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Cheap flights from Panama City, Florida to Knoxville from $289

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:32 pm - 5:16 pm
ECP
-
TYS
2h 44m1 stop
Delta Logo
5:40 am - 9:04 am
TYS
-
ECP
4h 24m1 stop
$289Delta
Wed, Jan 14 - Sun, Jan 18
Delta Logo
6:06 pm - 11:52 pm
ECP
-
TYS
4h 46m1 stop
Delta Logo
5:30 am - 8:41 am
TYS
-
ECP
4h 11m1 stop
$317Delta
Fri, Feb 13 - Wed, Feb 18
Delta Logo
6:06 pm - 11:52 pm
ECP
-
TYS
4h 46m1 stop
Delta Logo
6:55 am - 11:25 am
TYS
-
ECP
5h 30m1 stop
$327Delta
Fri, Feb 13 - Sun, Feb 15
American Airlines Logo
4:30 pm - 11:54 pm
ECP
-
TYS
6h 24m1 stop
American Airlines Logo
7:00 am - 9:55 am
TYS
-
ECP
3h 55m1 stop
$347American Airlines
Fri, Feb 13 - Sun, Feb 15
Delta Logo
1:32 pm - 5:16 pm
ECP
-
TYS
2h 44m1 stop
Delta Logo
5:40 am - 8:39 am
TYS
-
ECP
3h 59m1 stop
$357Delta
Fri, Jan 16 - Tue, Jan 20
Delta Logo
7:05 pm - 11:46 pm
ECP
-
TYS
3h 41m1 stop
Delta Logo
7:20 pm - 10:46 pm
TYS
-
ECP
4h 26m1 stop
$363Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
7:05 pm - 11:46 pm
ECP
-
TYS
3h 41m1 stop
Delta Logo
7:20 pm - 10:46 pm
TYS
-
ECP
4h 26m1 stop
$373Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
6:00 am - 10:15 am
ECP
-
TYS
3h 15m1 stop
Delta Logo
5:40 am - 8:39 am
TYS
-
ECP
3h 59m1 stop
$429Delta
Thu, Jan 15 - Mon, Jan 19
American Airlines Logo
6:03 pm - 10:54 pm
ECP
-
TYS
3h 51m1 stop
American Airlines Logo
8:09 am - 11:33 am
TYS
-
ECP
4h 24m1 stop
$468American Airlines
Sun, Jan 18 - Tue, Jan 20
American Airlines Logo
6:03 pm - 12:46 pm
ECP
-
TYS
17h 43m2 stops
American Airlines Logo
5:15 pm - 11:33 am
TYS
-
ECP
19h 18m2 stops
$472American Airlines
Sun, Feb 1 - Fri, Feb 6

Delta flights from Panama City, Florida to Knoxville

Our best Delta deals on Panama City, Florida to Knoxville flight tickets
Delta
Feb 13
ECP6:06 pmPanama City NW Florida Beaches
4h 46m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Feb 18
TYS5:30 amKnoxville McGhee Tyson
4h 11m
1 stop
ECP8:41 amPanama City NW Florida Beaches
$317
Find similar
Delta
Feb 13
ECP6:06 pmPanama City NW Florida Beaches
4h 46m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Feb 15
TYS6:55 amKnoxville McGhee Tyson
5h 30m
1 stop
ECP11:25 amPanama City NW Florida Beaches
$327
Find similar
Delta
Feb 1
ECP3:45 pmPanama City NW Florida Beaches
3h 15m
1 stop
TYS8:00 pmKnoxville McGhee Tyson
Feb 6
TYS4:06 pmKnoxville McGhee Tyson
4h 44m
1 stop
ECP7:50 pmPanama City NW Florida Beaches
$497
Find similar

American Airlines flights from Panama City, Florida to Knoxville

Our best American Airlines deals on Panama City, Florida to Knoxville flight tickets
American Airlines
Feb 13
ECP4:30 pmPanama City NW Florida Beaches
6h 24m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
Feb 15
TYS7:00 amKnoxville McGhee Tyson
3h 55m
1 stop
ECP9:55 amPanama City NW Florida Beaches
$347
Find similar
American Airlines
Jan 18
ECP6:03 pmPanama City NW Florida Beaches
3h 51m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Jan 20
TYS8:09 amKnoxville McGhee Tyson
4h 24m
1 stop
ECP11:33 amPanama City NW Florida Beaches
$468
Find similar
American Airlines
Feb 1
ECP6:03 pmPanama City NW Florida Beaches
17h 43m
2 stops
TYS12:46 pmKnoxville McGhee Tyson
Feb 6
TYS5:15 pmKnoxville McGhee Tyson
19h 18m
2 stops
ECP11:33 amPanama City NW Florida Beaches
$472
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 1/14

1:32 pm-5:16 pm

1 stop2h 44m

Knoxville McGhee Tyson

Sun 1/18

5:40 am-9:04 am

1 stop4h 24m

$289

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 2/13

6:06 pm-11:52 pm

1 stop4h 46m

Knoxville McGhee Tyson

Wed 2/18

5:30 am-8:41 am

1 stop4h 11m

$317

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 2/13

6:06 pm-11:52 pm

1 stop4h 46m

Knoxville McGhee Tyson

Sun 2/15

6:55 am-11:25 am

1 stop5h 30m

$327

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 2/13

4:30 pm-11:54 pm

1 stop6h 24m

Knoxville McGhee Tyson

Sun 2/15

7:00 am-9:55 am

1 stop3h 55m

$347

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 1/16

1:32 pm-5:16 pm

1 stop2h 44m

Knoxville McGhee Tyson

Tue 1/20

5:40 am-8:39 am

1 stop3h 59m

$357

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 4/17

7:05 pm-11:46 pm

1 stop3h 41m

Knoxville McGhee Tyson

Mon 4/20

7:20 pm-10:46 pm

1 stop4h 26m

$363

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 4/17

7:05 pm-11:46 pm

1 stop3h 41m

Knoxville McGhee Tyson

Mon 4/20

7:20 pm-10:46 pm

1 stop4h 26m

$373

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 1/15

6:00 am-10:15 am

1 stop3h 15m

Knoxville McGhee Tyson

Mon 1/19

5:40 am-8:39 am

1 stop3h 59m

$429

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 1/18

6:03 pm-10:54 pm

1 stop3h 51m

Knoxville McGhee Tyson

Tue 1/20

8:09 am-11:33 am

1 stop4h 24m

$468

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 2/1

6:03 pm-12:46 pm

2 stops17h 43m

Knoxville McGhee Tyson

Fri 2/6

5:15 pm-11:33 am

2 stops19h 18m

$472

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $326. If you aren’t able to travel during the month of October, then book flights to Knoxville from Panama City, Florida during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $328.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Panama City, Florida to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $498. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Panama City, Florida to Knoxville for around $663.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Fastest flight time

3h 15m

Direct flights

None
The fastest flight from Panama City, Florida to Knoxville takes 3h 15m
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 15m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $258Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $298Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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