Cheap flights from Panama City, Florida to Chicago from $173

The month of January is, on average, the cheapest month to fly to Chicago from Panama City, Florida, with most prices found around $269. If you’re not able to fly to Chicago in January, then February is your next best option. Flight prices from Panama City, Florida to Chicago during February average around $292.

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $410. This is often the case because there is less demand to fly during this day of the week. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Panama City, Florida to Chicago for around $566.

Fly from Panama City NW Florida Beaches to Chicago O'Hare Intl for the best Panama City NW Florida Beaches - Chicago flight prices

You are more likely to see cheaper flights to Chicago from Panama City, Florida when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $386 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama City, Florida for as low as $247 on momondo.

There are 4 cabin classes available to choose from on Panama City, Florida to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

As of October 2026, prices for Panama City, Florida to Chicago flights are approximately 45% cheaper when compared to flights at the same time last year.

Delta, American Airlines, and United Airlines are the most popular carriers operating from Panama City NW Florida Beaches to Chicago

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Chicago from Panama City, Florida according to our data. United Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 6 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

1 flights are operational daily from Panama City, Florida to Chicago as of October 2026. The most popular departure time for this route is 2:00PM, with 100% of flights per day taking off in the afternoon.

As of October 2026, 7 flights take off from Panama City, Florida and land in Chicago each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.