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Cheap flights from Panama City, Florida to Knoxville from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 5/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:55 am - 2:20 pm
ECP
-
TYS
5h 25m
1 stop
Southwest Logo
3:55 pm - 8:25 pm
TYS
-
ECP
5h 30m
1 stop
$257Southwest
mer., avr. 22 - sam., avr. 25
Southwest Logo
9:00 am - 7:40 pm
ECP
-
TYS
9h 40m
2 stops
Southwest Logo
6:40 am - 9:00 am
TYS
-
ECP
3h 20m
1 stop
$262Southwest
mer., avr. 22 - sam., avr. 25
Southwest Logo
10:10 am - 7:40 pm
ECP
-
TYS
8h 30m
2 stops
Southwest Logo
6:40 am - 1:00 pm
TYS
-
ECP
7h 20m
2 stops
$267Southwest
mer., avr. 22 - sam., avr. 25
Southwest Logo
7:55 am - 6:30 pm
ECP
-
TYS
9h 35m
2 stops
Southwest Logo
7:45 am - 3:45 pm
TYS
-
ECP
9h 00m
2 stops
$273Southwest
sam., avr. 25 - sam., mai 2
Southwest Logo
7:10 am - 6:10 pm
ECP
-
TYS
10h 00m
2 stops
Southwest Logo
7:45 am - 5:50 pm
TYS
-
ECP
11h 05m
1 stop
$279Southwest
jeu., mai 14 - sam., mai 16
Southwest Logo
7:10 am - 6:10 pm
ECP
-
TYS
10h 00m
2 stops
Southwest Logo
6:40 am - 4:50 pm
TYS
-
ECP
11h 10m
2 stops
$284Southwest
jeu., mai 14 - sam., mai 16
Delta Logo
7:05 am - 11:17 am
ECP
-
TYS
3h 12m
1 stop
Delta Logo
5:54 pm - 9:22 pm
TYS
-
ECP
4h 28m
1 stop
$309Delta
ven., avr. 17 - lun., avr. 20
Delta Logo
5:49 am - 11:17 am
ECP
-
TYS
4h 28m
1 stop
Delta Logo
5:54 pm - 9:22 pm
TYS
-
ECP
4h 28m
1 stop
$314Delta
ven., avr. 17 - lun., avr. 20
Southwest Logo
1:25 pm - 9:10 pm
ECP
-
TYS
6h 45m
2 stops
Southwest Logo
12:35 pm - 8:10 pm
TYS
-
ECP
8h 35m
2 stops
$318Southwest
ven., juin 5 - ven., juin 12
Delta Logo
7:05 pm - 11:46 pm
ECP
-
TYS
3h 41m
1 stop
Delta Logo
4:00 pm - 7:36 pm
TYS
-
ECP
4h 36m
1 stop
$319Delta
ven., juin 12 - lun., juin 15

Southwest flights from Panama City, Florida to Knoxville

Our best Southwest deals on Panama City, Florida to Knoxville flight tickets
Southwest
Apr 25
ECP12:40 pmPanama City NW Florida Beaches
4h 50m
1 stop
TYS6:30 pmKnoxville McGhee Tyson
May 2
TYS3:55 pmKnoxville McGhee Tyson
5h 30m
1 stop
ECP8:25 pmPanama City NW Florida Beaches
$257
Southwest
Apr 25
ECP12:40 pmPanama City NW Florida Beaches
4h 50m
1 stop
TYS6:30 pmKnoxville McGhee Tyson
May 2
TYS6:40 amKnoxville McGhee Tyson
7h 20m
2 stops
ECP1:00 pmPanama City NW Florida Beaches
$262
Southwest
Apr 22
ECP10:10 amPanama City NW Florida Beaches
8h 30m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS6:40 amKnoxville McGhee Tyson
7h 20m
2 stops
ECP1:00 pmPanama City NW Florida Beaches
$267

Delta flights from Panama City, Florida to Knoxville

Our best Delta deals on Panama City, Florida to Knoxville flight tickets
Delta
Apr 17
ECP7:05 amPanama City NW Florida Beaches
3h 12m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 20
TYS5:54 pmKnoxville McGhee Tyson
4h 28m
1 stop
ECP9:22 pmPanama City NW Florida Beaches
$309
Delta
Apr 17
ECP5:49 amPanama City NW Florida Beaches
4h 28m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 20
TYS5:54 pmKnoxville McGhee Tyson
4h 28m
1 stop
ECP9:22 pmPanama City NW Florida Beaches
$314
Delta
Jun 12
ECP7:05 pmPanama City NW Florida Beaches
3h 41m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Jun 15
TYS4:00 pmKnoxville McGhee Tyson
4h 36m
1 stop
ECP7:36 pmPanama City NW Florida Beaches
$319

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated mars 1, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

mer. 4/22

7:55 am-2:20 pm

1 stop5h 25m

Knoxville McGhee Tyson

sam. 4/25

3:55 pm-8:25 pm

1 stop5h 30m

$257

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

mer. 4/22

9:00 am-7:40 pm

2 stops9h 40m

Knoxville McGhee Tyson

sam. 4/25

6:40 am-9:00 am

1 stop3h 20m

$262

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

mer. 4/22

10:10 am-7:40 pm

2 stops8h 30m

Knoxville McGhee Tyson

sam. 4/25

6:40 am-1:00 pm

2 stops7h 20m

$267

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

sam. 4/25

7:55 am-6:30 pm

2 stops9h 35m

Knoxville McGhee Tyson

sam. 5/2

7:45 am-3:45 pm

2 stops9h 00m

$273

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

jeu. 5/14

7:10 am-6:10 pm

2 stops10h 00m

Knoxville McGhee Tyson

sam. 5/16

7:45 am-5:50 pm

1 stop11h 05m

$279

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

jeu. 5/14

7:10 am-6:10 pm

2 stops10h 00m

Knoxville McGhee Tyson

sam. 5/16

6:40 am-4:50 pm

2 stops11h 10m

$284

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ven. 4/17

7:05 am-11:17 am

1 stop3h 12m

Knoxville McGhee Tyson

lun. 4/20

5:54 pm-9:22 pm

1 stop4h 28m

$309

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ven. 4/17

5:49 am-11:17 am

1 stop4h 28m

Knoxville McGhee Tyson

lun. 4/20

5:54 pm-9:22 pm

1 stop4h 28m

$314

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ven. 6/5

1:25 pm-9:10 pm

2 stops6h 45m

Knoxville McGhee Tyson

ven. 6/12

12:35 pm-8:10 pm

2 stops8h 35m

$318

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ven. 6/12

7:05 pm-11:46 pm

1 stop3h 41m

Knoxville McGhee Tyson

lun. 6/15

4:00 pm-7:36 pm

1 stop4h 36m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $326. If you aren’t able to travel during the month of October, then book flights to Knoxville from Panama City, Florida during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $328.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Fastest flight time

4h 14m

Direct flights

None
The fastest flight from Panama City, Florida to Knoxville takes 4h 14m
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 14m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.9
8,237 reviews
Search Delta flights
American AirlinesPriceFrom $282Free CancellationRating
7.1
11,369 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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