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Cheap flights from Panama City, Florida to Knoxville from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Knoxville departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:29 pm - 11:56 pm
ECP
-
TYS
5h 27m
1 stop
Delta Logo
11:56 am - 4:37 pm
TYS
-
ECP
5h 41m
1 stop
$249Delta
Tue, May 26 - Wed, Jun 3
Southwest Logo
7:15 am - 5:10 pm
ECP
-
TYS
8h 55m
2 stops
Southwest Logo
7:05 am - 9:30 am
TYS
-
ECP
3h 25m
1 stop
$254Southwest
Tue, May 19 - Tue, May 26
Delta Logo
5:29 pm - 11:56 pm
ECP
-
TYS
5h 27m
1 stop
Delta Logo
5:40 am - 8:30 am
TYS
-
ECP
3h 50m
1 stop
$263Delta
Tue, May 26 - Sat, May 30
Southwest Logo
10:10 am - 7:40 pm
ECP
-
TYS
8h 30m
2 stops
Southwest Logo
7:05 am - 4:20 pm
TYS
-
ECP
10h 15m
2 stops
$265Southwest
Tue, May 19 - Tue, May 26
Southwest Logo
7:00 am - 7:35 pm
ECP
-
TYS
11h 35m
2 stops
Southwest Logo
7:10 am - 9:30 am
TYS
-
ECP
3h 20m
1 stop
$268Southwest
Sat, Jun 6 - Wed, Jun 10
Delta Logo
9:19 am - 1:10 pm
ECP
-
TYS
2h 51m
1 stop
Delta Logo
7:33 pm - 11:28 pm
TYS
-
ECP
4h 55m
1 stop
$274Delta
Tue, May 26 - Fri, May 29
Delta Logo
7:41 am - 2:33 pm
ECP
-
TYS
5h 52m
1 stop
Delta Logo
1:59 pm - 5:56 pm
TYS
-
ECP
4h 57m
1 stop
$277Delta
Mon, May 25 - Thu, May 28
Southwest Logo
6:35 am - 7:35 pm
ECP
-
TYS
12h 00m
2 stops
Southwest Logo
7:10 am - 4:45 pm
TYS
-
ECP
10h 35m
2 stops
$279Southwest
Sat, Jun 6 - Wed, Jun 10
Delta Logo
6:00 am - 11:09 am
ECP
-
TYS
4h 09m
1 stop
Delta Logo
3:30 pm - 7:09 pm
TYS
-
ECP
4h 39m
1 stop
$288Delta
Mon, May 25 - Fri, May 29
Delta Logo
6:00 am - 11:09 am
ECP
-
TYS
4h 09m
1 stop
Delta Logo
5:40 am - 8:30 am
TYS
-
ECP
3h 50m
1 stop
$299Delta
Fri, May 29 - Sun, May 31

United Airlines flights from Panama City, Florida to Knoxville

Our best United Airlines deals on Panama City, Florida to Knoxville flight tickets
United Airlines
Aug 11
ECP6:30 amPanama City NW Florida Beaches
10h 35m
1 stop
TYS6:05 pmKnoxville McGhee Tyson
Aug 12
TYS1:48 pmKnoxville McGhee Tyson
20h 51m
1 stop
ECP9:39 amPanama City NW Florida Beaches
$882
United Airlines
May 8
ECP10:30 amPanama City NW Florida Beaches
22h 36m
1 stop
TYS10:06 amKnoxville McGhee Tyson
May 10
TYS7:00 amKnoxville McGhee Tyson
16h 05m
2 stops
ECP10:05 pmPanama City NW Florida Beaches
$885
United Airlines
Aug 11
ECP6:30 amPanama City NW Florida Beaches
16h 55m
2 stops
TYS12:25 amKnoxville McGhee Tyson
Aug 12
TYS5:57 pmKnoxville McGhee Tyson
16h 42m
1 stop
ECP9:39 amPanama City NW Florida Beaches
$887

Southwest flights from Panama City, Florida to Knoxville

Our best Southwest deals on Panama City, Florida to Knoxville flight tickets
Southwest
May 19
ECP7:15 amPanama City NW Florida Beaches
8h 55m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
May 26
TYS7:05 amKnoxville McGhee Tyson
3h 25m
1 stop
ECP9:30 amPanama City NW Florida Beaches
$254
Southwest
May 19
ECP10:10 amPanama City NW Florida Beaches
8h 30m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
May 26
TYS7:05 amKnoxville McGhee Tyson
10h 15m
2 stops
ECP4:20 pmPanama City NW Florida Beaches
$265
Southwest
Jun 6
ECP7:00 amPanama City NW Florida Beaches
11h 35m
2 stops
TYS7:35 pmKnoxville McGhee Tyson
Jun 10
TYS7:10 amKnoxville McGhee Tyson
3h 20m
1 stop
ECP9:30 amPanama City NW Florida Beaches
$268

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/26

5:29 pm-11:56 pm

1 stop5h 27m

Knoxville McGhee Tyson

Wed 6/3

11:56 am-4:37 pm

1 stop5h 41m

$249

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/19

7:15 am-5:10 pm

2 stops8h 55m

Knoxville McGhee Tyson

Tue 5/26

7:05 am-9:30 am

1 stop3h 25m

$254

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/26

5:29 pm-11:56 pm

1 stop5h 27m

Knoxville McGhee Tyson

Sat 5/30

5:40 am-8:30 am

1 stop3h 50m

$263

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/19

10:10 am-7:40 pm

2 stops8h 30m

Knoxville McGhee Tyson

Tue 5/26

7:05 am-4:20 pm

2 stops10h 15m

$265

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 6/6

7:00 am-7:35 pm

2 stops11h 35m

Knoxville McGhee Tyson

Wed 6/10

7:10 am-9:30 am

1 stop3h 20m

$268
Quickest round-trip

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/26

9:19 am-1:10 pm

1 stop2h 51m

Knoxville McGhee Tyson

Fri 5/29

7:33 pm-11:28 pm

1 stop4h 55m

$274

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 5/25

7:41 am-2:33 pm

1 stop5h 52m

Knoxville McGhee Tyson

Thu 5/28

1:59 pm-5:56 pm

1 stop4h 57m

$277

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 6/6

6:35 am-7:35 pm

2 stops12h 00m

Knoxville McGhee Tyson

Wed 6/10

7:10 am-4:45 pm

2 stops10h 35m

$279

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 5/25

6:00 am-11:09 am

1 stop4h 09m

Knoxville McGhee Tyson

Fri 5/29

3:30 pm-7:09 pm

1 stop4h 39m

$288

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 5/29

6:00 am-11:09 am

1 stop4h 09m

Knoxville McGhee Tyson

Sun 5/31

5:40 am-8:30 am

1 stop3h 50m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Panama City, Florida to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Panama City, Florida, with most prices found around $326. If you aren’t able to travel during the month of October, then book flights to Knoxville from Panama City, Florida during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $328.

When to book flights from Panama City, Florida to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Knoxville (ECP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Knoxville

Fastest flight time

2h 52m

Direct flights

None
The fastest flight from Panama City, Florida to Knoxville takes 2h 52m
There are no direct flights from Panama City, Florida to Knoxville. There are no popular flight routes from Panama City, Florida to Knoxville.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Knoxville

  • How far is Panama City NW Florida Beaches to Knoxville McGhee Tyson by plane?

    There are 413.0 mi between Panama City NW Florida Beaches and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 2h 52m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Knoxville?

Best airlines flying from Panama City, Florida to Knoxville

Compare and see reviews for airlines that fly from Panama City, Florida to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.9
8,466 reviews
Search Delta flights
American AirlinesPriceFrom $282Free CancellationRating
7.1
11,678 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Knoxville?

Finding the right flight to Knoxville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Panama City to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama City to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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