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Cheap flights from Panama City, Florida to St. Louis from $114

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to St. Louis departing on 8/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:07 am - 1:20 pm
ECP
-
STL
6h 13m
1 stop
Delta Logo
5:35 pm - 11:18 pm
STL
-
ECP
5h 43m
1 stop
$237Delta
Sat, Oct 24 - Mon, Oct 26
Delta Logo
7:12 am - 1:20 pm
ECP
-
STL
6h 08m
1 stop
Delta Logo
5:28 pm - 11:18 pm
STL
-
ECP
5h 50m
1 stop
$237Delta
Sat, Oct 24 - Mon, Oct 26
American Airlines Logo
5:48 pm - 10:40 pm
ECP
-
STL
4h 52m
1 stop
American Airlines Logo
3:25 pm - 10:40 pm
STL
-
ECP
7h 15m
1 stop
$237American Airlines
Mon, Aug 17 - Thu, Aug 20
Delta Logo
5:30 pm - 11:48 pm
ECP
-
STL
6h 18m
1 stop
Delta Logo
12:00 pm - 5:35 pm
STL
-
ECP
5h 35m
1 stop
$237Delta
Sat, Oct 24 - Mon, Oct 26
Delta Logo
4:15 pm - 9:59 pm
ECP
-
STL
5h 44m
1 stop
Delta Logo
6:00 am - 10:42 am
STL
-
ECP
4h 42m
1 stop
$237Delta
Tue, Nov 3 - Wed, Nov 11
Southwest Logo
7:35 am - 4:50 pm
ECP
-
STL
9h 15m
2 stops
Southwest Logo
8:25 am - 3:35 pm
STL
-
ECP
7h 10m
1 stop
$242Southwest
Tue, Nov 3 - Wed, Nov 11
Southwest Logo
4:15 pm - 9:55 pm
ECP
-
STL
5h 40m
1 stop
Southwest Logo
8:25 am - 3:35 pm
STL
-
ECP
7h 10m
1 stop
$247Southwest
Tue, Nov 3 - Wed, Nov 11
American Airlines Logo
6:43 pm - 11:59 pm
ECP
-
STL
5h 16m
1 stop
American Airlines Logo
10:12 am - 6:13 pm
STL
-
ECP
8h 01m
1 stop
$247American Airlines
Sat, Oct 24 - Mon, Oct 26
Southwest Logo
7:35 am - 4:50 pm
ECP
-
STL
9h 15m
2 stops
Southwest Logo
8:25 am - 3:35 pm
STL
-
ECP
7h 10m
1 stop
$252Southwest
Tue, Nov 3 - Wed, Nov 11
American Airlines Logo
6:43 pm - 11:59 pm
ECP
-
STL
5h 16m
1 stop
American Airlines Logo
10:12 am - 6:13 pm
STL
-
ECP
8h 01m
1 stop
$268American Airlines
Sat, Oct 24 - Mon, Oct 26

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Southwest flights from Panama City, Florida to St. Louis

Our best Southwest deals on Panama City, Florida to St. Louis flight tickets
Southwest
Nov 3
ECP7:35 amPanama City NW Florida Beaches
9h 15m
2 stops
STL4:50 pmLambert-St Louis
Nov 11
STL8:25 amLambert-St Louis
7h 10m
1 stop
ECP3:35 pmPanama City NW Florida Beaches
$242
Southwest
Nov 3
ECP4:15 pmPanama City NW Florida Beaches
5h 40m
1 stop
STL9:55 pmLambert-St Louis
Nov 11
STL8:25 amLambert-St Louis
7h 10m
1 stop
ECP3:35 pmPanama City NW Florida Beaches
$247
Southwest
Nov 3
ECP7:35 amPanama City NW Florida Beaches
9h 15m
2 stops
STL4:50 pmLambert-St Louis
Nov 11
STL8:25 amLambert-St Louis
7h 10m
1 stop
ECP3:35 pmPanama City NW Florida Beaches
$252

Delta flights from Panama City, Florida to St. Louis

Our best Delta deals on Panama City, Florida to St. Louis flight tickets
Delta
Oct 24
ECP5:30 pmPanama City NW Florida Beaches
6h 18m
1 stop
STL11:48 pmLambert-St Louis
Oct 26
STL12:00 pmLambert-St Louis
5h 35m
1 stop
ECP5:35 pmPanama City NW Florida Beaches
$237
Delta
Aug 9
ECP6:00 amPanama City NW Florida Beaches
3h 39m
1 stop
STL9:39 amLambert-St Louis
Aug 13
STL5:23 pmLambert-St Louis
6h 07m
1 stop
ECP11:30 pmPanama City NW Florida Beaches
$537

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

7:07 am-1:20 pm

1 stop6h 13m

Lambert-St Louis

Mon 10/26

5:35 pm-11:18 pm

1 stop5h 43m

$237

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

7:12 am-1:20 pm

1 stop6h 08m

Lambert-St Louis

Mon 10/26

5:28 pm-11:18 pm

1 stop5h 50m

$237

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 8/17

5:48 pm-10:40 pm

1 stop4h 52m

Lambert-St Louis

Thu 8/20

3:25 pm-10:40 pm

1 stop7h 15m

$237

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

5:30 pm-11:48 pm

1 stop6h 18m

Lambert-St Louis

Mon 10/26

12:00 pm-5:35 pm

1 stop5h 35m

$237
Quickest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 11/3

4:15 pm-9:59 pm

1 stop5h 44m

Lambert-St Louis

Wed 11/11

6:00 am-10:42 am

1 stop4h 42m

$237

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 11/3

7:35 am-4:50 pm

2 stops9h 15m

Lambert-St Louis

Wed 11/11

8:25 am-3:35 pm

1 stop7h 10m

$242

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 11/3

4:15 pm-9:55 pm

1 stop5h 40m

Lambert-St Louis

Wed 11/11

8:25 am-3:35 pm

1 stop7h 10m

$247

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

6:43 pm-11:59 pm

1 stop5h 16m

Lambert-St Louis

Mon 10/26

10:12 am-6:13 pm

1 stop8h 01m

$247

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 11/3

7:35 am-4:50 pm

2 stops9h 15m

Lambert-St Louis

Wed 11/11

8:25 am-3:35 pm

1 stop7h 10m

$252

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/24

6:43 pm-11:59 pm

1 stop5h 16m

Lambert-St Louis

Mon 10/26

10:12 am-6:13 pm

1 stop8h 01m

$268

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and St. Louis?

Prices are currently typical for flights on this route.

Typical prices usually range from $194 to $345.
The lowest price recently found on this route was $237.

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $242. The month of September is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $253.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $378. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $557. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City, Florida to St. Louis flights?

There is only 1 cabin class available to choose from on Panama City, Florida to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Panama City, Florida to St. Louis.

How have Panama City, Florida to St. Louis flight prices changed over time?

As of July 2026, prices for Panama City, Florida to St. Louis flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$189

Fastest flight time

1h 50m

Direct flights

Mon, Tue, Wed, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Panama City, Florida in the past 72 hours is $189. The best round-trip flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $371.
The fastest flight from Panama City, Florida to St. Louis takes 1h 50m
Direct flights go from Panama City, Florida to St. Louis on Monday, Tuesday, Wednesday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Panama City, Florida there are direct flights to Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from Panama City, Florida to St. Louis

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 50m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $194Free CancellationRating
8.0
4,229 reviews
Search Southwest flights
DeltaPriceFrom $216Free CancellationRating
7.8
8,485 reviews
Search Delta flights

  • Southwest Flights From Panama City, Florida to St. Louis

    Southwest operates around 9 flights from Panama City, Florida to St. Louis every week. The average price of these flights found in the last 72 hours has been $316, but momondo users have found Southwest deals from Panama City, Florida to St. Louis from as low as $194 round-trip. Southwest has been scored 8.0/10 in 4,228 reviews.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
St. Peters
Maryland Heights
Florissant
Collinsville
O'Fallon
Alton
Fenton
Farmington
Clayton
Wentzville
Festus
Eureka
Litchfield
Edwardsville
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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