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Cheap flights from Panama City, Florida to St. Louis from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to St. Louis departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 11:09 am
ECP
-
STL
5h 09m1 stop
Delta Logo
4:21 pm - 9:22 pm
STL
-
ECP
5h 01m1 stop
$289Delta
Wed, Apr 1 - Mon, Apr 6
United Airlines Logo
4:54 pm - 10:00 pm
ECP
-
STL
5h 06m1 stop
United Airlines Logo
9:57 am - 9:59 pm
STL
-
ECP
12h 02m2 stops
$294United Airlines
Thu, Jan 22 - Sun, Jan 25
United Airlines Logo
6:30 am - 4:03 pm
ECP
-
STL
9h 33m2 stops
United Airlines Logo
9:57 am - 9:59 pm
STL
-
ECP
12h 02m2 stops
$299United Airlines
Thu, Jan 22 - Sun, Jan 25
Delta Logo
7:05 am - 11:09 am
ECP
-
STL
4h 04m1 stop
Delta Logo
6:04 am - 10:20 am
STL
-
ECP
4h 16m1 stop
$314Delta
Sun, Mar 29 - Wed, Apr 8
Southwest Logo
2:45 pm - 10:10 pm
ECP
-
STL
7h 25m2 stops
Southwest Logo
5:50 pm - 9:05 pm
STL
-
ECP
3h 15m1 stop
$319Southwest
Thu, Apr 2 - Sun, Apr 5
Delta Logo
10:01 am - 2:48 pm
ECP
-
STL
4h 47m1 stop
Delta Logo
6:00 am - 11:08 am
STL
-
ECP
5h 08m1 stop
$320Delta
Tue, Jan 13 - Tue, Jan 20
United Airlines Logo
1:10 pm - 10:58 pm
ECP
-
STL
9h 48m2 stops
United Airlines Logo
10:07 am - 4:12 pm
STL
-
ECP
6h 05m1 stop
$325United Airlines
Tue, Jan 13 - Tue, Jan 20
Southwest Logo
5:05 pm - 11:20 pm
ECP
-
STL
6h 15m1 stop
Southwest Logo
5:45 am - 12:50 pm
STL
-
ECP
7h 05m1 stop
$339Southwest
Sun, Mar 8 - Thu, Mar 12
United Airlines Logo
1:10 pm - 10:58 pm
ECP
-
STL
9h 48m2 stops
United Airlines Logo
6:30 am - 4:12 pm
STL
-
ECP
9h 42m2 stops
$349United Airlines
Tue, Jan 13 - Tue, Jan 20
Delta Logo
7:05 am - 11:09 am
ECP
-
STL
4h 04m1 stop
Delta Logo
6:59 pm - 11:04 pm
STL
-
ECP
4h 05m1 stop
$357Delta
Thu, Apr 2 - Thu, Apr 2

United Airlines flights from Panama City, Florida to St. Louis

Our best United Airlines deals on Panama City, Florida to St. Louis flight tickets
United Airlines
Jan 22
ECP4:54 pmPanama City NW Florida Beaches
5h 06m
1 stop
STL10:00 pmLambert-St Louis
Jan 25
STL9:57 amLambert-St Louis
12h 02m
2 stops
ECP9:59 pmPanama City NW Florida Beaches
$294
Find similar
United Airlines
Jan 22
ECP6:30 amPanama City NW Florida Beaches
9h 33m
2 stops
STL4:03 pmLambert-St Louis
Jan 25
STL9:57 amLambert-St Louis
12h 02m
2 stops
ECP9:59 pmPanama City NW Florida Beaches
$299
Find similar
United Airlines
Jan 13
ECP1:10 pmPanama City NW Florida Beaches
9h 48m
2 stops
STL10:58 pmLambert-St Louis
Jan 20
STL10:07 amLambert-St Louis
6h 05m
1 stop
ECP4:12 pmPanama City NW Florida Beaches
$325
Find similar

Southwest flights from Panama City, Florida to St. Louis

Our best Southwest deals on Panama City, Florida to St. Louis flight tickets
Southwest
Apr 2
ECP2:45 pmPanama City NW Florida Beaches
7h 25m
2 stops
STL10:10 pmLambert-St Louis
Apr 5
STL5:50 pmLambert-St Louis
3h 15m
1 stop
ECP9:05 pmPanama City NW Florida Beaches
$319
Find similar
Southwest
Mar 8
ECP5:05 pmPanama City NW Florida Beaches
6h 15m
1 stop
STL11:20 pmLambert-St Louis
Mar 12
STL5:45 amLambert-St Louis
7h 05m
1 stop
ECP12:50 pmPanama City NW Florida Beaches
$339
Find similar
Southwest
Apr 1
ECP7:00 amPanama City NW Florida Beaches
7h 30m
2 stops
STL2:30 pmLambert-St Louis
Apr 5
STL8:25 amLambert-St Louis
8h 05m
2 stops
ECP4:30 pmPanama City NW Florida Beaches
$359
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Panama City, Florida to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 4/1

6:00 am-11:09 am

1 stop5h 09m

Lambert-St Louis

Mon 4/6

4:21 pm-9:22 pm

1 stop5h 01m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 1/22

4:54 pm-10:00 pm

1 stop5h 06m

Lambert-St Louis

Sun 1/25

9:57 am-9:59 pm

2 stops12h 02m

$294

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 1/22

6:30 am-4:03 pm

2 stops9h 33m

Lambert-St Louis

Sun 1/25

9:57 am-9:59 pm

2 stops12h 02m

$299

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sun 3/29

7:05 am-11:09 am

1 stop4h 04m

Lambert-St Louis

Wed 4/8

6:04 am-10:20 am

1 stop4h 16m

$314

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 4/2

2:45 pm-10:10 pm

2 stops7h 25m

Lambert-St Louis

Sun 4/5

5:50 pm-9:05 pm

1 stop3h 15m

$319

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 1/13

10:01 am-2:48 pm

1 stop4h 47m

Lambert-St Louis

Tue 1/20

6:00 am-11:08 am

1 stop5h 08m

$320

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 1/13

1:10 pm-10:58 pm

2 stops9h 48m

Lambert-St Louis

Tue 1/20

10:07 am-4:12 pm

1 stop6h 05m

$325

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sun 3/8

5:05 pm-11:20 pm

1 stop6h 15m

Lambert-St Louis

Thu 3/12

5:45 am-12:50 pm

1 stop7h 05m

$339

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 1/13

1:10 pm-10:58 pm

2 stops9h 48m

Lambert-St Louis

Tue 1/20

6:30 am-4:12 pm

2 stops9h 42m

$349

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 4/2

7:05 am-11:09 am

1 stop4h 04m

Lambert-St Louis

Thu 4/2

6:59 pm-11:04 pm

1 stop4h 05m

$357

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City, Florida to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Panama City, Florida to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $197. The month of August is another great option to travel to St. Louis, with average flight prices from Panama City, Florida averaging around $246.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $357. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $506. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest Panama City NW Florida Beaches to Lambert-St Louis flight route?

Fly from Panama City NW Florida Beaches to Lambert-St Louis for the best Panama City NW Florida Beaches - Lambert-St Louis flight prices

What cabin class options are available on Panama City NW Florida Beaches to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Panama City NW Florida Beaches to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City, Florida to St. Louis flights?

You could potentially save up to 34% on your flight if you consider stops on a Panama City, Florida to St. Louis flight.

How have Panama City, Florida to St. Louis flight prices changed over time?

When to book flights from Panama City, Florida to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to St. Louis (ECP to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to St. Louis

Best Price Found

$497

Fastest flight time

1h 55m

Direct flights

Mon, Thu, Fri and Sat

Airports in St. Louis

1 airport
The best flight deal from Panama City, Florida to St. Louis found on momondo in the last 72 hours is $497
The fastest flight from Panama City, Florida to St. Louis takes 1h 55m
Direct flights go from Panama City, Florida to St. Louis on Monday, Thursday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Panama City, Florida there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is Panama City NW Florida Beaches to Lambert-St Louis by plane?

    There are 639.0 mi between Panama City NW Florida Beaches and Lambert-St Louis. In terms of flight time, this usually takes a little over 1h 55m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City, Florida to St. Louis?

  • What is the most popular airline from Panama City, Florida to St. Louis?

Best airlines flying from Panama City, Florida to St. Louis

Compare and see reviews for airlines that fly from Panama City, Florida to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $157Free CancellationRating
8.0
4,256 reviews
Search Southwest flights
DeltaPriceFrom $206Free CancellationRating
7.9
8,018 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Collinsville
St. Peters
Wentzville
Alton
Farmington
Clayton
Glencoe
Eureka
Festus
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to St. Louis for you.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search for Panama City to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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