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Cheap flights from Panama City, Florida to Knoxville from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Knoxville (ECP-TYS)

Cheap round-trip flights

Delta Logo
6:00 am - 10:25 amECP-TYS
3h 25m1 stop
Delta Logo
8:10 pm - 11:10 pmTYS-ECP
4h 00m1 stop
$283Delta
Find Deal
Sat, Oct 4 - Mon, Oct 6
Delta Logo
7:00 am - 10:56 amECP-TYS
2h 56m1 stop
Delta Logo
6:08 pm - 11:03 pmTYS-ECP
5h 55m1 stop
$293Delta
Find Deal
Tue, Sep 23 - Tue, Sep 30
Delta Logo
6:00 am - 10:56 amECP-TYS
3h 56m1 stop
Delta Logo
1:52 pm - 5:56 pmTYS-ECP
5h 04m1 stop
$327Delta
Find Deal
Tue, Sep 16 - Mon, Sep 22
Delta Logo
7:00 am - 1:10 pmECP-TYS
5h 10m1 stop
Delta Logo
8:10 pm - 11:10 pmTYS-ECP
4h 00m1 stop
$367Delta
Find Deal
Sat, Oct 4 - Fri, Oct 10
American Airlines Logo
6:06 pm - 11:03 pmECP-TYS
3h 57m1 stop
American Airlines Logo
8:37 pm - 11:44 pmTYS-ECP
4h 07m1 stop
$402American Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
American Airlines Logo
5:30 am - 10:31 amECP-TYS
4h 01m1 stop
American Airlines Logo
2:02 pm - 6:15 pmTYS-ECP
5h 13m1 stop
$407American Airlines
Find Deal
Sat, Oct 25 - Fri, Oct 31
American Airlines Logo
12:01 pm - 6:50 pmECP-TYS
5h 49m1 stop
American Airlines Logo
8:23 am - 11:31 amTYS-ECP
4h 08m1 stop
$436American Airlines
Find Deal
Tue, Sep 16 - Mon, Sep 22
United Airlines Logo
6:30 am - 11:44 pmECP-TYS
16h 14m1 stop
United Airlines Logo
4:55 pm - 1:47 pmTYS-ECP
21h 52m2 stops
$701United Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 7
United Airlines Logo
3:00 pm - 10:05 amECP-TYS
18h 05m2 stops
United Airlines Logo
4:55 pm - 1:47 pmTYS-ECP
21h 52m2 stops
$707United Airlines
Find Deal
Tue, Nov 4 - Fri, Nov 7
United Airlines Logo
5:00 pm - 2:43 pmECP-TYS
20h 43m2 stops
United Airlines Logo
4:55 pm - 1:47 pmTYS-ECP
21h 52m2 stops
$718United Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 7

Delta flights from Panama City, Florida to Knoxville

Our best Delta deals on Panama City, Florida to Knoxville flight tickets
Delta
Oct 4
ECP6:00 amPanama City NW Florida Beaches
3h 25m
1 stop
TYS10:25 amKnoxville McGhee Tyson
Oct 6
TYS8:10 pmKnoxville McGhee Tyson
4h 00m
1 stop
ECP11:10 pmPanama City NW Florida Beaches
$283
Find similar
Delta
Sep 23
ECP7:00 amPanama City NW Florida Beaches
2h 56m
1 stop
TYS10:56 amKnoxville McGhee Tyson
Sep 30
TYS6:08 pmKnoxville McGhee Tyson
5h 55m
1 stop
ECP11:03 pmPanama City NW Florida Beaches
$293
Find similar
Delta
Sep 16
ECP6:00 amPanama City NW Florida Beaches
3h 56m
1 stop
TYS10:56 amKnoxville McGhee Tyson
Sep 22
TYS1:52 pmKnoxville McGhee Tyson
5h 04m
1 stop
ECP5:56 pmPanama City NW Florida Beaches
$327
Find similar

American Airlines flights from Panama City, Florida to Knoxville

Our best American Airlines deals on Panama City, Florida to Knoxville flight tickets
American Airlines
Oct 4
ECP6:06 pmPanama City NW Florida Beaches
3h 57m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
Oct 10
TYS8:37 pmKnoxville McGhee Tyson
4h 07m
1 stop
ECP11:44 pmPanama City NW Florida Beaches
$402
Find similar
American Airlines
Oct 25
ECP5:30 amPanama City NW Florida Beaches
4h 01m
1 stop
TYS10:31 amKnoxville McGhee Tyson
Oct 31
TYS2:02 pmKnoxville McGhee Tyson
5h 13m
1 stop
ECP6:15 pmPanama City NW Florida Beaches
$407
Find similar
American Airlines
Sep 16
ECP12:01 pmPanama City NW Florida Beaches
5h 49m
1 stop
TYS6:50 pmKnoxville McGhee Tyson
Sep 22
TYS8:23 amKnoxville McGhee Tyson
4h 08m
1 stop
ECP11:31 amPanama City NW Florida Beaches
$436
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 10/4

6:00 am-10:25 am

1 stop3h 25m

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-11:10 pm

1 stop4h 00m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 9/23

7:00 am-10:56 am

1 stop2h 56m

Knoxville McGhee Tyson

Tue 9/30

6:08 pm-11:03 pm

1 stop5h 55m

$293

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 9/16

6:00 am-10:56 am

1 stop3h 56m

Knoxville McGhee Tyson

Mon 9/22

1:52 pm-5:56 pm

1 stop5h 04m

$327

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 10/4

7:00 am-1:10 pm

1 stop5h 10m

Knoxville McGhee Tyson

Fri 10/10

8:10 pm-11:10 pm

1 stop4h 00m

$367

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 10/4

6:06 pm-11:03 pm

1 stop3h 57m

Knoxville McGhee Tyson

Fri 10/10

8:37 pm-11:44 pm

1 stop4h 07m

$402

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 10/25

5:30 am-10:31 am

1 stop4h 01m

Knoxville McGhee Tyson

Fri 10/31

2:02 pm-6:15 pm

1 stop5h 13m

$407

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 9/16

12:01 pm-6:50 pm

1 stop5h 49m

Knoxville McGhee Tyson

Mon 9/22

8:23 am-11:31 am

1 stop4h 08m

$436

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 11/3

6:30 am-11:44 pm

1 stop16h 14m

Knoxville McGhee Tyson

Fri 11/7

4:55 pm-1:47 pm

2 stops21h 52m

$701

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

3:00 pm-10:05 am

2 stops18h 05m

Knoxville McGhee Tyson

Fri 11/7

4:55 pm-1:47 pm

2 stops21h 52m

$707

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 11/3

5:00 pm-2:43 pm

2 stops20h 43m

Knoxville McGhee Tyson

Fri 11/7

4:55 pm-1:47 pm

2 stops21h 52m

$718

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $328. If you aren’t able to travel during the month of August, then book flights to Knoxville from Panama City, Florida during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $394.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Panama City, Florida to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $498. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Panama City, Florida to Knoxville for around $663.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Direct flights

None
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 2h 56m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $286Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $312Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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