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Cheap flights from Panama City, Florida to St. Louis from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to St. Louis departing on 8/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:45 pm - 11:56 pm
ECP
-
STL
5h 11m
1 stop
Delta Logo
6:00 am - 12:26 pm
STL
-
ECP
6h 26m
1 stop
$315Delta
Fri, Jun 26 - Mon, Jun 29
Delta Logo
6:45 pm - 11:56 pm
ECP
-
STL
5h 11m
1 stop
Delta Logo
6:00 am - 10:54 am
STL
-
ECP
4h 54m
1 stop
$316Delta
Mon, Jun 8 - Tue, Jun 16
Delta Logo
6:00 am - 9:46 am
ECP
-
STL
3h 46m
1 stop
Delta Logo
3:57 pm - 8:47 pm
STL
-
ECP
4h 50m
1 stop
$317Delta
Wed, Jun 10 - Fri, Jun 12
Southwest Logo
9:40 am - 3:25 pm
ECP
-
STL
5h 45m
1 stop
Southwest Logo
5:45 am - 1:55 pm
STL
-
ECP
8h 10m
2 stops
$320Southwest
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
4:16 pm - 12:16 am
ECP
-
STL
8h 00m
2 stops
American Airlines Logo
6:12 pm - 11:40 pm
STL
-
ECP
5h 28m
1 stop
$322American Airlines
Wed, Jun 10 - Sat, Jun 13
American Airlines Logo
2:26 pm - 11:59 pm
ECP
-
STL
9h 33m
2 stops
American Airlines Logo
10:34 am - 6:50 pm
STL
-
ECP
8h 16m
2 stops
$325American Airlines
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
6:30 am - 4:20 pm
ECP
-
STL
9h 50m
2 stops
Southwest Logo
12:25 pm - 8:35 pm
STL
-
ECP
8h 10m
1 stop
$326Southwest
Thu, Oct 8 - Mon, Oct 12
Southwest Logo
9:40 am - 3:25 pm
ECP
-
STL
5h 45m
1 stop
Southwest Logo
10:10 am - 12:00 pm
STL
-
ECP
1h 50mnonstop
$338Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
1:55 pm - 3:45 pm
ECP
-
STL
1h 50mnonstop
Southwest Logo
5:35 am - 2:15 pm
STL
-
ECP
8h 40m
1 stop
$344Southwest
Thu, Oct 8 - Mon, Oct 12
Southwest Logo
6:20 pm - 10:45 pm
ECP
-
STL
4h 25m
1 stop
Southwest Logo
6:25 am - 11:30 am
STL
-
ECP
5h 05m
1 stop
$347Southwest
Mon, Jun 15 - Sun, Jun 21

American Airlines flights from Panama City, Florida to St. Louis

Our best American Airlines deals on Panama City, Florida to St. Louis flight tickets
American Airlines
Jun 10
ECP4:16 pmPanama City NW Florida Beaches
8h 00m
2 stops
STL12:16 amLambert-St Louis
Jun 13
STL6:12 pmLambert-St Louis
5h 28m
1 stop
ECP11:40 pmPanama City NW Florida Beaches
$322
American Airlines
Jun 26
ECP4:16 pmPanama City NW Florida Beaches
8h 00m
2 stops
STL12:16 amLambert-St Louis
Jun 29
STL6:15 amLambert-St Louis
6h 30m
1 stop
ECP12:45 pmPanama City NW Florida Beaches
$352
American Airlines
Jun 4
ECP4:16 pmPanama City NW Florida Beaches
8h 00m
2 stops
STL12:16 amLambert-St Louis
Jun 7
STL6:15 amLambert-St Louis
6h 30m
1 stop
ECP12:45 pmPanama City NW Florida Beaches
$383

Delta flights from Panama City, Florida to St. Louis

Our best Delta deals on Panama City, Florida to St. Louis flight tickets
Delta
Jun 26
ECP6:45 pmPanama City NW Florida Beaches
5h 11m
1 stop
STL11:56 pmLambert-St Louis
Jun 29
STL6:00 amLambert-St Louis
6h 26m
1 stop
ECP12:26 pmPanama City NW Florida Beaches
$315
Delta
Jun 8
ECP6:45 pmPanama City NW Florida Beaches
5h 11m
1 stop
STL11:56 pmLambert-St Louis
Jun 16
STL6:00 amLambert-St Louis
4h 54m
1 stop
ECP10:54 amPanama City NW Florida Beaches
$316
Delta
Jun 2
ECP2:50 pmPanama City NW Florida Beaches
6h 48m
1 stop
STL9:38 pmLambert-St Louis
Jun 5
STL7:01 pmLambert-St Louis
4h 27m
1 stop
ECP11:28 pmPanama City NW Florida Beaches
$317

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 21, 2026.
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 6/26

6:45 pm-11:56 pm

1 stop5h 11m

Lambert-St Louis

Mon 6/29

6:00 am-12:26 pm

1 stop6h 26m

$315

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 6/8

6:45 pm-11:56 pm

1 stop5h 11m

Lambert-St Louis

Tue 6/16

6:00 am-10:54 am

1 stop4h 54m

$316

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 6/10

6:00 am-9:46 am

1 stop3h 46m

Lambert-St Louis

Fri 6/12

3:57 pm-8:47 pm

1 stop4h 50m

$317

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 9/5

9:40 am-3:25 pm

1 stop5h 45m

Lambert-St Louis

Sat 9/12

5:45 am-1:55 pm

2 stops8h 10m

$320

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 6/10

4:16 pm-12:16 am

2 stops8h 00m

Lambert-St Louis

Sat 6/13

6:12 pm-11:40 pm

1 stop5h 28m

$322

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 9/5

2:26 pm-11:59 pm

2 stops9h 33m

Lambert-St Louis

Sat 9/12

10:34 am-6:50 pm

2 stops8h 16m

$325

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 10/8

6:30 am-4:20 pm

2 stops9h 50m

Lambert-St Louis

Mon 10/12

12:25 pm-8:35 pm

1 stop8h 10m

$326
Quickest round-trip

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 9/5

9:40 am-3:25 pm

1 stop5h 45m

Lambert-St Louis

Sat 9/12

10:10 am-12:00 pm

Nonstop1h 50m

$338

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 10/8

1:55 pm-3:45 pm

Nonstop1h 50m

Lambert-St Louis

Mon 10/12

5:35 am-2:15 pm

1 stop8h 40m

$344

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 6/15

6:20 pm-10:45 pm

1 stop4h 25m

Lambert-St Louis

Sun 6/21

6:25 am-11:30 am

1 stop5h 05m

$347

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $198. The month of August is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $246.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $309. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $516. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City, Florida to St. Louis flights?

There is only 1 cabin class available to choose from on Panama City, Florida to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

You could potentially save up to 28% on your flight if you consider stops on a Panama City, Florida to St. Louis flight.

How have Panama City, Florida to St. Louis flight prices changed over time?

As of May 2026, prices for Panama City, Florida to St. Louis flights are approximately 23% more expensive when compared to flights at the same time last year.

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$181

Fastest flight time

1h 50m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Panama City, Florida in the past 72 hours is $181. The best round-trip flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $398.
The fastest flight from Panama City, Florida to St. Louis takes 1h 50m
Direct flights go from Panama City, Florida to St. Louis every day.
There is 1 airport in St. Louis. From Panama City, Florida there are direct flights to Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from Panama City, Florida to St. Louis

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 50m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $157Free CancellationRating
7.9
4,282 reviews
Search Southwest flights
DeltaPriceFrom $206Free CancellationRating
7.9
8,452 reviews
Search Delta flights

  • Southwest Flights From Panama City, Florida to St. Louis

    Southwest operates around 5 flights from Panama City, Florida to St. Louis every week. The average price of these flights found in the last 72 hours has been $358, but momondo users have found Southwest deals from Panama City, Florida to St. Louis from as low as $157 round-trip. Southwest has been scored 7.9/10 in 4,284 reviews.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Eureka
Clayton
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your St. Louis trip

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