambert-St Louis

Sun 12/7

6:53 pm-11:55 pm

1 stop5h 02m

$254

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 2/12

10:30 am-9:31 pm

2 stops11h 01m

Lambert-St Louis

Sun 2/15

6:59 pm-11:50 pm

1 stop4h 51m

$264

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 2/12

5:00 pm-10:14 pm

1 stop5h 14m

Lambert-St Louis

Sun 2/15

6:00 am-12:04 pm

1 stop6h 04m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/26

4:04 pm-9:40 pm

1 stop5h 36m

Lambert-St Louis

Tue 12/30

1:22 pm-6:17 pm

1 stop4h 55m

$339

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 2/12

9:55 am-7:15 pm

2 stops9h 20m

Lambert-St Louis

Sun 2/15

5:25 am-3:45 pm

2 stops10h 20m

$359

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 11/20

3:00 pm-10:22 pm

1 stop7h 22m

Lambert-St Louis

Mon 11/24

8:20 am-1:57 pm

1 stop5h 37m

$544

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $243. The month of August is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $246.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $376. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $503. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City NW Florida Beaches to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Panama City NW Florida Beaches to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

You could potentially save up to 12% on your flight if you consider stops on a Panama City, Florida to St. Louis flight.

How have Panama City, Florida to St. Louis flight prices changed over time?

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$214

Fastest flight time

1h 55m

Direct flights

Mon, Tue, Fri, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Panama City, Florida in the past 72 hours is $214. The best round-trip flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $503.
The fastest flight from Panama City, Florida to St. Louis takes 1h 55m
Direct flights go from Panama City, Florida to St. Louis on Monday, Tuesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 55m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $157Free CancellationRating
8.0
4,240 reviews
Search Southwest flights
DeltaPriceFrom $206Free CancellationRating
7.9
8,004 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Wentzville
Fenton
Collinsville
St. Peters
Alton
Farmington
Festus
Glencoe
Edwardsville
Clayton
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your St. Louis trip

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