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Cheap flights from Panama City, Florida to Knoxville from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 6/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:40 am - 1:31 pm
ECP
-
TYS
5h 51m
1 stop
American Airlines Logo
6:05 pm - 10:40 pm
TYS
-
ECP
5h 35m
1 stop
$218American Airlines
Wed, Aug 12 - Sat, Aug 15
Southwest Logo
7:05 am - 12:00 pm
ECP
-
TYS
3h 55m
1 stop
Southwest Logo
2:05 pm - 9:00 pm
TYS
-
ECP
7h 55m
1 stop
$255Southwest
Mon, Aug 24 - Fri, Aug 28
Southwest Logo
7:05 am - 12:00 pm
ECP
-
TYS
3h 55m
1 stop
Southwest Logo
7:10 am - 12:50 pm
TYS
-
ECP
6h 40m
2 stops
$261Southwest
Mon, Aug 24 - Fri, Aug 28
Southwest Logo
5:10 am - 1:25 pm
ECP
-
TYS
7h 15m
2 stops
Southwest Logo
7:10 am - 12:50 pm
TYS
-
ECP
6h 40m
2 stops
$266Southwest
Mon, Aug 24 - Fri, Aug 28
Delta Logo
7:50 am - 1:16 pm
ECP
-
TYS
4h 26m
1 stop
Delta Logo
7:49 pm - 11:37 pm
TYS
-
ECP
4h 48m
1 stop
$284Delta
Tue, Jul 7 - Mon, Jul 13
Delta Logo
6:00 am - 11:05 am
ECP
-
TYS
4h 05m
1 stop
Delta Logo
5:45 am - 8:28 am
TYS
-
ECP
3h 43m
1 stop
$299Delta
Tue, Sep 15 - Mon, Sep 21
Southwest Logo
7:50 am - 12:00 pm
ECP
-
TYS
3h 10m
1 stop
Southwest Logo
1:35 pm - 10:00 pm
TYS
-
ECP
9h 25m
2 stops
$304Southwest
Mon, Jul 13 - Sat, Jul 18
Southwest Logo
7:40 am - 5:00 pm
ECP
-
TYS
8h 20m
2 stops
Southwest Logo
12:35 pm - 8:15 pm
TYS
-
ECP
8h 40m
2 stops
$305Southwest
Tue, Jul 7 - Mon, Jul 13
Southwest Logo
7:05 am - 5:10 pm
ECP
-
TYS
9h 05m
2 stops
Southwest Logo
7:10 am - 12:50 pm
TYS
-
ECP
6h 40m
2 stops
$309Southwest
Fri, Sep 18 - Mon, Sep 21
Delta Logo
5:30 pm - 11:50 pm
ECP
-
TYS
5h 20m
1 stop
Delta Logo
6:00 am - 8:18 am
TYS
-
ECP
3h 18m
1 stop
$319Delta
Tue, Sep 15 - Sat, Sep 19

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Delta flights from Panama City, Florida to Knoxville

Our best Delta deals on Panama City, Florida to Knoxville flight tickets
Delta
Jul 7
ECP7:50 amPanama City NW Florida Beaches
4h 26m
1 stop
TYS1:16 pmKnoxville McGhee Tyson
Jul 13
TYS7:49 pmKnoxville McGhee Tyson
4h 48m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$284
Delta
Sep 15
ECP6:00 amPanama City NW Florida Beaches
4h 05m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Sep 21
TYS5:45 amKnoxville McGhee Tyson
3h 43m
1 stop
ECP8:28 amPanama City NW Florida Beaches
$299
Delta
Sep 15
ECP5:30 pmPanama City NW Florida Beaches
5h 20m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Sep 19
TYS6:00 amKnoxville McGhee Tyson
3h 18m
1 stop
ECP8:18 amPanama City NW Florida Beaches
$319

Southwest flights from Panama City, Florida to Knoxville

Our best Southwest deals on Panama City, Florida to Knoxville flight tickets
Southwest
Aug 24
ECP7:05 amPanama City NW Florida Beaches
3h 55m
1 stop
TYS12:00 pmKnoxville McGhee Tyson
Aug 28
TYS2:05 pmKnoxville McGhee Tyson
7h 55m
1 stop
ECP9:00 pmPanama City NW Florida Beaches
$255
Southwest
Aug 24
ECP7:05 amPanama City NW Florida Beaches
3h 55m
1 stop
TYS12:00 pmKnoxville McGhee Tyson
Aug 28
TYS7:10 amKnoxville McGhee Tyson
6h 40m
2 stops
ECP12:50 pmPanama City NW Florida Beaches
$261
Southwest
Aug 24
ECP5:10 amPanama City NW Florida Beaches
7h 15m
2 stops
TYS1:25 pmKnoxville McGhee Tyson
Aug 28
TYS7:10 amKnoxville McGhee Tyson
6h 40m
2 stops
ECP12:50 pmPanama City NW Florida Beaches
$266

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 8/12

6:40 am-1:31 pm

1 stop5h 51m

Knoxville McGhee Tyson

Sat 8/15

6:05 pm-10:40 pm

1 stop5h 35m

$218

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 8/24

7:05 am-12:00 pm

1 stop3h 55m

Knoxville McGhee Tyson

Fri 8/28

2:05 pm-9:00 pm

1 stop7h 55m

$255

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 8/24

7:05 am-12:00 pm

1 stop3h 55m

Knoxville McGhee Tyson

Fri 8/28

7:10 am-12:50 pm

2 stops6h 40m

$261

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 8/24

5:10 am-1:25 pm

2 stops7h 15m

Knoxville McGhee Tyson

Fri 8/28

7:10 am-12:50 pm

2 stops6h 40m

$266

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 7/7

7:50 am-1:16 pm

1 stop4h 26m

Knoxville McGhee Tyson

Mon 7/13

7:49 pm-11:37 pm

1 stop4h 48m

$284
Quickest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 9/15

6:00 am-11:05 am

1 stop4h 05m

Knoxville McGhee Tyson

Mon 9/21

5:45 am-8:28 am

1 stop3h 43m

$299

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 7/13

7:50 am-12:00 pm

1 stop3h 10m

Knoxville McGhee Tyson

Sat 7/18

1:35 pm-10:00 pm

2 stops9h 25m

$304

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 7/7

7:40 am-5:00 pm

2 stops8h 20m

Knoxville McGhee Tyson

Mon 7/13

12:35 pm-8:15 pm

2 stops8h 40m

$305

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 9/18

7:05 am-5:10 pm

2 stops9h 05m

Knoxville McGhee Tyson

Mon 9/21

7:10 am-12:50 pm

2 stops6h 40m

$309

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 9/15

5:30 pm-11:50 pm

1 stop5h 20m

Knoxville McGhee Tyson

Sat 9/19

6:00 am-8:18 am

1 stop3h 18m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from Panama City, Florida during June instead. Flights to Knoxville in June, while not as cheap as those in April, still average around $262.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Panama City, Florida to Knoxville takes 4h 05m
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Knoxville

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 05m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $241Free CancellationRating
7.9
8,396 reviews
Search Delta flights
American AirlinesPriceFrom $282Free CancellationRating
7.1
11,635 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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