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Cheap flights from Panama City, Florida to Knoxville from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
9:19 am - 3:40 pm
ECP
-
TYS
5h 21m
1 stop
Delta Logo
5:45 am - 8:14 am
TYS
-
ECP
3h 29m
1 stop
$237Delta
Tue, Oct 6 - Thu, Oct 15
Southwest Logo
9:10 am - 7:50 pm
ECP
-
TYS
9h 40m
2 stops
Southwest Logo
7:00 am - 9:40 am
TYS
-
ECP
3h 40m
1 stop
$242Southwest
Wed, Aug 19 - Tue, Aug 25
American Airlines Logo
5:48 pm - 10:58 pm
ECP
-
TYS
4h 10m
1 stop
American Airlines Logo
5:15 am - 11:12 am
TYS
-
ECP
6h 57m
1 stop
$243American Airlines
Wed, Aug 19 - Tue, Aug 25
Delta Logo
6:20 pm - 11:55 pm
ECP
-
TYS
4h 35m
1 stop
Delta Logo
4:03 pm - 7:08 pm
TYS
-
ECP
4h 05m
1 stop
$247Delta
Mon, Sep 14 - Sat, Sep 19
Southwest Logo
9:10 am - 7:50 pm
ECP
-
TYS
9h 40m
2 stops
Southwest Logo
1:55 pm - 6:45 pm
TYS
-
ECP
5h 50m
1 stop
$248Southwest
Wed, Aug 19 - Tue, Aug 25
Southwest Logo
9:10 am - 7:50 pm
ECP
-
TYS
9h 40m
2 stops
Southwest Logo
1:55 pm - 8:30 pm
TYS
-
ECP
7h 35m
2 stops
$253Southwest
Wed, Aug 19 - Tue, Aug 25
Delta Logo
1:46 pm - 8:15 pm
ECP
-
TYS
5h 29m
1 stop
Delta Logo
10:26 am - 12:39 pm
TYS
-
ECP
3h 13m
1 stop
$259Delta
Thu, Sep 24 - Tue, Sep 29
Delta Logo
6:00 am - 11:01 am
ECP
-
TYS
4h 01m
1 stop
Delta Logo
5:45 am - 8:14 am
TYS
-
ECP
3h 29m
1 stop
$273Delta
Fri, Oct 9 - Wed, Oct 14
Delta Logo
6:00 am - 11:18 am
ECP
-
TYS
4h 18m
1 stop
Delta Logo
4:03 pm - 7:08 pm
TYS
-
ECP
4h 05m
1 stop
$278Delta
Fri, Sep 18 - Sat, Sep 19
Delta Logo
1:46 pm - 5:40 pm
ECP
-
TYS
2h 54m
1 stop
Delta Logo
12:23 pm - 3:31 pm
TYS
-
ECP
4h 08m
1 stop
$279Delta
Fri, Sep 25 - Mon, Sep 28

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American Airlines flights from Panama City, Florida to Knoxville

Our best American Airlines deals on Panama City, Florida to Knoxville flight tickets
American Airlines
Aug 19
ECP5:48 pmPanama City NW Florida Beaches
4h 10m
1 stop
TYS10:58 pmKnoxville McGhee Tyson
Aug 25
TYS5:15 amKnoxville McGhee Tyson
6h 57m
1 stop
ECP11:12 amPanama City NW Florida Beaches
$243
American Airlines
Dec 31
ECP7:19 amPanama City NW Florida Beaches
6h 02m
1 stop
TYS2:21 pmKnoxville McGhee Tyson
Jan 4
TYS11:35 amKnoxville McGhee Tyson
13h 18m
2 stops
ECP11:53 pmPanama City NW Florida Beaches
$541
American Airlines
Dec 31
ECP7:19 amPanama City NW Florida Beaches
6h 02m
1 stop
TYS2:21 pmKnoxville McGhee Tyson
Jan 4
TYS11:35 amKnoxville McGhee Tyson
13h 18m
2 stops
ECP11:53 pmPanama City NW Florida Beaches
$551

Southwest flights from Panama City, Florida to Knoxville

Our best Southwest deals on Panama City, Florida to Knoxville flight tickets
Southwest
Aug 19
ECP9:10 amPanama City NW Florida Beaches
9h 40m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Aug 25
TYS7:00 amKnoxville McGhee Tyson
3h 40m
1 stop
ECP9:40 amPanama City NW Florida Beaches
$242
Southwest
Aug 19
ECP9:10 amPanama City NW Florida Beaches
9h 40m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Aug 25
TYS1:55 pmKnoxville McGhee Tyson
5h 50m
1 stop
ECP6:45 pmPanama City NW Florida Beaches
$248
Southwest
Aug 19
ECP9:10 amPanama City NW Florida Beaches
9h 40m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Aug 25
TYS1:55 pmKnoxville McGhee Tyson
7h 35m
2 stops
ECP8:30 pmPanama City NW Florida Beaches
$253

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 10/6

9:19 am-3:40 pm

1 stop5h 21m

Knoxville McGhee Tyson

Thu 10/15

5:45 am-8:14 am

1 stop3h 29m

$237

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 8/19

9:10 am-7:50 pm

2 stops9h 40m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-9:40 am

1 stop3h 40m

$242

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 8/19

5:48 pm-10:58 pm

1 stop4h 10m

Knoxville McGhee Tyson

Tue 8/25

5:15 am-11:12 am

1 stop6h 57m

$243

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 9/14

6:20 pm-11:55 pm

1 stop4h 35m

Knoxville McGhee Tyson

Sat 9/19

4:03 pm-7:08 pm

1 stop4h 05m

$247

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 8/19

9:10 am-7:50 pm

2 stops9h 40m

Knoxville McGhee Tyson

Tue 8/25

1:55 pm-6:45 pm

1 stop5h 50m

$248

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 8/19

9:10 am-7:50 pm

2 stops9h 40m

Knoxville McGhee Tyson

Tue 8/25

1:55 pm-8:30 pm

2 stops7h 35m

$253

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 9/24

1:46 pm-8:15 pm

1 stop5h 29m

Knoxville McGhee Tyson

Tue 9/29

10:26 am-12:39 pm

1 stop3h 13m

$259

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 10/9

6:00 am-11:01 am

1 stop4h 01m

Knoxville McGhee Tyson

Wed 10/14

5:45 am-8:14 am

1 stop3h 29m

$273

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 9/18

6:00 am-11:18 am

1 stop4h 18m

Knoxville McGhee Tyson

Sat 9/19

4:03 pm-7:08 pm

1 stop4h 05m

$278
Quickest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 9/25

1:46 pm-5:40 pm

1 stop2h 54m

Knoxville McGhee Tyson

Mon 9/28

12:23 pm-3:31 pm

1 stop4h 08m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $328 to $490.
The lowest price recently found on this route was $237.

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from Panama City, Florida during June instead. Flights to Knoxville in June, while not as cheap as those in April, still average around $284.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Fastest flight time

3h 20m

Direct flights

None
The fastest flight from Panama City, Florida to Knoxville takes 3h 20m
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Knoxville

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 20m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $211Free CancellationRating
7.8
8,486 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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